Optimizing endothelial targeting by modulating the antibody density and particle concentration of anti-ICAM coated carriers

Journal of Controlled Release

Volumn 150, Issue 1, 2011, Pages 37-44

  Calderon, Andres J ^a   Bhowmick, Tridib ^b   Leferovich, John ^a   Burman, Bharat ^a   Pichette, Benjamin ^a   Muzykantov, Vladimir ^a   Eckmann, David M ^a   Muro, Silvia ^b,c,d  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

^c UNIVERSITY OF MARYLAND   (United States)

^d UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

Author keywords

Antibody surface density; Endothelial cell; Endothelium; ICAM 1; Optimization; Targeted drug carriers

Indexed keywords

BINDING KINETICS; BIODISTRIBUTIONS; CARRIER DESIGN; CELL ADHESION MOLECULES; DRUG CARRIER; ENDOTHELIUM; HYDRODYNAMIC FORCES; ICAM-1; ICAM-1 EXPRESSION; IN-VITRO; IN-VIVO; INTERCELLULAR ADHESION MOLECULE-1; PARTICLE CONCENTRATIONS; POLYMER CARRIER; SPLENIC UPTAKE; STATIC CONDITIONS; SURFACE DENSITY; SURFACE PROTEINS; TARGETED DRUG CARRIERS; TARGETING MOLECULES; THERAPEUTIC INTERVENTION; VASCULAR ENDOTHELIUM; VASCULATURE;

ADHESION; ANTIBODIES; BINDING SITES; BIOCHEMISTRY; BIOLOGICAL ORGANS; BLOOD VESSELS; CARRIER CONCENTRATION; CELL ADHESION; CONCENTRATION (PROCESS); DISEASES; FLUORESCENCE MICROSCOPY; MOLECULES; OPTIMIZATION; SELF ASSEMBLY;

ENDOTHELIAL CELLS;

DRUG CARRIER; FLUORESCEIN ISOTHIOCYANATE; INTERCELLULAR ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1 ANTIBODY; IODINE 125; POLYSTYRENE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIOLE; ARTICLE; BINDING KINETICS; CAPILLARY; CELL ACTIVATION; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DELIVERY SYSTEM; DRUG TARGETING; ENDOTHELIUM CELL; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; HYDRODYNAMICS; LIVER; LUNG; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHEAR STRESS; SPLEEN; VASCULAR ENDOTHELIUM; VENULE;

ANIMALS; ANTIBODIES, MONOCLONAL; CELL LINE; DRUG CARRIERS; ENDOTHELIAL CELLS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; MALE; MICE; MICE, INBRED C57BL;

EID: 79951944577     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.10.025     Document Type: Article

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