The dynamic regulation of myocardial oxidative phosphorylation: Analysis of the response time of oxygen consumption

Molecular and Cellular Biochemistry

Volumn 184, Issue 1-2, 1998, Pages 321-344

  Van Beek, J H G M ^a   Tian, X ^b   Zuurbier, C J ^c   De Groot, B ^a,b   Van Echteld, C J A ^b,c   Eijgelshoven, M H J ^c   Hak, J B ^a,c  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b Datong Medical College   (China)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Adenine nucleotides; Compartmentation; Creatine kinase; Dynamic responses; Heart; Metabolic wave; Mitochondria; NMR; Oxidative phosphorylation; Oxygen consumption; Stunning

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CREATINE KINASE; OXYGEN; PHOSPHATE; PHOSPHOTRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL OXYGEN TENSION; ARTICLE; CONTROLLED STUDY; DYNAMICS; HEART MITOCHONDRION; HEART MUSCLE OXYGEN CONSUMPTION; HEART RATE; METABOLIC REGULATION; MUSCLE FIBRIL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATIVE PHOSPHORYLATION; OXYGEN DIFFUSION; OXYGEN ELECTRODE; OXYGEN TRANSPORT; RABBIT; RESPONSE TIME; STUNNED HEART MUSCLE; VENOUS OXYGEN TENSION;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0031690122     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1007/978-1-4615-5653-4_21     Document Type: Article

References (95)

1. Van Beek JHGM, Elzinga G: Response time of mitochondrial oxygen consumption to heart rate changes in isolated rabbit heart. Proc. Int. Union Physiol Sci 16: 485, 1986
2. Van Beek JHGM, Westerhof N: Response time of mitochondrial oxygen consumption following stepwise changes in cardiac energy demand. In: J Piiper, TK Goldstick, M Meyer (eds). Oxygen Transport to Tissue XII. Plenum Press, New York, 1990, pp 415-423
3. Van Beek JHGM, Westerhof N: Response time of cardiac mitochondrial oxygen consumption to heart rate steps. Am J Physiol 260: H613-H625, 1991
4. Groot B de, Zuurbier CJ, Beek JHGM van: Response times of mitochondrial oxygen consumption, tissue oxygenation and venous oxygen concentration during steps in heart rate in isolated rabbit heart. Pflügers Arch. 430 (S4): R93, 1995
5. Beek JHGM van, Osbakken MD, Chance B: Measurement of the oxygenation status of the isolated perfused rat heart using near infrared detection. Adv Exp Med Biol 388: 147-154, 1996
6. Mast F, Elzinga G: Recovery heat production of isolated rabbit papillary muscle at 20°C. Pflügers Arch 411: 600-605, 1988
7. Zuurbier CJ, Mast F, Elzinga G, Beek JHGM van: Mitochondrial function is not decreased in stunned papillary muscle at 20°C. J Moll Cell Cardiol 29: 347-355, 1997
8. Kushmerick MJ, Meyer RA: Chemical changes in rat leg muscle by phosphorus nuclear magnetic resonance. Am J Physiol 248: C542-549, 1985
9. Meyer RA: A linear model of muscle respiration explains mono-exponential phosphocreatine changes. Am J Physiol 254: C548-C553, 1988
10. Massie B, Schwartz GG, Garcia J, Wisneski JA, Weiner MW, Owens T: Myocardial metabolism during increased work states in the porcine left ventricle in vivo. Circ Res 74: 64-73, 1994
11. Balaban RS, Kantor HL, Katz LA, Briggs RW: Relation between work and phosphate metabolites in the in vivo paced mammalian heart. Science 232: 1121-1123, 1986
12. Balaban RS: Regulation of mitochondrial oxidative phosphorylation in mammalian cells. Am J Physiol 258: C377-389, 1990
13. Chance B: Reaction of oxygen with the respiratory chain in cells and tissues. J Gen Physiol 49: 163-188, 1966
14. Saks VA, Khuchua ZA, Vasilyeva EV, Belikova OY, Kuzuetsov AV: Metabolic compartmentation and substrate channelling in muscle cells. Role of coupled creatine kineses in in vivo regulation of cellular respiration - a synthesis. Moll Cell Biochem 133/134: 155-192, 1994
