메뉴 건너뛰기




Volumn 20, Issue 2, 2011, Pages 273-286

Lenalidomide in the treatment of chronic lymphocytic leukemia

Author keywords

chemotherapy; CLL; IMiDS compounds; lenalidomide

Indexed keywords

ALLOPURINOL; CD40 LIGAND; FC RECEPTOR; FLUDARABINE; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 6; LENALIDOMIDE; METHYLPREDNISOLONE; PREDNISONE; RITUXIMAB; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1;

EID: 79951861397     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.2011.546343     Document Type: Article
Times cited : (8)

References (95)
  • 2
    • 0035412366 scopus 로고    scopus 로고
    • Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma
    • Davies FE, Raje N, Hideshima T, et al. Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma. Blood 2001;98:210-6.
    • (2001) Blood , vol.98 , pp. 210-6
    • Davies, F.E.1    Raje, N.2    Hideshima, T.3
  • 4
    • 79952945610 scopus 로고    scopus 로고
    • Chronic Lymphocytic Leukemia. National Cancer Institute Bethesda MD: National Cancer Institute [Last accessed 13 December 2010]
    • Chronic Lymphocytic Leukemia. National Cancer Institute. SEER Stat Fact Sheets. Bethesda, MD: National Cancer Institute 2009. Available from: http://seer.cancer.gov/ statfacts/html/clyl.html. [Last accessed 13 December 2010].
    • (2009) SEER Stat Fact Sheets
  • 7
    • 0017751562 scopus 로고
    • A clinical staging system for chronic lymphocytic leukemia. Prognostic significance
    • DOI 10.1002/1097-0142(197708)40:2<855::AID-CNCR2820400239>3.0.CO;2- 1
    • Binet JL, Lepoprier M, Dighiero G, et al. A clinical staging system for chronic lymphocytic leukemia: prognostic significance. Cancer 1977;40:855-64. (Pubitemid 8177910)
    • (1977) Cancer , vol.40 , Issue.2 , pp. 855-864
    • Binet, J.L.1    Leporrier, M.2    Dighiero, G.3
  • 8
    • 0016740933 scopus 로고
    • Clinical staging of chronic lymphocytic leukemia
    • Rai KR, Sawitsky A, Cronkite EP, et al. Clinical staging of chronic lymphocytic leukemia. Blood 1975;46:219-34.
    • (1975) Blood , vol.46 , pp. 219-34
    • Rai, K.R.1    Sawitsky, A.2    Cronkite, E.P.3
  • 10
    • 0036165916 scopus 로고    scopus 로고
    • CD38 expression and secondary 17p deletion are important prognostic factors in chronic lymphocytic leukaemia
    • Chevallier P, Penther D, Avet-Loiseau H, et al. CD38 expression and secondary 17p deletion are important prognostic factors in chronic lymphocytic leukaemia. Br J Haematol 2002;116:142-5.
    • (2002) Br J Haematol , vol.116 , pp. 142-5
    • Chevallier, P.1    Penther, D.2    Avet-Loiseau, H.3
  • 12
    • 0037441762 scopus 로고    scopus 로고
    • The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression
    • DOI 10.1182/blood-2002-06-1801
    • Ghia P, Guida G, Stella S, et al. The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression. Blood 2003;101:1262-9. (Pubitemid 36182494)
    • (2003) Blood , vol.101 , Issue.4 , pp. 1262-1269
    • Ghia, P.1    Guida, G.2    Stella, S.3    Gottardi, D.4    Geuna, M.5    Strola, G.6    Scielzo, C.7    Caligaris-Cappio, F.8
  • 13
    • 0035412375 scopus 로고    scopus 로고
    • CD38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia
    • Ibrahim S, Keating M, Do KA, et al. CD38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia. Blood 2001;98:181-6.
    • (2001) Blood , vol.98 , pp. 181-6
    • Ibrahim, S.1    Keating, M.2    Do, K.A.3
  • 15
    • 66949121753 scopus 로고    scopus 로고
    • Definition of progression risk based on combinations of cellular and molecular markers in patients with Binet stage A chronic lymphocytic leukaemia
    • Morabito F, Cutrona G, Gentile M, et al. Definition of progression risk based on combinations of cellular and molecular markers in patients with Binet stage A chronic lymphocytic leukaemia. Br J Haematol 2009;146:44-53.
    • (2009) Br J Haematol , vol.146 , pp. 44-53
    • Morabito, F.1    Cutrona, G.2    Gentile, M.3
  • 17
    • 52649143664 scopus 로고    scopus 로고
    • Relative value of ZAP-70, CD38, and immunoglobulin mutation status in predicting aggressive disease in chronic lymphocytic leukemia
    • Rassenti LZ, Jain S, Keating MJ, et al. Relative value of ZAP-70, CD38, and immunoglobulin mutation status in predicting aggressive disease in chronic lymphocytic leukemia. Blood 2008;112:1923-30.
    • (2008) Blood , vol.112 , pp. 1923-30
    • Rassenti, L.Z.1    Jain, S.2    Keating, M.J.3
  • 18
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • Hamblin TJ, Davis Z, Gardiner A, et al. Unmutated Ig VH genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999;94:1848-54. (Pubitemid 29430400)
    • (1999) Blood , vol.94 , Issue.6 , pp. 1848-1854
    • Hamblin, T.J.1    Davis, Z.2    Gardiner, A.3    Oscier, D.G.4    Stevenson, F.K.5
  • 21
    • 66749118874 scopus 로고    scopus 로고
    • Predictive value of beta2-microglobulin (beta2-m) levels in chronic lymphocytic leukemia since Binet A stages
