Aldosterone production in human adrenocortical cells is stimulated by high-density lipoprotein 2 (HDL2) through increased expression of aldosterone synthase (CYP11B2)

Endocrinology

Volumn 152, Issue 3, 2011, Pages 751-763

  Xing, Yewei ^a   Cohen, Anthony ^a   Rothblat, George ^b   Sankaranarayanan, Sandhya ^b   Weibel, Ginny ^b   Royer, Lori ^c   Francone, Omar L ^c   Rainey, William E ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; ALDOSTERONE SYNTHASE; ANGIOTENSIN II; CALCIUM CHANNEL BLOCKING AGENT; ENZYME INHIBITOR; HIGH DENSITY LIPOPROTEIN 2; HIGH DENSITY LIPOPROTEIN 3; MESSENGER RNA; NUCLEAR RECEPTOR RELATED FACTOR 1;

ADRENAL CORTEX CELL; ARTICLE; CALCIUM SIGNALING; CELL LEVEL; DRUG ACTIVITY; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; STEROIDOGENESIS;

ADRENAL CORTEX; ALDOSTERONE; ALDOSTERONE SYNTHASE; CALCIUM; CALCIUM SIGNALING; CELL LINE; CHOLESTEROL, HDL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 2; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; SCAVENGER RECEPTORS, CLASS B;

EID: 79951907620     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-1049     Document Type: Article

References (99)

1. Clark BJ, Soo SC, Caron KM, Ikeda Y, Parker KL, Stocco DM 1995 Hormonal and developmental regulation of the steroidogenic acute regulatory protein. Mol Endocrinol 9:1346-1355
2. Clark BJ, Wells J, King SR, Stocco DM 1994 The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR). J Biol Chem 269:28314-28322
3. Mornet E, Dupont J, Vitek A, White PC 1989 Characterization of two genes encoding human steroid 11β-hydroxylase (P-450(11)β). J Biol Chem 264:20961-20967 (Pubitemid 20017902)
4. Kater CE, Biglieri EG, Rost CR, Schambelan M, Hirai J, Chang BC, Brust N 1985 The constant plasma 18-hydroxycorticosterone to aldosterone ratio: an expression of the efficacy of corticosterone methyloxidase type II activity in disorders with variable aldosterone production. J Clin Endocrinol Metab 60:225-228 (Pubitemid 15129563)
5. Ogishima T, Suzuki H, Hata J, Mitani F, Ishimura Y 1992 Zone-specific expression of aldosterone synthase cytochrome P-450 and cytochrome P-45011β in rat adrenal cortex: histochemical basis for the functional zonation. Endocrinology 130:2971-2977
6. Wotus C, Levay-Young BK, Rogers LM, Gomez-Sanchez CE, Engel and WC 1998 Development of adrenal zonation in fetal rats defined by expression of aldosterone synthase and 11β-hydroxylase. Endocrinology 139:4397-4403 (Pubitemid 28513730)
7. Condon JC, Pezzi V,DrummondBM,Yin S, Rainey WE 2002 Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase. Endocrinology 143:3651-3657 (Pubitemid 34925742)
8. Pezzi V, Clyne CD, Ando S, Mathis JM, Rainey WE 1997 Ca2+-regulated expression of aldosterone synthase is mediated by calmodulin and calmodulin-dependent protein kinases. Endocrinology 138: 835-838 (Pubitemid 27110940)
9. Lu L, Suzuki T, Yoshikawa Y, Murakami O, Miki Y, Moriya T, Bassett MH, Rainey WE, Hayashi Y, Sasano H 2004 Nur-related factor 1 and nerve growth factor-induced clone B in human adrenal cortex and its disorders. J Clin Endocrinol Metab 89:4113-4118 (Pubitemid 39071520)
10. Bassett MH, White PC, Rainey WE 2004 A role for the NGFI-B family in adrenal zonation and adrenocortical disease. Endocr Res 30:567-574 (Pubitemid 40070132)
11. Bassett MH, Suzuki T, Sasano H, White PC, Rainey WE 2004 The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone production. Mol Endocrinol 18:279-290 (Pubitemid 38183928)
