-
1
-
-
38349006201
-
Polyunsaturated fatty acids induce {alpha}-synuclein-related pathogenic changes in neuronal cells
-
Assayag K., Yakunin E., Loeb V., Selkoe D. J. Sharon R. (2007) Polyunsaturated fatty acids induce {alpha}-synuclein-related pathogenic changes in neuronal cells. Am. J. Pathol. 171, 2000 2011.
-
(2007)
Am. J. Pathol.
, vol.171
, pp. 2000-2011
-
-
Assayag, K.1
Yakunin, E.2
Loeb, V.3
Selkoe, D.J.4
Sharon, R.5
-
2
-
-
34548189188
-
Structural characterization of the intrinsically unfolded protein beta-synuclein, a natural negative regulator of alpha-synuclein aggregation
-
Bertoncini C. W., Rasia R. M., Lamberto G. R., Binolfi A., Zweckstetter M., Griesinger C. Fernandez C. O. (2007) Structural characterization of the intrinsically unfolded protein beta-synuclein, a natural negative regulator of alpha-synuclein aggregation. J. Mol. Biol. 372, 708 722.
-
(2007)
J. Mol. Biol.
, vol.372
, pp. 708-722
-
-
Bertoncini, C.W.1
Rasia, R.M.2
Lamberto, G.R.3
Binolfi, A.4
Zweckstetter, M.5
Griesinger, C.6
Fernandez, C.O.7
-
3
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248 254.
-
(1976)
Anal. Biochem.
, vol.72
, pp. 248-254
-
-
Bradford, M.M.1
-
4
-
-
0025897160
-
Immortalization of embryonic mesencephalic dopaminergic neurons by somatic cell fusion
-
Choi H. K., Won L. A., Kontur P. J., Hammond D. N., Fox A. P., Wainer B. H., Hoffmann P. C. Heller A. (1991) Immortalization of embryonic mesencephalic dopaminergic neurons by somatic cell fusion. Brain Res. 552, 67 76.
-
(1991)
Brain Res.
, vol.552
, pp. 67-76
-
-
Choi, H.K.1
Won, L.A.2
Kontur, P.J.3
Hammond, D.N.4
Fox, A.P.5
Wainer, B.H.6
Hoffmann, P.C.7
Heller, A.8
-
5
-
-
0032102455
-
The synucleins: A family of proteins involved in synaptic function, plasticity, neurodegeneration and disease
-
Clayton D. F. George J. M. (1998) The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease. Trends Neurosci. 21, 249 254.
-
(1998)
Trends Neurosci.
, vol.21
, pp. 249-254
-
-
Clayton, D.F.1
George, J.M.2
-
6
-
-
0033215063
-
Synucleins in synaptic plasticity and neurodegenerative disorders
-
Clayton D. F. George J. M. (1999) Synucleins in synaptic plasticity and neurodegenerative disorders. J. Neurosci. Res. 58, 120 129.
-
(1999)
J. Neurosci. Res.
, vol.58
, pp. 120-129
-
-
Clayton, D.F.1
George, J.M.2
-
7
-
-
0141844595
-
Beta-synuclein displays an antiapoptotic p53-dependent phenotype and protects neurons from 6-hydroxydopamine-induced caspase 3 activation: Cross-talk with alpha-synuclein and implication for Parkinson's disease
-
da Costa C. A., Masliah E. Checler F. (2003) Beta-synuclein displays an antiapoptotic p53-dependent phenotype and protects neurons from 6-hydroxydopamine-induced caspase 3 activation: cross-talk with alpha-synuclein and implication for Parkinson's disease. J. Biol. Chem. 278, 37330 37335.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 37330-37335
-
-
Da Costa, C.A.1
Masliah, E.2
Checler, F.3
-
8
-
-
0026781572
-
A novel N18TG2 × mesencephalon cell hybrid expresses properties that suggest a dopaminergic cell line of substantia nigra origin
-
Crawford G. D. Jr., Le W. D., Smith R. G., Xie W. J., Stefani E. Appel S. H. (1992) A novel N18TG2 × mesencephalon cell hybrid expresses properties that suggest a dopaminergic cell line of substantia nigra origin. J. Neurosci. 12, 3392 3398.
