Evaluation of multivalent, functional polymeric nanoparticles for imaging applications

ACS Nano

Volumn 5, Issue 2, 2011, Pages 738-747

  Shokeen, Monica ^a   Pressly, Eric D ^c,d   Hagooly, Aviv ^a   Zheleznyak, Alexander ^a   Ramos, Nicholas ^a   Fiamengo, Ashley L ^a   Welch, Michael J ^a,b   Hawker, Craig J ^c,d   Anderson, Carolyn J ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d University of California   (United States)

Author keywords

cellular uptake; click chemistry; pharmacokinetics; polymeric nanoparticles

Indexed keywords

BLOOD CIRCULATION; CELLULAR UPTAKE; CLICK CHEMISTRY; FUNCTIONALIZED; GLIOBLASTOMA CELLS; IMAGING APPLICATIONS; IN-VIVO; INTEGRINS; LIVING FREE RADICAL POLYMERIZATION; MODEL SYSTEM; MODULAR APPROACH; MOLECULAR TARGETING; OPTIMAL PERFORMANCE; POLYMER NANOPARTICLES; POLYMERIC NANOPARTICLES; RGD PEPTIDE; UPPER LIMITS;

CARDIOVASCULAR SYSTEM; FREE RADICAL POLYMERIZATION; FREE RADICALS; FUNCTIONAL GROUPS; LIGANDS; LIVING POLYMERIZATION; LOADING; NANOPARTICLES; PEPTIDES; PHARMACOKINETICS;

FUNCTIONAL POLYMERS;

DIAGNOSTIC AGENT; NANOPARTICLE; POLYMER; VITRONECTIN RECEPTOR;

ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DIAGNOSTIC IMAGING; ENZYME SPECIFICITY; FEMALE; HUMAN; METABOLISM; METHODOLOGY; RAT; SPRAGUE DAWLEY RAT; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE;

ANIMALS; BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; DIAGNOSTIC IMAGING; FEMALE; HUMANS; INTEGRIN ALPHAVBETA3; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NANOPARTICLES; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; SUBSTRATE SPECIFICITY;

EID: 79951904994     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn102278w     Document Type: Article

References (41)

