Simvastatin treatment duration and cognitive preservation in experimental subarachnoid hemorrhage

Journal of Neurosurgical Anesthesiology

Volumn 21, Issue 4, 2009, Pages 326-333

  Takata, Ken ^a   Sheng, Huaxin ^a   Borel, Cecil O ^a   Laskowitz, Daniel T ^a   Warner, David S ^a   Lombard, Frederick W ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Cerebral blood flow; Cognitive impairment; Statins; Subarachnoid hemorrhage; Vasospasm

Indexed keywords

CREATINE KINASE; SIMVASTATIN;

ANIMAL EXPERIMENT; ARTERY DIAMETER; ARTICLE; BRAIN BLOOD FLOW; CELL SURVIVAL; COGNITIVE DEFECT; CONTROLLED STUDY; CORRELATION ANALYSIS; CREATINE KINASE BLOOD LEVEL; DETERIORATION; DOSE RESPONSE; DRUG EFFECT; ENDOTHELIAL DYSFUNCTION; EXPERIMENTAL SUBARACHNOID HEMORRHAGE; MALE; MAZE TEST; MOTOR PERFORMANCE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; ROTAROD TEST; SPATIAL MEMORY; SUBARACHNOID HEMORRHAGE; TREATMENT DURATION; VASOSPASM; VESTIBULAR FUNCTION; VISUAL MEMORY; WISTAR RAT;

ANIMALS; CELL SURVIVAL; CEREBRAL ARTERIES; CEREBROVASCULAR CIRCULATION; COGNITION; COGNITION DISORDERS; CREATINE KINASE; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MAZE LEARNING; NEURONS; POSTURAL BALANCE; RATS; RATS, WISTAR; SIMVASTATIN; SUBARACHNOID HEMORRHAGE;

EID: 70349748919     PISSN: 08984921     EISSN: None     Source Type: Journal    
DOI: 10.1097/ANA.0b013e3181acfde7     Document Type: Article

References (38)

