Aflatoxin B1 and fumonisin B1 affect the oxidative status of bovine peripheral blood mononuclear cells

Toxicology in Vitro

Volumn 25, Issue 3, 2011, Pages 684-691

  Bernabucci, Umberto ^a   Colavecchia, Luciana ^a   Danieli, Pier Paolo ^a   Basiricò, Loredana ^a   Lacetera, Nicola ^a   Nardone, Alessandro ^a   Ronchi, Bruno ^a  

^a UNIVERSITY OF TUSCIA   (Italy)

Author keywords

Aflatoxin B1; Dairy cattle; Fumonisin B1; Oxidative stress; PBMC

Indexed keywords

AFLATOXIN B1; FUMONISIN B1; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; THIOL DERIVATIVE; FUMONISIN; GLUTATHIONE; GLUTATHIONE PEROXIDASE 1; MYCOTOXIN;

ANIMAL CELL; ARTICLE; CELL LEVEL; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; COW; CYTOTOXICITY; FEMALE; GENE EXPRESSION; IN VITRO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PERIPHERAL BLOOD MONONUCLEAR CELL; ANIMAL; CATTLE; CELL CULTURE; CELL SURVIVAL; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MONONUCLEAR CELL;

BOS; BOVINAE;

AFLATOXIN B1; ANIMALS; CATTLE; CELL SURVIVAL; CELLS, CULTURED; FEMALE; FUMONISINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LEUKOCYTES, MONONUCLEAR; MALONDIALDEHYDE; MYCOTOXINS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SULFHYDRYL COMPOUNDS; SUPEROXIDE DISMUTASE;

EID: 79952041149     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2011.01.009     Document Type: Article

References (70)