1. Lu, W.; Arumugam, S. R.; Senapati, D.; Singh, A. K.; Arbneshi, T.; Khan, S. A.; Yu, H.; Paresh, C. R. Multifunctional Oval-Shaped Gold-Nanoparticle-Based Selective Detection of Breast Cancer Cells Using Simple Colorimetric and Highly Sensitive Two-Photon Scattering Assay ACS Nano 2010, 4, 1739-1749
2. Xu, H.; Minoia, A.; Tomović, Z.; Lazzaroni, R.; Meijer, E. W.; Schenning, A. P. H. J.; De Feyter, S. A Multivalent Hexapod: Conformational Dynamics of Six-Legged Molecules in Self-Assembled Monolayers at a Solid-Liquid Interface ACS Nano 2009, 3, 1016-1024
3. Kumar, A. M. S.; Sivakova, S; Fox, J. D.; Green, J. E.; Marchant, R. E.; Rowan, S. J. Molecular Engineering of Supramolecular Scaffold Coatings That Can Reduce Static Platelet Adhesion J. Am. Chem. Soc. 2008, 130, 1466-1476 (Pubitemid 351171025)
4. Sudeep, P. K.; Emrick, T. Functional Si and CdSe Quantum Dots: Synthesis, Conjugate Formation, and Photoluminescence Quenching by Surface Interactions ACS Nano 2009, 3, 4105-4109
5. Liu, J.; Zhang, Q.; Remsen, E. E.; Wooley, K. L. Nanostructured Materials Designed for Cell Binding and Transduction Biomacromolecules 2001, 2, 362-368 (Pubitemid 32707512)
6. Ostaci, R.-V.; Damiron, D.; Grohens, Y.; Léger, L.; Drockenmuller, E. Click Chemistry Grafting of Poly(ethylene glycol) Brushes to Alkyne-Functionalized Pseudobrushes Langmuir 2010, 26, 1304-1310
7. Zareie, H. M.; Boyer, C.; Bulmus, V.; Nateghi, E.; Davis, T. P. Temperature-Responsive Self-Assembled Monolayers of Oligo(ethylene glycol): Control of Biomolecular Recognition ACS Nano 2008, 2, 757-765
8. Stukel, J. M.; Li, R. C.; Maynard, H. D.; Caplan, M. R. Two-Step Synthesis of Multivalent Cancer-Targeting Constructs Biomacromolecules 2010, 11, 160-167
9. Zhang, L.; Gu, F. X.; Chan, J. M.; Wang, A. Z.; Langer, R. S.; Farokhzad, O. C. Nanoparticles in Medicine: Therapeutic Applications and Developments Clin. Pharmacol. Ther. 2008, 83, 761-769 (Pubitemid 351556021)
10. Wagner, V.; Dullaart, A.; Bock, A. K.; Zweck, A. The Emerging Nanomedicine Landscape Nat. Biotechnol. 2006, 24, 1211-1217 (Pubitemid 44564760)
11. Almutairi, A.; Rossin, R.; Shokeen, M.; Hagooly, A.; Ananth, A.; Capoccia, B.; Guillaudeu, S.; Abendschein, D.; Anderson, C. J.; Welch, M. J. et al. Biodegradable Dendritic Positron-Emitting Nanoprobes for the Noninvasive Imaging of Angiogenesis Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 685-690
12. Torchilin, V. P. Micellar Nanocarriers: Pharmaceutical Perspectives Pharm. Res. 2007, 24, 1-16 (Pubitemid 44902565)
13. El Bayoumi, T. A.; Torchilin, V. P. Tumor-Targeted Nanomedicines: Enhanced Antitumor Efficacy In Vivo of Doxorubicin-Loaded, Long-Circulating Liposomes Modified with Cancer-Specific Monoclonal Antibody Clin. Cancer Res. 2009, 15, 1973-1980
14. Glickson, J. D.; Lund-Katz, S.; Zhou, R.; Choi, H.; Chen, I. W.; Li, H.; Corbin, I.; Popov, A. V.; Cao, W.; Song, L. et al. Lipoprotein Nanoplatform for Targeted Delivery of Diagnostic and Therapeutic Agents Adv. Exp. Med. Biol. 2009, 645, 227-239
15. Nahrendorf, M.; Zhang, H.; Hembrador, S.; Panizzi, P.; Sosnovik, D. E.; Aikawa, E.; Libby, P.; Swirski, F. K.; Weissleder, R. Nanoparticle PET-CT Imaging of Macrophages in Inflammatory Atherosclerosis Circulation 2008, 117, 379-387
16. Prato, M.; Kostarelos, K.; Bianco, A. Functionalized Carbon Nanotubes in Drug Design and Discovery Acc. Chem. Res. 2008, 41, 60-68
17. Johnston, A. P. R.; Cortez, C.; Angelatos, A. S.; Caruso, F. Layer-by-Layer Engineered Capsules and Their Applications Colloid Interface Sci. 2006, 11, 203-209 (Pubitemid 44738642)
18. Gu, F.; Zhang, L.; Teply, B. A.; Mann, N.; Wang, A.; Radovic-Moreno, A. F.; Langer, R.; Farokhzad, O. C. Precise Engineering of Targeted Nanoparticles by Using Self-Assembled Biointegrated Block Copolymers Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 2586-2591 (Pubitemid 351520557)
19. Shokeen, M.; Fettig, N. M.; Rossin, R. Synthesis, In Vitro and In Vivo Evaluation of Radiolabeled Nanoparticles J. Nucl. Med. Mol. Imaging 2008, 52, 267-277
20. Hood, J. D.; Cheresh, D. A. Role of Integrins in Cell Invasion and Migration Nat. Rev. Cancer 2002, 2, 91-100 (Pubitemid 37328796)
21. Moghimi, S. M.; Hunter, A. C.; Murray, J. C. Long-Circulating and Target-Specific Nanoparticles: Theory to Practice Pharmocol. Rev. 2001, 53, 283-318 (Pubitemid 32476118)