15. Beek, JHGM van: Dynamics of cardiac mitochondrial oxygen consumption deduced from whole organ oxygen uptake. In: JB Bassingthwaighte, J Linehan (eds). Whole Organ Approach to Cellular Metabolism: Capillary Permeation, Cellular Transport and Reaction Kinetics, Springer, New York, in press
16. Lassen NA, Henriksen O, Sejrsen P: Indicator methods for measurement of organ and tissue blood flow. In: JT Shepherd, FM Abboud (eds). Handbook of Physiology. Section 2: The Cardiovascular System. Vol. III. Peripheral Circulation and Organ Blood Flow. Part 1, 1983, pp 21-63
17. Meier P, Zierler KL: On the theory of the indicator-dilution method for measurement of blood flow and volume. J Appl Physiol 6:731-744, 1954
18. Roberts GW, Larson KB, Spaeth EE: The interpretation of mean transit time measurements for multiphase tissue systems. J Theor Biol 39: 447-475, 1973
19. Loiselle DS, Van Beek JHGM, Mawson DA, Hunter PJ: The surface of the heart leaks oxygen. News Physiol Sciences 10: 129-133, 1995
20. Van Beek JHGM, Loiselle DS, Westerhof N: Calculation of oxygen diffusion across the surface of isolated perfused hearts. Am J Physiol 263: H1003-1010, 1992
21. Beauvoit B, Chance B: Time-resolved spectroscopy of mitochondria, cells and tissues under normal and pathological conditions. This volume.
22. Heinrich R, Rapoport TA: Mathematical analysis of multienzyme systems: II. Steady state and transient control. Biosystems 7: 130-136, 1975
23. King RB, Bassingthwaighte JB, Hales JRS, Rowell LB: Stability of heterogeneity of myocardial blood flow in normal awake baboons. Circ Res 57: 285-295, 1985
24. Gorman MW, Wangler RD, Sparks HV: Distribution of perfusate flow during vasodilation in isolated guinea pig heart. Am J Physiol 256: H297-301, 1989
25. Beek JHGM van, Bussemaker J, Barends JPF, Westerhof N: A 13C-NMR technique to determine absolute oxygen consumption in quickly frozen small myocardial samples. FASEB J 10: A325, 1996
26. Van Beek JHGM: Fractal models of heterogeneity in organ blood flow. In: S Egginton, H Ross (eds). Oxygen Transport in Biological Systems: modelling of pathways from environment to cell. Cambridge University Press, Cambridge, 1992, pp 135-163
27. Van Beek JHGM, Roger SA, Bassingthwaighte JB: Regional myocardial flow heterogeneity explained with fractal networks. Am J Physiol 257: H1670-1680, 1989
28. Van Beek JHGM, Barends JPF, and Westerhof N: The microvascular unit size for fractal flow heterogeneity relevant for oxygen transport. In: P Vaupel, R Zander, DF Bruley (eds). Oxygen Transport to Tissue XV, 1994, pp 901-908
29. Hak JB, Biessels PTM, Beek JHGM van, Bakker JC, and Westerhof N: Function of isolated rabbit hearts perfused with erythrocyte suspension is not stable but improvement may be feasible with hemoglobin solution. Adv Exp Med Biol 345: 291-297, 1994
30. Hak JB, Van Beek JHGM, Wijhe MH van, Westerhof N: Influence of temperature on the response time of mitochondrial oxygen consumption in isolated rabbit heart. J Physiol (Lond) 447: 17-31, 1992
31. Wittenberg JB: Myoglobin-facilitated oxygen diffusion: role of myoglobin in oxygen entry into muscle. Physiol Rev 50: 559-636, 1970
32. Zuurbier CJ, Beek JHGM van: Brief ischemia results in decreased mitochondrial function and contractility in isolated rabbit heart at 37°C. FASEB J 9, 1995
33. Eijgelshoven MHJ, Van Beek JHGM, Mottet I, Nederhoff MGJ, Van Echteid CJA, Westerhof N: Cardiac high-energy phosphates adapt faster than oxygen consumption to changes in heart rate. Circ Res 75: 751-759, 1994
34. Chance B: The energy-linked reaction of calcium with mitochondria. J Biol Chem 240: 2729-2748, 1965
35. Lemasters JJ, Hackenbrock CR: Continuous measurement and rapid kinetics of ATP synthesis in rat liver mitochondria, mitoplasts and inner membrane vesicles determined by firefly-luciferase luminescence. Eur J Biochem 67: 1-10, 1976
