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Volumn 15, Issue 2, 2011, Pages 339-349

Phosphatidylinositol 3-kinase interacts with the glucocorticoid receptor upon TLR2 activation

Author keywords

Glucocorticoid receptor; Lung mucosa inflammation; Phosphatidylinositol 3 kinase; TLR2

Indexed keywords

CYTOKINE; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PEPTIDE; PHOSPHATIDYLINOSITOL 3 KINASE; TLR2 PROTEIN, HUMAN; TOLL LIKE RECEPTOR 2; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA;

EID: 79951912903     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2009.00958.x     Document Type: Article
Times cited : (20)

References (45)
  • 1
    • 2442679177 scopus 로고    scopus 로고
    • Glucocorticoids and tumor necrosis factor alpha cooperatively regulate toll-like receptor 2 gene expression
    • Hermoso MA, Matsuguchi T, Smoak K, et al Glucocorticoids and tumor necrosis factor alpha cooperatively regulate toll-like receptor 2 gene expression. Mol Cell Biol. 2004; 24: 4743-56.
    • (2004) Mol Cell Biol. , vol.24 , pp. 4743-56
    • Hermoso, M.A.1    Matsuguchi, T.2    Smoak, K.3
  • 2
    • 0031916865 scopus 로고    scopus 로고
    • Cross-talk between nuclear factor-kappa b and the steroid hormone receptors: mechanisms of mutual antagonism
    • McKay LI, Cidlowski JA. Cross-talk between nuclear factor-kappa b and the steroid hormone receptors: mechanisms of mutual antagonism. Mol Endocrinol. 1998; 12: 45-56.
    • (1998) Mol Endocrinol. , vol.12 , pp. 45-56
    • McKay, L.I.1    Cidlowski, J.A.2
  • 3
    • 0031050034 scopus 로고    scopus 로고
    • Innate immunity: impact on the adaptive immune response
    • Medzhitov R, Janeway CA Jr. Innate immunity: impact on the adaptive immune response. Curr Opin Immunol. 1997; 9: 4-9.
    • (1997) Curr Opin Immunol. , vol.9 , pp. 4-9
    • Medzhitov, R.1    Janeway Jr, C.A.2
  • 4
    • 0030666222 scopus 로고    scopus 로고
    • Innate immunity: the virtues of a nonclonal system of recognition
    • Medzhitov R, Janeway CA Jr. Innate immunity: the virtues of a nonclonal system of recognition. Cell. 1997; 91: 295-8.
    • (1997) Cell. , vol.91 , pp. 295-8
    • Medzhitov, R.1    Janeway Jr, C.A.2
  • 5
    • 0031905311 scopus 로고    scopus 로고
    • A family of human receptors structurally related to drosophila toll
    • Rock FL, Hardiman G, Timans JC, et al A family of human receptors structurally related to drosophila toll. Proc Natl Acad Sci USA. 1998; 95: 588-93.
    • (1998) Proc Natl Acad Sci USA. , vol.95 , pp. 588-93
    • Rock, F.L.1    Hardiman, G.2    Timans, J.C.3
  • 6
    • 0033120081 scopus 로고    scopus 로고
    • Cutting edge: toll-like receptor 4 (tlr4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for tlr4 as the lps gene product
    • Hoshino K, Takeuchi O, Kawai T, et al Cutting edge: toll-like receptor 4 (tlr4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for tlr4 as the lps gene product. J Immunol. 1999; 162: 3749-52.
    • (1999) J Immunol. , vol.162 , pp. 3749-52
    • Hoshino, K.1    Takeuchi, O.2    Kawai, T.3
  • 7
    • 0034619794 scopus 로고    scopus 로고
    • A toll-like receptor recognizes bacterial DNA
    • Hemmi H, Takeuchi O, Kawai T, et al A toll-like receptor recognizes bacterial DNA. Nature. 2000; 408: 740-5.
