Novel strategies for poorly water soluble drugs

International Journal of Pharmaceutical Sciences Review and Research

Volumn 4, Issue 3, 2010, Pages 76-84

  Bindu, M B ^a   Kusum, B ^a   Banji, David ^a  

^a Nalanda College of Pharmacy   (India)

Author keywords

And solubility problems; Poor water solubility; Solubilization techniques

Indexed keywords

AMINO ACID PRODRUG; CAFFEINE; CLARITHROMYCIN; IBUPROFEN; NANOCRYSTAL; NANOMORPH; NANOPARTICLE; NANOSUSPENSION; PARACETAMOL; PHOSPHATE PRODRUG; PHOSPHOMONOXYMETHYL PRODRUG; POLYMER PRODRUG; PREDNISOLONE; PRODRUG; SURFACTANT; UNCLASSIFIED DRUG;

CHEMICAL MODIFICATION; COCRYSTALLIZATION; COMPLEX FORMATION; COSOLVENCY; CRYSTALLIZATION; DRUG ADSORPTION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG MIXTURE; DRUG RELEASE; DRUG SOLUBILITY; GLASSY SOLID SOLUTION; HYDROTROPHY; LIQUISOLID SYSTEM; LIQUISOLID TABLET; MICELLE; MICROCRYSTALLINE SUSPENSION; MICROEMULSION; NANOTECHNOLOGY; OSMOTIC DRUG DELIVERY SYSTEM; PARTICLE SIZE; PHARMACEUTICAL ENGINEERING; PHYSICAL CHEMISTRY; REVIEW; SALT FORMATION; SELF EMULSIFYING DRUG DELIVERY SYSTEM; SPRAY FREEZING INTO LIQUID PARTICLE ENGINEERING TECHNOLOGY;

EID: 79952026399     PISSN: None     EISSN: 0976044X     Source Type: Journal    
DOI: None     Document Type: Review

References (62)

