Treatment of postinfectious olfactory disorders with minocycline: A double-blind, placebo-controlled study

Laryngoscope

Volumn 121, Issue 3, 2011, Pages 679-682

  Reden, Jens ^a   Herting, Birgit ^b   Lill, Katja ^d   Kern, Robert ^c   Hummel, Thomas ^a  

^a UNIVERSITY OF DRESDEN MEDICAL SCHOOL   (Germany)

^b Diakonie Klinikum   (Germany)

^c NORTHWESTERN UNIVERSITY   (United States)

^d NONE

Author keywords

hyposmia; olfactory loss; Smell; therapy

Indexed keywords

MINOCYCLINE; PLACEBO;

APOPTOSIS; ARTICLE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; OLFACTORY NERVE DISEASE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PSYCHOPHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL;

ADMINISTRATION, ORAL; ANTI-BACTERIAL AGENTS; APOPTOSIS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; MINOCYCLINE; OLFACTION DISORDERS; OLFACTORY RECEPTOR NEURONS; PROSPECTIVE STUDIES; REMISSION, SPONTANEOUS; RESPIRATORY TRACT INFECTIONS; SENSORY THRESHOLDS; SMELL;

EID: 79951941017     PISSN: 0023852X     EISSN: None     Source Type: Journal    
DOI: 10.1002/lary.21401     Document Type: Article

References (21)

1. Farbman AI., Olfactory neurogenesis: genetic or environmental controls ? Trends Neurosci 1990; 13: 362-365. (Pubitemid 20260346)
2. Kern RC, Conley DB, Haines GK III, Robinson AM., Pathology of the olfactory mucosa: implications for the treatment of olfactory dysfunction. Laryngoscope 2004; 114: 279-285. (Pubitemid 38182623)
3. Nakagawa T, Aiba T, Shiotani H, Tomiyama K, Nakai Y., Apoptosis in the normal olfactory epithelium of the adult guinea pig. Eur Arch Otorhinolaryngol 1996; 253: 371-373. (Pubitemid 26258596)
4. Robinson AM, Conley DB, Shinners MJ, Kern RC., Apoptosis in the aging olfactory epithelium. Laryngoscope 2002; 112 (8 pt 1): 1431-1435. (Pubitemid 34875428)
5. Ge Y, Tsukatani T, Nishimura T, Furukawa M, Miwa T., Cell death of olfactory receptor neurons in a rat with nasosinusitis infected artificially with Staphylococcus. Chem Senses 2002; 27: 521-527.
6. Garner SE, Eady EA, Popescu C, Newton J, Li WA,. Minocycline for acne vulgaris: efficacy and safety. Cochrane Database Syst Rev 2003;(1):CD002086.
7. Wang X, Zhu S, Drozda M, et al. Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease. Proc Natl Acad Sci U S A 2003; 100: 10483-10487. (Pubitemid 37071904)
8. Thomas M, Le WD., Minocycline: neuroprotective mechanisms in Parkinson's disease. Curr Pharm Des 2004; 10: 679-686. (Pubitemid 38292395)
9. Yrjanheikki J, Keinanen R, Pellikka M, Hokfelt T, Koistinaho J., Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia. Proc Natl Acad Sci U S A 1998; 95: 15769-15774. (Pubitemid 29018775)
10. Sanchez Mejia RO, Ona VO, Li M, Friedlander RM., Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction. Neurosurgery 2001; 48: 1393-1399; discussion 1399-1401.
11. Hughes EH, Schlichtenbrede FC, Murphy CC, et al. Minocycline delays photoreceptor death in the rds mouse through a microglia-independent mechanism. Exp Eye Res 2004; 78: 1077-1084. (Pubitemid 38510345)
12. Kim HS, Suh YH., Minocycline and neurodegenerative diseases. Behav Brain Res 2009; 196: 168-179.
13. Kern RC, Conley DB, Haines GK 3rd, Robinson AM. Treatment of olfactory dysfunction, II: studies with minocycline. Laryngoscope 2004; 14: 2200-2204. (Pubitemid 39602489)
14. Hummel T, Sekinger B, Wolf SR, Pauli E, Kobal G,. "Sniffin' sticks": olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold. Chem Senses 1997; 22: 39-52. (Pubitemid 27142122)
15. Hummel T, Kobal G, Gudziol H, Mackay-Sim A., Normative data for the "Sniffin' Sticks" including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects. Eur Arch Otorhinolaryngol 2007; 264: 237-243. (Pubitemid 46214098)
16. Gudziol V, Lötsch J, Hähner A, et al. Clinical significance of results from olfactory testing. Laryngoscope 2006; 116: 1858-1863. (Pubitemid 44511376)
17. Smith K., Leyden JJ., Safety of doxycycline and minocycline: a systematic review. Clin Ther 2005; 27: 1329-1342. (Pubitemid 41598368)
18. Duncan HJ, Seiden AM., Long-term follow-up of olfactory loss secondary to head trauma and upper respiratory tract infection. Arch Otolaryngol Head Neck Surg 1995; 121: 1183-1187.
19. Mori J, Aiba T, Sugiura M, et al. Clinical study of olfactory disturbance. Acta Otolaryngol Suppl 1998; 538: 197-201. (Pubitemid 28563342)
20. Hendriks APJ., Olfactory dysfunction. Rhinology 1988; 26: 229-251. (Pubitemid 19022663)
21. Reden J, Mueller A, Mueller C, et al. Recovery of olfactory function following closed head injury or infections of the upper respiratory tract. Arch Otolaryngol Head Neck Surg 2006; 132: 265-269.