12. Bassett MH, Mayhew B, Rehman K, White PC, Mantero F, Arnaldi G, Stewart PM, Bujalska I, Rainey WE 2005 Expression profiles for steroidogenic enzymes in adrenocortical disease. J Clin Endocrinol Metab 90:5446-5455 (Pubitemid 41262314)
13. Nogueira EF, Bollag WB, Rainey WE 2009 Angiotensin II regulation of adrenocortical gene transcription. Mol Cell Endocrinol 302: 230-236
14. Higashijima M, Nawata H, Kato K, Ibayashi H 1987 Studies on lipoprotein and adrenal steroidogenesis: I. Roles of low density lipoprotein- and high density lipoprotein-cholesterol in steroid production in cultured human adrenocortical cells. Endocrinol Jpn 34: 635-645
15. Carr BR, Simpson ER 1981 Lipoprotein utilization and cholesterol synthesis by the human fetal adrenal gland. Endocr Rev 2:306-326
16. Simpson ER, Carr BR, Parker Jr CR, Milewich L, Porter JC, MacDonald PC 1979 The role of serum lipoproteins in steroidogenesis by the human fetal adrenal cortex. J Clin Endocrinol Metab 49:146-148 (Pubitemid 9211979)
17. Higashijima M, Kato K, Nawata H, Ibayashi H 1987 Studies on lipoprotein and adrenal steroidogenesis: II. Utilization of low density lipoprotein- and high density lipoprotein-cholesterol for steroid production in functioning human adrenocortical adenoma cells in culture. Endocrinol Jpn 34:647-657
18. Kraemer FB 2007 Adrenal cholesterol utilization. Mol Cell Endocrinol 265-266:42-45
19. Heikkilä P, Kahri AI, Ehnholm C, Kovanen PT 1989 The effect of low- and high-density lipoprotein cholesterol on steroid hormone production and ACTH-induced differentiation of rat adrenocortical cells in primary culture. Cell Tissue Res 256:487-494 (Pubitemid 19152875)
20. Carr BR, Parker Jr CR, Milewich L, Porter JC, MacDonald PC, Simpson ER 1980 The role of low density, high density, and very low density lipoproteins in steroidogenesis by the human fetal adrenal gland. Endocrinology 106:1854-1860 (Pubitemid 10122333)
21. Andersen JM, Dietschy JM 1978 Relative importance of high and low density lipoproteins in the regulation of cholesterol synthesis in the adrenal gland, ovary, and testis of the rat. J Biol Chem 253: 9024-9032 (Pubitemid 9117016)
22. Boggaram V, Funkenstein B, Waterman MR, Simpson ER 1984 Lipoproteins and the regulation of adrenal steroidogenesis. Endocr Res 10:387-409 (Pubitemid 15018393)
23. Grewal T, de Diego I, Kirchhoff MF, Tebar F, Heeren J, Rinninger F, Enrich C 2003 High density lipoprotein-induced signaling of the MAPK pathway involves scavenger receptor type BI-mediated activation of Ras. J Biol Chem 278:16478-16481 (Pubitemid 36799506)
24. Kimura T, Tomura H, Mogi C, Kuwabara A, Damirin A, Ishizuka T, Sekiguchi A, Ishiwara M, Im DS, Sato K, Murakami M, Okajima F 2006 Role of scavenger receptor class B type I and sphingosine 1-phosphate receptors in high density lipoprotein-induced inhibition of adhesion molecule expression in endothelial cells. J Biol Chem 281:37457-37467 (Pubitemid 46042049)
25. Mineo C, Shaul PW 2003 HDL stimulation of endothelial nitric oxide synthase: a novel mechanism of HDL action. Trends Cardiovasc Med 13:226-231 (Pubitemid 36960169)
26. Miura S, Fujino M, Matsuo Y, Kawamura A, Tanigawa H, Nishikawa H, Saku K 2003 High density lipoprotein-induced angiogenesis requires the activation of Ras/MAP kinase in human coronary artery endothelial cells. Arterioscler Thromb Vasc Biol 23:802-808 (Pubitemid 36566169)