    • (2000) Nature. , vol.408 , pp. 740-5
    • Hemmi, H.1    Takeuchi, O.2    Kawai, T.3
  • 8
    • 0035911644 scopus 로고    scopus 로고
    • Identification of htlr10: a novel human toll-like receptor preferentially expressed in immune cells
    • Chuang T, Ulevitch RJ. Identification of htlr10: a novel human toll-like receptor preferentially expressed in immune cells. Biochim Biophys Acta. 2001; 1518: 157-61.
    • (2001) Biochim Biophys Acta. , vol.1518 , pp. 157-61
    • Chuang, T.1    Ulevitch, R.J.2
  • 9
    • 0034577944 scopus 로고    scopus 로고
    • Toll-like receptor 2-mediated nf-kappa b activation requires a rac1-dependent pathway
    • Arbibe L, Mira JP, Teusch N, et al Toll-like receptor 2-mediated nf-kappa b activation requires a rac1-dependent pathway. Nat Immunol. 2000; 1: 533-40.
    • (2000) Nat Immunol. , vol.1 , pp. 533-40
    • Arbibe, L.1    Mira, J.P.2    Teusch, N.3
  • 10
    • 0033215123 scopus 로고    scopus 로고
    • Human toll-like receptors mediate cellular activation by mycobacterium tuberculosis
    • Means TK, Wang S, Lien E, et al Human toll-like receptors mediate cellular activation by mycobacterium tuberculosis. J Immunol. 1999; 163: 3920-7.
    • (1999) J Immunol. , vol.163 , pp. 3920-7
    • Means, T.K.1    Wang, S.2    Lien, E.3
  • 11
    • 0035104481 scopus 로고    scopus 로고
    • Differential expression of toll-like receptor 2 in human cells
    • Flo TH, Halaas O, Torp S, et al Differential expression of toll-like receptor 2 in human cells. J Leukoc Biol. 2001; 69: 474-81.
    • (2001) J Leukoc Biol. , vol.69 , pp. 474-81
    • Flo, T.H.1    Halaas, O.2    Torp, S.3
  • 12
    • 0033618630 scopus 로고    scopus 로고
    • Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2
    • Aliprantis AO, Yang RB, Mark MR, et al Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science. 1999; 285: 736-9.
    • (1999) Science. , vol.285 , pp. 736-9
    • Aliprantis, A.O.1    Yang, R.B.2    Mark, M.R.3
  • 13
    • 0034665748 scopus 로고    scopus 로고
    • The glucocorticoid receptor inhibits nfkappab by interfering with serine-2 phosphorylation of the rna polymerase ii carboxy-terminal domain
    • Nissen RM, Yamamoto KR. The glucocorticoid receptor inhibits nfkappab by interfering with serine-2 phosphorylation of the rna polymerase ii carboxy-terminal domain. Genes Dev. 2000; 14: 2314-29.
    • (2000) Genes Dev. , vol.14 , pp. 2314-29
    • Nissen, R.M.1    Yamamoto, K.R.2
  • 14
    • 0035084913 scopus 로고    scopus 로고
    • Micrococci and peptidoglycan activate tlr2- myd88-irak-traf-nik-ikk-nf-kappab signal transduction pathway that induces transcription of interleukin-8
    • Wang Q, Dziarski R, Kirschning CJ, et al Micrococci and peptidoglycan activate tlr2- myd88-irak-traf-nik-ikk-nf-kappab signal transduction pathway that induces transcription of interleukin-8. Infect Immun. 2001; 69: 2270-6.
    • (2001) Infect Immun. , vol.69 , pp. 2270-6
    • Wang, Q.1    Dziarski, R.2    Kirschning, C.J.3
  • 15
    • 0036235478 scopus 로고    scopus 로고
    • Involvement of erk, p38 and nf-kappab signal transduction in regulation of tlr2, tlr4 and tlr9 gene expression induced by lipopolysaccharide in mouse dendritic cells
    • An H, Yu Y, Zhang M, et al Involvement of erk, p38 and nf-kappab signal transduction in regulation of tlr2, tlr4 and tlr9 gene expression induced by lipopolysaccharide in mouse dendritic cells. Immunology. 2002; 106: 38-45.
