Evidence for a second receptor for prostacyclin on human airway epithelial cells that mediates inhibition of CXCL9 and CXCL10 release

Molecular Pharmacology

Volumn 79, Issue 3, 2011, Pages 586-595

  Wilson, Sylvia M ^a   Sheddan, Neil A ^b   Newton, Robert ^a   Giembycz, Mark A ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b INSTITUT FÜR ORGANISCHE CHEMIE   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

15 DEOXY 16 (3 TOLYL) 17,18,19,20 TETRANORISOCARBACYCLIN; 3 (4 FLUOROPHENYL) 2 [5 (4 FLUOROPHENYL)BENZOFURAN 2 YLMETHOXYCARBONYLAMINO)PROPIONIC ACID; 3 BENZYL 5 (6 CARBOXYHEXYL) 1 (2 CYCLOHEXYL 2 HYDROXYETHYLAMINO)HYDANTOIN; 5 BROMO 2 METHOXY N [3 (2 NAPHTHALEN 2 YLMETHYLPHENYL)ACRYLOYL]BENZENE SULFONAMIDE; 5 BUTYL 2,4 DIHYDRO[[2' [N (5 METHYL 2 THIOPHENECARBONYL)SULFAMOYL]BIPHENYL 4 YL]METHYL] 2 [(2 TRIFLUOROMETHYL)PHENYL] 1,2,4 TRIAZOL 3 ONE; CARBACYCLIN DERIVATIVE; CXCL9 CHEMOKINE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; ILOPROST; L 161982; L 798106; PROPIONIC ACID DERIVATIVE; PROSTACYCLIN; PROSTACYCLIN RECEPTOR; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E4 RECEPTOR; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; PROSTAGLANDIN RECEPTOR STIMULATING AGENT; RECEPTOR SUBTYPE; RECOMBINANT RECEPTOR; RO 3244794; SMALL INTERFERING RNA; TAPROSTENE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL STRAIN HEK293; CONCENTRATION RESPONSE; CYTOKINE RELEASE; DNA RESPONSIVE ELEMENT; EPITHELIUM CELL; GENE SILENCING; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RECEPTOR GENE; RESPIRATORY EPITHELIUM; TRANSACTIVATION; TRANSCRIPTION INITIATION;

BENZOFURANS; CELLS, CULTURED; CHEMOKINE CXCL10; CHEMOKINE CXCL9; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; EPOPROSTENOL; HEK293 CELLS; HUMANS; ILOPROST; PROPIONIC ACIDS; RECEPTORS, PROSTAGLANDIN; RECOMBINANT PROTEINS; RESPIRATORY MUCOSA;

EID: 79951992176     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.110.069674     Document Type: Article

References (30)