1. Abado-Becognee K., Mobio T.A., Ennamany R., Fleurat-Lessard F., Shier W.T., Badria F., Creppy E.E. Cytotoxicity of fumonisin B1: implication of lipid peroxidation and inhibition of protein and DNA syntheses. Arch. Toxicol. 1998, 72:233-234.
2. Abel S., Gelderblom W.C.A. Oxidative damage and fumonisin B1-induced toxicity in primary rat hepatocytes and rat liver in vivo. Toxicology 1998, 131:121-131.
3. Alpsoy L., Yildirim A., Agar G. The antioxidant effects of vitamin A, C and E on aflatoxin B1-induces oxidative stress in human lymphocytes. Toxicol. Ind. Health 2009, 25:121-127.
4. Atroshi F., Rizzo A., Biese I., Veijalainen P., Saloniemi H., Sankari S., Andersson K. Fumonisin B1-induced DNA damage in rat liver and spleen: effects of pretreatment with Coenzyme Q10, L-Carnitine, α-Tocopherol and Selenium. Pharmacol. Res. 1999, 40:459-467.
5. Atroshi F., Rizzo A., Westermarck T., Ali-Vehmas T. Effects of tamoxifen, melatonin, coenzyme Q10, and L-carnitine supplementation on bacterial growth in the presence of mycotoxins. Pharmacol. Res. 1998, 38:289-295.
6. Atroshi F., Rizzo A., Biese I., Veijalainen P., Antila E., Westermarck T. T-2 toxin-induced DNA damage in mouse livers: the effects of pretreatment with coenzyme Q10 and α-tocopherol. Mol. Aspects Med. 1997, 18:s255-s258.
7. Baudrimont I., Ahouandjivo R., Creppy E.E. Prevention of lipid peroxidation induced by ochratoxin A in Vero cells in culture by several agents. Chem. Biol. Interact. 1997, 104:29-40.
8. Bernabucci U., Ronchi B., Basificò L., Pirazzi D., Rueca F., Lacetera N., Nardone A. Abundance of mRNA of apolipoprotein B100, apolipoprotein E and microsomal triglyceride transfer protein in liver from periparturient dairy cows. J. Dairy Sci. 2004, 87:2881-2888.
9. Bernabucci U., Ronchi B., Lacetera N., Nardone A. Markers of oxidative status in plasma and erythrocytes of transition dairy cows during hot season. J. Dairy Sci. 2002, 85:2173-2179.
10. Betina V. Structure-activity relationships among mycotoxins. Chem. Biol. Interact. 1989, 71:105-146.
11. Bionda C., Portoukalian J., Schmitt D., Rodriguez-Lafrasse C., Ardail D. Subcellular compartmentalization of ceramide metabolism: MAM (mitochondria-associated membrane) and/or mitochondria?. Biochem. J. 2004, 382:527-533.
12. Bodine A.B., Fisher S.F., Gangjee S. Effect of aflatoxin B1 and major metabolites on phytohemeagglutinin-stimulated lymphoblastogenesis of bovine lymphocytes. J. Dairy Sci. 1984, 67:110-114.
13. Bondy G.S., Pestka J.J. Immunomodulation by fungal toxins. J. Toxicol. Environ. Health Part B, Crit. Rev. 2000, 3:109-143.
14. Brown V.M.D., Pier A.C., Richard J.L., Krogstad R.E. Effects of dietary aflatoxin on exiting bacterial intramammaru infections in dairy cows. Am. J. Vet. Res. 1981, 42:927-933.
15. Cadenas E., Sies H. The lag phase. Free Radic. Res. 1998, 28:601-609.
16. Charoenpornsook K., Fitzpatrick J.L., Smith J.E. The effects of four mycotoxins on the mitogen stimulated proliferation of bovine peripheral blood mononuclear cells in vitro. Mycopathologia 1998, 143:105-111.
17. Chen J.J., Yu B.P. Alteration in mitochondrial membrane fluidity by lipid peroxidation products. Free Radic. Biol. Med. 1994, 17:411-418.
18. Coppola S., Ghibelli L. GSH extrusion and the mitochondrial pathway of apoptotic signalling. Biochem. Soc. Trans. 2000, 28:56-61.
19. Csonka C., Pataki T., Kovacs P., Muller S.B., Schroeter M.L., Tosaki A., Blasig I.E. Effects of oxidative stress on the expression of antioxidative defence enzymes in the spontaneously hypertensive rat hearts. Free Rad. Biol. Med. 2000, 29:612-619.
20. De Lorenzi L., De Giovanni A., Malagutti L., Molteni L., Sciaraffia F., Tamburini A. Genotoxic activity of the Fumonisin B1 mycotoxin in cultures of bovine lymphocytes. Ital. J. Anim. Sci. 2005, 4:395-402.
21. Degan D.H., Neuman H.G. The major metabolite of AFB1 in the rat is a glutathione conjugate. Chem. Biol. Interact. 1978, 22:239-255.
22. Eriksen G.S., Pettersson H., Lundh T. Comparative cytotoxicity of deoxynivalenol, nivalenol and their acetylated derivatives and deepoxy metabolites. Food Chem. Toxicol. 2004, 42:619-624.
23. Esterbauer H., Cheeseman K.H., Dianzani M.U., Poli G., Slater T.F. Separation and characterization of the aldehydic products of lipid peroxidation stimulated by ADP-Fe2+ in rat liver microsomes. Biochem. J. 1982, 208:129-140.
