The immune privilege of the oral mucosa

Trends in Molecular Medicine

Volumn 14, Issue 5, 2008, Pages 191-198

  Novak, Natalija ^a   Haberstok, Jörg ^b   Bieber, Thomas ^a   Allam, Jean Pierre ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL FUNCTION; CELL TYPE; DENDRITIC CELL; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOGENESIS; IMMUNOTHERAPY; INTESTINE; INTESTINE MUCOSA; MORPHOLOGY; MOUTH MUCOSA; NONHUMAN; SALIVARY GLAND; SUBLINGUAL DRUG ADMINISTRATION; T LYMPHOCYTE;

ANIMALS; ANTIGEN-PRESENTING CELLS; DENDRITIC CELLS; HUMANS; IMMUNE SYSTEM; IMMUNOTHERAPY; INFLAMMATION; INTESTINAL MUCOSA; MODELS, BIOLOGICAL; MOUTH MUCOSA; T-LYMPHOCYTES;

BACTERIA (MICROORGANISMS);

EID: 42749086356     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmed.2008.03.001     Document Type: Article

References (59)

1. Lu F.X., and Jacobson R.S. Oral mucosal immunity and HIV/SIV infection. J. Dent. Res. 86 (2007) 216-226
2. Paster B.J., et al. Bacterial diversity in human subgingival plaque. J. Bacteriol. 183 (2001) 3770-3783
3. Brandtzaeg P., and Pabst R. Let's go mucosal: communication on slippery ground. Trends Immunol. 25 (2004) 570-577
4. Sun C.M., et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J. Exp. Med. 204 (2007) 1775-1785
5. Wertz P.W., and Squier C.A. Cellular and molecular basis of barrier function in oral epithelium. Crit. Rev. Ther. Drug Carrier Syst. 8 (1991) 237-269
6. Csencsits K.L., et al. Mucosal addressin expression and binding-interactions with naive lymphocytes vary among the cranial, oral, and nasal-associated lymphoid tissues. Eur. J. Immunol. 32 (2002) 3029-3039
7. Cutler C.W., and Jotwani R. Dendritic cells at the oral mucosal interface. J. Dent. Res. 85 (2006) 678-689
8. Kraal G., et al. The importance of regional lymph nodes for mucosal tolerance. Immunol. Rev. 213 (2006) 119-130
9. Pedersen A.M., et al. Saliva and gastrointestinal functions of taste, mastication, swallowing and digestion. Oral Dis. 8 (2002) 117-129
10. Iwasaki A. Mucosal dendritic cells. Annu. Rev. Immunol. 25 (2007) 381-418
11. Allam J.P., et al. Characterization of dendritic cells from human oral mucosa: a new Langerhans' cell type with high constitutive FcepsilonRI expression. J. Allergy Clin. Immunol. 112 (2003) 141-148
12. Viney J.L., et al. Expanding dendritic cells in vivo enhances the induction of oral tolerance. J. Immunol. 160 (1998) 5815-5825
13. Niess J.H., et al. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 307 (2005) 254-258
14. Allam, J.P. et al. Distribution of Langerhans cells and mast cells within the human oral mucosa: new application sites of allergens in sublingual immunotherapy? Allergy (in press)
15. Zavala W.D., and Cavicchia J.C. Deterioration of the Langerhans cell network of the human gingival epithelium with aging. Arch. Oral Biol. 51 (2006) 1150-1155
16. Ali A., et al. A possible CD1a Langerhans cell-mast cell interaction in chronic hyperplastic candidosis. J. Oral Pathol. Med. 36 (2007) 329-336
17. Cruchley A.T., et al. Regional variation in Langerhans cell distribution and density in normal human oral mucosa determined using monoclonal antibodies against CD1, HLADR, HLADQ and HLADP. J. Oral Pathol. Med. 18 (1989) 510-516
18. Le Borgne M., et al. Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo. Immunity 24 (2006) 191-201
19. Allam J.P., et al. Comparative analysis of nasal and oral mucosa dendritic cells. Allergy 61 (2006) 166-172
20. Santoro A., et al. Recruitment of dendritic cells in oral lichen planus. J. Pathol. 205 (2005) 426-434
21. Van Hoogstraten I.M., et al. Reduced frequency of nickel allergy upon oral nickel contact at an early age. Clin. Exp. Immunol. 85 (1991) 441-445
22. Samsom J.N. Regulation of antigen-specific regulatory T-cell induction via nasal and oral mucosa. Crit. Rev. Immunol. 24 (2004) 157-177
23. Novak N., et al. Engagement of fcepsilonri on human monocytes induces the production of il-10 and prevents their differentiation in dendritic cells. J. Immunol. 167 (2001) 797-804
24. Von Bubnoff D., et al. FcepsilonRI induces the tryptophan degradation pathway involved in regulating T Cell responses. J. Immunol. 169 (2002) 1810-1816
25. Samsom J.N., et al. Fc gamma RIIB regulates nasal and oral tolerance: a role for dendritic cells. J. Immunol. 174 (2005) 5279-5287
26. Kraft S., and Novak N. Fc receptors as determinants of allergic reactions. Trends Immunol. 27 (2006) 88-95
27. Allam J.P., et al. Toll-like receptor 4 ligation enforces tolerogenic properties of oral mucosal Langerhans cells. J. Allergy Clin. Immunol. 121 (2008) 368-374
28. Muthukuru M., et al. Oral mucosal endotoxin tolerance induction in chronic periodontitis. Infect. Immun. 73 (2005) 687-694