1. Ayer LM, Wilson SM, Traves SL, Proud D, and Giembycz MA (2008) 4,5-Dihydro- 1H-imidazol-2-yl)-[4-(4-isopropoxy-benzyl)-phenyl]-amine (RO1138452) is a selective, pseudo-irreversible orthosteric antagonist at the prostacyclin (IP)-receptor expressed by human airway epithelial cells: negative IP-receptor-mediated regulation of CXCL9 and CXCL10 release. J Pharmacol Exp Ther 324:815-826. (Pubitemid 351185859)
2. Bley KR, Bhattacharya A, Daniels DV, Gever J, Jahangir A, O'Yang C, Smith S, Srinivasan D, Ford AP, and Jett MF (2006) RO1138452 and RO3244794: characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists. Br J Pharmacol 147:335-345. (Pubitemid 43214691)
3. Chivers JE, Cambridge LM, Catley MC, Mak JC, Donnelly LE, Barnes PJ, and Newton R (2004) Differential effects of RU486 reveal distinct mechanisms for glucocorticoid repression of prostaglandin E release. Eur J Biochem 271:4042-4052. (Pubitemid 39423102)
4. Dong YJ, Jones RL, and Wilson NH (1986) Prostaglandin E receptor subtypes in smooth muscle: agonist activities of stable prostacyclin analogues. Br J Pharmacol 87:97-107. (Pubitemid 16165892)
5. Hébert RL, Regnier L, and Peterson LN (1995) Rabbit cortical collecting ducts express a novel prostacyclin receptor. Am J Physiol 268:F145-F154. (Pubitemid 124005470)
6. Jones RL, Giembycz MA, and Woodward DF (2009) Prostanoid receptor antagonists: development strategies and therapeutic applications. Br J Pharmacol 158:104-145.
7. Katsuyama M, Sugimoto Y, Namba T, Irie A, Negishi M, Narumiya S, and Ichikawa A (1994) Cloning and expression of a cDNA for the human prostacyclin receptor. FEBS Lett 344:74-78.
8. Kaur M, Chivers JE, Giembycz MA, and Newton R (2008) Long-acting β2-adrenoceptor agonists synergistically enhance glucocorticoid-dependent transcription in human airway epithelial and smooth muscle cells. Mol Pharmacol 73:203-214. (Pubitemid 350294211)
9. Kenakin TP (1987) Pharmacologic Analysis of Drug-Receptor Interaction. Raven Press, New York.
10. Kiriyama M, Ushikubi F, Kobayashi T, Hirata M, Sugimoto Y, and Narumiya S (1997) Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol 122:217-224. (Pubitemid 27397191)
11. Kotani M, Tanaka I, Ogawa Y, Usui T, Mori K, Ichikawa A, Narumiya S, Yoshimi T, and Nakao K (1995) Molecular cloning and expression of multiple isoforms of human prostaglandin E receptor EP3 subtype generated by alternative messenger RNA splicing: multiple second messenger systems and tissue-specific distributions. Mol Pharmacol 48:869-879.
12. Lazareno S and Birdsall NJ (1993) Estimation of competitive antagonist affinity from functional inhibition curves using the Gaddum, Schild and Cheng-Prusoff equations. Br J Pharmacol 109:1110-1119. (Pubitemid 23216780)
13. Meja KK, Catley MC, Cambridge LM, Barnes PJ, Lum H, Newton R, and Giembycz MA (2004) Adenovirus-mediated delivery and expression of a cAMP-dependent protein kinase inhibitor gene to BEAS-2B epithelial cells abolishes the anti-inflammatory effects of rolipram, salbutamol, and prostaglandin E2: a comparison with H-89. J Pharmacol Exp Ther 309:833-844. (Pubitemid 38542640)
14. 2 receptor agonist in human eosinophils. J Pharmacol Exp Ther 304:349-355.
15. Namba T, Oida H, Sugimoto Y, Kakizuka A, Negishi M, Ichikawa A, and Narumiya S (1994) cDNA cloning of a mouse prostacyclin receptor. Multiple signaling pathways and expression in thymic medulla. J Biol Chem 269:9986-9992.
16. Neubig RR, Spedding M, Kenakin T, and Christopoulos A (2003) International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on terms and symbols in quantitative pharmacology. Pharmacol Rev 55:597-606.
17. Satoh T, Ishikawa Y, Kataoka Y, Cui Y, Yanase H, Kato K, Watanabe Y, Nakadate K, Matsumura K, Hatanaka H, et al. (1999) CNS-specific prostacyclin ligands as neuronal survival-promoting factors in the brain. Eur J Neurosci 11:3115-3124. (Pubitemid 29431646)
18. Sheddan NA, Czybowski M, and Mulzer J (2007) Novel synthetic strategies for the preparation of prostacyclin and prostaglandin analogues - off the beaten track. Chem Commun (Camb) 21:2107-2120. (Pubitemid 47333693)
19. Sheddan NA and Mulzer J (2005) Access to isocarbacyclin derivatives via substratecontrolled enolate formation: total synthesis of 15-deoxy-16-(m-tolyl)- 17,18,19,20-tetranorisocarbacyclin. Org Lett 7:5115-5118.
20. Smyth EM, Nestor PV, and FitzGerald GA (1996) Agonist-dependent phosphorylation of an epitope-tagged human prostacyclin receptor. J Biol Chem 271:33698-33704. (Pubitemid 27010191)
21. Suzuki M, Kato K, Noyori R, Watanabe Y, Takechi H, Matsumura K, Langstrom B, and Watanabe Y (1996) (15R)-16-m-Tolyl-17,18,19,20-tetranorisocarbacyclin: a stable ligand with high binding affinity and selectivity for a prostacyclin receptor in the central nervous system. Angew Chem Int Ed Engl 35:334-336.
22. Suzuki M, Kato K, Watanabe Y, Satoh T, Matsumura K, Watanabe Y, and Noyori R (1999) 15-Deoxy-16-(m-tolyl)-17,18,19,20-tetranorisocarbacyclin: a simple TIC derivative with potent anti-apoptotic activity for neuronal cells. Chem Commun (Camb) 4:307-308. (Pubitemid 29097487)
23. Takechi H, Matsumura K, Watanabe Y, Kato K, Noyori R, Suzuki M, and Watanabe Y (1996) A novel subtype of the prostacyclin receptor expressed in the central nervous system. J Biol Chem 271:5901-5906. (Pubitemid 26083933)
24. Watanabe Y, Matsumura K, Takechi H, Kato K, Morii H, Björkman M, Långström B, Noyori R, Suzuki M, and Watanabe Y (1999) A novel subtype of prostacyclin receptor in the central nervous system. J Neurochem 72:2583-2592. (Pubitemid 29242211)
25. Waud DR, Son SL, and Waud BE (1978) Kinetic and empirical analysis of doseresponse curves illustrated with a cardiac example. Life Sci 22:1275-1285.
26. 2, DP and IP receptor subtypes. Br J Pharmacol 144:405-415.
27. 4 receptors. Eur J Pharmacol 501:49-58.
28. Wilson SM, Shen P, Rider CF, Traves SL, Proud D, Newton R, and Giembycz MA (2009) Selective prostacyclin receptor agonism augments glucocorticoid- induced gene expression in human bronchial epithelial cells. J Immunol 183:6788-6799.
29. Wise H and Jones R L (2000) Prostacyclin and Its Receptors. Kluwer Academic Publishers, Hingham, MA.
30. Wise H, Qian YM, and Jones RL (1995) A study of prostacyclin mimetics distinguishes neuronal from neutrophil IP receptors. Eur J Pharmacol 278:265-269.