-
(1992)
J. Neurosci.
, vol.12
, pp. 3392-3398
-
-
Crawford Jr., G.D.1
Le, W.D.2
Smith, R.G.3
Xie, W.J.4
Stefani, E.5
Appel, S.H.6
-
10
-
-
33749246152
-
Beta-synuclein modulates alpha-synuclein neurotoxicity by reducing alpha-synuclein protein expression
-
Fan Y., Limprasert P., Murray I. V., Smith A. C., Lee V. M., Trojanowski J. Q., Sopher B. L. La Spada A. R. (2006) Beta-synuclein modulates alpha-synuclein neurotoxicity by reducing alpha-synuclein protein expression. Hum. Mol. Genet. 15, 3002 3011.
-
(2006)
Hum. Mol. Genet.
, vol.15
, pp. 3002-3011
-
-
Fan, Y.1
Limprasert, P.2
Murray, I.V.3
Smith, A.C.4
Lee, V.M.5
Trojanowski, J.Q.6
Sopher, B.L.7
La Spada, A.R.8
-
11
-
-
70449158340
-
A simple method for the isolation and purification of total lipids from animal tissues
-
Folch J., Lees M. Sloane Stanley G. H. (1957) A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226, 497 509.
-
(1957)
J. Biol. Chem.
, vol.226
, pp. 497-509
-
-
Folch, J.1
Lees, M.2
Sloane Stanley, G.H.3
-
12
-
-
0033539664
-
Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein
-
Galvin J. E., Uryu K., Lee V. M. Trojanowski J. Q. (1999) Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein. Proc. Natl Acad. Sci. USA 96, 13450 13455.
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 13450-13455
-
-
Galvin, J.E.1
Uryu, K.2
Lee, V.M.3
Trojanowski, J.Q.4
-
13
-
-
0036150971
-
The synucleins
-
George J. M. (2002) The synucleins. Genome Biol. 3, 1 6.
-
(2002)
Genome Biol.
, vol.3
, pp. 1-6
-
-
George, J.M.1
-
14
-
-
0035950270
-
Beta-synuclein inhibits alpha-synuclein aggregation: A possible role as an anti-parkinsonian factor
-
Hashimoto M., Rockenstein E., Mante M., Mallory M. Masliah E. (2001) Beta-synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor. Neuron 32, 213 223.
-
(2001)
Neuron
, vol.32
, pp. 213-223
-
-
Hashimoto, M.1
Rockenstein, E.2
Mante, M.3
Mallory, M.4
Masliah, E.5
-
15
-
-
2542499831
-
Beta-synuclein regulates Akt activity in neuronal cells. a possible mechanism for neuroprotection in Parkinson's disease
-
Hashimoto M., Bar-On P., Ho G., Takenouchi T., Rockenstein E., Crews L. Masliah E. (2004) Beta-synuclein regulates Akt activity in neuronal cells. A possible mechanism for neuroprotection in Parkinson's disease. J. Biol. Chem. 279, 23622 23629.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 23622-23629
-
-
Hashimoto, M.1
Bar-On, P.2
Ho, G.3
Takenouchi, T.4
Rockenstein, E.5
Crews, L.6
Masliah, E.7
-
16
-
-
0036724202
-
Alpha-synuclein exhibits competitive interaction between calmodulin and synthetic membranes
-
Lee D., Lee S. Y., Lee E. N., Chang C. S. Paik S. R. (2002) Alpha-synuclein exhibits competitive interaction between calmodulin and synthetic membranes. J. Neurochem. 82, 1007 1017.
-
(2002)
J. Neurochem.
, vol.82
, pp. 1007-1017
-
-
Lee, D.1
Lee, S.Y.2
Lee, E.N.3
Chang, C.S.4
Paik, S.R.5
-
17
-
-
0023722437
-
Synuclein: A neuron-specific protein localized to the nucleus and presynaptic nerve terminal
-
Maroteaux L., Campanelli J. T. Scheller R. H. (1988) Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal. J. Neurosci. 8, 2804 2815.
