Proportional change of CD4+CD25+ regulatory T cells in decidua and peripheral blood in unexplained recurrent spontaneous abortion patients

Fertility and Sterility

Volumn 89, Issue 3, 2008, Pages 656-661

  Yang, Hui ^a   Qiu, Lihua ^a   Chen, Guangjie ^b   Ye, Zi ^a   Lü, Caijun ^a   Lin, Qide ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

decidua; pregnancy; recurrent; regulatory T cells; Spontaneous abortion

Indexed keywords

ADULT; ARTICLE; BLOOD; BLOOD ANALYSIS; BLOOD SAMPLING; CD4+ CD25+ T LYMPHOCYTE; CELL POPULATION; CHINA; CLINICAL ARTICLE; CONTROL GROUP; CONTROLLED STUDY; DECIDUA; FEMALE; HUMAN; PREGNANT WOMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; PUBLIC HOSPITAL; REGULATORY T LYMPHOCYTE; SPONTANEOUS ABORTION; STATISTICAL SIGNIFICANCE; UNEXPLAINED RECURRENT SPONTANEOUS ABORTION;

ABORTION, HABITUAL; CASE-CONTROL STUDIES; CHINA; DECIDUA; FEMALE; HUMANS; IMMUNE TOLERANCE; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; PREGNANCY; PROSPECTIVE STUDIES; T-LYMPHOCYTES, REGULATORY;

EID: 40249098721     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2007.03.037     Document Type: Article

References (20)

1. Lin Q.D. Investigation of the association between autoantibodies and recurrent abortions. Zhonghua Fu Chan Ke Za Zhi 28 (1993) 674-702
2. Patriarca A., Piccioni V., Gigante V., and Benedetto C. The use of intravenous immunoglobulin in sine causa or alloimmune recurrent spontaneous abortion (RSA). Panminerva Med 42 (2000) 193-195
3. Christiansen O.B., Nybo Andersen A.M., Bosch E., Daya S., Delves P.J., Hviid T.V., et al. Evidence-based investigations and treatments of recurrent pregnancy loss. Fertil Steril 83 (2005) 821-839
4. Bulletti C., Flamigni C., and Giacomucci E. Reproductive failure due to spontaneous abortion and recurrent miscarriage. Hum Reprod Update 2 (1996) 118-136
5. Darrasse-Jeze G., Klatzmann D., Charlotte F., Salomon B.L., and Cohen J.L. CD4+CD25+ regulatory/suppressor T cells prevent allogeneic fetus rejection in mice. Immunol Lett 102 (2006) 106-109
6. Zenclussen A.C., Gerlof K., Zenclussen M.L., Sollwedel A., Bertoja A.Z., Ritter T., et al. Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+CD25+ T regulatory cells prevents fetal rejection in a murine abortion model. Am J Pathol 166 (2005) 811-822
7. Qiu L.H., and Lin Q.D. Study on the relationship between regulatory T cells and unexplained recurrent spontaneous abortion. Zhonghua Fu Chan Ke Za Zhi 39 (2004) 816-818
8. World Health Organization. Laboratory manual for the examination of human semen and sperm-cervical mucus interaction (1999), Cambridge University Press, New York
9. Saito S., Nishikawa K., Morii T., Narita N., Enomoto M., and Ichijo M. Expression of activation antigens CD69, HLA-DR, interleukin-2 receptor-alpha (IL-2R alpha) and IL-2R beta on T cells of human decidua at an early stage of pregnancy. Immunology 75 (1992) 710-712
10. Tsuda H., Michimata T., Hayakawa S., Tanebe K., Sakai M., Fujimura M., et al. A Th2 chemokine, TARC, produced by trophoblasts and endometrial gland cells, regulates the infiltration of CCR4+ T lymphocytes into human decidua at early pregnancy. Am J Reprod Immunol 48 (2002) 1-8
11. Kuniyasu Y., Takahashi T., Itoh M., Shimizu J., Toda G., and Sakaguchi S. Naturally anergic and suppressive CD25(+)CD4(+) T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation. Int Immunol 12 (2000) 1145-1155
12. Baecher-Allan C., Brown J.A., Freeman G.J., and Hafler D.A. CD4+CD25high regulatory cells in human peripheral blood. J Immunol 167 (2001) 1245-1253
13. Cao D., Malmstrom V., Baecher-Allan C., Hafler D., Klareskog L., and Trollmo C. Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis. Eur J Immunol 33 (2003) 215-223
14. Somerset D.A., Zheng Y., Kilby M.D., Sansom D.M., and Drayson M.T. Normal human pregnancy is associated with an elevation in the immune suppressive CD25+CD4+ regulatory T-cell subset. Immunology 112 (2004) 38-43
15. Aluvihare V.R., Kallikourdis M., and Betz A.G. Regulatory T cells mediate maternal tolerance to the fetus. Nat Immunol 5 (2004) 266-271
16. Sasaki Y., Sakai M., Miyazaki S., Higuma S., Shiozaki A., Saito S., et al. Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases. Mol Hum Reprod 10 (2004) 347-353
17. Heikkinen J., Mottonen M., Alanen A., and Lassila O. Phenotypic characterization of regulatory T cells in the human decidua. Clin Exp Immunol 136 (2004) 373-378
18. Tilsburg T., Roelen D.L., van der Mast B.J., van Schip J.J., Kleijburg C., et al. Differential distribution of CD4(+)CD25(bright) and CD8(+)CD28(-) T-cells in decidua and maternal blood during human pregnancy. Placenta 27 Suppl A (2006) S47-S53
19. Vassiliadou N., Searle R.F., and Bulmer J.N. Elevated expression of activation molecules by decidual lymphocytes in women suffering spontaneous early pregnancy loss. Hum Reprod 14 (1999) 1194-1200
20. Quack K.C., Vassiliadou N., Pudney J., Anderson D.J., and Hill J.A. Leukocyte activation in the decidua of chromosomally normal and abnormal fetuses from women with recurrent abortion. Hum Reprod 16 (2001) 949-955