메뉴 건너뛰기




Volumn 17, Issue 4, 2008, Pages 445-449

Cholesteryl ester transfer protein inhibition and HDL increase: Has the dream ended?

Author keywords

Anacetrapib; Blood pressure; Cholesteryl ester transfer protein; High density lipoprotein cholesterol

Indexed keywords

2 METHYLPROPANETHIOIC ACID S [2 [1 (2 ETHYLBUTYL)CYCLOHEXYLCARBOXAMIDO]PHENYL] ESTER; ANACETRAPIB; ATORVASTATIN; C REACTIVE PROTEIN; CHOLESTEROL ESTER TRANSFER PROTEIN; CHOLESTEROL ESTER TRANSFER PROTEIN INHIBITOR; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYPOCHOLESTEROLEMIC AGENT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MK 0859; PLACEBO; PRAVASTATIN; TORCETRAPIB; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ANTILIPEMIC AGENT; CETP PROTEIN, HUMAN; QUINOLINE DERIVATIVE; THIOL DERIVATIVE;

EID: 42149143445     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.17.4.445     Document Type: Editorial
Times cited : (20)

References (32)
  • 1
    • 33847718179 scopus 로고    scopus 로고
    • Identifying and attaining LDL-C goals: Mission accomplished? Next target: new therapeutic options to raise HDL-C levels
    • Athyros VG, Mikhailidis DP, Kakafika AI, et al. Identifying and attaining LDL-C goals: mission accomplished? Next target: new therapeutic options to raise HDL-C levels. Curr Drug Targets 2007;8:483-8
    • (2007) Curr Drug Targets , vol.8 , pp. 483-488
    • Athyros, V.G.1    Mikhailidis, D.P.2    Kakafika, A.I.3
  • 2
    • 0036023515 scopus 로고    scopus 로고
    • Treatment with atorvastatin to the National Cholesterol Educational Program goals versus usual care in secondary Coronary Heart Disease prevention. The GREek Atorvastatin and Coronary-heart-disease Evaluation (GREACE) Study
    • Athyros VG, Papageorgiou AA, Mercouris BR, et al. Treatment with atorvastatin to the National Cholesterol Educational Program goals versus usual care in secondary Coronary Heart Disease prevention. The GREek Atorvastatin and Coronary-heart-disease Evaluation (GREACE) Study. Curr Med Res Opin 2002;18:220-8
    • (2002) Curr Med Res Opin , vol.18 , pp. 220-228
    • Athyros, V.G.1    Papageorgiou, A.A.2    Mercouris, B.R.3
  • 3
    • 2542497645 scopus 로고    scopus 로고
    • GREACE Collaborative Group. Effect of atorvastatin on high-density lipoprotein cholesterol and its relationship with coronary events: A subgroup analysis of the GREek Atorvastatin and Coronary heart-disease Evaluation (GREACE) Study
    • Athyros V G, Mikhailidis DP, Papageorgiou AA, et al; GREACE Collaborative Group. Effect of atorvastatin on high-density lipoprotein cholesterol and its relationship with coronary events: a subgroup analysis of the GREek Atorvastatin and Coronary heart-disease Evaluation (GREACE) Study. Curr Med Res Opin 2004;20:627-37
    • (2004) Curr Med Res Opin , vol.20 , pp. 627-637
    • Athyros, V.G.1    Mikhailidis, D.P.2    Papageorgiou, A.A.3
  • 4
    • 34748887666 scopus 로고    scopus 로고
    • HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events
    • Barter P, Gotto AM, Larosa JC, et al. HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events. N Engl J Med 2007;357:1301-10
    • (2007) N Engl J Med , vol.357 , pp. 1301-1310
    • Barter, P.1    Gotto, A.M.2    Larosa, J.C.3
  • 5
    • 33846863146 scopus 로고    scopus 로고
    • Statins, high-density lipoprotein cholesterol, and regression of coronary atherosclerosis
    • Nicholls SJ, Tuzcu EM, Sipahi I, et al. Statins, high-density lipoprotein cholesterol, and regression of coronary atherosclerosis. J Am Med Assoc 2007;297:499-508
    • (2007) J Am Med Assoc , vol.297 , pp. 499-508
    • Nicholls, S.J.1    Tuzcu, E.M.2    Sipahi, I.3
  • 7
    • 0037327033 scopus 로고    scopus 로고
    • Cholesteryl ester transfer protein: A novel target for raising HDL and inhibiting atherosclerosis
    • Barter PJ, Brewer HB Jr, Chapman MJ, et al. Cholesteryl ester transfer protein: a novel target for raising HDL and inhibiting atherosclerosis. Arterioscler Thromb Vasc Biol 2003;23:160-7
