Kukoamine B, a novel dual inhibitor of LPS and CpG DNA, is a potential candidate for sepsis treatment

British Journal of Pharmacology

Volumn 162, Issue 6, 2011, Pages 1274-1290

  Liu, Xin ^a   Zheng, Xinchuan ^a   Wang, Ning ^a   Cao, Hongwei ^a   Lu, Yongling ^a   Long, Yupeng ^a   Zhao, Kecen ^a   Zhou, Hong ^a   Zheng, Jiang ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

CpG DNA; Kukoamine B; lipopolysaccharide; sepsis

Indexed keywords

ALKALOID; DNA; INTERLEUKIN 6; KUKOAMINE B; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; BIOSENSOR; CELL ASSAY; CELL VIABILITY; CONTROLLED STUDY; CPG ISLAND; CYTOKINE RELEASE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG STRUCTURE; ESCHERICHIA COLI INFECTION; FEMALE; LIMULUS LYSATE TEST; LIPID BLOOD LEVEL; MALE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTECTION; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SEPSIS; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; SURVIVAL RATE; TREATMENT DURATION;

ANIMALS; CAFFEIC ACIDS; CPG ISLANDS; CYTOKINES; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; ESCHERICHIA COLI; FEMALE; GENE EXPRESSION; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MALE; MICE; SEPSIS; SPERMINE; SURVIVAL ANALYSIS;

EID: 79951973316     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.01114.x     Document Type: Article

References (47)