1. Rabasco AM, Ginesh JM, Fernandez Arevalo M, Holgado MA, Dissolution Rate of Diazepam from Polyethylene glycol 6000 solid dispersions, International Journal of Pharmaceutics, 67, 1991, 201-206.
2. Lobenberg R, Amidon GL, Modern bioavailability, bioequivalence and biopharmaceutics classification system: New scientific approaches to international regulatory standards. European Journal of Pharmaceutics and Biopharmaceutics, 50, 2000, 3-12.
3. Pedersen, Mullertz A, Brondsted H, Kristenson HC, A comparision of the solubility of danazol in human and simulated gastrointestinal fluids, Pharmaceutical Research, 17, 2000, 891-894.
4. Chaumeil JC, Micronisation: a method of improving the bioavailability of poorly soluble drugs, Methods and Findings in Experimental and Clinical Pharmacology, 20, 1998, 211-215.
5. Blagden N, De Matas M, Gavan PT, York P, Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates, Advanced Drug Delivery Reviews, 59, 2007, 617-630.
6. Jaymin C, Shah, Jivn R, Chen, Diana Chow. Preformulation study of etoposide: II. Increased solubility and dissolution rate by solid-solid dispersions, International Journal of Pharmaceutics, 113, 1995, 103-111.
7. Betageri GV, Makarla KR, Enhancement of dissolution of glyburide by solid dispersion and lyophilization techniques, International Journal of Pharmaceutics,126, 1995,155-160.
8. Jae-Young Jung, Sun Dong Yoo, Sang-Heon Lee, Kye- Hyun Kim, Doo-Sun Yoon, Kyu-Hyun Lee, Enhanced solubility and dissolution rate of itraconazole by a solid dispersion technique, International Journal of Pharmaceutics, 187, 1999, 209-218.
9. Li-Ping Ruan, Bo-Yang Yu, Guang-Miao Fu, Dan-ni Zh, Improving the solubility of ampelopsin by solid dispersions and inclusion complexes. Journal of Pharmaceutical and Biomedical Analysis, 38, 2005, 457-464.
10. Ahmad M, Abdul-Fattah, Hridaya N, Bhargava, Preparation and in vitro evaluation of solid dispersions of Halofantrine, International Journal of Pharmaceutics, 235, 2002, 17-33.
11. Chauhan B, Shimpi S, Paradkar A, Preparation and Characterization of Etoricoxib Solid Dispersions Using Lipid Carriers by Spray Drying Technique, AAPS Pharm Sci Tech, 6, 2005.
12. Chiou WL, Riegelman S, Pharmaceutical applications of solid dispersion systems, Journal of Pharmaceutical Sciences, 60, 1971, 1281-1302.
13. Sekiguchi K, Obi N, Studies on absorption of eutectic mixture. I. A comparison of the behavior of eutectic mixture of sulfathiazole and that of ordinary sulfathiazole in man, Chemistry and Pharmacy Bulletin, 9, 1961, 866-872.
14. Goldberg AH, Gibaldi M, Kanig JL, Increasing dissolution rates and gastrointestinal absorption of drugs via solid solutions and eutectic mixture II- Experimental evaluation of a eutectic mixture: Urea- Acetaminophen system, Journal of Pharmaceutical Sciences, 55, 1966, 482-487.
15. Sekiguchi K, Obi N, Ueda Y. Studies on absorption of eutectic mixtures. II. Absorption of fused conglomerates of chloramphenicol and urea in rabbits, Chemistry and Pharmacy Bulletin, 12, 1964, 134-44.
16. Rajewski RA, Stella VJ, Pharmaceutical applications of cyclodextrins In vivo drug delivery, Journal of Pharmaceutical Sciences, 85, 1996, 1142-69.
17. Uekama K, Design and evaluation of cyclodextrinbased drug formulation, Chemistry and Pharmacy Bulletin, 52, 2004, 900-915.
18. Dalmora ME, Dalmora SL, and Oliveira AG, Inclusion complex of piroxicam with b-cyclodextrin and incorporation in cationic microemulsion. In vitro drug release and in vivo topical anti-inflammatory effect, International Journal of Pharmaceutics, 222, 2001, 45-55.
19. Lawrence MJ, Rees GD, Microemulsions based media as novel drug delivery systems, Advanced Drug Delivery Reviews, 45, 2000, 89 - 121.
20. Lieberman HA, Rieger MM, Banker GS, Pharmaceutical Dosage Forms: Disperse Systems, 1, 2, Marcel Decker, New York, 1996, 211-281,315-370.
21. Palmer TN, Caride VJ, Caldecourt MA, Twickler J, Abdullah V, The mechanism of liposome accumulation in infarction, Biochim Biophys Acta,797, 1984, 363-368.
22. Torchilin VP, Structure and design of polymeric surfactant-base drug delivery systems, Journal of Control Release, 73, 2001, 137-172.
23. Gursoy RN, Benita S, Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs, Biomedical and Pharmacotherapeutics, 58, 2004, 173-182.
24. Prajapati BG, Patel MM, Conventional and alternative pharmaceutical methods to improve oral bioavailability of lipophilic drugs, Asian Journal of Pharmaceutics, 1, 2007, 1-8.
25. Spireas S, Sadu S, Enhancement of prednisolone dissolution properties using liquisolid compacts. International Journal of Pharmaceutics, 166, 1998, 177-188.
26. Humberstone AJ, Charman WN, Lipid-based vehicles for the oral delivery of poor water soluble drugs, Advanced Drug Delivery Reviews, 25, 1997, 103-128.
27. Spireas S. Liquisolid Systems and Methods of Preparing Same. U.S. Patent 2002, 6:423,339 B1.
28. Khaled KA, Asiri YA, El Sayed YM, In vivo evaluation of liquisolid tablets in beagle dogs. International Journal of Pharmaceutics, 222, 2001, 1-6.
29. Kobayashi Y, Ito S, Itai S, Yamamoto K. Physicochemical properties and bioavailability of carbamazepine polymorphs and dehydrate, International Journal of Pharmaceutics, 193, 2000, 137-146.
30. Vaughn JM, Gao X, Yacaman MJ, Johnston KP, Williams RO, Comparison of powder produced by evaporative precipitation into aqueous solution (EPAS) and spray freezing into liquid (SFL) technologies using Z-contrast STEM and complimentary technologies, European Journal of Pharmaceutics and Biopharmaceutics, 60, 2005, 81-89.
31. Hu J, Rogers TL, Brown J, Young T, Johnston KP, Williams RO, Improvement of dissolution rates of poorly water soluble APIs using novel spray freezing into liquid technology, Pharmaceutical Research,19, 2002, 1278-1284.
