Association between rs13266634 C/T polymorphisms of solute carrier family 30 member 8 (SLC30A8) and type 2 diabetes, impaired glucose tolerance, type 1 diabetes-A meta-analysis

Diabetes Research and Clinical Practice

Volumn 91, Issue 2, 2011, Pages 195-202

  Xu, Kuanfeng ^a   Zha, Min ^a   Wu, Xiaohong ^a   Yu, Zhangbin ^a   Yu, Rongbin ^a   Xu, Xinyu ^a   Chen, Heng ^a   Yang, Tao ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Impaired glucose tolerance; Meta analysis; SLC30A8; Type 1 diabetes; Type 2 diabetes

Indexed keywords

ARTICLE; DISEASE ASSOCIATION; ETHNIC DIFFERENCE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN DEPENDENT DIABETES MELLITUS; META ANALYSIS (TOPIC); NON INSULIN DEPENDENT DIABETES MELLITUS; RISK ASSESSMENT; RISK FACTOR; SLC30A8 GENE; SYSTEMATIC REVIEW;

CATION TRANSPORT PROTEINS; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GLUCOSE INTOLERANCE; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 79952039908     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2010.11.012     Document Type: Article

References (55)

1. Chimienti F., Devergnas S., Favier A., Seve M. Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. Diabetes 2004, 53:2330-2337.
2. Chimienti F., Favier A., Seve M. ZnT-8, a pancreatic betacell-specific zinc transporter. Biometals 2005, 18:313-317.
3. Palmer N.D., Goodarzi M.O., Langefeld C.D., Ziegler J., Norris J.M., Haffner S.M., et al. Quantitative trait analysis of type 2 diabetes susceptibility loci identified from whole genome association studies in the insulin resistance atherosclerosis family study. Diabetes 2008, 57:1093-1100.
4. Horikoshi M., Hara K., Ito C., Shojima N., Nagai R., Ueki K., et al. Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population. Diabetologia 2007, 50:2461-2466.
5. Saxena R., Voight B.F., Lyssenko V., Burtt N.P., de Bakker P.I., Chen H., et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 2007, 316:1331-1336.
6. Scott L.J., Mohlke K.L., Bonnycastle L.L., Willer C.J., Li Y., Duren W.L., et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 2007, 316:1341-1345.
7. Sladek R., Rocheleau G., Rung J., Dina C., Shen L., Serre D., et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 2007, 445:881-885.
8. Steinthorsdottir V., Thorleifsson G., Reynisdottir I., Benediktsson R., Jonsdottir T., Walters G.B., et al. A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet 2007, 39:770-775.
9. Zeggini E., Weedon M.N., Lindgren C.M., Frayling T.M., Elliott K.S., Lango H., et al. Replication of genome-wide association signals in U.K. samples reveals risk loci for type 2 diabetes. Science 2007, 317:1336-1341.
10. Bronstein M., Pisanté A., Yakir B., Darvasi A. Type 2 diabetes susceptibility loci in the Ashkenazi Jewish population. Hum Genet 2008, 124(1):101-104.
11. Cauchi S., Nead K.T., Choquet H., Horber F., Potoczna N., Balkau B., et al. The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies. BMC Med Genet 2008, 9:45-53.
12. Cauchi S., Meyre D., Durand E., Proença C., Marre M., Hadjadj S., et al. Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value. Plos One 2008, 3(5):e2031.
13. Furukawa Y., Shimada T., Furuta H., Matsuno S., Kusuyama A., Doi A., et al. Polymorphisms in the IDE-KIF11-HHEX gene locus are reproducibly associated with type 2 diabetes in a Japanese population. J Clin Endocrinol Metab 2008, 93:310-314.
14. Hertel J.K., Johansson S., Raeder H., Midthjell K., Lyssenko V., Groop L., et al. Genetic analysis of recently identified type 2 diabetes loci in 1638 unselected patients with type 2 diabetes and 1858 control participants from a Norwegian population-based cohort (the HUNT study). Diabetologia 2008, 51(6):971-977.