22. Owens, D. E., III; Peppas, N. A. Opsonization, Biodistribution, and Pharmacokinetics of Polymeric Nanoparticles Int. J. Pharm. 2006, 307, 93-102 (Pubitemid 41773257)
23. Lutz, J. F. 1,3-Dipolar Cycloadditions of Azides and Alkynes: A Universal Ligation Tool in Polymer and Materials Science Angew. Chem., Int. Ed. 2007, 46, 1018-1025
24. Parrish, B.; Breitenkamp, R. B.; Emrick, T. PEG- and Peptide-Grafted Aliphatic Polyesters by Click Chemistry J. Am. Chem. Soc. 2005, 127, 7404-7410 (Pubitemid 40746025)
25. Vestberg, R.; Piekarski, A. M.; Pressly, E. D.; Van Berkel, K. Y.; Malkoch, M.; Gerbac, J.; Ueno, N.; Hawker, C. J. A General Strategy for Highly Efficient Nanoparticle Dispersing Agents Based on Hybrid Dendritic Linear Block Copolymers J. Polym. Sci., Part A: Polym. Chem. 2009, 47, 1237-1258
26. Dechantsreiter, M. A.; Planker, E.; Matha, B.; Lohof, E.; Holzemann, G.; Jonczyk, A.; Goodman, S. L.; Kessler, H. N-Methylated Cyclic RGD Peptides as Highly Active and Selective Alpha(V)Beta(3) Integrin Antagonists J. Med. Chem. 1999, 42, 3033-3040 (Pubitemid 29384038)
27. Fiamengo, A. L. Y., Y; Achilefu, S.; Anderson, C. J. In Vitro and In Vivo Evaluation of Structurally Diverse Cu-64-Labeled RGD Peptides for PET Imaging of Alpha V Beta 3 Expression. J. Labelled Compd. Radiopharm. 2009, 52.
28. Pressly, E. D.; Rossin, R.; Hagooly, A.; Fukukawa, K.; Messmore, B. W.; Welch, M. J.; Wooley, K. L.; Lamm, M. S.; Hule, R. A.; Pochan, D. J. et al. Structural Effects on the Biodistribution and Positron Emission Tomography (PET) Imaging of Well-Defined (64)Cu-Labeled Nanoparticles Comprised of Amphiphilic Block Graft Copolymers Biomacromolecules 2007, 8, 3126-3134 (Pubitemid 350011634)
29. Alb, A. M.; Enohnyaket, P.; Drenski, M. F.; Shunmugan, R.; Tew, G. N.; Reed, W. F. Quantitative Contrasts in the Copolymerization of Acrylate- and Methacrylate-Based Comonomers Macromolecules 2006, 39, 8283-8292 (Pubitemid 46079667)
30. Rodlert, M.; Harth, E.; Rees, I.; Hawker, C. J. End-Group Fidelity in Nitroxide-Mediated Living Free-Radical Polymerizations J. Polym. Sci., Part A: Polym. Chem. 2000, 38, 4749-4763 (Pubitemid 32871605)
31. Wang, D.; Miller, S. C.; Sima, M.; Parker, D.; Buswell, H.; Goodrich, K. C.; Kopečková, P.; Kopeček, J. The Antrotropism of Macromolecules in Adjuvant-Induced Arthritis Rat Model: A Prelimary Study Pharm. Res. 2004, 21, 1741-1749 (Pubitemid 39390083)
32. Montet, X.; Funovics, M.; Montet-Abou, K.; Weissleder, R.; Josephson, L. Multivalent Effects of RGD Peptides Obtained by Nanoparticle Display J. Med. Chem. 2006, 49, 6087-6093 (Pubitemid 44484952)
33. Decuzzi, P.; Ferrari, M. The Role of Specific and Non-Specific Interactions in Receptor-Mediated Endocytosis of Nanoparticles Biomaterials 2007, 28, 2915-2922 (Pubitemid 46505030)
34. Popielarski, S. R.; Hu-Lieskovan, S.; French, S. W.; Triche, T. J.; Davis, M. E. A Nanoparticle-Based Model Delivery System to Guide the Rational Design of Gene Delivery to the Liver. 2. In Vitro and In Vivo Uptake Results Bioconjugate Chem. 2005, 16, 1071-1080 (Pubitemid 41368107)
35. 64Cu Using a Biomedical Cyclotron Nucl. Med. Biol. 1997, 24, 35-43 (Pubitemid 27145595)
36. Kilcher, G.; Wang, L.; Duckham, C.; Tirelli, N. Polysulfide Networks. In Situ Formation and Characterization of the Elastomeric Behavior Macromolecules 2007, 40, 5141-5149 (Pubitemid 47169934)
37. Sébastien, P.; Pittaya, T. Macromolecular Design via Reversible Addition-Fragmentation Chain Transfer (RAFT)/Xanthates (MADIX) Polymerization J. Polym. Sci., Part A: Polym. Chem. 2005, 43, 5347-5393
38. Faulkner, S.; Burton-Pye, B. P. pH Dependent Self-Assembly of Dimetallic Lanthanide Complexes Chem. Commun. 2005, 259-261
39. Malkoch, M.; Schleicher, K.; Drockenmuller, E.; Hawker, C. J.; Russell, T. P.; Wu, P.; Fokin, V. V. Structurally Diverse Dendritic Libraries: A Highly Efficient Functionalization Approach Using Click Chemistry Macromolecules 2005, 38, 3663-3678 (Pubitemid 40672495)
40. Morrison, I. D.; Grabowski, E. F.; Herb, C. A. Improved Techniques for Particle Size Determination by Quasi-Elastic Light Scattering Langmuir 1985, 1, 496-501 (Pubitemid 15546239)
41. Lee, H. B.; Blaufox, M. D. Blood Volume in the Rat J. Nucl. Med. 1985, 25, 72-76 (Pubitemid 15161428)