Slow V̇O2 kinetics during moderate-intensity exercise as markers of lower metabolic stability and lower exercise tolerance

European Journal of Applied Physiology

Volumn 111, Issue 3, 2011, Pages 345-355

  Grassi, Bruno ^a   Porcelli, Simone ^b,c   Salvadego, Desy ^a   Zoladz, Jerzy A ^d  

^a UNIVERSITY OF UDINE   (Italy)

^b INSTITUTE OF MOLECULAR BIOIMAGING AND PHYSIOLOGY   (Italy)

^c Università Telematica Internazionale   (Italy)

^d UNIVERSITY OF PHYSICAL EDUCATION   (Poland)

Author keywords

Exercise tolerance; Gas exchange kinetics; O2 deficit

Indexed keywords

BIOLOGICAL MARKER;

ENERGY METABOLISM; EXERCISE; EXERCISE TOLERANCE; HOMEOSTASIS; HUMAN; KINETICS; LUNG GAS EXCHANGE; METABOLISM; MITOCHONDRIAL MYOPATHY; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; SKELETAL MUSCLE;

BIOLOGICAL MARKERS; ENERGY METABOLISM; EXERCISE; EXERCISE TOLERANCE; HOMEOSTASIS; HUMANS; KINETICS; MITOCHONDRIAL MYOPATHIES; MUSCLE, SKELETAL; OXYGEN CONSUMPTION; PULMONARY GAS EXCHANGE;

EID: 79951956726     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-010-1609-1     Document Type: Article

References (95)

