Effects of intra-VMN mianserin and IL-1ra on meal number in anorectic tumor-bearing rats

Journal of Investigative Medicine

Volumn 48, Issue 1, 2000, Pages 40-48

  Laviano, Alessandro ^a   Gleason, John R ^b   Meguid, Michael M ^a,d   Yang, Zhong Jin ^a   Cangiano, Carlo ^c   Fanelli, Filippo Rossi ^c  

^a SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^b SYRACUSE UNIVERSITY   (United States)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d University Hospital   (United States)

Author keywords

Food intake; Interleukin 1; Meal number; Meal size; Serotonin

Indexed keywords

BOVINE SERUM ALBUMIN; DRUG VEHICLE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; MIANSERIN; SEROTONIN ANTAGONIST;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOREXIA; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FOOD INTAKE; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; MALE; MEAL; MICROINJECTION; NONHUMAN; OSTEOSARCOMA; RAT;

ANIMALIA; BOVINAE;

EID: 0033915258     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Woods SC, Seeley RJ, Porte D Jr, Schwanz MW. Signals that regulate food intake and energy homeostasis. Science 1998;280: 1378-83.
2. Meguid MM, Yang Z-J, Laviano A. Meal size and number: relationship to dopamine levels in the ventromedial hypothalamic nucleus. Am J Physiol 1997;272:R1925-30.
3. Yang Z-J, Koseki M, Meguid MM, Laviano A. Eating-related increase in dopamine concentration in the LHA with oro-nasal stimulation. Am J Physiol 1996;270:R315-18.
4. Torelli GF, Meguid MM, Moldawer LL, Kim H-J, Carter JL, Laviano A, Rossi Fanelli F. Use of a recombinant human soluble TNF receptor in anorectic tumor bearing rats. Am J Physiol 1999;46:850-5.
5. Laviano A, Meguid MM, Gleason JR, Yang Z-J, Cangiano C, Rossi Fanelli F. Effects of VMN and LHA functional inhibition on changes in meal number and meal size in anorectic tumor-bearing rats. J Investig Med 2000. In press.
6. Plata-Salaman CR. Cytokines and feeding suppression: an integrative view from neurological to molecular level. Nutrition 1995;11: 674-7.
7. Laviano A, Meguid MM, Yang Z-J, Gleason JR, Cangiano C, Rossi Fanelli F. Cracking the riddle of cancer anorexia. Nutrition 1996; 12:706-10.
8. Blaha V, Yang Z-J, Meguid MM, Laviano A, Zadak Z, Rossi Fanelli F. Cancer anorexia is modulated by interaction of hypothalamic VMN dopamine and serotonin and not solely serotonin as currently thought. Surgical Forum 1996;47:517-20.
9. Opara EI, Laviano A, Meguid MM, Yang Z-J. Correlation between food intake and CSF IL-1 in anorectic tumor bearing rats. Neuroreport 1995;6:750-2.
10. Yabuuchi K, Minami M, Katsumata S, Satoh M. Localization of type I interleukin-1 receptor mRNA in the rat brain. Mol Brain Res 1994;27:27-36.
11. Plata-Salaman CR, Ilyin SE, Gayle D. Brain cytokine mRNAs in anorectic rats bearing prostate adenocarcinoma tumor cells. Am. J Physiol 1998;275:R566-73.
12. Meguid MM, Muscaritoli M, Beverly JL, Yang Z-J, Cangiano C, Rossi Fanelli F. The early cancer anorexia paradigm: changes in plasma free tryptophan and feeding indexes. JPEN 1992;16(suppl 6):56S-59S.
13. Grignaschi G, Samanin R. Role of serotonin and catecholamines in brain in the feeding suppressant effect of fluoxetine. Neuropharmacol 1992;31:445-9.
14. Meguid MM, Kawashima Y, Campos AC, Gelling PD, Hill TW, Chen TY, Yang Z-J, Hitch DC, Hammond WG, Mueller WJ. Automated computerized rat eater meter: description and application. Physiol Behav 1990;48:759-63.
15. Chance WT, Zhang F-S, Foley-Nelson T, Fischer JE. Hyperammonemia and anorexia in Morris hepatoma-bearing rats. Physiol Behav 1991;50:397-401.
16. Pellegrino LJ, Pellegrino AS, Cusham AJ. A stereotaxic atlas of the rat brain. 2nd ed. New York, NY: Plenum Publishing Corporation, 1979.
17. Kent S, Rodriguez F, Kelley KW, Dantzer R. Reduction in food and water intake induced by microinjection of interleukin-1βin the ventromedial hypothalamus. Physiol Behav 1994;56:1031-6.
18. Hart JD, Wehrly TE. Kernel regression estimation using repeated measurements data. J Am Stat Assoc 1986;81:1080-8.
19. Leibowitz SF. The role of serotonin in eating disorders. Drugs 1990;39(suppl 3):33-48.
20. Becker EE, Kissileff HR. Inhibitory controls of feeding by ventromedial hypothalamus. Am J Physiol 1974;226:383-96.
21. Oomura Y, Ooyama H, Yamamoto T, Naka F. Reciprocal relationship of the lateral and ventromedial hypothalamus in the regulation of food intake. Physiol Behav 1967;2:97-115.
22. 6 (DSLET). Brain Res 1990;510:7-11.
23. Chance WT, von Meyenfeldt M, Fischer JE. Serotonin depletion by 5,7 dihydroxytryptamine or para-chloroamphetamine does not affect cancer anorexia. Pharmacol Biochem Behav 1983;18:115-21.
24. Schmitt H, Meves H. Bovine serum albumin selectively increases the low-voltage activated calcium current of NG108-15 neuroblastoma glioma cells. Brain Res 1994;656:375-80.
25. Gelin J, Moldawer LL, Lonnroth C, Sherry B, Chizzonite R, Lundholm K. Role of endogenous tumor necrosis factor alpha and interleukin-1 for experimental tumor growth and the development of cancer cachexia. Cancer Res 1991;51:415-21.
26. Debonis D, Meguid MM, Laviano A, Yang Z-J, Gleason JR, Koseki M. Temporal changes in meal number and meal size in response to rHu IL-1alpha. Neuroreport 1995;6:1752-6.
27. Kuriyama K, Hori T, Mori T, Nakashima T. Actions of interpheron-α and interleukin-1β on the glucose responsive neurons in the ventromedial hypothalamus. Brain Res Bull 1990;24:430-6.
28. Yang Z-J, Blaha V, Meguid MM, Laviano A, Oler A, Zadak Z. Interleukin-1α injection into ventromedial hypothalamic nucleus of normal rats depresses food intake and increases release of dopamine and serotonin. Pharmacol Biochem Behav 1999; 62:61-5.
29. Dunn AJ. Endotoxin-induced activation of cerebral catecholamine and serotonin metabolism: comparison with interleukin-1. J Pharmacol Exp Ther 1992;261:964-9.
30. Plata-Salaman CR. Anorexia during acute and chronic disease: relevance of neurotransmitter-peptide-cytokine interactions. Nutrition 1997;13:159-60.
31. Laviano A, Rossi Fanelli F, Meguid MM. The brain's normal function. Science 1998;280:503.