24. Fenaille F., Mottier P., Turesky R.J., Ali S., Guy P.A. Comparison of analytical techniques to quantify malondialdehyde in milk powder. J. Chromatogr. A 2001, 921:237-245.
25. Ferrante M.C., Meli R., Mattace Raso G., Esposito E., Severino L., Di Carlo G., Lucisano A. Effect of fumonisin B1 on structure and function of macrophage plasma membrane. Toxicol. Lett. 2002, 129:181-187.
26. Fink-Gremmels J. The role of mycotoxins in the health and performance of dairy cows. Vet. J. 2008, 176:84-92.
27. Gagliano N., Dalle Donne I., Torri C., Migliori M., Grizzi F., Milzani A., Filippi C., Annoni G., Colombo P., Costa F., Cava Grimaldi G., Bertelli A.A.E., Giovannini L., Gioia M. Early cytotoxic effects of Ochratoxin A in rat liver: a morphological, biochemical and molecular study. Toxicology 2006, 225:214-224.
28. García-Ruiz C., Colell A., Marí M., Morales A., Fernández-Checa J.C. Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione. J. Biol. Chem. 1997, 272:11369-11377.
29. Gautier J.-C., Holzhauser D., Markovic J., Gremaud E., Schilter B., Turesky R.J. Oxidative damage and stress response from Ochratoxin A exposure in rats. Free Radic. Biol. Med. 2001, 30:1089-1098.
30. Gelderblom W.C.A., Smuts C.M., Abel S., Snyman S.D., Van Der Westhuizen L., Huber W.W., Swanevelder S. Effect of Fumonisin B1 on the levels and fatty acid composition of selected lipids in rat liver in vivo. Food Chem. Toxic. 1997, 35:647-656.
31. Guerre P., Larrieu G., Burgat V., Galtier P. Cytochrome P450 decreases are correlated to increate microsomal oxidative damage in rabbit liver and primary cultures of rabbit hepatocytes exposed to AFB1. Toxicol. Lett. 1999, 104:117-125.
32. Halliwell B., Chirico S. Lipid peroxidation: its mechanism, measurement, and significance. Am. J. Clin. Nutr. 1993, 57:715S-725S.
33. Han D., Loukianoff S., McLaughlin L. Oxidative stress indices: analytical aspects and significance. Handbook of oxidants and antioxidants in exercise 2000, 433-484. Elsevier Science B.V, The Netherlands. C.H. Sen, L. Packer, O. Hanninen (Eds.).
34. Harrison L.R., Colvin B.M., Green J.T., Newman L.E., Cole J.R. Pulmonary oedema and hydrothorax in swine produced by fumonisin B1, a toxic metabolite of Fusarium moniliforme. J. Vet. Diagn. Invest. 1990, 2:217-221.
35. Hayes J.D., Pulford D.J., Ellis E.M., McLeod R., James R.F.L., Seidegard J., Mosialou E., Jernstrom B., Neal G.E. Regulation of rat liver glutathione-S-transferase A5 by cancer chemopreventive agents: mechanisms of inducible resistance to aflatoxin B1. Chem. Biol. Interact. 1998, 111-112:51-67.
36. Kang Y.J., Alexander J.M. Alterations of the glutathione redox cycle status in fumonisin B1-treated pig kidney cells. J. Biochem. Toxicol. 1996, 11:121-126.
37. Kellerman T.S., Mararas W.I.-O., Thiel G., Gelderblom W.C.A., Cawood M., Coetzer J.A.W. Leukoencephalomalacia in two horses induced by oral dosing of fumonisin B1. Ondersterpoort J. Vet. Res. 1990, 57:269-275.
38. Klaunig E.J., Kamendulis L.M. Role of oxidative stress in chemical carcinogenesis. Environmental Stressors in health and disease 2001, 81-102. Marcel Dekker Inc, New York. J. Fuchs, L. Packer (Eds.).
39. Kouadio J.H., Mobio T.A., Baudrimont I., Moukha S., Dano S.D., Creppy E.E. Comparative study of cytotoxicity and oxidative stress induced by deoxynivalenol, zearalenone or fumonisin B1 in human intestinal cell line Caco-2. Toxicology 2005, 213:56-65.
40. Kurtz R.S., Czuprynski C.J. Effect of aflatoxin on in vitro production of interleukin-1 by bovine mononuclear phagocytes. Vet. Immunol. Immunop. 1992, 34:149-158.
41. Lacetera N., Franci O., Scalia D., Bernabucci U., Ronchi B., Nardone A. Effects on functions of ovine blood mononuclear cells for each of several fatty acids at concentrations found in plasma of healthy and ketotic ewes. Am. J. Vet. Res. 2002, 63:958-962.
42. Lakritz J., Leonard M.J., Eichen P.A., Rottinghaus G.E., Johnson G.C., Spiers D.E. Whole-blood concentrations of glutathione in cattle exposed to heat stress or a combination of heat stress and endophyte-infected tall fescue toxins in controlled environmental conditions. Am. J. Vet. Res. 2002, 63:799-803.
43. Leal M., Shimada A., Ruiz F., de Mejia E.G. Effect of lycopene on lipid peroxidation and glutathione-dependent enzymes induced by T-2 toxin in vivo. Toxicol. Lett. 1999, 109:1-10.
44. Lim C.W., Parker H.M., Vesonder R.F., Haschek W.M. Intra-venous fumonisin B1 induces cell proliferation and apoptosis in the rat. Nat. Toxins 1996, 4:34-41.
