Influenza matrix 1-specific human CD4 +FOXP3 + and FOXP3 - regulatory T cells can be detected long after viral clearance

European Journal of Immunology

Volumn 40, Issue 11, 2010, Pages 3064-3074

  Piersma, Sytse J ^a   van der Hulst, Jeanette M ^a   Kwappenberg, Kitty M C ^a   Goedemans, Renske ^a   van der Minne, Caroline E ^a   van der Burg, Sjoerd H ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Acute infection; Human; IL 10; Influenza virus; Treg

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; IL10 PROTEIN, HUMAN; IL2 PROTEIN, HUMAN; MATRIX PROTEIN;

ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; HELPER CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLUENZA; LYMPHOCYTE CLONE; LYMPHOCYTE SUBPOPULATION; NORMAL HUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR UPREGULATION; REGULATORY T LYMPHOCYTE; VIRAL CLEARANCE; ANIMAL; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; INFLUENZA VIRUS A; MOUSE;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNE TOLERANCE; INFLUENZA A VIRUS; INTERLEUKIN-10; INTERLEUKIN-2; MICE; RECEPTORS, INTERLEUKIN-2; T-LYMPHOCYTES, REGULATORY; VIRAL MATRIX PROTEINS;

EID: 79952109414     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200940177     Document Type: Article

References (39)