36. Eijgelshoven MHJ, Lekkerkerk C, Van Beek JHGM, Van Echteid CJA: Oxygen measurement inside an NMR magnet with a catheter electrode. Magn Res Med 29: 559-562, 1993
37. 31P NMR studies of ATP synthesis and hydrolysis kinetics in the intact myocardium. Biochem 26: 7501-7510, 1987
38. Connett RJ, Gayeski TEJ, Honig CR: Energy sources in fully aerobic rest-work transitions: a new role for glycolysis. Am J Physiol 248: H922-H929, 1985
39. Hak JB, Van Beek JHGM, van Wijhe MH, Westerhof N: Dynamics of myocardial lactate effflux after a step in heart rate in isolated rabbit heart. Am J Physiol 265: H2081-2085, 1993
40. Eijgelshoven MHJ: Dynamics of cardiac energy metabolism, (thesis), Free University, Amsterdam, 1995, ISBN 90-9007857-6
41. 31P-NMR study. Am J Physiol 255: H185-188, 1988
42. Heineman FW, Balaban RS: Phosphorus-31 nuclear magnetic resonance analysis of transient changes of canine myocardial metabolism in vivo. J Clinic Invest 85: 843-852, 1990
43. 2+ as a second messenger within mitochondria. Trends Biochem Sci 11: 258-262, 1986
44. Hansford RG: Relation between mitochondrial calcium transport and control of energy metabolism. Rev Physiol Biochem Pharmacol 102: 1-72, 1985
45. Eng J, Lynch RM, Balaban RS: Nicotinamide adenine dinucleotide fluorescence spectroscopy and imaging of isolated cardiac myocytes. Biophys J 55: 621-630, 1989
46. 31P-NMR and NADH fluorescence study. FEBS Lett 221:270-276, 1987
47. Heineman FW, Kupriyanov W, Marshall R, Fralix TA, Balaban RS: Myocardial oxygenation in the isolated working rabbit heart as a function of work. Am J Physiol 262: H255-267, 1992
48. Heineman FW, Balaban RS: Effects of afterload and heart rate on NAD(P)H redox state in the isolated rabbit heart. Am J Physiol 264: H433-440, 1993
49. Chapman JB: Fluorometric studies of oxidative metabolism in isolated papillary muscle of the rabbit. J Gen Physiol 59: 135-154, 1972
50. White RL, Wittenberg BA: NADH fluorescence of isolated ventricular myocytes: effects of pacing, myoglobin and oxygen supply. Biophys J 65: 196-204, 1993
51. Ashruf JF, Coremans JMCC, Bruining HA, Ince C: Increase of cardiac work is associated with decrease of mitochondrial NADH in the Langendorff rat heart. Am J Physiol 269: H856-862, 1995
52. 2+ concentration in living single rat cardiac myocytes. Am J Physiol 261 :H1123-H1134, 1991
53. 2+ increases the mitochondrial NADH concentration during elevated work in intact cardiac muscle. Circ Res 80: 82-87, 1997
54. Harris DA, Das AM: Control of mitochondrial ATP synthesis in the heart. Biochem J 280: 561-573, 1991
55. Hak JB, Van Beek JHGM, Eijgelshoven MHJ, Westerhof N: Mitochondrial dehydrogenase activity affects adaptation of cardiac oxygen consumption to demand. Am J Physiol 264: H448-453, 1993
56. Elliott AC, Smith GL, Allen DG: The metabolic consequences of an increase in the frequency of stimulation in isolated ferret hearts. J Physiol (Lond) 474: 147-159, 1994
57. Wan B, Doumen C, Duszynski, Salama G, Vary TC, LaNoue KF: Effects of cardiac work on electrical potential gradient across mitochondrial membrane in perfused rat hearts. Am J Physiol 265: H453-460, 1993
58. From AHL, Zimmer SD, Michurski SP, Mohanokrishnan P, Ulstadt VK, Thoma WJ, Ugurbil K: Regulation of the oxidative phosphorylation in the intact cell. Biochem 29: 3731-3743, 1990
59. Kim DL, Heineman FW, Balaban RS: Effects of β-hydroxybutyrate on oxidative metabolism and phosphorylation potential in canine heart in vivo. Am J Physiol 260: H1767-1773, 1991
60. Eijgelshoven MHJ, Hak JB, Van Beek JHGM, Westerhof N: Adaptation speed of cardiac mitochondrial oxygen consumption to demand slows with higher hears rate. Am J Physiol 265: H1893-1898, 1993.