32. Rogers TL, Nelsen ZC, Sarkari M, Young T, Johnston KP, Williams RO, Enhanced aqueous dissolution of a poorly water soluble drug by novel particle engineering technology: spray-freezing into liquid with atmospheric freeze-drying, Pharmaceutical Research, 20, 2003, 485- 493.
33. Elamin ZA, Sebhatu T, Ahlneck C, The use of amorphous model substances to study mechanically activated materials in the solid state, International Journal of Pharmaceutics,199, 1995, 25-36.
34. Feeley JC, York P, Sumby ZS, Dicks Z, Determination of surface properties and flow characteristics of salbutamol sulphate, before and after micronisation, International Journal of Pharmaceutics, 172, 1998, 89-96.
35. Muller RH, Peters Z, Becker R, Kruss B. Nanosuspensions for the intravenous administration of poorly soluble drugs stability during sterilization and long-term storage, Control Release Bioactive Mater, 22, 1996, 574-575.
36. Jacobs C, Kayser O, Müller RH, Nanosuspensions as a new approach for the formulation for the poorly soluble drug tarazepide, International Journal of Pharmaceutics, 196, 2000, 161-164.
37. Norbert R, Helge H, Bernd WM. Microcrystals for dissolution rate enhancement of poorly watersoluble drugs, International Journal of Pharmaceutics, 254, 2003, 137-145.
38. Heike F, Bernd F, Karl K, Roland B, Dissolution rate improvement of poorly water-soluble drugs obtained by adsorbing solutions of drugs in hydrophilic solvents onto high surface area carriers, European Journal of Pharmaceutics and Biopharmaceutics, 62, 2006,171-177.
39. Abu TM, Serajuddin. Salt formation to improve drug solubility. Advanced Drug Delivery Reviews, 59, 2007,603-616
40. Detoledo JC, Ramsay RE, Fosphenytoin and phenytoin in patients with status epilepticus. Improved tolerability versus increased costs, Drug Safety, 22, 2000, 459-466.
41. Vicent MJ. Polymer-drug conjugates as modulators of cellular apoptosis. AAPS Pharm Sci Tech, 9, 2007, E200-207.
42. Shott H. Colloidal dispersions, Remington: The Science and Practice of Pharmacy, Mack Publishing Company, 1, 1995, Easton, PA, 252-277.
43. Pouton CW, Lipid formulations for oral administration of drugs on emulsifying, selfemulsifying and "self-microemulsifying" drug delivery systems, European Journal of Pharmaceutical Sciences,11, 2000, 93-98.
44. Radtke M, Pure dug nanoparticles for formulation of poorly soluble drugs, New Drugs, 3, 2001, 62-68.
45. Mazzola L, Commercializing nanotechnology, Natural Biotechnology, 10, 2003, 1137-1143.
46. Kondo N, Iwao T, Masuda H, Yamanouchi K, Ishihara Y, Yamada N, Haga T, Ogawa Y, Yokoyama K, Improved oral absorption of a poorly water-soluble drug, HO-221, by wet-bead milling producing particles in submicron region, Chemistry and Pharmacy Bulletin, 41, 1993, 737-740.
47. Hecq J, Deleers M, Fanara D, Vranckx H, Amighi K, Preparation and characterization of nanocrystals for solubility and dissolution rate enhancement of nifedipine, International Journal of Pharmaceuics, 299, 2005, 167-77.
48. Chung HR, Kwon E, Oikawa H, Kasai H, Nakanishi H. Effect of solvent on organic nanocrystal growth using the reprecipitation method. Journal of Crystal Growth, 2, 2006, 459-63.
49. Salvadori B, Capitani GC, Mellini M, Dei L, A novel method to prepare inorganic water-soluble nanocrystals, Journal of Colloid Interface Science,1, 2006, 487-490.
50. Dr. Roghieh Saffie- Siebert, Dr. Jill orden, Dr. Mark parry- billings, Nanotechnology approaches to solving the problems of poorly water soluble drugs, Drug discovery world summer, 1, 2005, 71-76.
51. Arun Kumar N, Deecaraman M, Rani C, Nanosuspensions techonology and its applications in drug delivery, Asian journal of pharmaceutics, 3, 2009, 168-73.
52. Aakeroy CB, Crystal engineering: Strategies and Architectures, Acta Cryst, B53, 1997, 569-586.
53. Amin K, Dannenfelser RM Zielinski J, Wang B, Lyophilization of polyethylene glycol mixtures. Journal of Pharmaceutical Sciences, 93, 2004, 2244-2249.
54. Lachman L, Liberman HA, Kanig JL. The Theory and Practice of Industrial Pharmacy, Indian edition, 3, Verghese Publishing, New Delhi, 1987, 462-426.
55. Rose S, Nelson JF, A continous long-term injector. Australian Journal of Experimental, Biological and Medical Sciences, 33, 1955, 415-20.
56. Theeuwes F, Swanson D, Wong P, Bonson P, Place V, Heimlich K, Kwan KC, Elementary osmotic pump for indomethacin, Journal of Pharmaceutical Sciences, 72, 1982, 253-258.
57. Bittner B, Thelly TH, Isel H, Mountfield RJ, The impact of co-solvents and the composition of experimental formulations on the pump rate of the alzet osmotic pump, International Journal of Pharmacy, 205, 2000, 195-198.
58. Higuchi T, Leeper HM, Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient, 1976;US Patent No.3:995, 631.
59. Prabakaran D, Singh P, Kanaujia P, Jaganathan KS, Rawat A, Vyas SP, Modified push-pull osmotic system for simultaneous delivery of theophylline and salbutamol: development and in vitro characterization, International Journal of Pharmacy, 284, 2004, 95-108.
60. Thombre AG, Appel LE, Chidlaw MB, Daugherity PD, Dumont F, Evans LAF, Sutton SC, Osmotic drug delivery using swellable-core technology, Journal of Control Release, 94, 2004, 75-89.
61. Yalkowsky SH, Krzyzaniak JF and Ward GH, Formulation related problems associated with intravenous drug delivery, Journal of Control Release, 87, 1998, 787-796.
62. Neelam S, Purshotam S, Solubility and stability enhancement of poorly soluble drugs clarithromycin and prednisolone by combination with other drugs, International journal of biological chemistry, 1, 2007, 229-236.