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Volumn 46, Issue 3, 2011, Pages 212-219

MBD2 contributes to developmental silencing of the human ε-globin gene

Author keywords

DNA methylation; Embryonic gene silencing; Globin gene; MBD2; Red cell

Indexed keywords

AZACITIDINE; BETA GLOBIN; BINDING PROTEIN; EPSILON GLOBIN; GAMMA GLOBIN; METHYLCYTOSINE BINDING DOMAIN PROTEIN 2; UNCLASSIFIED DRUG;

EID: 79952105619     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcmd.2011.01.001     Document Type: Article
Times cited : (14)

References (55)
  • 1
    • 78649348968 scopus 로고    scopus 로고
    • Decitabine increases fetal hemoglobin in P. anubis by increasing gamma-globin gene transcription
    • Akpan I., Banzon V., Ibanez V., et al. Decitabine increases fetal hemoglobin in P. anubis by increasing gamma-globin gene transcription. Exp. Hematol. 2010.
    • (2010) Exp. Hematol.
    • Akpan, I.1    Banzon, V.2    Ibanez, V.3
  • 3
    • 0004959517 scopus 로고
    • Treatment of sickle cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with nonrandom hypomethylation of DNA around the gamma-delta-beta-globin gene complex
    • Charache S., Dover G.J., Smith K. Treatment of sickle cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with nonrandom hypomethylation of DNA around the gamma-delta-beta-globin gene complex. Proc. Natl Acad. Sci. USA 1983, 80:4842-4846.
    • (1983) Proc. Natl Acad. Sci. USA , vol.80 , pp. 4842-4846
    • Charache, S.1    Dover, G.J.2    Smith, K.3
  • 4
    • 70249103769 scopus 로고    scopus 로고
    • Transcriptional activation of the gamma-globin gene in baboons treated with decitabine and in cultured erythroid progenitor cells involves different mechanisms
    • Chin J., Singh M., Banzon V., et al. Transcriptional activation of the gamma-globin gene in baboons treated with decitabine and in cultured erythroid progenitor cells involves different mechanisms. Exp. Hematol. 2009, 37:1131-1142.
    • (2009) Exp. Hematol. , vol.37 , pp. 1131-1142
    • Chin, J.1    Singh, M.2    Banzon, V.3
  • 5
    • 0024466232 scopus 로고
    • On the induction of fetal hemoglobin by butyrates: in vivo and in vitro studies with sodium butyrate and comparison of combination treatments with 5-AzaC and AraC
    • Constantoulakis P., Knitter G., Stamatoyannopoulos G. On the induction of fetal hemoglobin by butyrates: in vivo and in vitro studies with sodium butyrate and comparison of combination treatments with 5-AzaC and AraC. Blood 1989, 74:1963-1971.
    • (1989) Blood , vol.74 , pp. 1963-1971
    • Constantoulakis, P.1    Knitter, G.2    Stamatoyannopoulos, G.3
  • 6
    • 0344826011 scopus 로고    scopus 로고
    • Induction of an embryonic globin gene promoter by short-chain fatty acids
    • Dempsey N.J., Ojalvo L.S., Wu D.W., Little J.A. Induction of an embryonic globin gene promoter by short-chain fatty acids. Blood 2003, 102:4214-4222.
    • (2003) Blood , vol.102 , pp. 4214-4222
    • Dempsey, N.J.1    Ojalvo, L.S.2    Wu, D.W.3    Little, J.A.4
  • 7
    • 0000206049 scopus 로고
    • 5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons
    • DeSimone J., Heller P., Hall L., Zwiers D. 5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons. Proc. Natl. Acad. Sci. USA 1982, 79:4428-4431.
    • (1982) Proc. Natl. Acad. Sci. USA , vol.79 , pp. 4428-4431
    • DeSimone, J.1    Heller, P.2    Hall, L.3    Zwiers, D.4
  • 8
    • 0022270517 scopus 로고
    • Detection of an epsilon chain in baboons after treatment with 5-azacytidine
    • DeSimone J., Schroeder W.A., Shelton J.B., et al. Detection of an epsilon chain in baboons after treatment with 5-azacytidine. Hemoglobin 1985, 9:217-226.