61. Eijgelshoven MHJ, Tian X, Van Beek JHGM: Exogenous carbon substrate supply affects the time course of adaptation of cardiac mitochondrial oxygen consumption to demand in a temperature dependent fashion. In: MHJ Eijgelshoven. Dynamics of cardiac energy metabolism, (thesis), Free University, Amsterdam, 1995, ISBN 90-9007857-6, pp 73-98
62. Eijgelshoven MHJ, Tian X, Westerhof N, van Beek JHGM: Is the adaptation speed of myocardial oxidative phosphorylation to heart rate steps affected by the type of exogenous substrate? J. Physiol. 479P: 72-73 P, 1994
63. Isaacs GH, Sacktor B, Murphy TA: The role of the a-glycerophosphate cycle in the control of carbohydrate oxidation in heart and in the mechanism of action of thyroid hormone. Biochim Biophys Acta 177: 196-203, 1969
64. Zizi M, Forte M, Blachly-Dyson E, Colombini M: NADH regulates the gating of VDAC, the mitochondrial outer membrane channel. J Biol Chem 269: 1614-1616, 1994.
65. Tian X, van Beek JHGM, Eijgelshoven MHJ: Effects of inotropic stimulation and adenosine on the response time of cardiac mitochondrial oxygen consumption to heart rate steps in the isolated rabbit heart. J Physiol (Lond) 479: P132, 1994
66. Bessman SP, Geiger PJ: Transport of energy in muscle: the phosphorylcreatine shuttle. Science 211: 448-452, 1981
67. Meyer RA, Sweeney HL, Kuskmerick MJ: A simple analysis of the 'phosphocreatine shuttle'. Am J Physiol 246: C365-377, 1984
68. Mahler M: First order kinetics of muscle oxygen consumption and an equivalent proportionality between QO2 and phosphorylcreatine level. Implications for the control of respiration. J Gen Physiol 86: 135-165, 1985
69. van Beek JHGM, Eijgelshoven MHJ, Hak JB, Westerhof N: Control loop gain of cardiac oxidative phosphorylation via phosphate metabolites is high and partially explains the dynamic adaptation of oxygen consumption to demand. FASEB J 7: A313, 1993.
70. 31phosphorus NMR. J Biol Chem 260: 3947-3954, 1985
71. Holian A, Owen CS, Wilson DF: Control of respiration in isolated mitochondria: quantitative evaluation of the dependence of respiratory rates on [ATP], [ADP] and [P.]. Arch Biochem Biophys 181: 164-171, 1977
72. Ugurbil K, Petein M, Maidan R, Michurski S, From AHL: Measurement of an individual rate constant in the presence of multiple exchanges: application to myocardial creatine kinase reaction. Biochem 25: 100-107, 1986
73. Bittl JA, Ingwall JS: Reaction rates of creatine kinase and ATP synthesis in the isolated rat heart. J Biol Chem 260: 3512-3517, 1985
74. Conley CK, Kushmerick MJ: Buffering work transitions in myocardium: role of a poorly metabolized creatine analogue. Book of Abstracts. Society of Magnetic Resonance in Medicine. 9th Annual Meeting, p. 902, 1990
75. 31P-NMR. Biochim Biophys Acta 1133: 115-120, 1992
76. Gellerich FN, Khuchua ZA, Kuznetsov AV: Influence of the mitochondrial outer membrane and the binding of creatine kinase to the mitochondrial inner membrane on the compartmentation of adenine nucleotides in the intermembrane space of rat heart mitochondria. Biochim Biophys Acta 1140: 327-334, 1993
77. Gellerich FN, Wagner M, Kapischke M, Brdiczka D: Effect of macromolecules on ADP-channeling into mitochondria. In: JP Mazat. Proceedings of the 5th BTK-Workshop. Plenum, London, 1993
78. Saks VA, Vasileva E, Belikova YO, Kuznetsov AV, Lyapina S, Petrova L, Perov NA: Retarded diffusion of ADP in cardiomyocytes: possible role of mitochondrial outer membrane and creatine kinase in cellular regulation of oxidative phosphorylation. Biochim Biophys Acta 1144: 134-148, 1993
