Preparation and in vitro evaluation of solid dispersions of halofantrine

International Journal of Pharmaceutics

Volumn 235, Issue 1-2, 2002, Pages 17-33

  Abdul Fattah, Ahmad M ^a,b   Bhargava, Hridaya N ^a  

^a MASSACHUSETTS COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Dissolution rate; Gelucire 44 14; Halofantrine; PEG 8000; PVP K30; Sodium taurocholate; Solid dispersion

Indexed keywords

DRUG CARRIER; GELUCIRE; HALOFANTRINE; MACROGOL 8000; POVIDONE; POVIDONE K30;

ANALYTIC METHOD; AQUEOUS SOLUTION; ARTICLE; CONCENTRATION (PARAMETERS); DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG BIOAVAILABILITY; DRUG SCREENING; DRUG SOLUBILITY; DRUG STABILITY; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; INFRARED SPECTROSCOPY; PARTICLE SIZE; PHYSICAL CHEMISTRY; PREFORMULATION; PRIORITY JOURNAL; SOLID STATE; TABLET FORMULATION; TEMPERATURE SENSITIVITY; WETTABILITY;

ANTIMALARIALS; DRUG CARRIERS; DRUG EVALUATION, PRECLINICAL; DRUG STABILITY; PHENANTHRENES; SOLUBILITY;

EID: 0037139418     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00941-3     Document Type: Article

References (18)

1. Intramuscular toxicity and absorbance of a parenteral formulation of halofantrine HCL
2. Enhancement of dissolution of glyburide by solid dispersion and lyophilization techniques
3. Lipids, lymph and lipidic formulations
4. Pharmaceutical applications of solid dispersion systems
5. Pharmacokinetics of commercial halofantrine tablets versus the commercial suspension in healthy volunteers
6. A physicochemical basis for the effect of food on the absolute oral bioavailability of halofantrine
7. An improved high performance liquid chromatographic method for the simultaneous measurement of halofantrine and desbutylhalofantrine in human serum
8. Formulation design and bioavailability assessment of lipidic self-emulsifying formulations of halofantrine
9. Lymphatic transport of halofantrine in the triple cannulated anesthetized rat model: Effect of lipid vehicle dispersion
10. Formulation of self-emulsifying drug delivery systems
11. Effect of amphiphilicity on the dissolution and bioavailability of a poorly water soluble drug from solid dispersions
12. Physicochemical characterization of solid dispersions of temazepam with polyethylene glycol 6000 and PVP K30
13. Characteristics of drug-phospholipid coprecipitates: II. Bioavailability studies of griseofulvin in rats