    • (1985) Hemoglobin , vol.9 , pp. 217-226
    • DeSimone, J.1    Schroeder, W.A.2    Shelton, J.B.3
  • 9
    • 0025891950 scopus 로고
    • Human gamma-globin genes silenced independently of other genes in the beta-globin locus
    • Dillon N., Grosveld F. Human gamma-globin genes silenced independently of other genes in the beta-globin locus. Nature 1991, 350:252-254.
    • (1991) Nature , vol.350 , pp. 252-254
    • Dillon, N.1    Grosveld, F.2
  • 10
    • 0025329590 scopus 로고
    • Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice
    • Enver T., Raich N., Ebens A., et al. Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice. Nature 1990, 344:309-313.
    • (1990) Nature , vol.344 , pp. 309-313
    • Enver, T.1    Raich, N.2    Ebens, A.3
  • 11
    • 0035312289 scopus 로고    scopus 로고
    • The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes
    • Feng Q., Zhang Y. The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes. Genes Dev. 2001, 15:827-832.
    • (2001) Genes Dev. , vol.15 , pp. 827-832
    • Feng, Q.1    Zhang, Y.2
  • 12
    • 0025866045 scopus 로고
    • Physical mapping of yeast artificial chromosomes containing sequences from the human beta-globin gene region
    • Gaensler K.M., Burmeister M., Brownstein B.H., Taillon-Miller P., Myers R.M. Physical mapping of yeast artificial chromosomes containing sequences from the human beta-globin gene region. Genomics 1991, 10:976-984.
    • (1991) Genomics , vol.10 , pp. 976-984
    • Gaensler, K.M.1    Burmeister, M.2    Brownstein, B.H.3    Taillon-Miller, P.4    Myers, R.M.5
  • 13
    • 0027443269 scopus 로고
    • Germ-line transmission and developmental regulation of a 150-kb yeast artificial chromosome containing the human beta-globin locus in transgenic mice
    • Gaensler K.M., Kitamura M., Kan Y.W. Germ-line transmission and developmental regulation of a 150-kb yeast artificial chromosome containing the human beta-globin locus in transgenic mice. Proc. Natl. Acad. Sci. USA 1993, 90:11381-11385.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 11381-11385
    • Gaensler, K.M.1    Kitamura, M.2    Kan, Y.W.3
  • 14
    • 39049132485 scopus 로고    scopus 로고
    • The role of the epigenetic signal, DNA methylation, in gene regulation during erythroid development
    • Ginder G.D., Gnanapragasam M.N., Mian O.Y. The role of the epigenetic signal, DNA methylation, in gene regulation during erythroid development. Curr. Top. Dev. Biol. 2008, 82:85-116.
    • (2008) Curr. Top. Dev. Biol. , vol.82 , pp. 85-116
    • Ginder, G.D.1    Gnanapragasam, M.N.2    Mian, O.Y.3
  • 15
    • 0021203873 scopus 로고
    • Activation of a chicken embryonic globin gene in adult erythroid cells by 5-azacytidine and sodium butyrate
    • Ginder G.D., Whitters M.J., Pohlman J.K. Activation of a chicken embryonic globin gene in adult erythroid cells by 5-azacytidine and sodium butyrate. Proc. Natl. Acad. Sci. USA 1984, 81:3954-3958.
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 3954-3958
    • Ginder, G.D.1    Whitters, M.J.2    Pohlman, J.K.3
  • 16
    • 0036678156 scopus 로고    scopus 로고
    • A human embryonic hemoglobin inhibits Hb S polymerization in vitro and restores a normal phenotype to mouse models of sickle cell disease
    • He Z., Russell J.E. A human embryonic hemoglobin inhibits Hb S polymerization in vitro and restores a normal phenotype to mouse models of sickle cell disease. Proc. Natl. Acad. Sci. USA 2002, 99:10635-10640.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 10635-10640
    • He, Z.1    Russell, J.E.2
  • 17
    • 34347342790 scopus 로고    scopus 로고
    • CpG hypomethylation in a large domain encompassing the embryonic {beta}-like globin genes in primitive erythrocytes
    • Hsu M., Mabaera R., Lowrey C.H., Martin D.I., Fiering S. CpG hypomethylation in a large domain encompassing the embryonic {beta}-like globin genes in primitive erythrocytes. Mol. Cell. Biol. 2007, 27:5047-5054.
