The antioxidant effects of vitamin A, C, and E on aflatoxin B1-induced oxidative stress in human lymphocytes

Toxicology and Industrial Health

Volumn 25, Issue 2, 2009, Pages 121-127

  Alpsoy, L ^a   Yildirim, A ^b   Agar, G ^a  

^a FATIH UNIVERSITY   (Turkey)

^b ATATURK UNIVERSITY   (Turkey)

Author keywords

aflatoxin B1; antioxidant enzymes; genotoxicity; vitamin A, C and E

Indexed keywords

AFLATOXIN B1; ALPHA TOCOPHEROL; ASCORBIC ACID; DIMETHYL SULFOXIDE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; RETINOL; SUPEROXIDE DISMUTASE;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL STRESS; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; LYMPHOCYTE CULTURE; MALE; NORMAL HUMAN; OXIDATIVE STRESS;

AFLATOXIN B1; ANTIOXIDANTS; ASCORBIC ACID; CELL SURVIVAL; CELLS, CULTURED; FEMALE; FREE RADICALS; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HUMANS; LYMPHOCYTES; MALE; MALONDIALDEHYDE; OXIDATIVE STRESS; SUPEROXIDE DISMUTASE; VITAMIN A; VITAMIN E; VITAMINS;

EID: 66249101177     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1177/0748233709103413     Document Type: Article

References (47)

