Oxygen uptake kinetics: Why are they so slow? And what do they tell us?

Journal of Physiology and Pharmacology

Volumn 57, Issue SUPPL. 10, 2006, Pages 53-65

  Grassi, Bruno ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Bioenergetics; Gas exchange kinetics; Skeletal muscle oxidative metabolism

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CREATINE PHOSPHATE; NITRIC OXIDE; PYRUVATE DEHYDROGENASE;

AEROBIC METABOLISM; ANAEROBIC GLYCOLYSIS; BIOENERGY; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONFERENCE PAPER; CONGESTIVE HEART FAILURE; EXERCISE PHYSIOLOGY; EXERCISE TOLERANCE; GAS EXCHANGE; HUMAN; HYPOXEMIA; MITOCHONDRIAL RESPIRATION; MUSCLE METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; OXYGEN DIFFUSION; PERIPHERAL VASCULAR DISEASE; PROTEIN HYDROLYSIS; QUANTITATIVE ASSAY; SKELETAL MUSCLE;

ANIMALS; ENERGY METABOLISM; EXERCISE; EXERCISE TOLERANCE; HUMANS; KINETICS; MITOCHONDRIA, MUSCLE; MUSCLE FIBERS; MUSCLE, SKELETAL; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION;

EID: 34047253005     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (70)