27. Liu J, Voutilainen R, Heikkilä P, Kahri AI 1997 Ribonucleic acid expression of the CLA-1 gene, a human homolog to mouse high density lipoprotein receptor SR-BI, in human adrenal tumors and cultured adrenal cells. J Clin Endocrinol Metab 82:2522-2527 (Pubitemid 27337867)
28. Murao K, Terpstra V, Green SR, Kondratenko N, Steinberg D, Quehenberger O 1997 Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes. J Biol Chem 272:17551-17557 (Pubitemid 27311188)
29. Cherradi N, Bideau M, Arnaudeau S, Demaurex N, James RW, Azhar S, Capponi AM 2001 Angiotensin II promotes selective uptake of high density lipoprotein cholesterol esters in bovine adrenal glomerulosa and human adrenocortical carcinoma cells through induction of scavenger receptor class B type I. Endocrinology 142: 4540-4549 (Pubitemid 32907086)
30. Yancey PG, de la Llera-Moya M, Swarnakar S, Monzo P, Klein SM, Connelly MA, Johnson WJ, Williams DL, Rothblat GH 2000 High density lipoprotein phospholipid composition is a major determinant of the bi-directional flux and net movement of cellular free cholesterol mediated by scavenger receptor BI. J Biol Chem 275: 36596-36604 (Pubitemid 32002059)
31. Ye P, Mariniello B, Mantero F, Shibata H, Rainey WE 2007 G-protein-coupled receptors in aldosterone-producing adenomas: a potential cause of hyperaldosteronism. J Endocrinol 195:39-48 (Pubitemid 350055997)
32. Liu L, Bortnick AE, NickelM,Dhanasekaran P, Subbaiah PV, Lund-Katz S, Rothblat GH, Phillips MC 2003 Effects of apolipoprotein A-I on ATP-binding cassette transporter A1-mediated efflux of macrophage phospholipid and cholesterol: formation of nascent high density lipoprotein particles. J Biol Chem 278:42976-42984 (Pubitemid 37345910)
33. Holland OB, Mathis JM, Bird IM, Rainey WE 1993 Angiotensin increases aldosterone synthase mRNA levels in human NCI-H295 cells. Mol Cell Endocrinol 94:R9-R13 (Pubitemid 23246236)
34. 2+-regulated expression of 21-hydroxylase cytochrome P450 in H295R human adrenocortical cells. J Clin Endocrinol Metab 83:1592-1597
35. Lebrethon MC, Jaillard C, Defayes G, Begeot M, Saez JM 1994 Human cultured adrenal fasciculata-reticularis cells are targets for angiotensin-II: effects on cytochrome P450 cholesterol side-chain cleavage, cytochrome P450 17 alpha-hydroxylase, and 3 β-hydroxysteroid-dehydrogenase messenger ribonucleic acid and proteins and on steroidogenic responsiveness to corticotropin and angiotensin-II. J Clin Endocrinol Metab 78:1212-1219
36. Nogueira EF, Vargas CA, Otis M, Gallo-Payet N, Bollag WB, Rainey WE 2007 Angiotensin-II acute regulation of rapid response genes in human, bovine, and rat adrenocortical cells. J Mol Endocrinol 39:365-374
37. Denner K, Rainey WE, Pezzi V, Bird IM, Bernhardt R, Mathis JM 1996 Differential regulation of 11 β-hydroxylase and aldosterone synthase in human adrenocortical H295R cells. Mol Cell Endocrinol 121:87-91 (Pubitemid 26268056)
38. Tremblay A, Waterman MR, Parker KL, Lehoux JG 1991 Regulation of rat adrenal messenger RNA and protein levels for cytochrome P-450s and adrenodoxin by dietary sodium depletion or potassium intake. J Biol Chem 266:2245-2251 (Pubitemid 21909055)
39. Nogueira EF, Xing Y, Morris CA, Rainey WE 2009 Role of angiotensin II-induced rapid response genes in the regulation of enzymes needed for aldosterone synthesis. J Mol Endocrinol 42:319-330