    • (2002) Immunology. , vol.106 , pp. 38-45
    • An, H.1    Yu, Y.2    Zhang, M.3
  • 16
    • 33846899694 scopus 로고    scopus 로고
    • Glucocorticoid conditioning of myeloid progenitors enhances tlr4 signaling via negative regulation of the phosphatidylinositol 3-kinase-akt pathway
    • Zhang TY, Daynes RA. Glucocorticoid conditioning of myeloid progenitors enhances tlr4 signaling via negative regulation of the phosphatidylinositol 3-kinase-akt pathway. J Immunol. 2007; 178: 2517-26.
    • (2007) J Immunol. , vol.178 , pp. 2517-26
    • Zhang, T.Y.1    Daynes, R.A.2
  • 17
    • 0346259944 scopus 로고    scopus 로고
    • Inhibition of p38 mapk by glucocor-ticoids via induction of mapk phosphatase-1 enhances nontypeable haemophilus influenzae-induced expression of toll-like receptor 2
    • Imasato A, Desbois-Mouthon C, Han J, et al Inhibition of p38 mapk by glucocor-ticoids via induction of mapk phosphatase-1 enhances nontypeable haemophilus influenzae-induced expression of toll-like receptor 2. J Biol Chem. 2002; 277: 47444-50.
    • (2002) J Biol Chem. , vol.277 , pp. 47444-50
    • Imasato, A.1    Desbois-Mouthon, C.2    Han, J.3
  • 18
    • 0036135774 scopus 로고    scopus 로고
    • Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells
    • Galon J, Franchimont D, Hiroi N, et al Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells. FASEB J. 2002; 16: 61-71.
    • (2002) FASEB J. , vol.16 , pp. 61-71
    • Galon, J.1    Franchimont, D.2    Hiroi, N.3
  • 19
    • 20844437424 scopus 로고    scopus 로고
    • Translational regulatory mechanisms generate n-terminal glucocorticoid receptor isoforms with unique transcriptional target genes
    • Lu NZ, Cidlowski JA. Translational regulatory mechanisms generate n-terminal glucocorticoid receptor isoforms with unique transcriptional target genes. Mol Cell. 2005; 18: 331-42.
    • (2005) Mol Cell. , vol.18 , pp. 331-42
    • Lu, N.Z.1    Cidlowski, J.A.2
  • 20
    • 0025131067 scopus 로고
    • Novel antipeptide antibodies to the human glucocorticoid receptor: recognition of multiple receptor forms in vitro and distinct localization of cytoplasmic and nuclear receptors
    • Cidlowski JA, Bellingham DL, Powell-Oliver FE, et al Novel antipeptide antibodies to the human glucocorticoid receptor: recognition of multiple receptor forms in vitro and distinct localization of cytoplasmic and nuclear receptors. Mol Endocrinol. 1990; 4: 1427-37.
    • (1990) Mol Endocrinol. , vol.4 , pp. 1427-37
    • Cidlowski, J.A.1    Bellingham, D.L.2    Powell-Oliver, F.E.3
  • 21
    • 0037979126 scopus 로고    scopus 로고
    • Molecular origins for the dominant negative function of human glucocorticoid receptor beta
    • Yudt MR, Jewell CM, Bienstock RJ, et al Molecular origins for the dominant negative function of human glucocorticoid receptor beta. Mol Cell Biol. 2003; 23: 4319-30.
    • (2003) Mol Cell Biol. , vol.23 , pp. 4319-30
    • Yudt, M.R.1    Jewell, C.M.2    Bienstock, R.J.3
  • 22
    • 0033520304 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway
    • Delerive P, Martin-Nizard F, Chinetti G, et al Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway. Circ Res. 1999; 85: 394-402.
    • (1999) Circ Res. , vol.85 , pp. 394-402
    • Delerive, P.1    Martin-Nizard, F.2    Chinetti, G.3
  • 23
    • 0028598744 scopus 로고
    • Specificity in recognition of phosphopeptides by src-homology 2 domains
    • Cantley LC, Songyang Z. Specificity in recognition of phosphopeptides by src-homology 2 domains. Journal of cell science. 1994; 18: 121-6.