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 160-167
    • Barter, P.J.1    Brewer Jr, H.B.2    Chapman, M.J.3
  • 8
    • 17844373610 scopus 로고    scopus 로고
    • A review of CETP and its relation to atherosclerosis
    • De Grooth GJ, Klerkx AH, Stroes ES, et al. A review of CETP and its relation to atherosclerosis. J Lipid Res 2004;45:1967-74
    • (2004) J Lipid Res , vol.45 , pp. 1967-1974
    • De Grooth, G.J.1    Klerkx, A.H.2    Stroes, E.S.3
  • 9
    • 36348975228 scopus 로고    scopus 로고
    • The ILLUMINATE Investigators. Effects of torcetrapib in patients at high risk for coronary events
    • Barter PJ, Caulfield M, Eriksson M; The ILLUMINATE Investigators. Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med 2007;357:2109-22
    • (2007) N Engl J Med , vol.357 , pp. 2109-2122
    • Barter, P.J.1    Caulfield, M.2    Eriksson, M.3
  • 10
    • 34247241088 scopus 로고    scopus 로고
    • The RADIANCE 1 Investigators. Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia
    • Kastelein JJ, Van Leuven SI, Burgess L; The RADIANCE 1 Investigators. Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia. N Engl J Med 2007;356:1620-30
    • (2007) N Engl J Med , vol.356 , pp. 1620-1630
    • Kastelein, J.J.1    Van Leuven, S.I.2    Burgess, L.3
  • 11
    • 34447265547 scopus 로고    scopus 로고
    • The RADIANCE 2 Investigators. Torcetrapib and carotid intima-media thickness in mixed dyslipidaemia (RADIANCE 2 study): A randomised, double-blind trial
    • Bots ML, Visseren FL, Evans GW; The RADIANCE 2 Investigators. Torcetrapib and carotid intima-media thickness in mixed dyslipidaemia (RADIANCE 2 study): a randomised, double-blind trial. Lancet 2007;370:153-60
    • (2007) Lancet , vol.370 , pp. 153-160
    • Bots, M.L.1    Visseren, F.L.2    Evans, G.W.3
  • 12
    • 34047106220 scopus 로고    scopus 로고
    • The ILLUSTRATE Investigators. Effect of torcetrapib on the progression of coronary atherosclerosis
    • Nissen SE, Tardif JC, Nicholls SJ; The ILLUSTRATE Investigators. Effect of torcetrapib on the progression of coronary atherosclerosis. N Engl J Med 2007;356:1304-16
    • (2007) N Engl J Med , vol.356 , pp. 1304-1316
    • Nissen, S.E.1    Tardif, J.C.2    Nicholls, S.J.3
  • 13
    • 34247351950 scopus 로고    scopus 로고
    • The RADIANCE 1 and 2 Study Investigators. Designs of RADIANCE 1 and 2: Carotid ultrasound studies comparing the effects of torcetrapib/atorvastatin with atorvastatin alone on atherosclerosis
    • Kastelein JJ, Van Leuven SI, Evans GW, et al; The RADIANCE 1 and 2 Study Investigators. Designs of RADIANCE 1 and 2: carotid ultrasound studies comparing the effects of torcetrapib/atorvastatin with atorvastatin alone on atherosclerosis. Curr Med Res Opin 2007;23:885-94
    • (2007) Curr Med Res Opin , vol.23 , pp. 885-894
    • Kastelein, J.J.1    Van Leuven, S.I.2    Evans, G.W.3
  • 14
    • 34047183679 scopus 로고    scopus 로고
    • CETP inhibitors to increase HDL cholesterol levels
    • Tall AR. CETP inhibitors to increase HDL cholesterol levels. N Engl J Med 2007;356:1364-6
    • (2007) N Engl J Med , vol.356 , pp. 1364-1366
    • Tall, A.R.1
  • 15
    • 17444372760 scopus 로고    scopus 로고
    • Effectiveness of inhibition of cholesteryl ester transfer protein by JTT-705 in combination with pravastatin in type II dyslipidemia
    • Kuivenhoven JA, De Grooth GJ, Kawamura H, et al. Effectiveness of inhibition of cholesteryl ester transfer protein by JTT-705 in combination with pravastatin in type II dyslipidemia. Am J Cardiol 2005;95:1085-8
    • (2005) Am J Cardiol , vol.95 , pp. 1085-1088
    • Kuivenhoven, J.A.1    De Grooth, G.J.2    Kawamura, H.3
  • 16
    • 0037035459 scopus 로고    scopus 로고
    • Efficacy and safety of a novel cholesteryl ester transfer protein inhibitor, JTT-705, in humans: A randomized phase II dose-response study
    • De Grooth GJ, Kuivenhoven JA, Stalenhoef AF, et al. Efficacy and safety of a novel cholesteryl ester transfer protein inhibitor, JTT-705, in humans: a randomized phase II dose-response study. Circulation 2002;105:2159-65