79. Jeneson JAL, Wiseman RW, Westerhoff HV, Kushmerick MJ: Amplified ADP sensitivity of mitochondria. In: HV Westerhoff, JL Snoep, JE Wijker, FE Sluse, BN Kholodenko (eds). BioThermoKinetics of the Living Cell. BioThermoKinetics Press, Amsterdam, 1996, pp 94-95
80. O'Rourke B, Ramza BM, Marban E: Oscillations of membrane current and excitability driven by metabolic oscillations in heart cells. Science 265: 962-966, 1994
81. Cristea E: Effect of amytal, pyridine nucleotides, and oxaloacetate on the respiratory inhibition-activation cycles in mitochondria. Arch Biochem Biophys 113: 273-280, 1966
82. Chance B, Williamson JR, Jamieson D, Schoener B: Properties and kinetics of reduced pyridine nucleotide fluorescence of the isolated and in vivo rat heart. Biochem Z 341: 357-377, 1965
83. Van der Laarse WJ, Diegenbach PC, Elzinga G: Maximum rate of oxygen consumption and quantitative histochemistry of succinate dehydrogenase in single muscle fibres of Xenopus laevis. J Muscle Res Cell Motil 10: 221-228, 1989
84. Gollnick PD, Bertocci LA, Kelso TB, Witt EH, Hodgson DR: The effect of high-intensity exercise on the respiratory capacity of skeletal muscle. Pflügers Arch 415: 407-413, 1990
85. Hak JB, Van Beek JHGM, Westerhof N: Acidosis slows the response of oxidative phosphorylation to metabolic demand in isolated rabbit heart. Pflügers Arch. 423: 324-329, 1993
86. Nakanishi T, Seguchi M, Tsuchiya T, Yasukuochi S, Takao A: Effect of acidosis on intracellular pH and calcium concentrations in the newborn and adult rabbit myocardium. Circ Res 67: 111-123, 1990
87. van Wijhe MH, van Beek JHGM: Effects of respiratory and metabolic acidosis on oxidative phosphorylation in isolated rabbit heart mitochondria. Europ J Physiol 430: R174, 1995
88. Flameng W, Andres J, Ferdinande P, Mattheussen M, Van Belle H. Mitochondrial function in myocardial stunning. J Moll Cell Cardiol 23: 1-11, 1991
89. Mekhfi H, Veksler V, Mateo P, Maupoil V, Rochette L, Ventura-Clapier R: Creatine kinase is the main target of reactive oxygen species in cardiac myofibrils. Circ Res 78: 1016-1027, 1996
90. Bittl JA, Weisfeldt ML, Jacobus WE: Creatine kinase of heart mitochondria. The progressive loss of enzyme activity during in vivo ischemia and its correlation to depressed myocardial function. J Biol Chem 260: 208-214, 1985
91. Zuurbier CJ, Beek JHGM van: The dynamic control of mitochondrial oxygen consumption in isolated perfused rabbit heart is not affected by a short period of ischaemia. J Physiol 479: 71-72P, 1994
92. Beek JHGM van, Hak JB, Wijhe MH van. Eijgelshoven MHJ, Westerhof N: The myocardial mitochondrial aerobic capacity is partially limiting for cardiac oxygen consumption and contractility. Europ J Physiol 430 (S4): R9, 1995
93. Groot B de, Dijk FJ, Beek JHGM van: Response of cardiac respiration to steps in heart rate is not slowed after reduction of mitochondrial capacity in normal and pressure overloaded hearts. Proceedings of the Congress of the International Union of Physiological Sciences, St. Petersburg, Russia, p. 063.06, 1997
94. JHGM van Beek, JB Hak, MH Wijhe van, N Westerhof: The control exerted by oxidative phosphorylation on respiration in the intact heart. In: HV Westerhoff, JL Snoep, JE Wijker, FE Sluse and BN Kholodenko (eds). Biothermokinetics of the Living Cell, BioThermoKinetics Press, Amsterdam, 1996, pp 119-123
95. Groot B de, Dijk FJ, Beek JHGM van: Limitation of contractile function and respiration by mitochondrial aerobic capacity in normal and pressure overloaded isolated rabbit hearts. Europ J Physiol, abstract 434: R45, 1997