    • (1994) Journal of cell science , vol.18 , pp. 121-6
    • Cantley, L.C.1    Songyang, Z.2
  • 24
    • 0031470652 scopus 로고    scopus 로고
    • The structural basis for 14-3-3:Phosphopeptide binding specificity
    • Yaffe MB, Rittinger K, Volinia S, et al The structural basis for 14-3-3:Phosphopeptide binding specificity. Cell. 1997; 91: 961-71.
    • (1997) Cell. , vol.91 , pp. 961-71
    • Yaffe, M.B.1    Rittinger, K.2    Volinia, S.3
  • 25
    • 0033013866 scopus 로고    scopus 로고
    • Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor
    • Wennstrom S, Downward J. Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor. Mol Cell Biol. 1999; 19: 4279-88.
    • (1999) Mol Cell Biol. , vol.19 , pp. 4279-88
    • Wennstrom, S.1    Downward, J.2
  • 26
    • 0027196668 scopus 로고
    • Glucocorticoid therapy alters hormonal and cytokine responses to endotoxin in man
    • Barber AE, Coyle SM, Marano MA, et al Glucocorticoid therapy alters hormonal and cytokine responses to endotoxin in man. J Immunol. 1993; 150: 1999-2006.
    • (1993) J Immunol. , vol.150 , pp. 1999-2006
    • Barber, A.E.1    Coyle, S.M.2    Marano, M.A.3
  • 27
    • 0028809055 scopus 로고
    • The upregulating effect of dexamethasone on tumor necrosis factor production is mediated by a nitric oxide-producing cytochrome p450
    • Fantuzzi G, Galli G, Zinetti M, et al The upregulating effect of dexamethasone on tumor necrosis factor production is mediated by a nitric oxide-producing cytochrome p450. Cell Immunol. 1995; 160: 305-8.
    • (1995) Cell Immunol. , vol.160 , pp. 305-8
    • Fantuzzi, G.1    Galli, G.2    Zinetti, M.3
  • 28
    • 20844461891 scopus 로고    scopus 로고
    • Role of lipoteichoic acid in the phagocyte response to group b streptococcus
    • Henneke P, Morath S, Uematsu S, et al Role of lipoteichoic acid in the phagocyte response to group b streptococcus. J Immunol. 2005; 174: 6449-55.
    • (2005) J Immunol. , vol.174 , pp. 6449-55
    • Henneke, P.1    Morath, S.2    Uematsu, S.3
  • 29
    • 0842312950 scopus 로고    scopus 로고
    • Glucocorticoid receptor counteracts tumorigenic activity of akt in skin through interference with the phosphatidylinositol 3-kinase signaling pathway
    • Leis H, Page A, Ramirez A, et al Glucocorticoid receptor counteracts tumorigenic activity of akt in skin through interference with the phosphatidylinositol 3-kinase signaling pathway. Mol Endocrinol. 2004; 18: 303-11.
    • (2004) Mol Endocrinol. , vol.18 , pp. 303-11
    • Leis, H.1    Page, A.2    Ramirez, A.3
  • 30
    • 57349115215 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3beta-mediated serine phosphorylation of the human glucocorticoid receptor redirects gene expression profiles
    • Galliher-Beckley AJ, Williams JG, Collins JB, et al Glycogen synthase kinase 3beta-mediated serine phosphorylation of the human glucocorticoid receptor redirects gene expression profiles. Mol Cell Biol. 2008; 28: 7309-22.
    • (2008) Mol Cell Biol. , vol.28 , pp. 7309-22
    • Galliher-Beckley, A.J.1    Williams, J.G.2    Collins, J.B.3
  • 31
    • 48249157970 scopus 로고    scopus 로고
    • Glucocorticoid receptor phosphorylation differentially affects target gene expression
    • Chen W, Dang T, Blind RD, et al Glucocorticoid receptor phosphorylation differentially affects target gene expression. Mol Endocrinol. 2008; 22: 1754-66.