45. Marnett L.J. Lipid peroxidation-DNA damage by malondialdehyde. Mutat. Res. 1999, 424:83-95.
46. Meister A., Anderson M.E. Glutathione. Annu. Rev. Biochem. 1983, 52:711-760.
47. Morales A., García-Ruiz C., Miranda M., Marí M., Colell A., Ardite E., Fernández-Checa J.C. Tumor necrosis factor increases hepatocellular glutathione by transcriptional regulation of the heavy subunit chain of γ-glutamylcysteine synthetase. J. Biol. Chem. 1997, 272:30371-30379.
48. Müller G., Burkert B., Möller U., Diller R., Rohrmann B., Rosner H., Köhler H. Ochratoxin A and some of its derivatives modulate radical formation of porcine blood monocytes and granulocytes. Toxicology 2004, 199:251-259.
49. Neldon-Ortiz D.L., Qureshi M.A. The effects of direct and microsomal activated aflatoxin B1 on chicken peritoneal macrophages in vitro. Vet. Immunol. Immunopathol. 1992, 31:61-76.
50. Pestka J.L., Bondy G.S. Alteration of immune function following dietary mycotoxin exposure. Can. J. Physiol. Pharmacol. 1990, 68:1009-1016.
51. Pugh G.W., Richard J.L., Kpecky K.E., McDonald T.J. Effect of aflatoxin ingestion on the development of Moraxella bovis infectious bovine keratoconjunctivitis. Cornell Vet. 1984, 74:96-110.
52. Rumora L., Domijan A.-M., Žanić Grubišić T., Peraica M. Mycotoxin fumonisin B1 alters cellular redox balance and signalling pathways in rat liver and kidney. Toxicology 2007, 242:31-38.
53. SAS user's guide statistics 8th version 1999, SAS, SAS Inc., Cary, NC.
54. Šegvić-Klarić M., Pepeljnjak S., Domijan A.-M., Petrik J. Lipid peroxidation and glutathione levels in porcine kidney PK15 cells after individual and combined treatment with fumonisin B1, beauvericin and ochratoxin A. Basic Clin. Pharmacol. Toxicol. 2006, 100:157-164.
55. Selkirk J.K., Croy R.G., Whitlock J.P., Gelboin H.V. In vitro metabolism of benzo(a)pyrene by human liver microsomes and lymphocytes. Cancer Res. 1975, 35:3651-3655.
56. Shen H.M., Shi C.Y., Shen Y., Ong C.N. Detection of elevated reactive oxygen species level in cultured rat hepatocytes treated with aflatoxin B1. Free Radic. Biol. Med. 1996, 2:139-146.
57. Sivanesan D., Begum V.H. Preventive role of Gynandropsis gynandra L., against aflatoxin B1 induced lipid peroxidation and antioxidant defence mechanism in rat. Indian J. Exper. Biol. 2007, 45:299-303.
58. Smith J.E., Solomons G., Lewis C., Anderson J.G. The role of mycotoxins in human and animal nutrition and health. Nat. Toxins 1995, 3:187-192.
59. Stockmann-Juvala H., Mikkola J., Naarala J., Loikkanen J., Elovaara E., Savolainen K. Oxidative stress induced by fumonisin B1 in continuous human and rodent neural cell cultures. Free Radic. Res. 2004, 38:933-942.
60. Taranu I., Marin D.E., Bouhet S., Pascale F., Bailly J.-D., Miller J.D., Pinton P., Oswald I.P. Mycotoxin Fumonisin B1 alters the cytokine profile and decreases the vaccinal antibody titer in pigs. Toxicol. Sci. 2005, 84:301-307.
61. Towner R.A., Qian S.Y., Kadiiska M.B., Mason R.P. In vivo identification of aflatoxin-induced free radicals in rat bile. Free Radic. Biol. Med. 2003, 35:1330-1340.
62. Vaca C.E., Fang J.-L., Mutanen M., Valsta L. 32P-postlabeling determination of DNA adducts of malonaldehyde in humans: total white blood cells and breast tissue. Carcinogenesis 1995, 16:1847-1851.
63. Vaca C.E., Wilhelm J., Hartwig A., Harms-Ringdahl M. Interaction of lipid peroxidation products with DNA. A review. Mutat. Res. 1988, 195:137-149.
64. Valko M., Leibfritz D., Moncol J., Cronin M.T.D., Mazur M., Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Biol. 2007, 39:44-84.
65. Valko M., Rhodes C.J., Moncol J., Izakovic M., Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem. Biol. Interact. 2006, 160:1-40.
66. van den Berg J.J.M., Op den Kamp J.A.F., Lubin B.H., Roelofsen B., Kuipers F.A. Kinetic and site specificity of hydroperoxide-induced oxidative damage in red blood cells. Free Radic. Biol. Med. 1992, 12:487-498.
67. Verma R.J. Aflatoxin cause DNA damage. Int. J. Hum. Genet. 2004, 4:231-236.
68. Wang M.Y., Liehr J.G. Lipid hydroperoxide-induced endogenous DNA adducts in hamsters: possible mechanism of lipid hydroperoxide-mediated carcinogenesis. Arch. Biochem. Biophys. 1995, 316:38-46.
69. Wogan G.N. Aflatoxin as a human carcinogen. Hepatology 1999, 30:217-221.
70. Yin J.J., Smith M.J., Eppley R.M., Page S.W., Sphon J.A. Effects of fumonisin B1 on lipid peroxidation in membranes. Bioch. Biophys. Acta 1998, 1371:134-142.