40. Hoekstra M, Ye D, Hildebrand RB, Zhao Y, Lammers B, Stitzinger M, Kuiper J, Van Berkel TJ, Van Eck M 2009 Scavenger receptor class B type I-mediated uptake of serum cholesterol is essential for optimal adrenal glucocorticoid production. J Lipid Res 50:1039-1046
41. Rajapaksha WR, McBride M, Robertson L, O'Shaughnessy PJ 1997 Sequence of the bovine HDL-receptor (SR-BI)cDNA and changes in receptor mRNA expression during granulosa cell luteinization in vivo and in vitro. Mol Cell Endocrinol 134:59-67 (Pubitemid 27490289)
42. Ritsch A, Tancevski I, Schgoer W, Pfeifhofer C, Gander R, Eller P, Foeger B, Stanzl U, Patsch JR 2004 Molecular characterization of rabbit scavenger receptor class B types I and II: portal to central vein gradient of expression in the liver. J Lipid Res 45:214-222 (Pubitemid 38228818)
43. Reaven E, Cortez Y, Leers-Sucheta S, Nomoto A, Azhar S 2004 Dimerization of the scavenger receptor class B type I: formation, function, and localization in diverse cells and tissues. J Lipid Res 45:513-528 (Pubitemid 38337998)
44. McLean MP, Sandhoff TW 1998 Expression and hormonal regulation of the high-density lipoprotein (HDL) receptor scavenger receptor class B type I messenger ribonucleic acid in the rat ovary. Endocrine 9:243-252 (Pubitemid 29091511)
45. Imachi H, Murao K, Sato M, Hosokawa H, Ishida T, Takahara J 1999 CD36 LIMPII analogous-1, a human homolog of the rodent scavenger receptor B1, provides the cholesterol ester for steroidogenesis in adrenocortical cells. Metabolism 48:627-630 (Pubitemid 29230524)
46. Burnay MM, Python CP, Vallotton MB, Capponi AM, Rossier MF 1994 Role of the capacitative calcium influx in the activation of steroidogenesis by angiotensin-II in adrenal glomerulosa cells. Endocrinology 135:751-758 (Pubitemid 24241259)
47. Quinn SJ, Williams GH, Tillotson DL 1988 Calcium oscillations in single adrenal glomerulosa cells stimulated by angiotensin II. Proc Natl Acad Sci USA 85:5754-5758
48. Startchik I, Morabito D, Lang U, Rossier MF 2002 Control of calcium homeostasis by angiotensin II in adrenal glomerulosa cells through activation of p38 MAPK. J Biol Chem 277:24265-24273 (Pubitemid 34951944)
49. Kraemer FB, Shen WJ, Patel S, Osuga J, Ishibashi S, Azhar S 2007 The LDL receptor is not necessary for acute adrenal steroidogenesis in mouse adrenocortical cells. Am J Physiol Endocrinol Metab 292: E408-E412 (Pubitemid 46220564)
50. Gwynne JT, Hess B 1980 The role of high density lipoproteins in rat adrenal cholesterol metabolism and steroidogenesis. J Biol Chem 255:10875-10883 (Pubitemid 11171743)
51. Travert C, Fofana M, Carreau S, Le Goff D 2000 Rat Leydig cells use apolipoprotein E depleted high density lipoprotein to regulate testosterone production. Mol Cell Biochem 213:51-59
52. Reyland ME, Evans RM, White EK 2000 Lipoproteins regulate expression of the steroidogenic acute regulatory protein (StAR) in mouse adrenocortical cells. J Biol Chem 275:36637-36644 (Pubitemid 32002065)
53. Murao K, Imachi H, Cao W, Yu X, Li J, Yoshida K, Ahmed RA, Matsumoto K, Nishiuchi T, Wong NC, Ishida T 2006 High-density lipoprotein is a potential growth factor for adrenocortical cells. Biochem Biophys Res Commun 344:226-232
54. Rainey WE, Rodgers RJ, Mason JI 1992 The role of bovine lipoproteins in the regulation of steroidogenesis and HMG-CoA reductase in bovine adrenocortical cells. Steroids 57:167-173
