Drastically abnormal gluco- and galactosylceramide composition does not affect ganglioside metabolism in the brain of mice deficient in galactosylceramide synthase

Neurochemical Research

Volumn 24, Issue 4, 1999, Pages 471-474

  Suzuki, Kunihiko ^a,b,c   Vanier, Marie T ^d   Coetzee, Timothy ^a   Popko, Brian ^a,c  

^a Natl Institutes Hlth/Natl I   (United States)

^b Departments of Neurology and Psychiatry   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d INSERM   (France)

Author keywords

Animal model; Ceramide galactosyltransferase; Galactosylceramide; Ganglioside; Knockout mouse; Myelin; Sulfatide; UDP galactose

Indexed keywords

GALACTOSYLCERAMIDE; GANGLIOSIDE; GLUCOSYLCERAMIDE; HYDROXY FATTY ACID; LACTOSE SYNTHASE; SPHINGOMYELIN; SULFATIDE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; ENZYME DEFICIENCY; KNOCKOUT MOUSE; LIPID ANALYSIS; LIPID BRAIN LEVEL; LIPID COMPOSITION; LIPID METABOLISM; MOUSE; NEUROCHEMISTRY; NEWBORN; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA;

EID: 0032947050     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022571410445     Document Type: Article

References (23)

1. Morell, P., and Radin, N.S. 1969. Synthesis of cerebroside by brain from uridine diphosphate galactose and ceramide containing hydroxy fatty acid. Biochemistry. 8:506-512.
2. Costantino-Ceccarini, E., and Morell, P. 1972. Biosynthesis of brain sphingolipids and myelin accumulation in the mouse. Lipids. 7:656-659.
3. Schaeren-Wiemers, N., Van der Bijl, P., and Schwab, M.E. 1995. The UDP-galactose:ceramide galactosyltransferase: Expression pattern in oligodendrocytes and schwann cells during myelination and substrate preference for hydroxyceramide. J. Neurochem. 65:2267-2278.
4. Schulte, S., and Stoffel, W. 1993. Ceramide UDPgalactosyltransferase from myelinating rat brain: Purification, cloning, and expression. Proc. Natl. Acad. Sci., USA. 90:10265-10269.
5. Stahl, N., Jurevics, H., Morell, P., Suzuki, K., and Popko, B. 1994. Isolation, characterization, and expression of cDNA clones that encode rat UDP-galactose:ceramide galactosyltransferase. J. Neurosci. Res. 38:234-242.
6. Coetzee, T., Fujita, N., Dupree, J., Shi, R., Blight, A., Suzuki, K., and Popko, B. 1996. Myelination in the absence of galactocerebroside and sulfatide: Normal structure with abnormal function and regional instability. Cell. 86:209-219.
7. Bosio, A., Binczek, E., Haupt, W.F., and Stoffel, W. 1998. Composition and biophysical properties of myelin lipid define the neurological defects in galactocerebroside- and sulfatide-deficient mice. J. Neurochem. 70:308-315.
8. Bosio, A., Binczek, E., and Stoffel, W. 1996. Functional break-down of the lipid bilayer of the myelin membrane in central and peripheral nervous system by disrupted galactocerebroside synthesis. Proc. Natl. Acad. Sci. USA. 93:13280-13285.
9. Dupree, J.L., Coetzee, T., Blight, A., Suzuki, K., and Popko, B. 1998. Myelin galactolipids are essential for proper node of Ranvier formation in the CNS. Journal of Neuroscience. 18:1642-1649.
10. Svennerholm, L., and Fredman, P. 1980. A procedure for the quantitative isolation of brain gangliosides. Biochim. Biophys. Acta 617:97-109.
11. Svennerholm, L., Boström, K., Helander, C.G., and Jungbjer, B. 1991. Membrane lipids in the aging human brain. J. Neurochem. 56:2051-2059.
12. Wells, M.A., and Dittmer, J.C. 1963. The use of Sephadex for the removal of non-lipid contaminants from lipid extracts. Biochemistry. 2:1259-1263.
13. Svennerholm, L. 1957. Estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. Biochim. Biophys. Acta. 24:604-611.
14. Miettinen, T., and Takki-Luukkainen, I.-T. 1959. Use of butylacetate for determination of sialic acid. Acta Chem. Scand: 13:856-858.
15. Van der Bijl, P., Strous, G.J., Lopes-Cardozo, M., Thomas-Oates, J., and Van Meer, G. 1996. Synthesis of non-hydroxy-galactosylceramides and galactosyldiglycerides by hydroxy-ceramide galactosyltransferase. Biochem. J. 317:589-597.
16. Suzuki, K., Poduslo, S.E., and Norton, W.T. 1967. Gangliosides in the myelin fraction of developing rats. Biochim. Biophys. Acta. 144:375-381.
17. Suzuki, K., Poduslo, J.F., and Poduslo, S.E. 1998. Further evidence for a specific ganglioside fraction closely associated with myelin. Biochim. Biophys. Acta. 152:576-586.
18. Hildebrand, J., Stoffyn, P., and Hauser, G. 1970. Biosynthesis of lactosylceramide by rat brain preparations and comparison with the formation of ganglioside GM1 and psychosine during development. J. Neurochem. 17:403-411.
19. Nomura, T., Takizawa, M., Wakisaka, E., Hattori, M., Inoue, K., Arai, H., and Matsuo, N. 1997. Purification and characterization of lactosylceramide synthase. Glycoconjugate J. 14:S51(Abst. PO16, #63).
20. Stoffel, W., and Bosio, A. 1997. Myelin glycolipids and their functions. Curr. Opin. Neurobiol. 7:654-661.
21. Coetzee, T., Suzuki, K., and Popko, B. 1998. New perspectives on the function of myelin galactolipids. Trends Neurosci. 21:126-130.
22. Suzuki, K., Vanier, M.T., and Suzuki, K. 1998. Induced mouse models of abnormal sphingolipid metabolism. J. Biochem. 124:8-19.
23. Yu, R.K., and Yen, S.I. 1975. Gangliosides in developing mouse brain myelin. J. Neurochem. 25:229-232.