-
(1988)
J. Neurosci.
, vol.8
, pp. 2804-2815
-
-
Maroteaux, L.1
Campanelli, J.T.2
Scheller, R.H.3
-
18
-
-
0036777590
-
Development of new treatments for Parkinson's disease in transgenic animal models: A role for beta-synuclein
-
Masliah E. Hashimoto M. (2002) Development of new treatments for Parkinson's disease in transgenic animal models: a role for beta-synuclein. Neurotoxicology 23, 461 468.
-
(2002)
Neurotoxicology
, vol.23
, pp. 461-468
-
-
Masliah, E.1
Hashimoto, M.2
-
19
-
-
0037218641
-
Autoimmune encephalomyelitis and uveitis induced by T cell immunity to self beta-synuclein
-
Mor F., Quintana F., Mimran A. Cohen I. R. (2003) Autoimmune encephalomyelitis and uveitis induced by T cell immunity to self beta-synuclein. J. Immunol. 170, 628 634.
-
(2003)
J. Immunol.
, vol.170
, pp. 628-634
-
-
Mor, F.1
Quintana, F.2
Mimran, A.3
Cohen, I.R.4
-
20
-
-
4644359042
-
Beta-synuclein gene alterations in dementia with Lewy bodies
-
Ohtake H., Limprasert P., Fan Y. et al. (2004) Beta-synuclein gene alterations in dementia with Lewy bodies. Neurology 63, 805 811.
-
(2004)
Neurology
, vol.63
, pp. 805-811
-
-
Ohtake, H.1
Limprasert, P.2
Fan, Y.3
-
21
-
-
0037426346
-
Beta-synuclein inhibits formation of alpha-synuclein protofibrils: A possible therapeutic strategy against Parkinson's disease
-
Park J. Y. Lansbury P. T. Jr. (2003) Beta-synuclein inhibits formation of alpha-synuclein protofibrils: a possible therapeutic strategy against Parkinson's disease. Biochemistry 42, 3696 3700.
-
(2003)
Biochemistry
, vol.42
, pp. 3696-3700
-
-
Park, J.Y.1
Lansbury Jr., P.T.2
-
22
-
-
34548496276
-
An investigation into the lipid-binding properties of alpha-, beta- and gamma-synucleins in human brain and cerebrospinal fluid
-
Salem S. A., Allsop D., Mann D. M., Tokuda T. El-Agnaf O. M. (2007) An investigation into the lipid-binding properties of alpha-, beta- and gamma-synucleins in human brain and cerebrospinal fluid. Brain Res. 1170, 103 111.
-
(2007)
Brain Res.
, vol.1170
, pp. 103-111
-
-
Salem, S.A.1
Allsop, D.2
Mann, D.M.3
Tokuda, T.4
El-Agnaf, O.M.5
-
23
-
-
0035979233
-
Alpha-synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins
-
Sharon R., Goldberg M. S., Bar-Josef I., Betensky R. A., Shen J. Selkoe D. J. (2001) Alpha-synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins. Proc. Natl Acad. Sci. USA 98, 9110 9115.
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 9110-9115
-
-
Sharon, R.1
Goldberg, M.S.2
Bar-Josef, I.3
Betensky, R.A.4
Shen, J.5
Selkoe, D.J.6
-
24
-
-
0347379922
-
Altered fatty acid composition of dopaminergic neurons expressing alpha-synuclein and human brains with alpha-synucleinopathies
-
Sharon R., Bar-Joseph I., Mirick G. E., Serhan C. N. Selkoe D. J. (2003a) Altered fatty acid composition of dopaminergic neurons expressing alpha-synuclein and human brains with alpha-synucleinopathies. J. Biol. Chem. 278, 49874 49881.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 49874-49881
-
-
Sharon, R.1
Bar-Joseph, I.2
Mirick, G.E.3
Serhan, C.N.4
Selkoe, D.J.5
-
25
-
-
0037456578
-
The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease
-
Sharon R., Bar-Joseph I., Frosch M. P., Walsh D. M., Hamilton J. A. Selkoe D. J. (2003b) The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease. Neuron 37, 583 595.