1. Krogh A, Lindhard J. The regulation of respiration and circulation during the initial stages of muscular work. J Physiol 1913; 47: 112-136.
2. Hill AV, Lupton H. Muscular exercise, lactic acid, and the supply and utilization of oxygen. Q J Med 1923; 16: 135-171.
3. di Prampero PE. Energetics of muscular exercise. Rev Physiol Biochem Pharmacol 1981; 89: 143-222.
4. Cerretelli P, di Prampero PE. Gas exchange in exercise. In Handbook of Physiology, Section 3, The Respiratory System, vol. IV, Gas Exchange, LE Fahri, SM Tenney SM (eds.). Bethesda, MD, USA, American Physiological Society, 1987, pp. 297-339.
5. 2 on-response and early blood lactate. J Appl Physiol 1979; 47: 761-769.
6. Cerretelli P, Rennie DW, Pendergast DR. Kinetics of metabolic transients during exercise. In Exercise Bioenergetics and Gas Exchange. P. Cerretelli, BJ Whipp (eds.). Amsterdam, The Netherlands, Elsevier, 1980, pp. 187-209.
7. 2 debt in exercise. Pflüg Arch 1968; 304: 11-19.
8. Margaria R, Mangili F, Cuttica F, Cerretelli P. The kinetics of the oxygen consumption at the onset of muscular exercise in man. Ergonomics 1965; 8: 49-54.
9. Whipp BJ, Mahler M. Dynamics of pulmonary gas exchange during exercise. In Pulmonary Gas Exchange, Vol. II, JB West (ed.). New York, NY, USA, Academic, 1980, pp. 33-96.
10. Grassi B. Delayed activation of oxidative phosphorylation in skeletal muscle at exercise onset. Med Sci Sports Exerc 2005; 37: 1567-1573.
11. Hughson RL, Tschakowsky ME, Houston ME. Regulation of oxygen consumption at the onset of exercise. Exerc Sport Sci Rev 2001; 29: 129-133.
12. Tschakovsky ME, Hughson RL. Interaction of factors determining oxygen uptake at the onset of exercise. J Appl Physiol 1999; 86: 1101-1113.
13. Whipp BJ, Rossiter HB, Ward SA. Exertional oxygen uptake kinetics: a stamen of stamina? Biochem Soc Trans 2002; 30: 237-247.
14. 2 kinetics. In Oxygen Uptake Kinetics in Sport, Exercise and Medicine. AM Jones & DC Poole (eds), London, UK, Routledge, 2005 pp. 294-328.
15. Piiper J, di Prampero PE, Cerretelli P. Oxygen debt and high energy phosphates in gastrocnemius muscle of the dog. Am J Physiol 1968; 215: 523-531.
16. Bangsbo J, Krustrup P, Gonzalez-Alonso J, Boushel R, Saltin B. Muscle oxygen kinetics at onset of intense dynamic exercise in humans. Am J Physiol 2000; 279: R899-R906.
17. 2 uptake kinetics in humans: implications for metabolic control. J Appl Physiol 1996; 80: 988-998.
18. 2 on blood flow dynamics at the onset of forearm exercise. J Appl Physiol 1996; 81: 1619-1626.
19. Behnke BJ, Kindig CA, Musch TI, Sexton WL, Poole DC. Effects of prior contractions on muscle microvascular oxygen pressure at onset of subsequent contractions. J Physiol 2002; 593: 927-934.
20. Grassi B, Pogliaghi S, Rampichini S, et al. Muscle oxygenation and gas exchange kinetics during cycling exercise on-transitions in humans. J Appl Physiol 2003; 95: 149-158.
21. Radegran G, Saltin B. Muscle blood flow at onset of dynamic exercise in humans. Am J Physiol 1998; 274: H314-H322.
22. 2 utilization? New insights into an old issue. Med Sci Sports Exerc 2000; 32: 108-116.
23. 2 on-kinetics in dog gastrocnemius in situ following activation of pyruvate dehydrogenase by dichloroacetate. J Physiol 2002; 538: 195-207.
24. 2 at the onset of contractions in Xenopus single skeletal muscle fibers. J Appl Physiol 2001; 90: 1871-1876.
25. 2 on-kinetics in isolated in situ canine muscle. J Appl Physiol 1998; 85: 1394-1403.
26. 2 on-kinetics in isolated in situ canine muscle. J Appl Physiol 1998; 85: 1404-1412.
27. 2. J Appl Physiol 2000; 89: 1293-1301.
28. Grassi B, Hogan MC, Kelley KM, Howlett RA, Gladden LB. Effects of NOS inhibition by L-NAME on oxygen uptake kinetics in isolated canine muscle in situ. J Physiol 2005; 568: 1021-1033.
29. 2 kinetics in different disease states. In Oxygen Uptake Kinetics in Sport, Exercise and Medicine, AM Jones & DC Poole (eds), London, UK, Routledge, 2005 pp. 353-372.
30. Timmons JA, Poucher SM, Constantin-Teodosiu D, MacDonald IA, Greenhaff PL. Metabolic responses from rest to steady state determine contractile function in ischemic skeletal muscle. Am J Physiol 1997; 273: E233-E238.
31. Timmons JA, Gustafsson T, Sundberg CJ, Jansson E, Greenhaff PL. Muscle acetyl group availability is a major determinant of oxygen deficit in humans during submaximal exercise. Am J Physiol 1998; 274: E377-E380.
32. Stacpoole PW. The pharmacology of dichloroacetate. Metabolism 1989; 38: 1124-1144.
33. 2 uptake at onset of intense exercise in humans. Am J Physiol 2002; 282: R273-R280.
34. 31P metabolite kinetics during high-intensity exercise in humans. J Appl Physiol 2003; 95: 105-115.
35. Berzin RM, Wolfe C, Kwasman M, et al. Improved hemodynamic function and mechanical efficiency in congestive heart failure with sodium dichloroacetate. J Am Coll Cardiol 1994; 23: 1617-1624.
36. Brown GC. Nitric oxide as a competitive inhibitor of oxygen consumption in the mitochondrial respiratory chain. Acta Physiol Scand 2000; 168: 667-674.