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 5047-5054
    • Hsu, M.1    Mabaera, R.2    Lowrey, C.H.3    Martin, D.I.4    Fiering, S.5
  • 18
    • 0031837109 scopus 로고    scopus 로고
    • Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
    • Jones P.L., Veenstra G.J., Wade P.A., et al. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat. Genet. 1998, 19:187-191.
    • (1998) Nat. Genet. , vol.19 , pp. 187-191
    • Jones, P.L.1    Veenstra, G.J.2    Wade, P.A.3
  • 20
    • 33749465873 scopus 로고    scopus 로고
    • MBD2 is a critical component of a methyl cytosine-binding protein complex isolated from primary erythroid cells
    • Kransdorf E.P., Wang S.Z., Zhu S.Z., et al. MBD2 is a critical component of a methyl cytosine-binding protein complex isolated from primary erythroid cells. Blood 2006, 108:2836-2845.
    • (2006) Blood , vol.108 , pp. 2836-2845
    • Kransdorf, E.P.1    Wang, S.Z.2    Zhu, S.Z.3
  • 21
    • 35548990205 scopus 로고    scopus 로고
    • Oral decitabine reactivates expression of the methylated gamma-globin gene in Papio anubis
    • Lavelle D., Chin J., Vaitkus K., et al. Oral decitabine reactivates expression of the methylated gamma-globin gene in Papio anubis. Am. J. Hematol. 2007, 82:981-985.
    • (2007) Am. J. Hematol. , vol.82 , pp. 981-985
    • Lavelle, D.1    Chin, J.2    Vaitkus, K.3
  • 22
    • 0020466344 scopus 로고
    • 5-Azacytidine selectively increases gamma-globin synthesis in a patient with beta+ thalassemia
    • Ley T.J., DeSimone J., Anagnou N.P., et al. 5-Azacytidine selectively increases gamma-globin synthesis in a patient with beta+ thalassemia. N. Engl. J. Med. 1982, 307:1469-1475.
    • (1982) N. Engl. J. Med. , vol.307 , pp. 1469-1475
    • Ley, T.J.1    DeSimone, J.2    Anagnou, N.P.3
  • 24
    • 38049156451 scopus 로고    scopus 로고
    • Neither DNA hypomethylation nor changes in the kinetics of erythroid differentiation explain 5-azacytidine's ability to induce human fetal hemoglobin
    • Mabaera R., Greene M.R., Richardson C.A., et al. Neither DNA hypomethylation nor changes in the kinetics of erythroid differentiation explain 5-azacytidine's ability to induce human fetal hemoglobin. Blood 2008, 111:411-420.
    • (2008) Blood , vol.111 , pp. 411-420
    • Mabaera, R.1    Greene, M.R.2    Richardson, C.A.3
  • 25
    • 0034927094 scopus 로고    scopus 로고
    • Valproic acid, trichostatin and their combination with hemin preferentially enhance gamma-globin gene expression in human erythroid liquid cultures
    • Marianna P., Kollia P., Akel S., et al. Valproic acid, trichostatin and their combination with hemin preferentially enhance gamma-globin gene expression in human erythroid liquid cultures. Haematologica 2001, 86:700-705.
    • (2001) Haematologica , vol.86 , pp. 700-705
    • Marianna, P.1    Kollia, P.2    Akel, S.3
  • 26
    • 0021034956 scopus 로고
    • Molecular mechanisms of human hemoglobin switching: selective undermethylation and expression of globin genes in embryonic, fetal, and adult erythroblasts
    • Mavilio F., Giampaolo A., Care A., et al. Molecular mechanisms of human hemoglobin switching: selective undermethylation and expression of globin genes in embryonic, fetal, and adult erythroblasts. Proc. Natl. Acad. Sci. USA 1983, 80:6907-6911.
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 6907-6911
    • Mavilio, F.1    Giampaolo, A.2    Care, A.3
  • 27
    • 0018774697 scopus 로고
    • Specific DNA methylation sites in the vicinity of the chicken beta-globin genes
    • McGhee J.D., Ginder G.D. Specific DNA methylation sites in the vicinity of the chicken beta-globin genes. Nature 1979, 280:419-420.