-
(2003)
Neuron
, vol.37
, pp. 583-595
-
-
Sharon, R.1
Bar-Joseph, I.2
Frosch, M.P.3
Walsh, D.M.4
Hamilton, J.A.5
Selkoe, D.J.6
-
26
-
-
20044365775
-
Beta-synuclein reduces proteasomal inhibition by alpha-synuclein but not gamma-synuclein
-
Snyder H., Mensah K., Hsu C., Hashimoto M., Surgucheva I. G., Festoff B., Surguchov A., Masliah E., Matouschek A. Wolozin B. (2005) Beta-synuclein reduces proteasomal inhibition by alpha-synuclein but not gamma-synuclein. J. Biol. Chem. 280, 7562 7569.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 7562-7569
-
-
Snyder, H.1
Mensah, K.2
Hsu, C.3
Hashimoto, M.4
Surgucheva, I.G.5
Festoff, B.6
Surguchov, A.7
Masliah, E.8
Matouschek, A.9
Wolozin, B.10
-
27
-
-
0035789203
-
Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice
-
Specht C. G. Schoepfer R. (2001) Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice. BMC Neurosci. 2, 11.
-
(2001)
BMC Neurosci.
, vol.2
, pp. 11
-
-
Specht, C.G.1
Schoepfer, R.2
-
28
-
-
33646156188
-
Secondary structure and dynamics of micelle bound beta- and gamma-synuclein
-
Sung Y. H. Eliezer D. (2006) Secondary structure and dynamics of micelle bound beta- and gamma-synuclein. Protein Sci. 15, 1162 1174.
-
(2006)
Protein Sci.
, vol.15
, pp. 1162-1174
-
-
Sung, Y.H.1
Eliezer, D.2
-
29
-
-
33947210032
-
Dynamics of alpha-synuclein aggregation and inhibition of pore-like oligomer development by beta-synuclein
-
Tsigelny I. F., Bar-On P., Sharikov Y., Crews L., Hashimoto M., Miller M. A., Keller S. H., Platoshyn O., Yuan J. X. Masliah E. (2007) Dynamics of alpha-synuclein aggregation and inhibition of pore-like oligomer development by beta-synuclein. FEBS J. 274, 1862 1877.
-
(2007)
FEBS J.
, vol.274
, pp. 1862-1877
-
-
Tsigelny, I.F.1
Bar-On, P.2
Sharikov, Y.3
Crews, L.4
Hashimoto, M.5
Miller, M.A.6
Keller, S.H.7
Platoshyn, O.8
Yuan, J.X.9
Masliah, E.10
-
30
-
-
0037023699
-
Biophysical properties of the synucleins and their propensities to fibrillate: Inhibition of alpha-synuclein assembly by beta- and gamma-synucleins
-
Uversky V. N., Li J., Souillac P., Millett I. S., Doniach S., Jakes R., Goedert M. Fink A. L. (2002) Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins. J. Biol. Chem. 277, 11970 11978.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 11970-11978
-
-
Uversky, V.N.1
Li, J.2
Souillac, P.3
Millett, I.S.4
Doniach, S.5
Jakes, R.6
Goedert, M.7
Fink, A.L.8
-
31
-
-
35348957237
-
Enhanced lysosomal pathology caused by beta-synuclein mutants linked to dementia with Lewy bodies
-
Wei J., Fujita M., Nakai M., Waragai M., Watabe K., Akatsu H., Rockenstein E., Masliah E. Hashimoto M. (2007) Enhanced lysosomal pathology caused by beta-synuclein mutants linked to dementia with Lewy bodies. J. Biol. Chem. 282, 28904 28914.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 28904-28914
-
-
Wei, J.1
Fujita, M.2
Nakai, M.3
Waragai, M.4
Watabe, K.5
Akatsu, H.6
Rockenstein, E.7
Masliah, E.8
Hashimoto, M.9
-
32
-
-
21744444004
-
Forcing nonamyloidogenic beta-synuclein to fibrillate
-
Yamin G., Munishkina L. A., Karymov M. A., Lyubchenko Y. L., Uversky V. N. Fink A. L. (2005) Forcing nonamyloidogenic beta-synuclein to fibrillate. Biochemistry 44, 9096 9107.
-
(2005)
Biochemistry
, vol.44
, pp. 9096-9107
-
-
Yamin, G.1
Munishkina, L.A.2
Karymov, M.A.3
Lyubchenko, Y.L.4
Uversky, V.N.5
Fink, A.L.6
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