Grhl3 and GEF19 in the front rho

Small GTPases

Volumn 1, Issue 2, 2010, Pages 104-107

  Darido, Charbel ^a   Jane, Stephen M ^a,b  

^a Rotary Bone Marrow Res Laboratories   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Cell migration; Epidermis; Grhl3; PCP; RhoA; RhoGEF19; Transcription; Wound healing

Indexed keywords

ACTIN; CYTOSKELETON PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR 19; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PROTEIN CDC42; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GRHL3; UNCLASSIFIED DRUG;

ARTICLE; CELL MIGRATION; CELL MOTILITY; CELL MOTION; CELL POLARITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME REGULATION; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; GRHL3 GENE; HUMAN; MICROTUBULE ORGANIZING CENTER; NONHUMAN; PROTEIN DEFECT; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; RHOGEF19 GENE; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION; WOUND HEALING;

EID: 79952053610     PISSN: 21541248     EISSN: 21541256     Source Type: Journal    
DOI: 10.4161/sgtp.1.2.13620     Document Type: Article

References (32)

1. Etienne-Manneville S, Hall A. Rho GTPases in cell biology. Nature 2002; 420:629-35.
2. Burridge K, Wennerberg K. Rho and Rac take center stage. Cell 2004; 116:167-79.
3. Sahai E, Marshall CJ. RHO-GTPases and cancer. Nat Rev Cancer 2002; 2:133-42.
4. Iden S, Collard JG. Crosstalk between small GTPases and polarity proteins in cell polarization. Nat Rev Mol Cell Biol 2008; 9:846-59.
5. Fukata M, Nakagawa M, Kaibuchi K. Roles of Rhofamily GTPases in cell polarisation and directional migration. Curr Opin Cell Biol 2003; 15:590-7.
6. Nabi IR. The polarization of the motile cell. J Cell Sci 1999; 112:1803-11.
7. Jaffe AB, Hall A. Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 2005; 21:247-69.
8. Heasman SJ, Ridley AJ. Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat Rev Mol Cell Biol 2008; 9:690-701.
9. Cau J, Hall A. Cdc42 controls the polarity of the actin and microtubule cytoskeletons through two distinct signal transduction pathways. J Cell Sci 2005; 118:2579-87.
10. Sorokina EM, Chernoff J. Rho-GTPases: new members, new pathways. J Cell Biochem 2005; 94:225-31.
11. Schiller MR. Coupling receptor tyrosine kinases to Rho GTPases-GEFs what's the link. Cell Signal 2006; 18:1834-43.
12. Wennerberg K, Der CJ. Rho-family GTPases: it's not only Rac and Rho (and I like it). J Cell Sci 2004; 117:1301-12.
13. Vasilaki E, Papadimitriou E, Tajadura V, Ridley AJ, Stournaras C, Kardassis D. Transcriptional regulation of the small GTPase RhoB gene by TGF{beta}-induced signaling pathways. FASEB J 2010; 24:891-905.
14. Schiavone D, Dewilde S, Vallania F, Turkson J, Di Cunto F, Poli V. The RhoU/Wrch1 Rho GTPase gene is a common transcriptional target of both the gp130/STAT3 and Wnt-1 pathways. Biochem J 2009; 421:283-92.
15. Caddy J, Wilanowski T, Darido C, Dworkin S, Ting SB, Zhao Q, et al. Epidermal wound repair is regulated by the planar cell polarity signaling pathway. Dev Cell 2010; 19:138-47.
16. Wilanowski T, Tuckfield A, Cerruti L, O'Connell S, Saint R, Parekh V, et al. A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead. Mech Dev 2002; 114:37-50.
17. Ostrowski S, Dierick HA, Bejsovec A. Genetic control of cuticle formation during embryonic development of Drosophila melanogaster. Genetics 2002; 161:171-82.
18. Mace KA, Pearson JC, McGinnis W. An epidermal barrier wound repair pathway in Drosophila is mediated by grainy head. Science 2005; 308:381-5.
19. Lee H, Adler PN. The grainy head transcription factor is essential for the function of the frizzled pathway in the Drosophila wing. Mech Dev 2004; 121:37-49.
20. Hislop NR, Caddy J, Ting SB, Auden A, Vasudevan S, King SL, et al. Grhl3 and Lmo4 play coordinate roles in epidermal migration. Dev Biol 2008; 321:263-72.
21. Ting SB, Wilanowski T, Auden A, Hall M, Voss AK, Thomas T, et al. Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3. Nat Med 2003; 9:1513-9.
22. Ting SB, Caddy J, Hislop N, Wilanowski T, Auden A, Zhao LL, et al. A homolog of Drosophila grainy head is essential for epidermal integrity in mice. Science 2005; 308:411-3.
23. Tabu K, Ohba Y, Suzuki T, Makino Y, Kimura T, Ohnishi A, et al. Oligodendrocyte lineage transcription factor 2 inhibits the motility of a human glial tumor cell line by activating RhoA. Mol Cancer Res 2007; 5:1099-109.
24. Tsapara A, Luthert P, Greenwood J, Hill CS, Matter K, Balda MS. The RhoA activator GEF-H1/Lfc is a transforming growth factor-beta target gene and effector that regulates alpha-smooth muscle actin expression and cell migration. Mol Biol Cell 2010; 21:860-70.
25. Shen X, Li J, Hu PP, Waddell D, Zhang J, Wang XF. The activity of guanine exchange factor NET1 is essential for transforming growth factor-betamediated stress fiber formation. J Biol Chem 2001; 276:15362-8.
26. Su ZJ, Hahn CN, Goodall GJ, Reck NM, Leske AF, Davy A, et al. A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis. Proc Natl Acad Sci USA 2004; 101:12212-7.
27. Gentile A, D'Alessandro L, Lazzari L, Martinoglio B, Bertotti A, Mira A, et al. Met-driven invasive growth involves transcriptional regulation of Arhgap12. Oncogene 2008; 27:5590-8.
28. Mzali R, Seguin L, Liot C, Auger A, Pacaud P, Loirand G, et al. Regulation of Rho signaling pathways in interleukin-2-stimulated human T-lymphocytes. FASEB J 2005; 19:1911-3.
29. Montell DJ. Developmental regulation of cell migration. Insight from a genetic approach in Drosophila. Cell Biochem Biophys 1999; 31:219-29.
30. Wang S, Tsarouhas V, Xylourgidis N, Sabri N, Tiklova K, Nautiyal N, et al. The tyrosine kinase Stitcher activates Grainy head and epidermal wound healing in Drosophila. Nat Cell Biol 2009; 11:890-5.
31. Hemphala J, Uv A, Cantera R, Bray S, Samakovlis C. Grainy head controls apical membrane growth and tube elongation in response to Branchless/FGF signalling. Development 2003; 130:249-58.
32. Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound repair and regeneration. Nature 2008; 453:314-21.