15. Horikawa Y., Miyake K., Yasuda K., Enya M., Hirota Y., Yamagata K., et al. Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan. J Clin Endocrinol Metab 2008, 93:3136-3141.
16. Lee Y.H., Kang E.S., Kim S.H., Han S.J., Kim C.H., Kim H.J., et al. Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population. J Hum Genet 2008, 53:991-998.
17. Lewis J.P., Palmer N.D., Hicks P.J., Sale M.M., Langefeld C.D., Freedman B.I., et al. Association analysis in African Americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies. Diabetes 2008, 57:2220-2225.
18. Lyssenko V., Jonsson A., Almgren P., Pulizzi N., Isomaa B., Tuomi T., et al. Clinical risk factors, DNA variants, and the development of Type 2 diabetes. N Engl J Med 2008, 359:2220-2232.
19. Ng M.C., Park K.S., Oh B., Tam C.H., Cho Y.M., Shin H.D., et al. Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6719 Asians. Diabetes 2008, 57(8):2226-2233.
20. Omori S., Tanaka Y., Takahashi A., Hirose H., Kashiwagi A., Kaku K., et al. Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population. Diabetes 2008, 57:791-795.
21. Sanghera D.K., Ortega L., Han S., Singh J., Ralhan S.K., Wander G.S., et al. Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk. BMC Med Genet 2008, 9(59):1-9.
22. van Hoek M., Dehghan A., Witteman J.C., van Duijn C.M., Uitterlinden A.G., Oostra B.A., et al. Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study. Diabetes 2008, 57(11):3122-3128.
23. Wu Y., Li H., Loos R.J., Yu Z., Ye X., Chen L., et al. Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. Diabetes 2008, 57(10):2834-2842.
24. Xiang J., Li X.Y., Xu M., Hong J., Huang Y., Tan J.R., et al. Zinc Transporter-8 gene (SLC30A8) is associated with type 2 diabetes in Chinese. J Clin Endocrinol Metab 2008, 93:4107-4112.
25. Hu C., Zhang R., Wang C., Wang J., Ma X., Lu J., et al. PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population. PLoS One 2009, 4(10):e7643.
26. Rong R., Hanson R.L., Ortiz D., Wiedrich C., Kobes S., Knowler W.C., et al. Association Analysis of Variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians. Diabetes 2009, 58:478-488.
27. Tabara Y., Osawa H., Kawamoto R., Onuma H., Shimizu I., Miki T., et al. Replication study of candidate genes associated with Type 2 diabetes based on genome-wide screening. Diabetes 2009, 58:493-498.
28. Takeuchi F., Serizawa M., Yamamoto K., Fujisawa T., Nakashima E., Ohnaka K., et al. Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. Diabetes 2009, 58(7):1690-1699.
29. Timpson N.J., Lindgren C.M., Weedon M.N., Randall J., Ouwehand W.H., Strachan D.P., et al. Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data. Diabetes 2009, 58:505-510.
30. Chauhan G., Spurgeon C.J., Tabassum R., Bhaskar S., Kulkarni S.R., Mahajan A., et al. Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2 and CDKAL1 on the risk of type 2 diabetes in 5164 Indians. Diabetes 2010, [Epub ahead of print].
31. Han X., Luo Y., Ren Q., Zhang X., Wang F., Sun X., et al. Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population. BMC Med Genet 2010, 11:81-89.
32. Lin Y., Li P., Cai L., Zhang B., Tang X., Zhang X., et al. Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population. BMC Med Genet 2010, 11:97-103.
33. Tan J.T., Ng D.P., Nurbaya S., Ye S., Lim X.L., Leong H., et al. Polymorphisms identified through genome-wide association studies and their associations with type 2 diabetes in Chinese, Malays, and Asian-Indians in Singapore. J Clin Endocrinol Metab 2010, 95(1):390-397.
34. Huang Q., Yin J.Y., Dai X.P., Wu J., Chen X., Deng C.S., Yu M., Gong Z.C., Zhou H.H., Liu Z.Q. Association analysis of SLC30A8 rs13266634 and rs16889462 polymorphisms with type 2 diabetes mellitus and repaglinide response in Chinese patients. Eur J Clin Pharmacol 2010 Aug 31, [Epub ahead of print].