    • (2008) Mol Endocrinol. , vol.22 , pp. 1754-66
    • Chen, W.1    Dang, T.2    Blind, R.D.3
  • 32
    • 0042191732 scopus 로고    scopus 로고
    • The phosphatidylinositol (pi)-5-phosphate 4-kinase type ii enzyme controls insulin signaling by regulating pi-3,4,5-trisphosphate degradation
    • Carricaburu V, Lamia KA, Lo E, et al The phosphatidylinositol (pi)-5-phosphate 4-kinase type ii enzyme controls insulin signaling by regulating pi-3, 4, 5-trisphosphate degradation. Proc Natl Acad Sci USA. 2003; 100: 9867-72.
    • (2003) Proc Natl Acad Sci USA. , vol.100 , pp. 9867-72
    • Carricaburu, V.1    Lamia, K.A.2    Lo, E.3
  • 33
    • 2142652249 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase and akt occupy central roles in inflammatory responses of toll-like receptor 2-stimulated neutrophils
    • Strassheim D, Asehnoune K, Park JS, et al Phosphoinositide 3-kinase and akt occupy central roles in inflammatory responses of toll-like receptor 2-stimulated neutrophils. J Immunol. 2004; 172: 5727-33.
    • (2004) J Immunol. , vol.172 , pp. 5727-33
    • Strassheim, D.1    Asehnoune, K.2    Park, J.S.3
  • 34
    • 0036707521 scopus 로고    scopus 로고
    • Pi3k-mediated negative feedback regulation of il-12 production in dcs
    • Fukao T, Tanabe M, Terauchi Y, et al Pi3k-mediated negative feedback regulation of il-12 production in dcs. Nat Immunol. 2002; 3: 875-81.
    • (2002) Nat Immunol. , vol.3 , pp. 875-81
    • Fukao, T.1    Tanabe, M.2    Terauchi, Y.3
  • 35
    • 60549102071 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by giardia lamblia
    • Kamda JD, Singer SM. Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by giardia lamblia. Infect Immun. 2009; 77: 685-93.
    • (2009) Infect Immun. , vol.77 , pp. 685-93
    • Kamda, J.D.1    Singer, S.M.2
  • 36
    • 0345826140 scopus 로고    scopus 로고
    • Cell type-specific expression of the ikappab kinases determines the significance of phosphatidylinositol 3-kinase/akt signaling to nf-kappa b activation
    • Gustin JA, Ozes ON, Akca H, et al Cell type-specific expression of the ikappab kinases determines the significance of phosphatidylinositol 3-kinase/akt signaling to nf-kappa b activation. J Biol Chem. 2004; 279: 1615-20.
    • (2004) J Biol Chem. , vol.279 , pp. 1615-20
    • Gustin, J.A.1    Ozes, O.N.2    Akca, H.3
  • 37
    • 0037199972 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells
    • Guha M, Mackman N. The phosphatidylinositol 3-kinase-akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J Biol Chem. 2002; 277: 32124-32.
    • (2002) J Biol Chem. , vol.277 , pp. 32124-32
    • Guha, M.1    Mackman, N.2
  • 38
    • 1842424697 scopus 로고    scopus 로고
    • The inositol 3-phosphatase pten negatively regulates fc gamma receptor signaling, but supports toll-like receptor 4 signaling in murine peritoneal macrophages
    • Cao X, Wei G, Fang H, et al The inositol 3-phosphatase pten negatively regulates fc gamma receptor signaling, but supports toll-like receptor 4 signaling in murine peritoneal macrophages. J Immunol. 2004; 172: 4851-7.
    • (2004) J Immunol. , vol.172 , pp. 4851-7
    • Cao, X.1    Wei, G.2    Fang, H.3
  • 39
    • 2942700196 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced macrophage inflammatory response is regulated by ship
    • Fang H, Pengal RA, Cao X, et al Lipopolysaccharide-induced macrophage inflammatory response is regulated by ship. J Immunol. 2004; 173: 360-6.