    • (2002) Circulation , vol.105 , pp. 2159-2165
    • De Grooth, G.J.1    Kuivenhoven, J.A.2    Stalenhoef, A.F.3
  • 17
    • 36549078679 scopus 로고    scopus 로고
    • Effect of the cholesteryl-ester transfer protein inhibitor, anacetrapib, on lipoproteins in patients with dyslipidaemia and on 24-h ambulatory blood pressure in healthy individuals: Two double-blind, randomised placebo-controlled phase I studies
    • Krishna R, Anderson MS, Bergman AJ, et al. Effect of the cholesteryl-ester transfer protein inhibitor, anacetrapib, on lipoproteins in patients with dyslipidaemia and on 24-h ambulatory blood pressure in healthy individuals: two double-blind, randomised placebo-controlled phase I studies. Lancet 2007;370:1907-14
    • (2007) Lancet , vol.370 , pp. 1907-1914
    • Krishna, R.1    Anderson, M.S.2    Bergman, A.J.3
  • 18
    • 36549050392 scopus 로고    scopus 로고
    • CETP inhibition
    • Duriez P. CETP inhibition. Lancet 2007;370:1882-3
    • (2007) Lancet , vol.370 , pp. 1882-1883
    • Duriez, P.1
  • 19
    • 33646689775 scopus 로고    scopus 로고
    • Effect of inhibiting cholesteryl ester transfer protein on the kinetics of high-density lipoprotein cholesteryl ester transport in plasma: In vivo studies in rabbits
    • Kee P, Caiazza D, Rye KA, et al. Effect of inhibiting cholesteryl ester transfer protein on the kinetics of high-density lipoprotein cholesteryl ester transport in plasma: in vivo studies in rabbits. Arterioscler Thromb Vasc Biol 2006;26:884-90
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 884-890
    • Kee, P.1    Caiazza, D.2    Rye, K.A.3
  • 20
    • 20944437770 scopus 로고    scopus 로고
    • Effeccs of cholesteryl ester transfer protein inhibition on high-density lipoprotein subspecies, apolipoprotein A-I metabolism, and fecal sterol excretion
    • Brousseau ME, Diffenderfer MR, Millar JS, et al. Effeccs of cholesteryl ester transfer protein inhibition on high-density lipoprotein subspecies, apolipoprotein A-I metabolism, and fecal sterol excretion. Arterioscler Thromb Vasc Biol 2005;25:1057-64
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1057-1064
    • Brousseau, M.E.1    Diffenderfer, M.R.2    Millar, J.S.3
  • 21
    • 39749120838 scopus 로고    scopus 로고
    • The effect of cholesteryl ester transport protein overexpression and inhibition on reverse cholesterol transport
    • Epub Jan 16
    • Tchoua U, D'Souza W, Mukhamedova N, et al. The effect of cholesteryl ester transport protein overexpression and inhibition on reverse cholesterol transport. Cardiovasc Res. Epub 2008 Jan 16
    • (2008) Cardiovasc Res
    • Tchoua, U.1    D'Souza, W.2    Mukhamedova, N.3
  • 22
    • 34247352806 scopus 로고    scopus 로고
    • Inhibition of cholesteryl ester transfer protein by torcetrapib modestly increases macrophage cholesterol efflux to HDL
    • Yvan-Charvet L, Matsuura F, Wang N, et al. Inhibition of cholesteryl ester transfer protein by torcetrapib modestly increases macrophage cholesterol efflux to HDL. Arterioscler Thromb Vasc Biol 2007;27:1132-8
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 1132-1138
    • Yvan-Charvet, L.1    Matsuura, F.2    Wang, N.3
  • 23
    • 0027435542 scopus 로고
    • The role of high density lipoprotein and lipid-soluble antioxidant vitamins in inhibiting low-density lipoprotein oxidation
    • Mackness MI, Abbott C, Arrof S, Durrington PN. The role of high density lipoprotein and lipid-soluble antioxidant vitamins in inhibiting low-density lipoprotein oxidation. Biochem J 1993;294:829-34
    • (1993) Biochem J , vol.294 , pp. 829-834
    • Mackness, M.I.1    Abbott, C.2    Arrof, S.3    Durrington, P.N.4
  • 24
    • 0030045883 scopus 로고    scopus 로고
    • High density lipoproteins and coronary heart disease
    • Barter PJ, Rye K-A. High density lipoproteins and coronary heart disease. Atherosclerosis 1996;121:1-12
    • (1996) Atherosclerosis , vol.121 , pp. 1-12
    • Barter, P.J.1    Rye, K.-A.2
  • 25
    • 16944362351 scopus 로고    scopus 로고
