Stimulation of the nicotine antiinflammatory pathway improves food intake and body composition in tumor-bearing rats

Nutrition and Cancer

Volumn 63, Issue 2, 2011, Pages 295-299

  Molfino, Alessio ^a,b   Logorelli, Ferdinando ^a   Citro, Gennaro ^c   Bertini, Giuseppe ^c   Ramaccini, Cesarina ^a   Bollea, Maria Rosa ^b   Fanelli, Filippo Rossi ^a   Laviano, Alessandro ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c Istituti Fisioterapici Ospitalieri Rome   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 6; NICOTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANOREXIA; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BODY COMPOSITION; BODY MASS; BODY WEIGHT; CACHEXIA; CONTROLLED STUDY; FOOD INTAKE; INFLAMMATION; MALE; NONHUMAN; RAT; SARCOMA;

ANALYSIS OF VARIANCE; ANIMALS; ANOREXIA; ANTI-INFLAMMATORY AGENTS; BODY COMPOSITION; BODY WEIGHT; CACHEXIA; CYTOKINES; EATING; INTERLEUKIN-1; INTERLEUKIN-6; MALE; MODELS, ANIMAL; NEOPLASMS; NICOTINE; RATS; RATS, INBRED F344;

RATTUS;

EID: 79951911114     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1080/01635581.2011.530736     Document Type: Article

References (25)

1. Mantovani A: Cancer: inflaming metastasis. Nature 457, 36-37, 2009.
2. McMillan DC: Systemic inflammation, nutritional status, and survival in patients with cancer. Curr Opin Clin Nutr Metab Care 12, 223-226, 2009.
3. Apolone G, De Carli G, Brunetti M, and Garattini S: Health-related quality of life (HR-QOL) and regulatory issues: an assessement of the European Agency for the Evaluation of Medical Products (EMEA) recommendations on the use of HR-QOL measures in drug approval. Pharmacoeconomics 19, 1727-1729, 2001.
4. DeWys WD, Begg C, Lavin PT, Band PR, Bennet JM, et al.: Prognostic effect of weight loss prior to chemotherapy in cancer patients, Eastern Cooperative Oncology Group. Am J Med 69, 491-497, 1980. (Pubitemid 10018703)
5. Laviano A and Meguid MM: Nutritional issues in cancer management. Nutrition 12, 358-371, 1996. (Pubitemid 26294999)
6. Laviano A, Meguid MM, and Rossi Fanelli F: Cancer anorexia: clinical implications, pathogenesis, and therapeutic strategies. Lancet Oncol 4, 686-694, 2003. (Pubitemid 37407436)
7. Laviano A, Inui A, Marks DL, Meguid MM, Pichard C, et al.: Neural control of the anorexia-cachexia syndrome. Am J Physiol Endocrinol Metab 295, E1000-E1008, 2008.
8. Bossola M, Muscaritoli M, Costelli P, Bellantone R, Pacelli F, et al.: Increased muscle ubiquitin mRNA levels in gastric cancer patients. Am J Physiol Regul Integr Comp Physiol 280, R1518-R1523, 2001.
9. Falconer JS, Fearon KCH, Plester CE, Ross A, and Carter DC: Cytokines, the acute-phase response and resting energy expenditure in cachectic patients with pancreatic cancer. Ann Surg 219, 325-331, 1994. (Pubitemid 24121444)
10. De Jonge WJ, Van Der Zanden EP, The FO, Bijlsma MF, van Westerloo DJ, et al.: Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway. Nat Immunol 6, 844-851, 2005.
11. Ulloa L: The vagus nerve and the nicotinic antiinflammatory pathway. Nat Rev Drug Discov 4, 673-684, 2005.
12. Borovikova LV, Ivanova S, Zhang M, Yang H, Botchkina GI, et al.: Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 405, 458-462, 2000. (Pubitemid 30367422)
13. Ramos EJ, Suzuki S, Marks D, Inui A, Asakawa A, et al.: Cancer anorexiacachexia syndrome: cytokines and neuropeptides. Curr Opin Clin Nutr Metab Care 7, 427-434, 2004. (Pubitemid 40340650)
14. Meguid MM, Sato T, Torelli GF, Laviano A, and Rossi Fanelli F: An analysis of temporal changes in meal number and meal size at onset of anorexia in male tumor-bearing rats. Nutrition 16, 305-305, 2000.
15. Suzuki H, Rouns JD, and Wilmore DW: Does multifrequency bioelectrical impedance relate to body composition? J Surg Res 65, 63-69, 1996. (Pubitemid 26339196)
16. Wang H, Liao H, Ochani M, Justiniani M, Lin X, et al.: Cholinergic agonist inhibits HMGB1 release and improve survival in experimental sepsis. Nat Med 10, 1216-1221, 2004. (Pubitemid 39540438)
17. Tisdale MJ: Cachexia in cancer patients. Nat Rev Cancer 2, 862-871, 2002.
18. van Westerloo DJ, Giebelen IA, Florquin S, Daalhuisen J, Bruno MJ, et al.: The cholinergic antiinflammatory pathway regulates the host response during septic peritonitis. J Infect Dis 191, 2138-2148, 2005. (Pubitemid 40800586)
19. Wang H, Yu M, Ochani M, Amella CA, Tanovic M, et al.: Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation. Nature 421, 384-368, 2003.
20. Laviano A, Meguid MM, Inui A, Muscaritoli M, and Rossi Fanelli F: Therapy insight: cancer anorexia-cachexia syndrome: when all you can eat is yourself. Nat Clin Pract Oncol 2, 158-165, 2005. (Pubitemid 40823167)
21. Opara EI, Laviano A, Meguid MM, and Yang ZJ: Correlation between food intake and CSF IL-1alpha in anorectic tumor-bearing rats. Neuroreport 6, 750-752, 1995.
22. Laviano A, Gleason JR, Meguid MM, Yang ZJ, Cangiano C, et al.: Effects of intra-VMN mianserin and IL-1ra on meal number in anorectic tumor-bearing rats. J Investig Med 48, 40-48, 2000. (Pubitemid 30485620)
23. Ramos EJ, Meguid MM, Zhang L, Miyata G, Fetissov SO, et al.: Nicotine infusion into rat ventromedial nuclei and effects on monoaminergic system. Neuroreport 15, 2293-2297, 2004. (Pubitemid 39392258)
24. Pullan RD, Rhodes J, Ganesh S, Mani V, Morris JS, et al.: Transdermal nicotine for active ulcerative colitis. N Engl J Med 330, 811-815, 1994. (Pubitemid 24083559)
25. Czernin J and Waldherr: Cigarette smoking and coronary blood flow. Prog Cardiovasc Dis 45, 395-404, 2004.