55. Simpson HD, Shepherd R, Shepherd J, Fraser R, Lever AF, Kenyon CJ 1989 Effects of cholesterol and lipoproteins on aldosterone secretion by bovine zona glomerulosa cells. J Endocrinol 121:125-131 (Pubitemid 19105007)
56. Acton SL, Scherer PE, Lodish HF, KriegerM1994 Expression cloning of SR-BI, a CD36-related class B scavenger receptor. J Biol Chem 269:21003-21009
57. Altmann SW, Davis Jr HR, Yao X, Laverty M, Compton DS, Zhu LJ, Crona JH, Caplen MA, Hoos LM, Tetzloff G, Priestley T, Burnett DA, Strader CD, Graziano MP 2002 The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorption. Biochim Biophys Acta 1580:77-93 (Pubitemid 34260848)
58. Viñals M, Xu S, Vasile E, Krieger M 2003 Identification of the N-linked glycosylation sites on the high density lipoprotein (HDL) receptor SR-BI and assessment of their effects on HDL binding and selective lipid uptake. J Biol Chem 278:5325-5332 (Pubitemid 36801048)
59. Gu X, Trigatti B, Xu S, Acton S, Babitt J, Krieger M 1998 The efficient cellular uptake of high density lipoprotein lipids via scavenger receptor class B type I requires not only receptor-mediated surface binding but also receptor-specific lipid transfer mediated by its extracellular domain. J Biol Chem 273:26338-26348 (Pubitemid 28471637)
60. Nieland TJ, Penman M, Dori L, Krieger M, Kirchhausen T 2002 Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BI. Proc Natl Acad Sci USA 99: 15422-15427 (Pubitemid 35403950)
61. Lamarche B, Moorjani S, Cantin B, Dagenais GR, Lupien PJ, Després JP 1997 Associations of HDL2 and HDL3 subfractions with ischemic heart disease in men. Prospective results from the Quebec Cardiovascular Study. Arterioscler Thromb Vasc Biol 17:1098-1105
62. Yoshikawa M, Sakuma N, Hibino T, Sato T, Fujinami T 1997 HDL3 exerts more powerful anti-oxidative, protective effects against copper-catalyzed LDL oxidation than HDL2. Clin Biochem 30:221-225 (Pubitemid 27225355)
63. Roche D, Migueres ML, Lequang NT, Burstein M, Ekindjian OG, Girard-Globa A 1991 Concentrations of high-density lipoprotein subfraction HDL2 and lipoprotein A-I in a random population of healthy subjects. Clin Chem 37:2111-2113
64. Kontush A, Therond P, Zerrad A, Couturier M, Négre-Salvayre A, de Souza JA, Chantepie S, Chapman MJ 2007 Preferential sphingosine-1-phosphate enrichment and sphingomyelin depletion are key features of small dense HDL3 particles: relevance to antiapoptotic and antioxidative activities. Arterioscler Thromb Vasc Biol 27:1843-1849 (Pubitemid 47207181)
65. Kennedy AL, Wasan KM 1999 Preferential distribution of amphotericin B lipid complex into human HDL3 is a consequence of high density lipoprotein coat lipid content. J Pharm Sci 88:1149-1155 (Pubitemid 29526300)
66. Lemieux S, Després JP, Moorjani S, Nadeau A, Thériault G, Prud'homme D, Tremblay A, Bouchard C, Lupien PJ 1994 Are gender differences in cardiovascular disease risk factors explained by the level of visceral adipose tissue? Diabetologia 37:757-764
67. Sgouraki E, Tsopanakis A, Tsopanakis C 2001 Acute exercise: response of HDL-C, LDL-C lipoproteins and HDL-C subfractions levels in selected sport disciplines. J Sports Med Phys Fitness 41: 386-391 (Pubitemid 33031852)
68. Spate-Douglas T, KeyserRE1999 Exercise intensity: its effect on the high-density lipoprotein profile. Arch Phys Med Rehabil 80:691-695
69. Ushiroyama T, Sakuma K, Ikeda A, UekiM2005 TheHDL2/HDL3 ratio in menopause. Int J Gynaecol Obstet 88:303-308
