Tocotrienol-treated MCF-7 human breast cancer cells show down-regulation of API5 and up-regulation of MIG6 genes

Cancer Genomics and Proteomics

Volumn 8, Issue 1, 2011, Pages 19-32

  Ramdas, Premdass ^a,b   Rajihuzzaman, Mohammed ^a   Veerasenan, Sheela Devi ^b   Selvaduray, Kanga Rani ^b   Nesaretnam, Kalanithi ^b   Radhakrishnan, Ammu Kutty ^a  

^a INTERNATIONAL MEDICAL UNIVERSITY   (Malaysia)

^b MALAYSIAN PALM OIL BOARD   (Malaysia)

Author keywords

API5; Apoptosis inhibitors; Breast cancer; EGFR inhibitor; Gene expression; MIG6; Tocotrienols; Vitamin E

Indexed keywords

ALPHA TOCOTRIENOL; GAMMA TOCOTRIENOL; PALM OIL; PROTEIN;

APOPTOSIS; APOPTOSIS INHIBITOR 5 GENE; ARTICLE; BREAST CANCER; CANCER CELL; CANCER INHIBITION; CELL STRAIN MCF 7; CONTROLLED STUDY; FEMALE; GENE; GENE EXPRESSION; GENETIC CODE; HUMAN; HUMAN CELL; IC 50; IMMUNE RESPONSE; ISOMER; MITOGEN INDUCED GENE 6; NUCLEOTIDE SEQUENCE; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; TUMOR GROWTH;