1. Aliverti A, Kayser B, Macklem P (2004) Breath-by-breath assessment of alveolar gas stores and exchange. J Appl Physiol 96:1464-1469 (Pubitemid 38392685)
2. 2 stores are considered. Respir Physiol Neurobiol 169:78-82
3. Balaban RS, Kantor HL, Katz LA, Briggs RW (1986) Relation between work and phosphate metabolite in the in vivo paced mammalian heart. Science 232:1121-1123 (Pubitemid 16050798)
4. 2 kinetics: effects of maturation and ageing. In: Jones AM, Poole DC (eds) Oxygen uptake kinetics in sport, exercise and medicine. Routledge, London, pp 331-352
5. 2 uptakes by circulatory dynamics during exercise. J Appl Physiol 68:979-989
6. Barstow TJ, Jones AM, Nguyen PH, Casaburi R (1996) Influence of muscle fiber type and pedal frequency on oxygen uptake kinetics of heavy exercise. J Appl Physiol 81:1642-1650 (Pubitemid 26349620)
7. Capelli C, Cautero M, di Prampero PE (2001) New perspectives in breath-by-breath determination of alveolar gas exchange in humans. Pflüg Arch 441:566-577 (Pubitemid 32140467)
8. Capelli C, Adami A, Antonutto G, Cautero M, Tam E (2009) Oxygen deficits and oxygen delivery kinetics during submaximal intensity exercise in humans after 14 days of head-down tilt-bed rest. Eur J Appl Physiol 107:51-59
9. Cautero M, di Prampero PE, Tam E, Capelli C (2005) Alveolar oxygen uptake kinetics with step, impulse and ramp exercise in humans. Eur J Appl Physiol 95:474-485 (Pubitemid 41762553)
10. 2 nell'uomo. Boll Soc Ital Biol Sper 34:679-682
11. Cerretelli P, di Prampero PE (1987) Gas exchange in exercise. In: Fahri LE, Tenney SM (eds) Handbook of physiology, Section 3, The Respiratory System, vol IV, Gas Exchange. American Physiological Society, Bethesda, pp 297-339
12. Cerretelli P, Sikand R, Fahri LE (1966) Readjustments in cardiac output and gas exchange during onset of exercise and recovery. J Appl Physiol 21:1345-1350
13. Cerretelli P, Shindell D, Pendergast DP, di Prampero PE, Rennie DW (1977) Oxygen uptake transients at the onset and offset of arm and leg work. Respir Physiol 30:81-97 (Pubitemid 8095121)
14. 2 on-response and early blood lactate. J Appl Physiol 47:761-769
15. 31P-NMR spectroscopy of chronically stimulated canine skeletal muscle. Am J Physiol Cell Physiol 254:C258-C266
16. Constable SH, Favier RJ, McLane JA, Fell RD, Chen M, Holloszy JO (1987) Energy metabolism in contracting rat skeletal muscle: adaptation to exercise training. Am J Physiol 253:C316-C322
17. Davies CTM, di Prampero PE, Cerretelli P (1972) Kinetics of cardiac output and respiratory gas exchange during exercise and recovery. J Appl Physiol 32:618-625
18. di Prampero PE (1981) Energetics of muscular exercise. Rev Physiol Biochem Pharmacol 89:143-222
19. di Prampero PE, Lafortuna CL (1989) Breath-by-breath estimate of alveolar gas transfer variability in man at rest and during exercise. J Physiol 415:459-475
20. 2 debt in exercise. Pflüg Arch 304:11-19
21. 2 debt contracted in submaximal exercise. J Appl Physiol 29:547-551
22. di Prampero PE, Boutellier U, Pietsch P (1983) Oxygen deficit and stores at onset of muscular exercise in humans. J Appl Physiol 55:146-153 (Pubitemid 13075333)
23. 2 deficit at the onset of stepping and cycling. J Appl Physiol 66:2023-2031
24. di Prampero PE, Francescato MP, Cettolo V (2003) Energetics of muscular exercise at work onset: the steady-state approach. Pflüg Arch 445:741-746 (Pubitemid 36403368)
25. di Prampero PE, Salvadego D, Fusi S, Grassi B (2009) A simple method for assessing the energy cost of running during incremental tests. J Appl Physiol 107:1068-1075
26. Dudley GA, Tullson PC, Terjung RL (1987) Influence of mitochondrial content on the sensitivity of respiratory control. J Biol Chem 262:9109-9114