    • (1979) Nature , vol.280 , pp. 419-420
    • McGhee, J.D.1    Ginder, G.D.2
  • 28
    • 0035051594 scopus 로고    scopus 로고
    • Sequences flanking hypersensitive sites of the beta-globin locus control region are required for synergistic enhancement
    • Molete J.M., Petrykowska H., Bouhassira E.E., et al. Sequences flanking hypersensitive sites of the beta-globin locus control region are required for synergistic enhancement. Mol. Cell. Biol. 2001, 21:2969-2980.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 2969-2980
    • Molete, J.M.1    Petrykowska, H.2    Bouhassira, E.E.3
  • 29
    • 0032574977 scopus 로고    scopus 로고
    • Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
    • Nan X., Ng H.H., Johnson C.A., et al. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 1998, 393:386-389.
    • (1998) Nature , vol.393 , pp. 386-389
    • Nan, X.1    Ng, H.H.2    Johnson, C.A.3
  • 30
    • 33644682311 scopus 로고    scopus 로고
    • Investigations of a human embryonic globin gene silencing element using YAC transgenic mice
    • Navas P.A., Li Q., Peterson K.R., Stamatoyannopoulos G. Investigations of a human embryonic globin gene silencing element using YAC transgenic mice. Exp. Biol. Med. (Maywood) 2006, 231:328-334.
    • (2006) Exp. Biol. Med. (Maywood) , vol.231 , pp. 328-334
    • Navas, P.A.1    Li, Q.2    Peterson, K.R.3    Stamatoyannopoulos, G.4
  • 31
    • 0022273995 scopus 로고
    • Pharmacological manipulation of fetal hemoglobin synthesis in patients with severe beta-thalassemia
    • Nienhuis A.W., Ley T.J., Humphries R.K., Young N.S., Dover G. Pharmacological manipulation of fetal hemoglobin synthesis in patients with severe beta-thalassemia. Ann. NY Acad. Sci. 1985, 445:198-211.
    • (1985) Ann. NY Acad. Sci. , vol.445 , pp. 198-211
    • Nienhuis, A.W.1    Ley, T.J.2    Humphries, R.K.3    Young, N.S.4    Dover, G.5
  • 32
    • 0028170523 scopus 로고
    • Alpha-Amino butyric acid cannot reactivate the silenced gamma gene of the beta locus YAC transgenic mouse
    • Pace B., Li Q., Peterson K., Stamatoyannopoulos G. alpha-Amino butyric acid cannot reactivate the silenced gamma gene of the beta locus YAC transgenic mouse. Blood 1994, 84:4344-4353.
    • (1994) Blood , vol.84 , pp. 4344-4353
    • Pace, B.1    Li, Q.2    Peterson, K.3    Stamatoyannopoulos, G.4
  • 33
    • 0037114756 scopus 로고    scopus 로고
    • Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo
    • Pace B.S., White G.L., Dover G.J., et al. Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo. Blood 2002, 100:4640-4648.
    • (2002) Blood , vol.100 , pp. 4640-4648
    • Pace, B.S.1    White, G.L.2    Dover, G.J.3
  • 34
    • 0027078611 scopus 로고
    • A short-term trial of butyrate to stimulate fetal-globin-gene expression in the beta-globin disorders
    • Perrine S.P., Ginder G.D., Faller D.V., et al. A short-term trial of butyrate to stimulate fetal-globin-gene expression in the beta-globin disorders. N. Engl. J. Med. 1993, 328:81-86.
    • (1993) N. Engl. J. Med. , vol.328 , pp. 81-86
    • Perrine, S.P.1    Ginder, G.D.2    Faller, D.V.3
  • 35
    • 0023525824 scopus 로고
    • Butyric acid analogues augment gamma globin gene expression in neonatal erythroid progenitors
    • Perrine S.P., Miller B.A., Greene M.F., et al. Butyric acid analogues augment gamma globin gene expression in neonatal erythroid progenitors. Biochem. Biophys. Res. Commun. 1987, 148:694-700.
    • (1987) Biochem. Biophys. Res. Commun. , vol.148 , pp. 694-700
    • Perrine, S.P.1    Miller, B.A.2    Greene, M.F.3
  • 37
    • 0027443260 scopus 로고
    • Use of yeast artificial chromosomes (YACs) for studying control of gene expression: correct regulation of the genes of a human beta-globin locus YAC following transfer to mouse erythroleukemia cell lines
    • Peterson K.R., Zitnik G., Huxley C., et al. Use of yeast artificial chromosomes (YACs) for studying control of gene expression: correct regulation of the genes of a human beta-globin locus YAC following transfer to mouse erythroleukemia cell lines. Proc. Natl. Acad. Sci. USA 1993, 90:11207-11211.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 11207-11211
    • Peterson, K.R.1    Zitnik, G.2    Huxley, C.3
  • 38
    • 0028939923 scopus 로고
    • GATA1 and YY1 are developmental repressors of the human epsilon-globin gene
    • Raich N., Clegg C.H., Grofti J., Romeo P.H., Stamatoyannopoulos G. GATA1 and YY1 are developmental repressors of the human epsilon-globin gene. EMBO J. 1995, 14:801-809.