    • (2004) J Immunol. , vol.173 , pp. 360-6
    • Fang, H.1    Pengal, R.A.2    Cao, X.3
  • 40
    • 0037451357 scopus 로고    scopus 로고
    • Transcriptional activation of the nf-kappab p65 subunit by mitogen- and stress-activated protein kinase-1 (msk1)
    • Vermeulen L, De Wilde G, Van Damme P, et al Transcriptional activation of the nf-kappab p65 subunit by mitogen- and stress-activated protein kinase-1 (msk1). EMBO J. 2003; 22: 1313-24.
    • (2003) EMBO J. , vol.22 , pp. 1313-24
    • Vermeulen, L.1    De Wilde, G.2    Van Damme, P.3
  • 41
    • 0037064052 scopus 로고    scopus 로고
    • Ikk beta and phosphatidylinositol 3-kinase/akt participate in non-pathogenic gram-negative enteric bacteria-induced rela phosphorylation and nf-kappa b activation in both primary and intestinal epithelial cell lines
    • Haller D, Russo MP, Sartor RB, et al Ikk beta and phosphatidylinositol 3-kinase/akt participate in non-pathogenic gram-negative enteric bacteria-induced rela phosphorylation and nf-kappa b activation in both primary and intestinal epithelial cell lines. J Biol Chem. 2002; 277: 38168-78.
    • (2002) J Biol Chem. , vol.277 , pp. 38168-78
    • Haller, D.1    Russo, M.P.2    Sartor, R.B.3
  • 42
    • 0033961280 scopus 로고    scopus 로고
    • Akt suppresses apoptosis by stimulating the transactivation potential of the rela/p65 subunit of nf-kappab
    • Madrid LV, Wang CY, Guttridge DC, et al Akt suppresses apoptosis by stimulating the transactivation potential of the rela/p65 subunit of nf-kappab. Mol Cell Biol. 2000; 20: 1626-38.
    • (2000) Mol Cell Biol. , vol.20 , pp. 1626-38
    • Madrid, L.V.1    Wang, C.Y.2    Guttridge, D.C.3
  • 43
    • 0037192829 scopus 로고    scopus 로고
    • Pten blocks tumor necrosis factor-induced nf-kappa b-dependent transcription by inhibiting the transactivation potential of the p65 subunit
    • Mayo MW, Madrid LV, Westerheide SD, et al Pten blocks tumor necrosis factor-induced nf-kappa b-dependent transcription by inhibiting the transactivation potential of the p65 subunit. J Biol Chem. 2002; 277: 11116-25.
    • (2002) J Biol Chem. , vol.277 , pp. 11116-25
    • Mayo, M.W.1    Madrid, L.V.2    Westerheide, S.D.3
  • 44
    • 0037039665 scopus 로고    scopus 로고
    • Distinct roles of the ikappa b kinase alpha and beta subunits in liberating nuclear factor kappa b (nf-kappa b) from ikappa b and in phosphorylating the p65 subunit of nf-kappa b
    • Sizemore N, Lerner N, Dombrowski N, et al Distinct roles of the ikappa b kinase alpha and beta subunits in liberating nuclear factor kappa b (nf-kappa b) from ikappa b and in phosphorylating the p65 subunit of nf-kappa b. J Biol Chem. 2002; 277: 3863-9.
    • (2002) J Biol Chem. , vol.277 , pp. 3863-9
    • Sizemore, N.1    Lerner, N.2    Dombrowski, N.3
  • 45
    • 34248361539 scopus 로고    scopus 로고
    • Specific activation of the glucocorticoid receptor and modulation of signal transduction pathways in human lens epithelial cells
    • Gupta V, Awasthi N, Wagner BJ. Specific activation of the glucocorticoid receptor and modulation of signal transduction pathways in human lens epithelial cells. Investigative ophthalmology & visual science. 2007; 48: 1724-34.
    • (2007) Investigative ophthalmology & visual science , vol.48 , pp. 1724-34
    • Gupta, V.1    Awasthi, N.2    Wagner, B.J.3


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