27. Fitts RH (2008) The cross-bridge cycle and skeletal muscle fatigue. J Appl Physiol 104:551-558
28. 2 deficit and high-energy phosphates during calf exercise in humans. Pflüg Arch 445:622-628
29. Francescato MP, Cettolo V, di Prampero PE (2008) Influence of phosphagen concentration on phosphocreatine breakdown kinetics. Data from human gastrocnemius muscle. J Appl Physiol 105:158-164
30. 2 on- and off-kinetics in 50 yr old subjects. Pflüg Arch 443:690-697
31. Giezendanner D, Cerretelli P, di Prampero PE (1983) Breath-by-breath alveolar gas exchange. J Appl Physiol 55:583-590 (Pubitemid 13044092)
32. Glancy B, Barstow T, Willis WT (2008) Linear relation between time constant of oxygen uptake kinetics, total creatine, and mitochondrial content in vitro. Am J Physiol Cell Physiol 294:C79-C87
33. Gollnick PD, Piehl K, Saltin B (1974) Selective glycogen depletion pattern in human muscle fibers after exercise of varying intensity and at varying pedalling rates. J Physiol 241:45-57
34. Grassi B (2005) Delayed activation of oxidative phosphorylation in skeletal muscle at exercise onset. Med Sci Sports Exerc 37:1567-1573
35. Grassi B (2006) Oxygen uptake kinetics: why are they so slow? And what do they tell us? J Physiol Pharmacol 57(Suppl. 10):53-65
36. 2 uptake kinetics in humans: implications for metabolic control. J Appl Physiol 80:988-998
37. 2 uptake kinetics. Med Sci Sports Exerc 38:S519 (Abstract)
38. Grassi B, Marzorati M, Lanfranconi F, Ferri A, Longaretti M, Stucchi A, Vago P, Marconi C, Morandi L (2007) Impaired oxygen extraction in metabolic myopathies: detection and quantification by near-infrared spectroscopy. Muscle Nerve 35:510-520 (Pubitemid 46542972)
39. Grassi B, Porcelli S, Marzorati M, Lanfranconi F, Vago P, Marconi C, Morandi L (2009) Metabolic myopathies: functional evaluation by analysis of oxygen uptake kinetics. Med Sci Sports Exerc 41:2120-2127
40. Green HJ, Bombardier E, Burnett ME, Smith IC, Tupling SM, Ranney DA (2009) Time-dependent effects of short-term training on muscle metabolism during the early phase of exercise. Am J Physiol Regul Integr Comp Physiol 297:R1383-R1391
41. Greenhaff PL (2001) The creatine-phosphocreatine system: there's more than one song in its repertoire. J Physiol 537:657
42. Gustafson LA, van Beek JHGM (2002) Activation time of myocardial oxidative phosphorylation in creatine kinase and adenylate kinase knockout mice. Am J Physiol Heart Circ Physiol 282:H2259-H2264 (Pubitemid 34663037)
43. Hancock CR, Brault JJ, Terjung RL (2006) Protecting the cellular energy state during contractions: role of AMP deaminase. J Physiol Pharmacol 57(Suppl. 10):17-29 (Pubitemid 46548764)
44. Harrison GJ, van Wijhe MH, de Groot B, Dijk FJ, van Beek JHGM (1999) CK inhibition accelerates transcytosolic energy signalling during rapid workload steps in isolated rabbit heart. Am J Physiol Heart Circ Physiol 276:H134-H140 (Pubitemid 29065631)
45. Hochachka PW (1994) Muscle as molecular and metabolic machines. CRC Press, Boca Raton, pp 95-118
46. Hochachka PW, Matheson GO (1992) Regulating ATP turnover rates over broad dynamic work ranges in skeletal muscles. J Appl Physiol 73:1697-1703
47. Hochachka PW, McClelland GB (1997) Cellular metabolic homeostasis during large-scale change in ATP turnover rates in muscles. J Exp Biol 200:381-386 (Pubitemid 27126470)
48. Holloszy JO (2008) Regulation by exercise of skeletal muscle content of mitochondria and GLUT4. J Physiol Pharmacol 59(Suppl. 7):5-18
49. Holloszy JO, Booth FW (1976) Biochemical adaptations to endurance exercise in muscle. Annu Rev Physiol 38:273-291
50. Hood DA, Gorski J, Terjung RL (1986) Oxygen cost of twitch and tetanic isometric contractions of rat skeletal muscle. Am J Physiol Endocrinol Metab 250:E449-E456