70. Schäfer C, Parlesak A, Eckoldt J, Bode C, Bode JC,März W, Winkler K 2007 Beyond HDL-cholesterol increase: phospholipid enrichment and shift from HDL3 to HDL2 in alcohol consumers. J Lipid Res 48:1550-1558 (Pubitemid 47312016)
71. Verges B, Brun JM, Vaillant G, Quantin C, Brunet-Lecomte P, Farnier M, Gambert P 1992 Influence of obesity and hypertriglyceridaemia on the low HDL2-cholesterol level and on its relationship with prevalence of atherosclerosis in type 2 diabetes. Diabetes Metab 18:289-297
72. Moffatt RJ, Chelland SA, Pecott DL, Stamford BA 2004 Acute exposure to environmental tobacco smoke reduces HDL-C and HDL2-C. Prev Med 38:637-641 (Pubitemid 38452890)
73. Moorjani S, Dupont A, Labrie F, Lupien PJ, Gagné C, Brun D, Giguère M, Bélanger A, Cusan L 1988 Changes in plasma lipoproteins during various androgen suppression therapies in men with prostatic carcinoma: effects of orchiectomy, estrogen, and combination treatment with luteinizing hormone-releasing hormone agonist and flutamide. J Clin Endocrinol Metab 66:314-322 (Pubitemid 18065174)
74. Avogaro P, Cazzolato G 1975 Familial hyper-HDL-(a)-cholesterolemia. Atherosclerosis 22:63-77
75. Tilly-Kiesi M, Tikkanen MJ 1992 Effects of lovastatin and gemfibrozil on high-density lipoprotein subfraction density and composition in patients with familial hypercholesterolemia. J Lab ClinMed 120:103-110
76. Imachi H, Murao K, Sayo Y, Hosokawa H, Sato M, Niimi M, Kobayashi S, Miyauchi A, Ishida T, Takahara J 1999 Evidence for a potential role for HDL as an important source of cholesterol in human adrenocortical tumors via the CLA-1 pathway. Endocr J 46:27-34 (Pubitemid 29197745)
77. Rodríguez C, González-Díez M, Badimon L, Martínez-González J 2009 Sphingosine-1-phosphate: A bioactive lipid that confers highdensity lipoprotein with vasculoprotection mediated by nitric oxide and prostacyclin. Thromb Haemost 101:665-673
78. Sattler K, Levkau B 2009 Sphingosine-1-phosphate as a mediator of high-density lipoprotein effects in cardiovascular protection. Cardiovasc Res 82:201-211
79. Brizuela L, Rábano M, Peña A, Gangoiti P, Macarulla JM, Trueba M, Gómez-Muñoz A 2006 Sphingosine 1-phosphate: a novel stimulator of aldosterone secretion. J Lipid Res 47:1238-1249 (Pubitemid 43830716)
80. Stern N, Yanagawa N, Saito F, HoriM,Natarajan R, Nadler J, Tuck M1993 Potential role of 12 hydroxyeicosatetraenoic acid in angiotensin II-induced calcium signal in rat glomerulosa cells. Endocrinology 133:843-847
81. Natarajan R, Dunn WD, Stern N, Nadler J 1990 Key role of diacylglycerol-mediated 12-lipoxygenase product formation in angiotensin II-induced aldosterone synthesis. Mol Cell Endocrinol 72: 73-80 (Pubitemid 20262162)
82. Natarajan R, Stern N, Hsueh W, Do Y, Nadler J 1988 Role of the lipoxygenase pathway in angiotensin II-mediated aldosterone biosynthesis in human adrenal glomerulosa cells. J Clin Endocrinol Metab 67:584-591
83. Argraves KM, Argraves WS 2007 HDL serves as a S1P signaling platform mediating a multitude of cardiovascular effects. J Lipid Res 48:2325-2333 (Pubitemid 350058744)
84. Tölle M, Schuchardt M, van der Giet M 2010 Relevance of sphingolipids in the pleiotropic protective effects of high-density lipoproteins. Curr Pharm Des 16:1468-1479