35. Cauchi S., Proença C., Choquet H., Gaget S., De Graeve F., Marre M., et al. Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study. J Mol Med 2008, 86(3):341-348.
36. Wenzlau J.M., Juhl K., Yu L., Moua O., Sarkar S.A., Gottlieb P., et al. The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad Sci USA 2008, 104:17040-17045.
37. Brorsson C., Bergholdt R., Sjögren M., Eising S., Sørensen K.M., Hougaard D.M., et al. A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population. Mol Genet Metab 2008, 94:386-388.
38. Gohlke H., Ferrari U., Koczwara K., Bonifacio E., Illig T., Ziegler A.G. SLC30A8 (ZnT8) polymorphism is associated with young age at type 1 diabetes onset. Rev Diabetes Stud 2008, 5:25-27.
39. Kawasaki E., Uga M., Nakamura K., Kuriya G., Satoh T., Fujishima K., et al. Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes. Diabetologia 2008, 51:2299-2302.
40. Raj S.M., Howson J.M., Walker N.M., Cooper J.D., Smyth D.J., Field S.F., et al. No association of multiple type 2 diabetes loci with type 1 diabetes. Diabetologia 2009, 52(10):2109-2116.
41. Egger M., Juni P., Bartlett C., Holenstein F., Sterne J. How important are comprehensive literature searches and the assessment of trial quality in systematic reviews? Empirical study. Health Technol Assess 2003, 7:1-76.
42. Parmar M.K.B., Torri V., Stewart L. Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Stat Med 1998, 17:2815-2834.
43. Higgins J.P., Thompson S.G. Quantifying heterogeneity in a meta-analysis. Stat Med 2002, 21:1539-1558.
44. Higgins J.P., Thompson S.G., Deeks J.J., Altman D.G. Measuring inconsistency in meta analyses. BMJ 2003, 327:557-560.
45. Cho Y.M., Kim T.H., Lim S., Choi S.H., Shin H.D., Lee H.K., et al. Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population. Diabetologia 2009, 52(2):253-261.
46. Lauenborg J., Grarup N., Damm P., Borch-Johnsen K., Jørgensen T., Pedersen O., et al. Common type 2 diabetes risk gene variants associate with gestational diabetes. J Clin Endocrinol Metab 2009, 94(1):145-150.
47. Cauchi S., Del Guerra S., Choquet H., D'Aleo V., Groves C.J., Lupi R., et al. Meta-analysis and functional effects of the SLC30A8 rs13266634 polymorphism on isolated human pancreatic islets. Mol Genet Metab 2010, 100(1):77-82.
48. Jing Y.L., Sun Q.M., Bi Y., Shen S.M., Zhu D.L. SLC30A8 polymorphism and type 2 diabetes risk: evidence from 27 study groups. Nutr Metab Cardiovasc Dis 2010, [Epub ahead of print].
49. Lango H., Palmer C.N., Morris A.D., Zeggini E., Hattersley A.T., et al. Type 2 diabetes genetics consortium U.K. Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Diabetes 2008, 57(11):3129-3135.
50. Moore A.F., Jablonski K.A., McAteer J.B., Saxena R., Pollin T.I., Franks P.W., et al. Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program. Diabetes 2008, 57(9):2503-2510.
51. Stancáková A., Kuulasmaa T., Paananen J., Jackson A.U., Bonnycastle L.L., Collins F.S., et al. Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5327 nondiabetic Finnish men. Diabetes 2009, 58(9):2129-2136.
52. Kirchhoff K., Machicao F., Haupt A., Schäfer S.A., Tschritter O., Staiger H., et al. Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion. Diabetologia 2008, 51:597-601.
53. Munafo M.R., Flint J. Meta-analysis of genetic association studies. Trends Genet 2008, 20:439-444.
54. Moher D., Pham B., Lawson M.L., Klassen T.P. The inclusion of reports of randomised trials published in languages other than English in systematic reviews. Health Technol Assess 2003, 7:1-90.
55. Jüni P., Holenstein F., Sterne J., Bartlett C., Egger M. Direction and impact of language bias in meta analyses of controlled trials: empirical study. Int J Epidemiol 2002, 31:115-123.