    • (1995) EMBO J. , vol.14 , pp. 801-809
    • Raich, N.1    Clegg, C.H.2    Grofti, J.3    Romeo, P.H.4    Stamatoyannopoulos, G.5
  • 39
    • 0025602457 scopus 로고
    • Autonomous developmental control of human embryonic globin gene switching in transgenic mice
    • Raich N., Enver T., Nakamoto B., et al. Autonomous developmental control of human embryonic globin gene switching in transgenic mice. Science 1990, 250:1147-1149.
    • (1990) Science , vol.250 , pp. 1147-1149
    • Raich, N.1    Enver, T.2    Nakamoto, B.3
  • 40
    • 33646267956 scopus 로고    scopus 로고
    • Methyl binding domain protein 2 mediates {gamma}-globin gene silencing in adult human betaYAC transgenic mice
    • Rupon J.W., Wang S.Z., Gaensler K., Lloyd J., Ginder G.D. Methyl binding domain protein 2 mediates {gamma}-globin gene silencing in adult human betaYAC transgenic mice. Proc. Natl. Acad. Sci. USA 2006, 103:6617-6622.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 6617-6622
    • Rupon, J.W.1    Wang, S.Z.2    Gaensler, K.3    Lloyd, J.4    Ginder, G.D.5
  • 41
    • 57849083996 scopus 로고    scopus 로고
    • Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A
    • Sankaran V.G., Menne T.F., Xu J., et al. Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science 2008, 322:1839-1842.
    • (2008) Science , vol.322 , pp. 1839-1842
    • Sankaran, V.G.1    Menne, T.F.2    Xu, J.3
  • 42
  • 43
    • 69349092063 scopus 로고    scopus 로고
    • Developmental and species-divergent globin switching are driven by BCL11A
    • Sankaran V.G., Xu J., Ragoczy T., et al. Developmental and species-divergent globin switching are driven by BCL11A. Nature 2009, 460:1093-1097.
    • (2009) Nature , vol.460 , pp. 1093-1097
    • Sankaran, V.G.1    Xu, J.2    Ragoczy, T.3
  • 44
    • 0032957457 scopus 로고    scopus 로고
    • The gamma-globin promoter has a major role in competitive inhibition of beta-globin gene expression in early erythroid development
    • Sargent T.G., Buller A.M., Teachey D.T., McCanna K.S., Lloyd J.A. The gamma-globin promoter has a major role in competitive inhibition of beta-globin gene expression in early erythroid development. DNA Cell Biol. 1999, 18:293-303.
    • (1999) DNA Cell Biol. , vol.18 , pp. 293-303
    • Sargent, T.G.1    Buller, A.M.2    Teachey, D.T.3    McCanna, K.S.4    Lloyd, J.A.5
  • 45
    • 0019194794 scopus 로고
    • Tissue-specific DNA methylation in a cluster of rabbit beta-like globin genes
    • Shen C.K., Maniatis T. Tissue-specific DNA methylation in a cluster of rabbit beta-like globin genes. Proc. Natl. Acad. Sci. USA 1980, 77:6634-6638.
    • (1980) Proc. Natl. Acad. Sci. USA , vol.77 , pp. 6634-6638
    • Shen, C.K.1    Maniatis, T.2
  • 46
    • 0031459894 scopus 로고    scopus 로고
    • Methylation of the minimal promoter of an embryonic globin gene silences transcription in primary erythroid cells
    • Singal R., Ferris R., Little J.A., Wang S.Z., Ginder G.D. Methylation of the minimal promoter of an embryonic globin gene silences transcription in primary erythroid cells. Proc. Natl. Acad. Sci. USA 1997, 94:13724-13729.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 13724-13729
    • Singal, R.1    Ferris, R.2    Little, J.A.3    Wang, S.Z.4    Ginder, G.D.5
  • 47
    • 0036893198 scopus 로고    scopus 로고
    • Methylation of alpha-type embryonic globin gene alpha pi represses transcription in primary erythroid cells
    • Singal R., vanWert J.M., Ferdinand L. Methylation of alpha-type embryonic globin gene alpha pi represses transcription in primary erythroid cells. Blood 2002, 100:4217-4222.