EID: 79952001301     PISSN: 11096535     EISSN: 17906245     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Lawrence G: Screening histories of invasive breast cancers diagnosed 1989-2006 in the West Midlands, UK: variation with time and impact in 10-years. J Med Screen 16: 186-192, 2009.
2. Kasule OH: Epidemiology of breast cancer in Malaysia. Biomed Imaging Interv J 1: e6-14, 2005.
3. Machlin L: Vitamin E. In: Handbook of Vitamins. Machlin L and Dekker M (eds.). New York, pp. 99-144, 1991.
4. Kamal-Eldin A and Appelqvist L: The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids 31: 671-701, 1996. (Pubitemid 26240763)
5. Combs GF: The Vitamins. Fundamental Aspects in Nutrition and Health. Combs GF Jr. (ed.). Academic Press, Inc. USA, pp. 63-93, 1992.
6. Sundram K and Gapor A: Vitamin E from palm oil: its extraction and nutritional properties. Lipid Technol 4: 137-141, 1992.
7. Sookwong P, Nakagava K, Murata K, Kojima Y and Miyazawa T: Quantitation of tocotrienol and tocopherol in various rice bran. J Agri Food Chem 55: 461-465, 2007.
8. Serbinova E, Kagan V, Han D and Packer L: Free radical recycling and intramembrane mobility in the antioxidant properties of α-tocopherol and α-tocotrienol. Free Radical Biol Med 10: 263-275, 1991. (Pubitemid 121003898)
9. Yu W, Simmons-Menchaca M, Gapor A, Sander BG and Kline K: Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols. Nutr Cancer 33: 26-32, 1999. (Pubitemid 29196119)
10. Gould MN, Haag JD, Kennan WS, Tanner MA and Elson CE: A comparison of tocopherol and tocotrienols for the chemoprevention of chemically induced rat mammary tumours. Am J Clin Nutr 53: 1068S-1070S, 1991.
11. Sen CK, Khanna S, Roy S and Packer L: Tocotrienol potently inhibits glutamate-induced Pp60 (c-Src) kinase activation and death of HT4 neuronal cells. J Biol Chem 275: 13049-13055, 2000. (Pubitemid 30241466)
12. Sakai M, Okabe M, Tachibana H and Yamada K: Apoptosis induction by γ-tocotrienol in human hepatoma Hep3B cells. J Nutr Biochem 17: 10, 672-676, 2006. (Pubitemid 44380370)
13. Shah SJ and Sylvester PW: Tocotrienol-induced cytotoxicity is unrelated to mitochondrial stress apoptotic signaling in neoplastic mammary epithelial cells. Biochem Cell Biol 83: 86-95, 2005.
14. Shun MC, Yu W, Gapor A, Parsons R, Atkinson J, Sanders BG and Kline K: Pro-apoptotic mechanisms of action of a novel vitamin E analog (alpha-TEA) and a naturally occurring form of vitamin E (delta-tocotrienol) in MDA-MB-435 human breast cancer cells. Nutr Cancer 48: 95-105, 2004. (Pubitemid 38823551)
15. Numakawa Y, Numakawa T, Matsumoto T, Yagasaki Y, Kumamara E, Kunugi H, Taguchi T and Niki E: Vitamin E protected cultured cortical neurons from oxidative stress-induced cell death through the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. J Neurochem 97: 1191-1202, 2006.
16. Nesaretnam K, Stephen R, Dils R and Darbre P: Tocotrienols inhibit the growth of human breast cancer cells irrespective of estrogen receptor status. Lipids 33: 461-469, 1998. (Pubitemid 28261949)
17. Samant GV and Sylvester PW: Gamma-tocotrienol inhibits ErbB3-dependent PI3K/Akt mitogenic signalling in neoplastic mammary epithelial cells. Cell Prolif 39: 563-574. 2006. (Pubitemid 44760206)
18. Saeed AI, Sharov V, White J, Li J, Liang W and Bhagabati N: TM4: a free, open-source system for microarray data management and analysis. Biotechniques 34: 374-378, 2003. (Pubitemid 36184095)
19. Welch BL: The generalization of 'students' problem when several different population variances are involved. Biometrika 34: 28-35, 1947.
20. Tusher VG, Tibshirani R and Chu G: Significance analysis of microarrays applied to the ionizing radiation response. Proc USA 98: 5116-5121, 2001. (Pubitemid 32397092)
21. Nesaretnam K, Dorasamy S and Darbre PD: Tocotrienols inhibit growth of ZR-75-1 mammary cancer cells. Int J Food Sci Nut 51: 97-105, 2000.
22. Nesaretnam K, Guthrie N, Chambers AF and Carroll KK: Effect of tocotrienols on the growth of a human breast cancer cell line in culture: Lipids 30: 1139-1143, 1995.
23. Caroll KK, Guthrie N, Nesaretnam K, Gapor A and Chambers AF: Anti-cancer properties of tocotrienols from palm oil in nutrition. In: Palm Oil Development. Ong ASH, Niki E, Packer L (eds.). AOCS Press, Champaign, pp. 117-121, 1995.
24. Guha M, Xia F, Raskett CM and Altieri DC: Caspase 2-mediated tumor suppression involves survivin gene silencing caspase 2 regulation of tumor growth. Oncogene 29: 1280-1292, 2010.
25. Krejci P, Pejchalova K, Barry ER, Fred PR, Elizabeth LT, Laurell H and William RW: The antiapoptotic protein Api5 and its partner, high molecular weight FGF2, are up-regulated in B-cell chronic lymphoid leukemia. J LeuKocyte Bio 82: 1363-1364, 2007.
26. Watson AJ: Apoptosis and colorectal cancer. Gut 53: 1701-1709, 2004.
27. Kim JW, Cho HS and Kim JH: AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis. Lab Invest 80: 587-594, 2000. (Pubitemid 30226639)
28. Tewari M, Yu M, Ross B, Dean C, Giordano A and Rubin R: AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal. Cancer Res 57: 4063-4069, 1997. (Pubitemid 27427698)
29. Morris EJ, Michaud WA and Ji JY: Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo. PLoS Genet 2: e196, 2006.
30. Sasaki A, Taketomi T, Wakioka T, Kato R and Yoshimura A: Identification of a dominant negative mutant of Sprouty that potentiates fibroblast growth factor- but not epidermal growth factor-induced ERK activation. J Biol Chem 276: 36804-36808, 2001.
31. Anastasi S, Sala G, Huiping C, Caprini E, Russo G, Iacovelli S, Lucini F, Ingvarsson S and Segatto O: Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ERBB-2 oncogenic potency and favors resistance to Herceptin. Oncogene 24: 4540-4548, 2005. (Pubitemid 41032617)
32. Amatschek S, Koenig U, Auer H, Steinlein P, Pacher M, Gruenfelder A, Dekan G, Vogl S, Kubista E and Heider KH: Tissue-wide expression profiling using cDNA subtraction and microarrays to identify tumour-specific genes. Cancer Res 64: 844-856, 2004. (Pubitemid 38176883)
33. Koshikawa K, Nomoto S, Yamashita K, Ishigure K, Takeda S and Nakao A: Allelic imbalance at 1p36 in the pathogenesis of human hepatocellular carcinoma. Hepatogastroenterology 51: 186-191, 2004. (Pubitemid 38283090)
34. Ogunbiyi OA, Goodfellow PJ, Gagliardi G, Swanson PE, Birnbaum EH, Fleshman JW, Kodner IJ and Moley JF: Prognostic value of chromosome 1p allelic loss in colon cancer. Gastroenterology 113: 761-766, 1997. (Pubitemid 27381134)
35. Hackel PO, Gishizky M and Ullrich A: Mig-6 is a negative regulator of the epidermal growth factor receptor signal. Biol Chem 382: 1649-1662, 2001. (Pubitemid 34100596)
36. Ferby I, Reschke M, Kudlacek, O, Knyazev P, Pante G, Amann K, Sommergruber W, Kraut N, Ullrich A, Fassler R and Klein R: Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation. Nat Med 12: 568-573, 2006.
37. Tseng RC, Chang JW, Hsien FJ, Chang YH, Hsiao CF, Chen JT, Chen CY, Jou YS and Wang YC: Genome-wide loss of heterozygosity and its clinical associations in non-small cell lung cancer. Int J Cancer 117: 241-247, 2005.
38. Li R, Meng Z and Xie J: Effects of sulfur dioxide on the expressions of EGF, EGFR, and COX-2 in airway of asthmatic rats. Arc Env Con Tox 54: 748-757, 2007.
39. Mahalingam D, Radhakrishnan AK, Amom Z, Ibrahim N and Nesaretnam K: Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers. Eur J Clin Nut 21: 1-7, 2010.
40. Nesaretnam K, Mahalingam D, Radhakrishnan A and Premier R: Supplementation of tocotrienol-rich fraction increases interferon-gamma production in ovalbumin-immunized mice. Eur J Lipid Sci Technol 112: 531-536, 2010.