Reciprocal control of hERG stability by Hsp70 and Hsc70 with implication for restoration of LQT2 mutant stability

Circulation Research

Volumn 108, Issue 4, 2011, Pages 458-468

  Li, Peili ^a   Ninomiya, Haruaki ^b   Kurata, Yasutaka ^c   Kato, Masaru ^b   Miake, Junichiro ^a   Yamamoto, Yasutaka ^a   Igawa, Osamu ^b   Nakai, Akira ^d   Higaki, Katsumi ^b   Toyoda, Futoshi ^e   Wu, Jie ^e   Horie, Minoru ^e   Matsuura, Hiroshi ^e   Yoshida, Akio ^a   Shirayoshi, Yasuaki ^a   Hiraoka, Masayasu ^f   Hisatome, Ichiro ^a  

^a Institute of Regenerative Medicine and Biofunction   (Japan)

^b TOTTORI UNIVERSITY   (Japan)

^c KANAZAWA MEDICAL UNIVERSITY   (Japan)

^d YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^f TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

hERG; Hsc70; Hsp70; long QT2; stabilization

Indexed keywords

HEAT SHOCK COGNATE PROTEIN 70; HEAT SHOCK PROTEIN 70; POTASSIUM CHANNEL HERG;

ARTICLE; ENDOPLASMIC RETICULUM; GENETIC STABILITY; HEART MUSCLE CELL; HUMAN; HUMAN CELL; LONG QT SYNDROME; LONG QT SYNDROME TYPE 2; MISSENSE MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; UBIQUITINATION;

ACTION POTENTIALS; ANIMALS; CELL MEMBRANE; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; ENDOPLASMIC RETICULUM; ETHER-A-GO-GO POTASSIUM CHANNELS; HEAT-SHOCK RESPONSE; HEK293 CELLS; HSC70 HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; LONG QT SYNDROME; MICE; MUTATION, MISSENSE; MYOCYTES, CARDIAC; RNA, SMALL INTERFERING;

EID: 79952071386     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.110.227835     Document Type: Article

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