    • (2002) Blood , vol.100 , pp. 4217-4222
    • Singal, R.1    vanWert, J.M.2    Ferdinand, L.3
  • 48
    • 0037127259 scopus 로고    scopus 로고
    • Methylation of promoter proximal-transcribed sequences of an embryonic globin gene inhibits transcription in primary erythroid cells and promotes formation of a cell type-specific methyl cytosine binding complex
    • Singal R., Wang S.Z., Sargent T., Zhu S.Z., Ginder G.D. Methylation of promoter proximal-transcribed sequences of an embryonic globin gene inhibits transcription in primary erythroid cells and promotes formation of a cell type-specific methyl cytosine binding complex. J. Biol. Chem. 2002, 277:1897-1905.
    • (2002) J. Biol. Chem. , vol.277 , pp. 1897-1905
    • Singal, R.1    Wang, S.Z.2    Sargent, T.3    Zhu, S.Z.4    Ginder, G.D.5
  • 49
    • 13844318521 scopus 로고    scopus 로고
    • Control of globin gene expression during development and erythroid differentiation
    • Stamatoyannopoulos G. Control of globin gene expression during development and erythroid differentiation. Exp. Hematol. 2005, 33:259-271.
    • (2005) Exp. Hematol. , vol.33 , pp. 259-271
    • Stamatoyannopoulos, G.1
  • 50
    • 0028099605 scopus 로고
    • Fetal hemoglobin induction by acetate, a product of butyrate catabolism
    • Stamatoyannopoulos G., Blau C.A., Nakamoto B., et al. Fetal hemoglobin induction by acetate, a product of butyrate catabolism. Blood 1994, 84:3198-3204.
    • (1994) Blood , vol.84 , pp. 3198-3204
    • Stamatoyannopoulos, G.1    Blau, C.A.2    Nakamoto, B.3
  • 51
    • 0026655863 scopus 로고
    • Developmental regulation of a complete 70-kb human beta-globin locus in transgenic mice
    • Strouboulis J., Dillon N., Grosveld F. Developmental regulation of a complete 70-kb human beta-globin locus in transgenic mice. Genes Dev. 1992, 6:1857-1864.
    • (1992) Genes Dev. , vol.6 , pp. 1857-1864
    • Strouboulis, J.1    Dillon, N.2    Grosveld, F.3
  • 52
    • 0036646514 scopus 로고    scopus 로고
    • An emryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer
    • Tanabe O., Katsuoka F., Campbell A., et al. An emryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer. EMBO J. 2002, 21:3434-3442.
    • (2002) EMBO J. , vol.21 , pp. 3434-3442
    • Tanabe, O.1    Katsuoka, F.2    Campbell, A.3
  • 53
    • 0034312291 scopus 로고    scopus 로고
    • Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice
    • Tanimoto K., Liu Q., Grosveld F., Bungert J., Engel J.D. Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice. Genes Dev. 2000, 14:2778-2794.
    • (2000) Genes Dev. , vol.14 , pp. 2778-2794
    • Tanimoto, K.1    Liu, Q.2    Grosveld, F.3    Bungert, J.4    Engel, J.D.5
  • 54
    • 77949807007 scopus 로고    scopus 로고
    • Control of fetal hemoglobin: new insights emerging from genomics and clinical implications
    • Thein S.L., Menzel S., Lathrop M., Garner C. Control of fetal hemoglobin: new insights emerging from genomics and clinical implications. Hum. Mol. Genet. 2009, 18:R216-R223.
    • (2009) Hum. Mol. Genet. , vol.18
    • Thein, S.L.1    Menzel, S.2    Lathrop, M.3    Garner, C.4
  • 55
    • 0018905582 scopus 로고
    • DNA methylation in the human gamma delta beta-globin locus in erythroid and nonerythroid tissues
    • van der Ploeg L.H., Flavell R.A. DNA methylation in the human gamma delta beta-globin locus in erythroid and nonerythroid tissues. Cell 1980, 19:947-958.
    • (1980) Cell , vol.19 , pp. 947-958
    • van der Ploeg, L.H.1    Flavell, R.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.