    • Genetic cholesteryl ester transfer protein deficiency is extremely frequent in the Omagari area of Japan. Marked hyperalphalipoproteinemia caused by CETP gene mutation is not associated with longevity
    • Hirano K, Yamashita S, Nakajima N, et al. Genetic cholesteryl ester transfer protein deficiency is extremely frequent in the Omagari area of Japan. Marked hyperalphalipoproteinemia caused by CETP gene mutation is not associated with longevity. Arterioscler Thromb Vasc Biol 1997;17:1053-9
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 1053-1059
    • Hirano, K.1    Yamashita, S.2    Nakajima, N.3
  • 26
    • 4644265970 scopus 로고    scopus 로고
    • Molecular mechanisms of cholesteryl ester transfer protein deficiency in Japanese
    • Nagano M, Yamashita S, Hirano K, et al. Molecular mechanisms of cholesteryl ester transfer protein deficiency in Japanese. J Atheroscler Thromb 2004;11:110-21
    • (2004) J Atheroscler Thromb , vol.11 , pp. 110-121
    • Nagano, M.1    Yamashita, S.2    Hirano, K.3
  • 27
    • 17444448251 scopus 로고    scopus 로고
    • A low prevalence of coronary heart disease among subjects with increased high-density lipoprotein cholesterol levels, including those with plasma cholesteryl ester transfer protein deficiency
    • Moriyama Y, Okamura T, Inazu A, et al. A low prevalence of coronary heart disease among subjects with increased high-density lipoprotein cholesterol levels, including those with plasma cholesteryl ester transfer protein deficiency. Prev Med 1998;27:659-267
    • (1998) Prev Med , vol.27 , pp. 659-267
    • Moriyama, Y.1    Okamura, T.2    Inazu, A.3
  • 28
    • 36248963194 scopus 로고    scopus 로고
    • GREACE Study Collaborative Group. Atorvastatin decreases triacylglycerol-associated risk of vascular events in coronary heart disease patients
    • Athyros VG, Kakafika AI, Papageorgiou AA, et al; GREACE Study Collaborative Group. Atorvastatin decreases triacylglycerol-associated risk of vascular events in coronary heart disease patients. Lipids 2007;42:999-1009
    • (2007) Lipids , vol.42 , pp. 999-1009
    • Athyros, V.G.1    Kakafika, A.I.2    Papageorgiou, A.A.3
  • 29
    • 33846637379 scopus 로고    scopus 로고
    • Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies
    • Sarwar N, Danesh J, Eiriksdottir G, et al. Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies. Circulation 2007;115:4510-8
    • (2007) Circulation , vol.115 , pp. 4510-4518
    • Sarwar, N.1    Danesh, J.2    Eiriksdottir, G.3
  • 30
    • 34548397201 scopus 로고    scopus 로고
    • C-reactive protein in cardiovascular risk assessment: A review of the evidence
    • Abraham J, Campbell CY, Cheema A, et al. C-reactive protein in cardiovascular risk assessment: a review of the evidence. J Cardiometab Syndr 2007;2:119-23
    • (2007) J Cardiometab Syndr , vol.2 , pp. 119-123
    • Abraham, J.1    Campbell, C.Y.2    Cheema, A.3
  • 31
    • 33846192751 scopus 로고    scopus 로고
    • Clinical importance and therapeutic modulation of small dense low-density lipoprotein particles
    • Gazi IF, Tsimihodimos V, Tselepis AD, et al. Clinical importance and therapeutic modulation of small dense low-density lipoprotein particles. Expert Opin Biol Ther 2007;7:53-72
    • (2007) Expert Opin Biol Ther , vol.7 , pp. 53-72
    • Gazi, I.F.1    Tsimihodimos, V.2    Tselepis, A.D.3
  • 32
    • 33750477286 scopus 로고    scopus 로고
    • Efficacy and safety of torcetrapib, a novel cholesteryl ester transfer protein inhibitor, in individuals with below-average high-density lipoprotein cholesterol levels
    • Davidson MH, McKenney JM, Shear CL, Revkin JH. Efficacy and safety of torcetrapib, a novel cholesteryl ester transfer protein inhibitor, in individuals with below-average high-density lipoprotein cholesterol levels. J Am Coll Cardiol 2006;48:1774-81
    • (2006) J Am Coll Cardiol , vol.48 , pp. 1774-1781
    • Davidson, M.H.1    McKenney, J.M.2    Shear, C.L.3    Revkin, J.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.