Decidual CD4 + CD25 + CD127 dim/- regulatory T cells in patients with unexplained recurrent spontaneous miscarriage

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 155, Issue 1, 2011, Pages 94-98

  Bao, Shi Hua ^a,b   Wang, Xi Peng ^a   De Lin, Qi ^b   Wang, Wen Juan ^b   Yin, Guang Jie ^b   Qiu, Li Hua ^b  

^a TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Interleukin 10; Recurrent spontaneous miscarriage; Transforming growth factor

Indexed keywords

ANTIBODY; FICOLL; INTERLEUKIN 10; TRANSFORMING GROWTH FACTOR BETA;

ADULT; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL PROLIFERATION; CELL SELECTION; CLINICAL ARTICLE; CONTROLLED STUDY; DECIDUA; DENSITY GRADIENT CENTRIFUGATION; EFFECTOR CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; LYMPHOCYTE FUNCTION; PREGNANT WOMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECURRENT DISEASE; REGULATORY T LYMPHOCYTE; SPONTANEOUS ABORTION;

EID: 79952036751     PISSN: 03012115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejogrb.2010.11.007     Document Type: Article

References (25)

1. Practice Committee of the American Society for Reproductive Medicine Definitions of infertility and recurrent pregnancy loss Fertil Steril 90 Suppl 3 2008 S60
2. American Society for Reproductive Medicine. Patient's fact sheet: recurrent pregnancy loss [Available at: http://www.asrm.org/uploadedFiles/ASRM- Content/Resources/Patient-Resources/Fact-Sheets-and-Info. Accessed September 4, 2010].
3. O.B. Christiansen, A.M. Nybo Andersen, and E. Bosch Evidence-based investigations and treatments of recurrent pregnancy loss Fertil Steril 83 2005 821 839
4. V.R. Aluvihare, M. Kallikourdis, and A.G. Betz Regulatory T cells mediate maternal tolerance to the fetus Nat Immunol 5 2004 266 271 (Pubitemid 38332123)
5. S. Sakaguchi, N. Sakaguchi, M. Asano, M. Itoh, and M. Toda Immunologic self-tolerance by activated T cells expressing IL-2 receptor α chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune disease J Immunol 155 1995 1151 1164
6. S.F. Ziegler FOXP3: of mice and men Annu Rev Immunol 24 2006 209 226
7. C. Baecher-Allan, E. Wolf, and D.A. Hafler MHC class II expression identifies functionally distinct human regulatory T cells J Immunol 176 2006 4622 4631
8. + regulatory T cells Semin Immunol 16 2004 89 98
9. N. Seddiki, B. Santner-Nanan, and J. Martinson Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells J Exp Med 203 2006 693 700
10. + Treg cells J Exp Med 203 2006 1701 1711 (Pubitemid 44036276)
11. + regulatory T cells in decidua and peripheral blood in unexplained recurrent spontaneous abortion patients Fertil Steril 89 2008 656 661 (Pubitemid 351335024)
12. + T regulatory cells prevents fetal rejection in a murine abortion model Am J Pathol 166 2005 811 822 (Pubitemid 40315638)
13. S. Saito, K. Nishikawa, T. Morii, N. Narita, M. Enomoto, and M. Ichijo Expression of activation antigens CD69 HLA-DR, interleukin-2 receptor-alpha (IL-2Rα) and IL-2Rβ on T cells of human decidua at an early stage of pregnancy Immunology 75 1992 710 712
14. + regulatory T cells in early pregnancy subjects and spontaneous abortion Mol Hum Reprod 10 2004 347 353 (Pubitemid 38714366)
15. + regulatory T-cell subset Immunology 112 2004 38 43 (Pubitemid 38609820)
16. J. Heikkinen, M. Mottonen, A. Alanen, and O. Lassila Phenotype characterization of regulatory T cells in the human decidua Clin Exp Immunol 136 2004 373 378 (Pubitemid 38543459)
17. + and Foxp3+ regulatory T cells during the follicular phase of menstrual cycle: implications for human reproduction J Immunol 178 2007 2572 2578 (Pubitemid 46233460)
18. + T cells Cell Mol Immunol 3 2006 189 195
19. + CD25 high regulatory cells in human peripheral blood J Immunol 167 2001 1245 1253 (Pubitemid 32703119)
20. C. Dejaco, C. Duftner, and M. Schirmer Analysis of FOXP3 protein expression in human CD4(+)CD25(+) regulatory T cells at the single-cell level Eur J Immunol 36 2006 245 246
21. + regulatory T cells for immunologic self-tolerance and negative control of immune responses Annu Rev Immunol 22 2004 531 562 (Pubitemid 38680433)
22. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production J Exp Med 188 1998 287 296 (Pubitemid 28357757)
23. C.A. Piccirillo, J.J. Letterio, and A.M. Thornton CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness J Exp Med 196 2002 237 246
24. + regulatory T cell activity in both humans and mice J Immunol 172 2004 834 842 (Pubitemid 38113739)
25. K. Nakamura, A. Kitani, and W. Strober Cell contact dependent immunosuppression by CD4(+)CD25(+)regulatory T cells is mediated by cell surface-bound transforming growth factor beta J Exp Med 194 2001 629 644 (Pubitemid 32844773)