51. 2 kinetics and performance. In: Jones AM, Poole DC (eds) Oxygen uptake kinetics in sport, exercise and medicine. Routledge, London, pp 373-398
52. Jones AM, Poole DC (2005) Introduction to oxygen uptake kinetics and historical development of the discipline. In: Jones AM, Poole DC (eds) Oxygen uptake kinetics in sport, exercise and medicine. Routledge, London, pp 3-36
53. Jones AM, Carter H, Pringle JSM, Campbell IT (2002) Effect of creatine supplementation on oxygen uptake kinetics during submaximal cycle exercise. J Appl Physiol 92:2571-2577 (Pubitemid 34666386)
54. Jones AM, Wilkerson DP, Fulford J (2009) Influence of dietary creatine supplementation on muscle phosphocreatine kinetics during knee-extensor exercise in humans. Am J Physiol Regul Integr Comp Physiol 296:R1078-R1087
55. Kaasik A, Minajeva A, De Sousa E, Ventura-Clapier R, Veksler V (1999) Nitric oxide inhibits cardiac energy production via inhibition of mitochondrial creatine kinase. FEBS Lett 444:75-77 (Pubitemid 29094641)
56. Karlsson J, Nordesjo LO, Jorfeldt L, Saltin B (1972) Muscle lactate, ATP, and CP levels during exercise after physical training in man. J Appl Physiol 33:199-203
57. Katz LA, Swain JA, Portman MA, Balaban RS (1989) Relation between phosphate metabolites and oxygen consumption of heart in vivo. Am J Physiol Heart Circ Physiol 256:H265-H274
58. Kindig CA, Howlett RA, Stary CM, Walsh B, Hogan MC (2005) Effects of acute creatine kinase inhibition on metabolism and tension development in isolated single myocytes. J Appl Physiol 98:541-549 (Pubitemid 40129963)
59. Knuttgen HG, Saltin B (1972) Muscle metabolites and oxygen uptake in short-term submaximal exercise in man. J Appl Physiol 32:690-694
60. Korzeniewski B (1998) Regulation of ATP supply during muscle contraction: theoretical studies. Biochem J 330:1189-1195
61. Korzeniewski B, Zoladz JA (2001) A model of oxidative phosphorylation in mammalian skeletal muscle. Biophys Chem 92:17-34 (Pubitemid 32799123)
62. Korzeniewski B, Zoladz JA (2003) Training-induced adaptation of oxidative phosphorylation in skeletal muscles. Biochem J 374:37-40 (Pubitemid 37046926)
63. 2) on-kinetics in skeletal muscles. Biochem J 379:703-710
64. Kushmerick MJ, Meyer RA, Brown TR (1992) Regulation of oxygen consumption in fast- and slow-twitch muscle. Am J Physiol Cell Physiol 263:C598-C606
65. Lanfranconi F, Borrelli E, Ferri A, Porcelli S, Maccherini M, Chiavarelli M, Grassi B (2006) Non-invasive evaluation of skeletal muscle oxidative metabolism after heart transplant. Med Sci Sports Exerc 38:1374-1383 (Pubitemid 44215743)
66. Löfberg M, Lindholm H, Näveri H, Majander A, Suomalainen A, Paetau A, Sovijärvi A, Härkönen M, Somer H (2001) ATP, phosphocreatine and lactate in exercising muscle in mitochondrial disease and McArdle's disease. Neuromuscul Dis 11:370-375 (Pubitemid 32448082)
67. Mahler M (1980) Kinetics and control of oxygen consumption in skeletal muscle. In: Cerretelli P, Whipp BJ (eds) Exercise bioenergetics and gas exchange. Elsevier, Amsterdam, pp 53-66
68. Margaria R, Mangili F, Cuttica F, Cerretelli P (1965) The kinetics of the oxygen consumption at the onset of muscular exercise in man. Ergonomics 8:49-54
69. 31P-NMR study of Andean natives and lowlanders. J Appl Physiol 70:1963-1976
70. Meyer RA (1988) Linear dependence of muscle phosphocreatine kinetics on total creatine content. Am J Physiol Cell Physiol 257:C1149-C1157
71. Meyer RA, Sweeney HL, Kushmerick MJ (1984) A simple analysis of the "phosphocreatine shuttle". Am J Physiol Cell Physiol 246:C365-C377
72. Nemeth PM, Lowry OH (1984) Myoglobin levels in individual human skeletal muscle of different types. J Histochem Cytochem 32:1211-1216 (Pubitemid 14023054)