1. Abraham E, Laterre PF, Garg R, Levy H, Talwar D, Trzaskoma BL, et al. (2005). Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death. N Engl J Med 353: 1332-1341. (Pubitemid 41362701)
2. Agrawal S, Kandimalla ER, (2002). Medicinal chemistry and therapeutic potential of CpG DNA. Trends Mol Med 8: 114-121. (Pubitemid 34532636)
3. Bianchi ME, (2007). DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol 81: 1-5. (Pubitemid 46028489)
4. Brandenburg K, David A, Howe J, Koch MH, Andra J, Garidel P, (2005). Temperature dependence of the binding of endotoxins to the polycationic peptides polymyxin B and its nonapeptide. Biophys J 88: 1845-1858. (Pubitemid 40976198)
5. Buras JA, Holzmann B, Sitkovsky M, (2005). Animal models of sepsis: setting the stage. Nat Rev Drug Discov 4: 854-865. (Pubitemid 41553966)
6. Cavaillon JM, Haeffner-Cavaillon N, (1986). Polymyxin-B inhibition of LPS-induced interleukin-1 secretion by human monocytes is dependent upon the LPS origin. Mol Immunol 23: 965-969. (Pubitemid 16040324)
7. Christ WJ, Asano O, Robidoux AL, Perez M, Wang Y, Dubuc GR, et al. (1995). E5531, a pure endotoxin antagonist of high potency. Science 268: 80-83.
8. Cowdery JS, Chace JH, Yi AK, Krieg AM, (1996). Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides. J Immunol 156: 4570-4575. (Pubitemid 26174435)
9. Crouser E, Exline M, Knoell D, Wewers MD, (2008). Sepsis: links between pathogen sensing and organ damage. Curr Pharm Des 14: 1840-1852.
10. De Nardo D, De Nardo CM, Nguyen T, Hamilton JA, Scholz GM, (2009). Signaling crosstalk during sequential TLR4 and TLR9 activation amplifies the inflammatory response of mouse macrophages. J Immunol 183: 8110-8118.
11. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, et al. (2008). Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 36: 296-327.
12. Dombrovskiy VY, Martin AA, Sunderram J, Paz HL, (2007). Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit Care Med 35: 1244-1250. (Pubitemid 46642649)
13. Ferguson AD, Welte W, Hofmann E, Lindner B, Holst O, Coulton JW, et al. (2000). A conserved structural motif for lipopolysaccharide recognition by procaryotic and eucaryotic proteins. Structure 8: 585-592. (Pubitemid 30409311)
14. Funayama SZ, Zhang GR, Nozoe S, (1995). Kukoamine B, a spermine alkaloid from Lycium chinense. Phytochemistry 38: 1539-1531.
15. Gasse P, Mary C, Guenon I, Noulin N, Charron S, Schnyder-Candrian S, et al. (2007). IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice. J Clin Invest 117: 3786-3799. (Pubitemid 350224089)
16. Genfa L, Jiang Z, Hong Z, Yimin Z, Liangxi W, Guo W, et al. (2005). The screening and isolation of an effective anti-endotoxin monomer from Radix Paeoniae Rubra using affinity biosensor technology. Int Immunopharmacol 5: 1007-1017.
17. Hacker H, Karin M, (2006). Regulation and function of IKK and IKK-related Kinases. Sci STKE 2006: re13.
18. Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, et al. (2000). A Toll-like receptor recognizes bacterial DNA. Nature 408: 740-745. (Pubitemid 32015992)
19. Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, et al. (1999). Cutting edge: toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162: 3749-3752. (Pubitemid 29314747)
20. Hotchkiss RS, Karl IE, (2003). The pathophysiology and treatment of sepsis. N Engl J Med 348: 138-150. (Pubitemid 36056721)
21. Hume DA, Underhill DM, Sweet MJ, Ozinsky AO, Liew FY, Aderem A, (2001). Macrophages exposed continuously to lipopolysaccharide and other agonists that act via toll-like receptors exhibit a sustained and additive activation state. BMC Immunol 2: 11.
22. Jiang Z, Hong Z, Guo W, Xiaoyun G, Gengfa L, Yongning L, et al. (2004). A synthetic peptide derived from bactericidal/permeability-increasing protein neutralizes endotoxin in vitro and in vivo. Int Immunopharmacol 4: 527-537. (Pubitemid 38501660)
23. Kagan JC, Medzhitov R, (2006). Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell 125: 943-955. (Pubitemid 43795199)
24. Kagan JC, Su T, Horng T, Chow A, Akira S, Medzhitov R, (2008). TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol 9: 361-368. (Pubitemid 351405105)
25. Kawagoe T, Sato S, Matsushita K, Kato H, Matsui K, Kumagai Y, et al. (2008). Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2. Nat Immunol 9: 684-691. (Pubitemid 351712639)
26. Kawai T, Akira S, (2010). The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11: 373-384.
27. Kumar H, Kawai T, Akira S, (2009). Pathogen recognition in the innate immune response. Biochem J 420: 1-16.
28. Leone M, Textoris J, Michel F, Wiramus S, Martin C, (2010). Emerging drugs in sepsis. Expert Opin Emerg Drugs 15: 41-52.
29. Liu X, Cheng J, Zheng X, Chen Y, Wu C, Li B, et al. (2009). Targeting CpG DNA to screen and isolate anti-sepsis fraction and monomers from traditional Chinese herbs using affinity biosensor technology. Int Immunopharmacol 9: 1021-1031.
30. Livak KJ, Schmittgen TD, (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408. (Pubitemid 34164012)
31. Martin GS, Mannino DM, Eaton S, Moss M, (2003). The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 348: 1546-1554. (Pubitemid 36437931)
32. Medzhitov R, Horng T, (2009). Transcriptional control of the inflammatory response. Nat Rev Immunol 9: 692-703.
33. Nahra R, Dellinger RP, (2008). Targeting the lipopolysaccharides: still a matter of debate? Curr Opin Anaesthesiol 21: 98-104.
34. Nathan CF, Terry WD, (1975). Differential stimulation of murine lymphoma growth in vitro by normal and BCG-activated macrophages. J Exp Med 142: 887-902.
35. Neuder LE, Keener JM, Eckert RE, Trujillo JC, Jones SL, (2009). Role of p38 MAPK in LPS induced pro-inflammatory cytokine and chemokine gene expression in equine leukocytes. Vet Immunol Immunopathol 129: 192-199.
36. O'Neill LA, Bowie AG, (2007). The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol 7: 353-364. (Pubitemid 46674493)
37. Paromov V, Qui M, Yang H, Smith M, Stone WL, (2008). The influence of N-acetyl-L-cysteine on oxidative stress and nitric oxide synthesis in stimulated macrophages treated with a mustard gas analogue. BMC Cell Biol 9: 33.
38. Parrish WR, Gallowitsch-Puerta M, Czura CJ, Tracey KJ, (2008). Experimental therapeutic strategies for severe sepsis: mediators and mechanisms. Ann N Y Acad Sci 1144: 210-236.
39. Potterat O, (2010). Goji (Lycium barbarum and L. chinense): phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity. Planta Med 76: 7-19.
40. Quinn JG, O'Neill S, Doyle A, McAtamney C, Diamond D, MacCraith BD, et al. (2000). Development and application of surface plasmon resonance-based biosensors for the detection of cell-ligand interactions. Anal Biochem 281: 135-143. (Pubitemid 30346491)
41. Rowe DC, McGettrick AF, Latz E, Monks BG, Gay NJ, Yamamoto M, et al. (2006). The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction. Proc Natl Acad Sci U S A 103: 6299-6304.
42. Saemann MD, Weichhart T, Zeyda M, Staffler G, Schunn M, Stuhlmeier KM, et al. (2005). Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism. J Clin Invest 115: 468-475. (Pubitemid 40385489)
43. Sparwasser T, Miethke T, Lipford G, Borschert K, Hacker H, Heeg K, et al. (1997). Bacterial DNA causes septic shock. Nature 386: 336-337. (Pubitemid 27154466)
44. Ulloa L, Tracey KJ, (2005). The 'cytokine profile': a code for sepsis. Trends Mol Med 11: 56-63. (Pubitemid 40193483)
45. Wagner M, (1993). Findings halt clinical trials of centoxin. Mod Healthc 23: 16.
46. Wiese A, Gutsmann T, Seydel U, (2003). Towards antibacterial strategies: studies on the mechanisms of interaction between antibacterial peptides and model membranes. J Endotoxin Res 9: 67-84. (Pubitemid 36603680)
47. Yamamoto M, Yamazaki S, Uematsu S, Sato S, Hemmi H, Hoshino K, et al. (2004). Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta. Nature 430: 218-222. (Pubitemid 38902431)