1. Piersma, S. J., Welters, M. J. and van der Burg, S. H., Tumor-specific regulatory T cells in cancer patients. Hum. Immunol. 2008. 69: 241-249.
2. Kretschmer, K., Apostolou, I., Hawiger, D., Khazaie, K., Nussenzweig, M. C. and von Boehmer, H., Inducing and expanding regulatory T cell populations by foreign antigen. Nat. Immunol. 2005. 6: 1219-1227.
3. Zhou, G., Drake, C. G. and Levitsky, H. I., Amplification of tumor-specific regulatory T cells following therapeutic cancer vaccines. Blood 2006. 107: 628-636.
4. Curotto de Lafaille, M. A., Kutchukhidze, N., Shen, S., Ding, Y., Yee, H. and Lafaille, J. J., Adaptive Foxp31regulatory T cell-dependent and -independent control of allergic inflammation. Immunity 2008. 29: 114-126.
5. van der Burg, S. H., Piersma, S. J., de Jong, A., van der Hulst, J. M., Kwappenberg, K. M., van den Hende, M., Welters, M. J. et al., Association of cervical cancer with the presence of CD4+regulatory T cells specific for human papillomavirus antigens. Proc. Natl. Acad. Sci. USA 2007. 104: 12087-12092.
6. Suffia, I. J., Reckling, S. K., Piccirillo, C. A., Goldszmid, R. S. and Belkaid, Y., Infected site-restricted Foxp31natural regulatory T cells are specific for microbial antigens. J. Exp. Med. 2006. 203: 777-788.
7. Ebinuma, H., Nakamoto, N., Li, Y., Price, D. A., Gostick, E., Levine, B. L., Tobias, J. et al., Identification and in vitro expansion of functional antigen-specific CD25+FoxP3+regulatory T cells in hepatitis C virus infection. J. Virol. 2008. 82: 5043-5053.
8. de Vos van Steenwijk, P. J., Piersma, S. J., Welters, M. J., van der Hulst, J. M., Fleuren, G., Hellebrekers, B. W., Kenter, G. G. and van der Burg, S. H., Surgery followed by persistence of high-grade squamous intraepithelial lesions is associated with the induction of a dysfunctional HPV16-specific T-cell response. Clin. Cancer Res. 2008. 14: 7188-7195.
9. Belkaid, Y., Regulatory T cells and infection: a dangerous necessity. Nat. Rev. Immunol. 2007. 7: 875-888.
10. Rouse, B. T., Sarangi, P. P. and Suvas, S., Regulatory T cells in virus infections. Immunol. Rev. 2006. 212: 272-286.
11. Wong, S. S. Y. and Yuen, K., Avian influenza virus infections in humans. Chest 2006. 129: 156-168.
12. Rothberg, M. B., Haessler, S. D. and Brown, R. B., Complications of viral influenza. Am. J. Med. 2008. 121: 258-264.
13. Carding, S. R., Allan, W., McMickle, A. and Doherty, P. C., Activation of cytokine genes in T cells during primary and secondary murine influenza pneumonia. J. Exp. Med. 1993. 177: 475-482.
14. Moore, K. W., de Waal Malefyt, R., Coffman, R. L. and O'Garra, A., Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 2001. 19: 683-765.
15. Debes, G. F., Dahl, M. E., Mahiny, A. J., Bonhagen, K., Campbell, D. J., Siegmund, K., Erb, K. J., et al., Chemotactic responses of IL-4-, IL-10-, and IFN-gamma-producing CD4+T cells depend on tissue origin and microbial stimulus. J. Immunol. 2006. 176: 557-566.
16. de Jong, A., van der Hulst, J. M., Kenter, G. G., Drijfhout, J. W., Franken, K. L., Vermeij, P., Offringa, R. et al., Rapid enrichment of human papillomavirus (HPV)-specific polyclonal T cell populations for adoptive immunotherapy of cervical cancer. Int. J. Cancer 2005. 114: 274-282.
17. van der Burg, S. H., Ressing, M. E., Kwappenberg, K. M., de Jong, A., Straathof, K., de Jong, J., Geluk, A. et al., Natural T-helper immunity against human papillomavirus type 16 (HPV16) E7-derived peptide epitopes in patients with HPV16-positive cervical lesions: identification of 3 human leukocyte antigen class II-restricted epitopes. Int. J. Cancer 2001. 91: 612-618.
18. Welters, M. J., de Jong, A., van den Eeden, S. J., van der Hulst, J. M., Kwappenberg, K. M., Hassane, S., Franken, K. L. et al., Frequent display of human papillomavirus type 16 E6-specific memory t-Helper cells in the healthy population as witness of previous viral encounter. Cancer Res 2003. 63: 636-641.
19. Welters, M. J., van der Logt, P., van den Eeden, S. J., Kwappenberg, K. M., Drijfhout, J. W., Fleuren, G. J., Kenter, G. G. et al., Detection of human papillomavirus type 18 E6 and E7-specific CD4+T-helper 1 immunity in relation to health versus disease. Int. J. Cancer 2006. 118: 950-956.
20. Wang, H. Y., Lee, D. A., Peng, G., Guo, Z., Li, Y., Kiniwa, Y., Shevach, E. M. and Wang, R. F., Tumor-specific human CD4+regulatory T cells and their ligands: implications for immunotherapy. Immunity 2004. 20: 107-118.
21. Shevach, E. M., McHugh, R. S., Piccirillo, C. A. and Thornton, A. M., Control of T-cell activation by CD4+CD25+suppressor T cells. Immunol. Rev. 2001. 182: 58-67.
22. Waldmann, T. A., The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design. Nat. Rev. Immunol. 2006. 6: 595-601.
23. Sabbagh, L., Snell, L. M. and Watts, T. H., TNF family ligands define niches for T cell memory. Trends Immunol. 2007. 28: 333-339.
24. Piccirillo, C. A. and Shevach, E. M., Cutting edge: control of CD8+T cell activation by CD4+CD25+immunoregulatory cells. J. Immunol. 2001. 167: 1137-1140.
25. O'Garra, A. and Vieira, P., T(H)1 cells control themselves by producing interleukin-10. Nat. Rev. Immunol. 2007. 7: 425-428.
26. Chen, J. and Liu, X. S., Development and function of IL-10 IFN-gamma-secreting CD4(+) T cells. J. Leukoc. Biol. 2009. 86: 1305-1310.
27. Liu, X. S., Leerberg, J., MacDonald, K., Leggatt, G. R. and Frazer, I. H., IFN-gamma promotes generation of IL-10 secreting CD4+T cells that suppress generation of CD8 responses in an antigen-experienced host. J. Immunol. 2009. 183: 51-58.
28. Torheim, E. A., Ndhlovu, L. C., Pettersen, F. O., Larsen, T. L., Jha, A. R., Torgersen, K. M., Kvale, D. et al., Interleukin-10-secreting T cells define a suppressive subset within the HIV-1-specific T-cell population. Eur. J. Immunol. 2009. 39: 1280-1287.
29. Cheung, C. Y., Poon, L. L., Lau, A. S., Luk, W., Lau, Y. L., Shortridge, K. F., Gordon, S. et al., Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease? Lancet 2002. 360: 1831-1837.
30. de Jong, M. D., Simmons, C. P., Thanh, T. T., Hien, V. M., Smith, G. J., Chau, T. N., Hoang, D. M. et al., Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat. Med. 2006. 12: 1203-1207.
31. dKobasa, D., Jones, S. M., Shinya, K., Kash, J. C., Copps, J., Ebihara, H., Hatta, Y. et al., Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature 2007. 445: 319-323.
32. Sun, J., Madan, R., Karp, C. L. and Braciale, T. J., Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10. Nat. Med. 2009. 15: 277-284.
33. Thornton, A. M. and Shevach, E. M., CD4+CD25+immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med.s 1998. 188: 287-296.
34. Dieckmann, D., Plottner, H., Berchtold, S., Berger, T. and Schuler, G., Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood. J. Exp. Med. 2001. 193: 1303-1310.
35. Jonuleit, H., Schmitt, E., Stassen, M., Tuettenberg, A., Knop, J. and Enk, A. H., Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J. Exp. Med. 2001. 193: 1285-1294.
36. Rubtsov, Y. P., Rasmussen, J. P., Chi, E. Y., Fontenot, J., Castelli, L., Ye, X., Treuting, P. et al., Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity 2008. 28: 546-558.
37. Letourneau, S., Krieg, C., Pantaleo, G. and Boyman, O., IL-2- and CD25-dependent immunoregulatory mechanisms in the homeostasis of T-cell subsets. J. Allergy Clin. Immunol. 2009. 123: 758-762.
38. Piersma, S. J., Welters, M. J., van der Hulst, J. M., Kloth, J. N., Kwappenberg, K. M., Trimbos, B. J., Melief, C. J. et al., Human papilloma virus specific T cells infiltrating cervical cancer and draining lymph nodes show remarkably frequent use of HLA-DQ and -DP as a restriction element. Int. J. Cancer 2008. 122: 486-494.
39. Welters, M. J. P., Kenter, G. G., Piersma, S. J., Vloon, A. P. G., Löwik, M. J. G., Berends-van der Meer, T. M. A., Drijfhout, J. W. et al., Induction of tumorspecific CD4+and CD8+T-cell immunity in cervical cancer patients by a human papillomavirus type 16 E6 and E7 long peptides vaccine. Clin. Cancer Res. 2008. 14: 178-187.