1. Ahmad S, Afzal M (2004) Amelioration of genotoxic damage by certain phytoproducts in human lymphocyte cultures. Chem Biol Interact 149: 107–115.
2. Anderson ME (1985) Determination of glutathione and glutathione disulfide in biological samples. Methods Enzymol 113: 548–555.
3. Bonorden WR, Pariza MW (1994) Antioxidant nutrients and protection from free radicals. In: Kolsonis, FN, Mackey, M, Hielle, J, (eds), Nut Toxicol. New York: Review press.
4. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248–254.
5. Cadenas E, Packer L (2001) Handbook of Antioxidants. New York: CRC Press, pp. 8.
6. Eraslan G, Akdoğan M, Yarsan E, Şahindokuyucu F, Eşsiz D, Altıntaş L (2005) The effects of aflatoxins on oxidative stress in broiler chickens. Turk J Vet Anim Sci 29: 701–707.
7. Foote CS, Denny RW, Eavel L, Chang Y, Peters J (1970) Quenching by singlet oxygen. Ann N Y Acad Sci 171: 139–148.
8. Gajecka M, Kujawski LM, Gawecki J, Szyfter K (1999) The protective effect of vitamins C and E against B(a)P-induced genotoxicity in human lymphocytes. J Environ Pathol Toxicol Oncol 18: 159–167.
9. Goldfarb AH, McIntosh MK, Boyer BT (1996) Vitamin E attenuates myocardial oxidative stress induced by DHEA in rested and exercised rats. J Appl Physiol 80: 486–490.
10. Halliwell B, Gutteridge JMC (1999) Free radical in biology and medicine. Oxford: Oxford University press.
11. Hojo Y, Okado A, Kawazoe S, Mizutani T (2000) Direct evidence for in vivo hydroxyl radical generation in blood of mice after acute chromium (VI) intake. Biol Trace Elem Res 76: 75–84.
12. James AO (1996) Benefits and liabilities of vitamin A and carotenoids. J Nutrition 12694: 1221–1227.
13. Janssen YM, Van Houten B, Borm PJ, Mossman BT (1993) Cell and tissue responses to oxidative damage. Lab Invest 69: 261–274.
14. Johnson F, Giulivi C (2005) Superoxide dismutases and their impact upon human health. Mol Aspects Med 26: 340–352.
15. Kashif SM, Zaidi R, Banu N (2004) Antioxidant potential of vitamins A, E and C in modulating oxidative stress in rat brain. Clinica Chimica Acta 340: 229–233.
16. Kayanoki Y, Fujii J, Islam KN, Suzuki K, Kawata S, Matsurzawa Y (1996) The protective role of glutathione peroxidase in apoptosis induced by reactive oxygen species. J Biochem 119: 817–822.
17. Klein PJ, Van Vleet TR, Hall JO, Coulombe RA (2002) Biochemical factors underlying the age-related sensitivity of turkeys to aflatoxin B(1). Comp Biochem Physiol 132: 193–201.
18. Krishnamoorthy G, Venkataraman P, Arunkumar A, Vignesh RC, Aruldhas MM, Arunakaran J (2007) Ameliorative effect of vitamins (α -tocopherol and ascorbic acid) on PCB (Aroclor 1254) induced oxidative stress in rat epididymal sperm. Reprod Toxicol 23: 239–245.
19. Kumar CT, Reddy VK, Prasad M, Thyagaraju K, Reddanna P (1992) Dietary supplementation of vitamin E protects heart tissue from exercise induced oxidant stress. Mol Cell Biochem 111: 109–115.
20. Larsson P, Busk L, Tjalve H (1994) Hepatic and extrahepatic bioactivation and GSH conjugation of aflatoxin B1 in sheep. Carcinogenesis 15: 947–955.
21. Levi L, Basuaj E (2000) An introduction clinical and neuroendocrinology, vol. 1. Basel: Karger, pp. 78.
22. Masella R, Di Benedetto R, Vari R, Filesi C, Giovannini C (2005) Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes. J Nutr Biochem 16: 577–586.
23. Meister A, Anderson ME (1991) Glutathione. Annu Rev Biochem 52: 711–722.
24. Muthuvel R, Venkataraman P, Krishnamoorthy G, Gunadharini DN, Kanagaraj P, Jone Stanley A (2006) Antioxidant effect of ascorbic acid on PCB (Aroclor 1254) induced oxidative stress in hypothalamus of albino rats. Clinica Chimica Acta 365: 297–303.
25. Niki E, Yoshida Y, Saito Y, Noguchi N (2005) Lipid peroxidation: mechanisms, inhibition, and biological effects. Biochem Biophys Res Commun 338: 668–676.
26. Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxidase in animal tissues by thiobarbituric acid reaction. Anal Biochem 95: 351–358.
27. Packer L; Traber MG; Kraemer K; Frei B; (2002) The antioxidant vitamins C and E: vitamins C and E for health. J Am Oil Chem Soc.
28. Paglia DE, Valentine WN (1967) Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70: 158–169.
29. Patel JW (1987) Stimulation of cyclophosphamide induced pulmonary microsomal lipid peroxidation by oxygen. Toxicology 45: 71.
30. Preetha SP, Kanniappan M, Selvakumar E, Nagaraj M, Varalakshmi P (2006) Lupeol ameliorates aflatoxin B1-induced peroxidative hepatic damage in rats. Comp Biochem Physiol 143: 333–339.
31. Preston RJ, Williams GM (2005) DNA-reactive carcinogens: mode of action and human cancer hazard. Crit Rev Toxicol 35: 673–683.
32. Rastogi R, Srivastava AK, Rastogi AK (2001) Long term effect of aflatoxin B(1) on lipid peroxidation in rat liver and kidney: effect of picroliv and silymarin. Phytother Res 15: 307–310.
33. Reddy KV, Kumar TC, Prasad M, Reddanna P (1998) Pulmonary lipid peroxidation and antioxidant defenses during exhaustive physical exercise: the role of vitamin E and selenium. Nutrition 14: 448–451.
34. Rokitzki L, Logemann E, Huber G, Keck E, Keul J (1994) Alpha-Tocopherol supplementation in racing cyclists during extreme endurance training. Int J Sport Nutr 4: 253–264.
35. Sharma RA, Farmer PB (2004) Biological relevance of adduct detection to the chemoprevention of cancer. Clin Cancer Res 10: 4901–4912.
36. Shen HM, Shi CY, Lee HP, Ong CN (1994) Aflatoxin B1-Induced lipid peroxidation in rat liver. Toxicol Appl Pharmacol 127: 145–150.
37. Simic MG (1993) Carotenoid free radicals. Methods Enzymology 213: 444–453.
38. Sohn DH, Kim YC, Oh SH, Park EJ, Li X, Lee BH (2003) Hepatoprotective and free radical scavenging effects of Nelumbo nucifera. Phytomedicine 10: 165–169.
39. Sun Y, Oberley LW, Li Y (1988) A simple method for clinical assay of superoxide dismutase. Clin Chem 34: 497–500.
40. Tietze F (1969) Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 27: 502–522.
41. Towner RA, Qian SY, Kadiiska MB, Mason RP (2003) In vivo identification of aflatoxin-induced free radicals in rat bile. Free Radic Biol Med 35: 1330–1340.
42. Vandana S; Ram S; Ilavazhagan M; Kumar GD; Banerjee PK; (2006) Comparative cytoprotective activity of vitamin C, E and beta-carotene against chromium induced oxidative stress in murine macrophages. Biomedecine and Pharmacotherapy 60: 71–76.
43. Venkataraman P, Sridhar M, Dhanammal S, Vijayababu MR, Arunkumar A, Srinivasan N (2004) Effects of vitamins supplementation on PCB (Aroclor 1254)-induced changes in ventral prostatic androgen and Estrogen receptors. Endocr Res 30: 469–480.
44. Venkateswaran PS, Millman I, Blumberg BS (1987) Effects of an extract from Phyllanthus niruri on hepatitis B and woodchuck hepatitis viruses: in vivo and in vitro studies. Proc Natl Acad Sci 84: 274.
45. Verma RJ (2004) Aflatoxin cause DNA damage. Int J Hum Genet 4: 231–236.
46. Verma RJ, Nair A (2001) Ameliorative effect of vitamin E on aflatoxin-induced lipid peroxidation in the testis of mice. Asian J Androl 3: 217–221.
47. Wogan GN (1999) Aflatoxin as a human carcinogen. Hepatology 30: 573–575.