37. Kindig CA, McDonough P, Erickson HH, Poole DC. Effect of L-NAME on oxygen uptake kinetics during heavy-intensity exercise in the horse. J Appl Physiol 2001; 91: 891-896.
38. Kindig CA, McDonough P, Erickson HH, Poole DC. Nitric oxide synthase inhibition speeds oxygen uptake kinetics in horses during moderate domain running. Respir Physiol Neurobiol 2002; 132: 169-178.
39. 2 kinetics in the transition to moderate intensity exercise in man. J Physiol 2003; 552: 265-272.
40. 2 uptake kinetics during heavy-intensity cycle exercise. J Appl Physiol 2004; 96: 1033-1038.
41. 2 uptake kinetics during supra-maximal exercise in humans. J Physiol 2004: 561: 623-635.
42. 2 kinetics. J Physiol 2006; 568: 563-564.
43. 2 kinetics. J Physiol 2006; 573. 565-566.
44. Kindig CA, Howlett RA, Stary CM, Walsh B, Hogan MC. Effects of acute creatine kinase inhibition on metabolism and tension development in isolated single myocytes. J Appl Physiol 2005; 98: 541-549.
45. Harrison GJ, Van Wijhe MH, De Groot B, Dijk FJ, Gustafson LA, Van Beek JHGM. Glycolytic buffering affects cardiac bioenergetic signaling and contractile reserve similar to creatine kinase. Am J Physiol 2003; 285: H883-H890.
46. Gustafson LA, Van Beek JHGM. Activation time of myocardial oxidative phosphorylation in creatine kinase and adenylate kinase knockout mice. Am J Physiol 2002; 282: H2259-H2264.
47. 2 uptake kinetics. Med Sci Sports Exerc 2006; 38: S519.
48. di Prampero PE, Ferretti G. Factors limiting maximal oxygen consumption in humans. Respir Physiol 1990; 80: 113-128.
49. 2 kinetics at onset of submaximal exercise. J Appl Physiol 1995; 79:1914-1920.
50. 2 on- and off-kinetics in 50-yr old subjects. Pflüg Arch 2002; 443: 690-697.
51. 2 kinetics early after heart transplantation. Med Sci Sports Exerc 2003; 35: 1798-1804.
52. Nery LE, Wasserman K, Andrews JD, Huntsman DJ, Hansen JE, Whipp BJ. Ventilatory and gas exchange kinetics during exercise in chronic obstructive pulmonary disease. J Appl Physiol 1982; 53: 1594-1602.
53. Sietsema KE, Ben-Dov I, Zhang YY, Sullivan C, Wasserman K. Dynamics of oxygen uptake for submaximal exercise and recovery in patients with chronic heart failure. Chest 1994; 105: 1693-1700.
54. Bauer TA, Regensteiner JG, Brass EP, Hiatt WR. Oxygen uptake kinetics are slowed in patients with peripheral arterial disease. J Appl Physiol 1999; 87: 809-819.
55. Regensteiner JG, Bauer TA, Reusch JEB, et al. Abnormal oxygen uptake kinetics in women with type II diabetes mellitus. J Appl Physiol 1998; 85: 310-317.
56. 2 uptake and heart rate kinetics during heavy exercise. J Appl Physiol 1996; 81: 2500-2508.
57. MacDonald MJ, Shoemaker JK, Tschakowsky ME, Hughson RL. Alveolar oxygen uptake and femoral artery blood flow dynamics in upright and supine leg exercise in humans. J Appl Physiol 1998; 85: 1622-1628.
58. Hughson RL. Alterations in the oxygen deficit-oxygen debt relationship with beta-adrenergic receptor blockade in man. J Physiol 1984; 349: 375-387.
59. Lunde PK, Sjastad I, Schiotz Thorud H-M, Sejersted OM. Skeletal muscle disorders in heart failure. Acta Physiol Scand 2001; 171: 277-294.
60. Palange P, Wagner PD. "The skeletal muscle in chronic respiratory diseases", summary of the ERS research seminar in Rome, Italy, February 11-12, 1999. Eur Resp J 2001; 15: 807-815.
61. Hiatt WR, Wolfel EE, Regensteiner JG, Brass EP. Skeletal muscle carnitine metabolism in patients with unilateral peripheral arterial disease. J Appl Physiol 1992; 73: 346-353.
62. 2 difference in Type 2 diabetes. J Appl Physiol 2003; 94: 1033-1038.
63. Cerretelli P, Grassi B, Colombini A, Caru B, Marconi C. Gas exchange and metabolic transients in heart transplant recipients. Respir Physiol 1988; 74: 355-371.
64. Cerretelli P, Marconi C, Meyer M, Ferretti G, Grassi B. Gas exchange kinetics in heart transplant recipients. Chest 1992; 101 (Suppl. 1): 199S-205S.
65. Grassi B, Marconi C, Meyer M, Rieu M, Cerretelli P. Gas exchange and cardiovascular kinetics upon different exercise protocols in heart transplant recipients. J Appl Physiol 1997; 82: 1952-1962.
66. Lanfranconi F, Borrelli E, Ferri A, et al. B. Non-invasive evaluation of skeletal muscle oxidative metabolism after heart transplant. Med Sci Sports Exerc 2006; 38: 1374-1383.
67. Behnke BJ, Kindig CA, McDonough P, Poole DC, Sexton WL. Dynamic of microvascular oxygen pressure during rest-contraction transition in skeletal muscle of diabetic rats. Am J Physiol 2002; 283: H926-H932.
68. Diederich ER, Behnke BJ, McDonough P, et al. Dynamics of microvascular oxygen partial pressure in contracting skeletal muscle of rats with chronic heart failure. Cardiov Research 2002; 56: 479-486.
69. Jones AM, Poole DC. Introduction to oxygen uptake kinetics and historical development of the discipline. In Oxygen Uptake Kinetics in Sport, Exercise and Medicine. AM Jones & DC Poole (eds), London, UK, Routledge, 2005 pp. 3-35.
70. Schalcher C, Rickli H, Brehn M, et al. Prolonged oxygen uptake kinetics during low-intensity exercise are related to poor prognosis in patients with mild-to-moderate congestive heart failure. Chest 2003; 124: 580-586.