85. Argraves KM, Gazzolo PJ, Groh EM, Wilkerson BA, Matsuura BS, Twal WO, Hammad SM, Argraves WS 2008 High density lipoprotein-associated sphingosine 1-phosphate promotes endothelial barrier function. J Biol Chem 283:25074-25081
86. Keul P, Sattler K, Levkau B 2007 HDL and its sphingosine-1-phosphate content in cardioprotection. Heart Fail Rev 12:301-306 (Pubitemid 350176703)
87. Frias MA, James RW, Gerber-Wicht C, Lang U 2009 Native and reconstituted HDL activate Stat3 in ventricular cardiomyocytes via ERK1/2: role of sphingosine-1-phosphate. Cardiovasc Res 82:313-323
88. Lee MH, Hammad SM, Semler AJ, Luttrell LM, Lopes-Virella MF, Klein RL 2010 HDL3, but not HDL2, stimulates plasminogen activator inhibitor-1 release from adipocytes: the role of sphingosine-1-phosphate. J Lipid Res 51:2619-2628
89. Gu J, Wen Y, Mison A, Nadler JL 2003 12-Lipoxygenase pathway increases aldosterone production, 3′,5′-cyclic adenosine monophosphate response element-binding protein phosphorylation, and p38 mitogen-activated protein kinase activation in H295R human adrenocortical cells. Endocrinology 144:534-543 (Pubitemid 36205225)
90. Natarajan R, Yang DC, Lanting L, Nadler JL 2002 Key role of P38 mitogen-activated protein kinase and the lipoxygenase pathway in angiotensin II actions in H295R adrenocortical cells. Endocrine 18: 295-301
91. Stern N, Natarajan R, Tuck ML, Laird E, Nadler JL 1989 Selective inhibition of angiotensin-II-mediated aldosterone secretion by 5-hydroxyeicosatetraenoic acid. Endocrinology 125:3090-3095 (Pubitemid 20010687)
92. Shibata H, Kojima I 1991 Involvement of protein kinase C in angiotensin II-mediated release of 12-hydroxyeicosatetraenoic acid in bovine adrenal glomerulosa cells. Endocrinol Jpn 38:611-617
93. Brousseau ME, Schaefer EJ, Wolfe ML, Bloedon LT, Digenio AG, Clark RW, Mancuso JP, Rader DJ 2004 Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol. N Engl J Med 350:1505-1515 (Pubitemid 38477775)
94. Nissen SE, Tardif JC, Nicholls SJ, Revkin JH, Shear CL, Duggan WT, Ruzyllo W, Bachinsky WB, Lasala GP, Lasala GP, Tuzcu EM 2007 Effect of torcetrapib on the progression of coronary atherosclerosis. N Engl J Med 356:1304-1316 (Pubitemid 46513296)
95. Barter PJ, Caulfield M, Eriksson M, Grundy SM, Kastelein JJ, Komajda M, Lopez-Sendon J, Mosca L, Tardif JC, Waters DD, Shear CL, Revkin JH, Buhr KA, FisherMR,Tall AR, Brewer B 2007 Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med 357:2109-2122 (Pubitemid 350146106)
96. Athyros VG, Kakafika A, Tziomalos K, Karagiannis A, Mikhailidis DP 2008 Cholesteryl ester transfer protein inhibition and HDL increase: has the dream ended? Expert Opin Investig Drugs 17:445-449
97. Hu X, Dietz JD, Xia C, Knight DR, Loging WT, Smith AH, Yuan H, Perry DA, Keiser J 2009 Torcetrapib induces aldosterone and cortisol production by an intracellular calcium-mediated mechanism independently of cholesteryl ester transfer protein inhibition. Endocrinology 150:2211-2219
98. Forrest MJ, Bloomfield D, Briscoe RJ, Brown PN, Cumiskey AM, Ehrhart J, Hershey JC, Keller WJ, Ma X, McPherson HE, Messina E, Peterson LB, Sharif-Rodriguez W, Siegl PK, Sinclair PJ, Sparrow CP, Stevenson AS, Sun SY, Tsai C, Vargas H, Walker 3rd M, West SH, White V, Woltmann RF 2008 Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone. Br J Pharmacol 154: 1465-1473
99. Stein EA, Stroes ES, Steiner G, Buckley BM, Capponi AM, Burgess T, Niesor EJ, Kallend D, Kastelein JJ 2009 Safety and tolerability of dalcetrapib. Am J Cardiol 104:82-91