29. Uehara A., et al. Chemically synthesized pathogen-associated molecular patterns increase the expression of peptidoglycan recognition proteins via toll-like receptors, NOD1 and NOD2 in human oral epithelial cells. Cell. Microbiol. 7 (2005) 675-686
30. Levings M.K., et al. Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells. Blood 105 (2005) 1162-1169
31. Iliev I.D., et al. The yin and yang of intestinal epithelial cells in controlling dendritic cell function. J. Exp. Med. 204 (2007) 2253-2257
32. Jotwani R., et al. Mature dendritic cells infiltrate the T cell-rich region of oral mucosa in chronic periodontitis: in situ, in vivo, and in vitro studies. J. Immunol. 167 (2001) 4693-4700
33. Brandtzaeg P., and Johansen F.E. Mucosal B cells: phenotypic characteristics, transcriptional regulation, and homing properties. Immunol. Rev. 260 (2005) 32-63
34. Neutra M.R., and Kozlowski P.A. Mucosal vaccines: the promise and the challenge. Nat. Rev. Immunol. 6 (2006) 148-158
35. Dunsche A., et al. The novel human beta-defensin-3 is widely expressed in oral tissues. Eur. J. Oral Sci. 110 (2002) 121-124
36. Fabian T.K., et al. Hsp70 is present in human saliva. Med. Sci. Monit. 9 (2003) BR62-BR65
37. Komori H.K., et al. Epithelial and mucosal gamma delta T cells. Curr. Opin. Immunol. 18 (2006) 534-538
38. Cuburu N., et al. Sublingual immunization induces broad-based systemic and mucosal immune responses in mice. Vaccine 25 (2007) 8598-8610
39. Holt P.G., et al. Sublingual allergen administration. I. Selective suppression of IgE production in rats by high allergen doses. Clin. Allergy 18 (1988) 229-234
40. Larche M., et al. Immunological mechanisms of allergen-specific immunotherapy. Nat. Rev. Immunol. 6 (2006) 761-771
41. Marcucci F., et al. Dose dependence of immunological response to sublingual immunotherapy. Allergy 60 (2005) 952-956
42. Brimnes J., et al. Sublingual immunotherapy reduces allergic symptoms in a mouse model of rhinitis. Clin. Exp. Allergy 37 (2007) 488-497
43. Akdis C.A., et al. Immunological mechanisms of sublingual immunotherapy. Allergy 61 (2006) 11-14
44. Moingeon P., et al. Immune mechanisms of allergen-specific sublingual immunotherapy. Allergy 61 (2006) 151-165
45. Bohle B., et al. Sublingual immunotherapy induces IL-10-producing T regulatory cells, allergen-specific T-cell tolerance, and immune deviation. J. Allergy Clin. Immunol. 120 (2007) 707-713
46. Savolainen J., et al. Allergen-induced in vitro expression of IL-18, SLAM and GATA-3 mRNA in PBMC during sublingual immunotherapy. Allergy 62 (2007) 949-953
47. Kildsgaard J., et al. Sublingual immunotherapy in sensitized mice. Ann. Allergy Asthma Immunol. 98 (2007) 366-372
48. Yoshitomi T., et al. Intraoral administration of a T-cell epitope peptide induces immunological tolerance in Cry j 2-sensitized mice. J. Pept. Sci. 13 (2007) 499-503
49. Wilson D.R., et al. Sublingual immunotherapy for allergic rhinitis: systematic review and meta-analysis. Allergy 60 (2005) 4-12
50. Penagos M., et al. Efficacy of sublingual immunotherapy in the treatment of allergic rhinitis in pediatric patients 3 to 18 years of age: a meta-analysis of randomized, placebo-controlled, double-blind trials. Ann. Allergy Asthma Immunol. 97 (2006) 141-148
51. Enrique E., et al. Sublingual immunotherapy for hazelnut food allergy: a randomized, double-blind, placebo-controlled study with a standardized hazelnut extract. J. Allergy Clin. Immunol. 116 (2005) 1073-1079
52. Huang C.F., et al. Effect of sublingual administration with a native or denatured protein allergen and adjuvant CpG oligodeoxynucleotides or cholera toxin on systemic T(H)2 immune responses and mucosal immunity in mice. Ann. Allergy Asthma Immunol. 99 (2007) 443-452
53. Mascarell L., et al. Novel ways for immune intervention in immunotherapy: mucosal allergy vaccines. Immunol. Allergy Clin. North Am. 26 (2006) 283-306
54. Sun J.B., et al. Sublingual tolerance induction with antigen conjugated to cholera toxin B subunit induces Foxp3+CD25+CD4+ regulatory T cells and suppresses delayed-type hypersensitivity reactions. Scand. J. Immunol. 64 (2006) 251-259
55. Van Overtvelt L., et al. IL-10-inducing adjuvants enhance sublingual immunotherapy efficacy in a murine asthma model. Int. Arch. Allergy Immunol. 145 (2007) 152-162
56. Klavinskis L.S., et al. Intranasal immunization with plasmid DNA-lipid complexes elicits mucosal immunity in the female genital and rectal tracts. J. Immunol. 162 (1999) 254-262
57. Razafindratsita A., et al. Improvement of sublingual immunotherapy efficacy with a mucoadhesive allergen formulation. J. Allergy Clin. Immunol. 120 (2007) 278-285
58. Bagnasco M., et al. Pharmacokinetics of Der p 2 allergen and derived monomeric allergoid in allergic volunteers. Int. Arch. Allergy Immunol. 138 (2005) 197-202
59. Kurosaki Y., and Kimura T. Regional variation in oral mucosal drug permeability. Crit. Rev. Ther. Drug Carrier Syst. 17 (2000) 467-508