73. 2 kinetics at onset of submaximal exercise. J Appl Physiol 79:1914-1920
74. Piiper J, di Prampero PE, Cerretelli P (1968) Oxygen debt and high energy phosphates in gastrocnemius muscle of the dog. Am J Physiol 215:523-531
75. 2 kinetics in different disease states. In: Jones AM, Poole DC (eds) Oxygen uptake kinetics in sport, exercise and medicine. Routledge, London, pp 353-372
76. Porcelli S, Marzorati M, Lanfranconi F, Vago P, Pisot R, Grassi B (2010) Role of skeletal muscle impairment and brain oxygenation in limiting oxidative metabolism during exercise after bed rest. J Appl Physiol 109:101-111
77. Powers SK, Dodd S, Beadle RE (1985) Oxygen uptake kinetics in trained athletes differing in V̇ O2. Eur J Appl Physiol 54:306-308 (Pubitemid 15242555)
78. 2 desaturation during exercise. Evidence of limited O2 transport. J Clin Invest 96:1916-1926
79. 2 uptake with respect to intramuscular [phosphocreatine] kinetics during moderate exercise in humans. J Physiol 518:921-932
80. 2 uptake between the on- and off-transients of moderate- anf high-intensity exercise in humans. J Physiol 541:991-1002
81. 2 kinetics during exercise: implications for control of skeletal muscle oxygen consumption. In: Jones AM, Poole DC (eds) Oxygen Uptake kinetics in sport, exercise and medicine. Routledge, London, pp 154-184
82. Schalcher C, Rickli H, Brehn M, Weilenmann D, Oechslin E, Kiowski W, Brunner-La Rocca HP (2003) Prolonged oxygen uptake kinetics during low-intensity exercise are related to poor prognosis in patients with mild-to-moderate congestive heart failure. Chest 124:580-586 (Pubitemid 37000137)
83. Stratton JR, Kemp GJ, Daly RC, Yacoub M, Rajagopalan B (2000) Effects of cardiac transplantation on bioenergetic abnormalities of skeletal muscle in congestive heart failure. Circulation 89:1624-1631
84. Turner DL, Hoppeler H (1999) Muscle energetics: aerobic strategies. In: Whipp BJ, Sargeant AJ (eds) Physiological determinants of exercise tolerance in humans. Studies in Physiology 4. Portland Press, London, pp 29-47
85. van Beek JHGM, Tian X, Zuurbier CJ, de Groot B, van Echteld CJA, Eijgelshoven MH, Hak JB (1998) The dynamic regulation of myocardial oxidative phosphorylation: analysis of the response time of oxygen consumption. Mol Cell Biochem 184:321-344 (Pubitemid 28398616)
86. Walsh B, Tonkonogi M, Söderlund K, Hultman E, Saks V, Sahlin K (2001) The role of phosphorylcreatine and creatine in the regulation of mitochondrial respiration in human skeletal muscle. J Physiol 537:971-978 (Pubitemid 34026622)
87. Whipp BJ, Mahler M (1980) Dynamics of pulmonary gas exchange during exercise. In: West JB (ed) Pulmonary gas exchange, vol II. Academic, New York, pp 33-96
88. Whipp BJ, Rossiter HB (2005) The kinetics of oxygen uptake: physiological inferences from the parameters. In: Jones AM, Poole DC (eds) Oxygen uptake kinetics in sport, exercise and medicine. Routledge, London, pp 62-94
89. Whipp BJ, Rossiter HB, Ward SA (2002) Exertional oxygen uptake kinetics: a stamen of stamina? Biochem Soc Trans 30:237-247
90. Woledge RC (1998) Possible effects of fatigue on muscle efficiency. Acta Physiol Scand 162:267-273
91. Wüst RCI, Aliverti A, Capelli C, Kayser B (2008) Breath-by-breath changes in lung oxygen stores at rest and during exercise in humans. Respir Physiol Neurobiol 164:291-299
92. 2 and the slow component of oxygen uptake kinetics. J Physiol Pharmacol 52:167-184 (Review)
93. 2 kinetics at the onset of a high-power-output exercise in humans. J Appl Physiol 98:895-904
94. Zoladz JA, Korzeniewski B, Grassi B (2006) Training-induced acceleration of oxygen uptake kinetics in skeletal muscle: the underlying mechanisms. J Physiol Pharmacol 57(Suppl. 10):67-84 (Pubitemid 46548768)
95. 2 kinetics. J Appl Physiol 105:575-580