Role of skeletal muscles impairment and brain oxygenation in limiting oxidative metabolism during exercise after bed rest

Journal of Applied Physiology

Volumn 109, Issue 1, 2010, Pages 101-111

  Porcelli, Simone ^a,b   Marzorati, Mauro ^a   Lanfranconi, Francesca ^c   Vago, Paola ^c   Pišot, Rado ^d   Grassi, Bruno ^e  

^a Istituto di Chimica del Riconoscimento Molecolare   (United States)

^b Universita Telematica Internazionale   (United States)

^c UNIVERSITY OF MILAN   (Italy)

^d UNIVERSITY OF PRIMORSKA   (Slovenia)

^e UNIVERSITY OF UDINE   (Italy)

Author keywords

Deconditioning; Gas exchange kinetics; Microgravity; Near infrared spectroscopy; Skeletal muscle bioenergetics

Indexed keywords

OXYGEN;

ADULT; ARTICLE; BED REST; BLOOD; BRAIN; ENERGY METABOLISM; EXERCISE; HEART OUTPUT; HEART RATE; HUMAN; LUNG GAS EXCHANGE; MALE; METABOLISM; OXYGEN CONSUMPTION; PHYSIOLOGY; SKELETAL MUSCLE; VASCULARIZATION; YOUNG ADULT;

ADULT; BED REST; BRAIN; CARDIAC OUTPUT; ENERGY METABOLISM; EXERCISE; HEART RATE; HUMANS; MALE; MUSCLE, SKELETAL; OXYGEN; OXYGEN CONSUMPTION; PULMONARY GAS EXCHANGE; YOUNG ADULT;

EID: 77954318387     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00782.2009     Document Type: Article

References (48)

