The study of amorphous phase separation in a model polymer phase-separating system using raman microscopy and a low-temperature stage: Effect of cooling rate and nucleation temperature

Journal of Pharmaceutical Sciences

Volumn 100, Issue 4, 2011, Pages 1362-1376

  Padilla, Adora M ^a,b,c   Chou, Shin G ^a,d   Luthra, Sumit ^a   Pikal, Michael J ^b  

^a PFIZER INC   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

^c EISAI INC   (United States)

^d NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY   (United States)

Author keywords

Cooling rate; DSC; Freeze drying; Glass transition; Lyophilization; Nucleation process control; Phase separation; Raman spectroscopy

Indexed keywords

POLYMER; POLYVINYLPYRROLIDONE:DEXTRAN; POVIDONE; UNCLASSIFIED DRUG; DEXTRAN;

ARTICLE; COOLING; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; FREEZE DRYING; GLASS TRANSITION TEMPERATURE; LOW TEMPERATURE; MICROSCOPY; MOLECULAR WEIGHT; NUCLEATION TEMPERATURE; PHASE SEPARATION; PROTEIN ANALYSIS; RAMAN MICROSCOPY; SHELF LIFE; TEMPERATURE; TEMPERATURE SENSITIVITY; CHEMISTRY; COLD; DEVICES; FREEZING; PHASE TRANSITION; RAMAN SPECTROMETRY;

COLD TEMPERATURE; CRYSTALLIZATION; DEXTRANS; FREEZE DRYING; FREEZING; MICROSCOPY; PHASE TRANSITION; POVIDONE; SPECTRUM ANALYSIS, RAMAN;

EID: 79951889087     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22357     Document Type: Article

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