1. Weyer GW, Nolan CP, Macdonald RL. Evidence-based cerebral vasospasm management. Neurosurg Focus. 2006;21:E8.
2. Anderson SW, Todd MM, Hindman BJ, et al. Effects of intraoperative hypothermia on neuropsychological outcomes after intracranial aneurysm surgery. Ann Neurol. 2006;60:518-527.
3. Hackett ML, Anderson CS. Health outcomes 1 year after subarachnoid hemorrhage: an international population-based study. The Australian Cooperative Research on Subarachnoid Hemorrhage Study Group. Neurology. 2000;55:658-662.
4. Mayer SA, Kreiter KT, Copeland D, et al. Global and domain-specific cognitive impairment and outcome after subarachnoid hemorrhage. Neurology. 2002;59:1750-1758. (Pubitemid 35424458)
5. Ogden JA, Mee EW, Henning M. A prospective study of impairment of cognition and memory and recovery after subarachnoid hemorrhage. Neurosurgery. 1993;33:572-586; discussion 586-587. (Pubitemid 23292748)
6. Haley EC Jr. Measuring cognitive outcome after subarachnoid hemorrhage. Ann Neurol. 2006;60:502-504. (Pubitemid 44871791)
7. Haley EC Jr, Kassell NF, Torner JC, et al. A randomized trial of two doses of nicardipine in aneurysmal subarachnoid hemorrhage. A report of the Cooperative Aneurysm Study. J Neurosurg. 1994; 80:788-796.
8. Sillberg VA, Wells GA, Perry JJ. Do statins improve outcomes and reduce the incidence of vasospasm after aneurysmal subarachnoid hemorrhage: a meta-analysis. Stroke. 2008;39:2622-2626.
9. Lynch JR, Wang H, McGirt MJ, et al. Simvastatin reduces vasospasm after aneurysmal subarachnoid hemorrhage: results of a pilot randomized clinical trial. Stroke. 2005;36:2024-2026. (Pubitemid 41266547)
10. Tseng MY, Czosnyka M, Richards H, et al. Effects of acute treatment with pravastatin on cerebral vasospasm, autoregulation, and delayed ischemic deficits after aneurysmal subarachnoid hemorrhage: a phase II randomized placebo-controlled trial. Stroke. 2005;36:1627-1632. (Pubitemid 41098752)
11. McGirt MJ, Parra A, Sheng H, et al. Attenuation of cerebral vasospasm after subarachnoid hemorrhage in mice overexpressing extracellular superoxide dismutase. Stroke. 2002;33: 2317-2323. (Pubitemid 35014649)
12. McGirt MJ, Pradilla G, Legnani FG, et al. Systemic administration of simvastatin after the onset of experimental subarachnoid hemorrhage attenuates cerebral vasospasm. Neurosurgery. 2006;58: 945-951; discussion 945-951. (Pubitemid 43772438)
13. Alvarez de Sotomayor M, Perez-Guerrero C, Herrera MD, et al. Effects of chronic treatment with simvastatin on endothelial dysfunction in spontaneously hypertensive rats. J Hypertens. 1999; 17:769-776. (Pubitemid 29322163)
14. Takata K, Sheng H, Borel CO, et al. Long-term cognitive dysfunction following experimental subarachnoid hemorrhage: new perspectives. Exp Neurol. 2008;213:336-344.
15. Jones BJ, Roberts DJ. The quantitative measurement of motor incoordination in naive mice using an accelerating rotarod. J Pharm Pharmacol. 1968;20:302-304.
16. Elsersy H, Sheng H, Lynch JR, et al. Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the rat. Anesthesiology. 2004;100: 1160-1166. (Pubitemid 38541971)
17. Hutter BO, Kreitschmann-Andermahr I, Gilsbach JM. Cognitive deficits in the acute stage after subarachnoid hemorrhage. Neurosurgery. 1998;43:1054-1065. (Pubitemid 28481104)
18. Parra A, McGirt MJ, Sheng H, et al. Mouse model of subarachnoid hemorrhage associated cerebral vasospasm: methodological analysis. Neurol Res. 2002;24:510-516. (Pubitemid 34742689)
19. Sakurada O, Kennedy C, Jehle J, et al. Measurement of local cerebral blood flow with iodo [14C] antipyrine. Am J Physiol. 1978; 234:H59-H66. (Pubitemid 9174482)
20. Mackensen GB, Nellgard B, Kudo M, et al. Periischemic cerebral blood flow (CBF) does not explain beneficial effects of isoflurane on outcome from near-complete forebrain ischemia in rats. Anesthesiology. 2000;93:1102-1106. (Pubitemid 30764210)
21. Reivich M, Jehle J, Sokoloff L, et al. Measurement of regional cerebral blood flow with antipyrine-14C in awake cats. J Appl Physiol. 1969;27:296-300.
22. Macdonald RL. Randomized trial of clazosentan for prevention of vasospasm after subarachnoid hemorrhage (abstract). Stroke. 2007;38:462.
23. Hansen-Schwartz J, Vajkoczy P, Macdonald RL, et al. Cerebral vasospasm: looking beyond vasoconstriction. Trends Pharmacol Sci. 2007;28:252-256. (Pubitemid 46818461)
24. Macdonald RL, Pluta RM, Zhang JH. Cerebral vasospasm after subarachnoid hemorrhage: the emerging revolution. Nat Clin Pract Neurol. 2007;3:256-263. (Pubitemid 46745473)
25. Cahill J, Zhang JH. Subarachnoid hemorrhage. Is it time for a new direction? Stroke. 2009;40:S86-S87.
26. Megyesi JF, Vollrath B, Cook DA, et al. In vivo animal models of cerebral vasospasm: a review. Neurosurgery. 2000;46:448-460; discussion 460-461.
27. Nolan CP, Macdonald RL. Can angiographic vasospasm be used as a surrogate marker in evaluating therapeutic interventions for cerebral vasospasm? Neurosurg Focus. 2006;21:E1.
28. Davignon J. Beneficial cardiovascular pleiotropic effects of statins. Circulation. 2004;109:III39-III43. (Pubitemid 38786442)
29. Liao JK, Laufs U. Pleiotropic effects of statins. Annu Rev Pharmacol Toxicol. 2005;45:89-118.
30. Endres M, Laufs U. Discontinuation of statin treatment in stroke patients. Stroke. 2006;37:2640-2643. (Pubitemid 44454692)
31. Faraci FM, Heistad DD. Regulation of large cerebral arteries and cerebral microvascular pressure. Circ Res. 1990;66:8-17.
32. Heistad DD. What's new in the cerebral microcirculation? Landis Award lecture. Microcirculation. 2001;8:365-375.
33. Farkas E, Luiten PG. Cerebral microvascular pathology in aging and Alzheimer's disease. Prog Neurobiol. 2001;64:575-611. (Pubitemid 32304447)
34. Libon DJ, Heilman KM. Assessing the impact of vascular disease in demented and nondemented patients. Stroke. 2008;39: 783-784.
35. Frisbee JC, James ME, Muller-Delp JM, et al. HMG-CoA reductase inhibitors improve microvascular outcomes in the metabolic syndrome independent of plasma cholesterol profile (abstract). FASEB J. 2007;21:A854.
36. Danesh FR, Kanwar YS. Modulatory effects of HMG-CoA reductase inhibitors in diabetic microangiopathy. FASEB J. 2004; 18:805-815. (Pubitemid 38544499)
37. McGirt MJ, Lynch JR, Parra A, et al. Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage. Stroke. 2002;33:2950-2956. (Pubitemid 35462871)
38. Westwood FR, Bigley A, Randall K, et al. Statin-induced muscle necrosis in the rat: distribution, development, and fibre selectivity. Toxicol Pathol. 2005;33:246-257. (Pubitemid 40381453)