1. Amann M, Romer ML, Subudhi AW, Pegelow DF, Dempsey JA. Severity of arterial hypoxemia affects the relative contributions of peripheral muscle fatigue to exercise performance in healthy humans. J Physiol 581: 389-403, 2007.
2. Beaver WL, Wasserman K, Whipp BJ. A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol 60: 2020-2027, 1986.
3. Berger NJA, Tolfrey K, Williams AG, Jones AM. Influence of continuous and interval training on oxygen uptake on-kinetics. Med Sci Sports Exerc 38: 504-512, 2006.
4. Bloomfield SA. Changes in musculoskeletal structure and function with prolonged bed rest. Med Sci Sports Exerc 29: 197-206, 1997.
5. Borg G. Ratings of perceived exertion and heart rates during short-term cycle exercise and their use in a new cycling strength test. Int J Sports Med 3: 153-158, 1982.
6. Boushel R, Langberg H, Olesen J, Gonzales-Alonso J, Bülow J, Kjær M. Monitoring tissue oxygen availability with near infrared spectroscopy (NIRS) in health, and disease. Scand J Med Sci Sports 11: 213-222, 2001.
7. Carter H, Jones AM, Barstow TJ, Burnley M, Williams C, Doust JH. Effect of endurance training on oxygen uptake kinetics during treadmill running. J Appl Physiol 89: 1744-1752, 2000.
8. 2max limitation. Eur J Appl Physiol 98: 152-160, 2006.
9. Convertino VA. Cardiovascular consequences of bed rest: effect on maximal oxygen, uptake. Med Sci Sports Exerc 29: 191-196, 1997.
10. Convertino VA, Goldwater DJ, Sandler H. V02 kinetics of constantload exercise following bed-rest-induced deconditioning. J. Appl Physiol 57: 1545-1550, 1984.
11. 2 uptake kinetics and muscle deoxygenation during moderate-intensity exercise. J Appl Physiol 95: 113-120, 2003.
12. di Prampero PE. Factors limiting maximal performance in humans. Eur J Appl Physiol 90: 420-429, 2005.
13. di Prampero PE, Narici MV. Muscles in microgravity: from fibres to human motion. J Biomech 36: 403-412, 2003.
14. Ferrari M, Binzoni T, Quaresima V. Oxidative metabolism in muscle. Philos Trans R Soc Land B Biol Sci 352: 677-683, 1997.
15. Ferrari M, Mottola L, Quaresima V. Principles, techniques, and limitations of near-infrared spectroscopy. Can J Appl Physiol 29: 463-487, 2004.
16. 2 extraction during ramp exercise. J Appl Physiol 103: 1999-2004, 2007.
17. 2 exchange. Respir Physiol Neurobiol 147: 91-103, 2005.
18. 2 consumption in man after prolonged bed rest. J Physiol 501: 677-686, 1997.
19. Fitts RH, Riley DR, Widrick JJ. Physiology of a Microgravity Environment. Microgravity and skeletal muscle. J Appl Physiol 89: 823-839, 2000.
20. Fortney SM, Schneider VS, Greenleaf JE. The physiology of bed rest. In: Handbook of Physiology. Environmental Physiology. Bethesda, MD: Am. Physiol Soc, 1996, sect. 4, vol. 2, p. 889-939.
21. Grassi B. Oxygen uptake kinetics: why are they so slow? And what do they tell us? J Physiol Pharmacol 57, Suppl 10: 53-65, 2006.
22. Grassi B, Marzorati M, Lanfranconi F, Ferri A, Longaretti M, Stucchi A, Vago P, Marconi C, Morandi L. Impaired oxygen extraction in metabolic myopathies: detection and quantification by near-infrared spectroscopy. Muscle Nerve 35: 510-520, 2007.
23. Grassi B, Pogliaghi S, Rampichini S, Quaresima V, Ferrari M, Marconi C, Cerretelli P. Muscle oxygenation and pulmonary gas exchange kinetics during cycling exercise on-transition in humans. J Appl Physiol 95: 149-158, 2003.
24. 2 uptake kinetics in humans: implications for metabolic control. J Appl Physiol 80: 988-998, 1996.
25. Henson LC, Calalang C, Temp JA, Ward DS. Accuracy of a cerebral oximeter in healthy volunteers under conditions of isocapnic hypoxia. Anesthesiology 88: 58-65, 1998.
26. Hortobagyi T, Dempsey L, Fraser D, Zheng D, Hamilton G, Lambert J, Dohn L. Changes in muscle strength, muscle fibre size and myofibrillar gene expression after immobilization. J Physiol 524: 293-304, 2000.
27. Imray CH, Myers SD, Pattinson KT, Bradwell AR, Chan CW, Harris S, Collins P, Wright AD. Effect of exercise on cerebral perfusion in humans at high altitude. J Appl Physiol 99: 699-706, 2005.
28. 2 kinetics. In: Oxygen Uptake Kinetics in Sport, Exercise and Medicine, edited by Jones AM, Poole DC. London: Routledge, 2005, p. 261-293.
29. Kalliokowski KK, Oikonen V, Takala TO, Sipila H, Knuuti J, Nuutila P. Enhanced oxygen extraction and reduced flow heterogeneity in exercising muscle in endurance-trained men. Am J Physiol Endocrinol Metab 280: E1015-E1021, 2001.
30. Kowalchuk JM, Rossiter HB, Ward SA, Whipp BJ. The effect of resistive breathing on leg muscle oxygenation using near-infrared spectroscopy during exercise in men. Exp Physiol 87: 601-611, 2002.
31. Krustrup P, Secher NH, Relu MU, Hellsten Y, Söderlund K, Bangsbo J. Neuromuscular blockade of slow twitch muscle fibres elevates muscle oxygen uptake and energy turnover during submaximal exercise in humans. J Physiol 586: 6037-6048, 2008.
32. Lanfranconi F, Borrelli E, Ferri A, Porcelli S, Maccherini M, Chiavarelli M, Grassi B. Noninvasive evaluation of skeletal muscle oxidative metabolism, after heart transplant. Med Sci Sports Exerc 38: 1374-1383, 2006.
33. Levine BD, Lane LD, Watenpaugh DE, Gaffney FA, Buckey JC, Blomqvist CG. Maximal exercise performance after adaptation to microgravity. J Appl Physiol 81: 686-694, 1996.
34. 2 supplementation. Am J Physiol Heart Circ Physiol 277: H1045-H1052, 1999.
35. Nybo L, Rasmussen P. Inadequate cerebral oxygen delivery and central fatigue during strenuous exercise. Exerc Sport Sci Rev 35: 110-118, 2007.
36. Pavy-Le Traon A, Heer M, Narici MV, Rittweger M, Vernikos J. From space to Earth: advances in human physiology from 20 years of bed rest studies. Eur J Appl Physiol 101: 143-194, 2007.
37. Powers SK, Kavazis AN, McClung JM. Oxidative stress and disuse muscle atrophy. J Appl Physiol 102: 2389-2397, 2007.
38. Richard R, Lonsdorfer-Wolf E, Charloux A, Doutreleau S, Bucheit M, Oswald-Mammosser M, Lampert E, Mettauer B, Geny B, Lonsdorfer J. Non-invasive cardiac output evaluation during a maximal progressive exercise test, using a new impedance cardiograph device. Eur J Appl Physiol 85: 202-207, 2001.
39. 2 uptake between the on- and off-transients of moderate- and high-intensity exercise in humans. J Physiol 541: 991-1002, 2002.
40. Subudhi AW, Dimmen AC, Roach RC. Effects of acute hypoxia on cerebral and muscle oxygenation during incremental exercise. J Appl Physiol 103: 177-183, 2007.
41. Subudhi AW, Lorenz MC, Fulco CS, Roach RC. Cerebrovascular responses to incremental exercise during hypobaric hypoxia: effect of oxygenation on maximal performance. Am J Physiol Heart Circ Physiol 294: H164-H171, 2008.
42. Subudhi AW, Miramon BR, Granger ME, Roach RC. Frontal and motor cortex oxygenation during maximal exercise in normoxia and hypoxia. J Appl Physiol 106: 1153-1158, 2009.
43. Trappe T, Trappe S, Lee G, Widrick J, Fitts R, Costill D. Cardiorespiratory responses to physical work during and following 17 days of bed rest and spaceflight. J Appl Physiol 100: 951-957, 2006.
44. Warburton DER, Haykowsky MJF, Quinney HA, Humen DP, Teo KK. Reliability and validity of measures of cardiac output during incremental to maximal aerobic exercise. Part I: conventional techniques. Sports Med 1: 23-41, 1999.
45. Whipp BJ, Rossiter HB, Ward SA. Exertional oxygen uptake kinetics: a stamen of stamina? Biochem Soc Trans 30: 237-247, 2002.
46. Wilson JR, Mancini DM, McCully K, Ferraro N, Lanoce V, Chance B. Noninvasive detection of skeletal muscle underperfusion with near-infrared spectroscopy in patients with heart failure. Circulation 80: 1668-1674, 1989.
47. Zoladz JA, Gladden LB, Hogan MC, Nieckarz Z, Grassi B. Progressive recruitment of muscle fibers is not necessary for the slow component of Vo2 kinetics. J Appl Physiol 105: 575-580, 2008.
48. Zoladz JA, Korzeniewski B, Grassi B. Training-induced acceleration of oxygen uptake kinetics in skeletal muscle: the underlying mechanisms. J Physiol Pharmacol 57, Suppl 10: 67-84, 2006.