    • Gentile M, Cutrona G, Neri A, et al. Predictive value of beta2-microglobulin (beta2-m) levels in chronic lymphocytic leukemia since Binet A stages. Haematologica 2009;94:887-8.
    • (2009) Haematologica , vol.94 , pp. 887-8
    • Gentile, M.1    Cutrona, G.2    Neri, A.3
  • 24
    • 1842328565 scopus 로고    scopus 로고
    • 11q deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis
    • Dohner H, Stilgenbauer S, James MR, et al. 11q deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis. Blood 1997;89:2516-22. (Pubitemid 27143300)
    • (1997) Blood , vol.89 , Issue.7 , pp. 2516-2522
    • Dohner, H.1    Stilgenbauer, S.2    James, M.R.3    Benner, A.4    Weilguni, T.5    Bentz, M.6    Fischer, K.7    Hunstein, W.8    Lichter, P.9
  • 25
    • 0028987180 scopus 로고
    • P53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias
    • Dohner H, Fischer K, Bentz M, et al. p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias. Blood 1995;85:1580-9.
    • (1995) Blood , vol.85 , pp. 1580-9
    • Dohner, H.1    Fischer, K.2    Bentz, M.3
  • 27
    • 76949091824 scopus 로고    scopus 로고
    • First-line treatment with fludarabine (F), cyclophosphamide (C), and rituximab (R) (FCR) improves overall survival (OS) in previously untreated patients (pts) with advanced chronic lymphocytic leukemia (CLL): Results of a randomized phase III trial on behalf of an international group of investigators and the German CLL study group. ASH Annual Meeting Abstracts
    • Hallek M, Fingerle-Rowson G, Fink AM, et al. First-line treatment with fludarabine (F), cyclophosphamide (C), and rituximab (R) (FCR) improves overall survival (OS) in previously untreated patients (pts) with advanced chronic lymphocytic leukemia (CLL): results of a randomized phase III trial on behalf of an international group of investigators and the German CLL study group. ASH Annual Meeting Abstracts. Blood 2009;114:535.
    • (2009) Blood , vol.114 , pp. 535
    • Hallek, M.1    Fingerle-Rowson, G.2    Fink, A.M.3
  • 29
    • 27144548424 scopus 로고    scopus 로고
    • Efficacy of bendamustine in patients with relapsed or refractory chronic lymphocytic leukemia: Results of a phase I/II study of the German CLL Study Group
    • Bergmann MA, Goebeler ME, Herold M, et al. Efficacy of bendamustine in patients with relapsed or refractory chronic lymphocytic leukemia: results of a phase I/II study of the German CLL Study Group. Haematologica 2005;90:1357-64. (Pubitemid 41503651)
    • (2005) Haematologica , vol.90 , Issue.10 , pp. 1357-1364
    • Bergmann, M.A.1    Goebeler, M.E.2    Herold, M.3    Emmerich, B.4    Wilhelm, M.5    Ruelfs, C.6    Boening, L.7    Hallek, M.J.8
  • 31
    • 38349163290 scopus 로고    scopus 로고
    • Phase I-II study of oxaliplatin, fludarabine, cytarabine, and rituximab combination therapy in patients with Richter's syndrome or fludarabine- refractory chronic lymphocytic leukemia
    • Tsimberidou AM, Wierda WG, Plunkett W, et al. Phase I-II study of oxaliplatin, fludarabine, cytarabine, and rituximab combination therapy in patients with Richter's syndrome or fludarabine-refractory chronic lymphocytic leukemia. J Clin Oncol 2008;26:196-203.
    • (2008) J Clin Oncol , vol.26 , pp. 196-203
    • Tsimberidou, A.M.1    Wierda, W.G.2    Plunkett, W.3
  • 34
    • 84941364288 scopus 로고    scopus 로고
    • Summit, NJ: Celgene corporation [Last accesssed 13 December 2010]
    • Lenalidomide prescribing information. Summit, NJ: Celgene corporation,. http://www. revlimid.com/pdf/REVLIMID-PI.pdf [Last accesssed 13 December 2010].
    • Lenalidomide Prescribing Information
  • 35
    • 32844458638 scopus 로고    scopus 로고
    • Multi-dose phamacokinetics and safety of CC-5013 in 15 multiple myeloma patients
    • Wu A, Scheffler MR. Multi-dose phamacokinetics and safety of CC-5013 in 15 multiple myeloma patients. J Clin Oncol 2004;22:141s.
    • (2004) J Clin Oncol , vol.22 , pp. 141
    • Wu, A.1    Scheffler, M.R.2
  • 36
    • 1942534043 scopus 로고    scopus 로고
    • The evolution of thalidomide and its IMiD derivatives as anticancer agents
    • Bartlett JB, Dredge K, Dalgleish AG. The evolution of thalidomide and its IMiD derivatives as anticancer agents. Nat Rev Cancer 2004;4:314-22. (Pubitemid 38525287)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.4 , pp. 314-322
    • Bartlett, J.B.1    Dredge, K.2    Dalgleish, A.G.3
  • 39
    • 45949100928 scopus 로고    scopus 로고
    • Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia
    • Ferrajoli A, Lee BN, Schlette EJ, et al. Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia. Blood 2008;111:5291-7.
    • (2008) Blood , vol.111 , pp. 5291-7
    • Ferrajoli, A.1    Lee, B.N.2    Schlette, E.J.3
  • 40
    • 70349150560 scopus 로고    scopus 로고
    • Lenalidomide-induced upregulation of CD80 on tumor cells correlates with T-cell activation, the rapid onset of a cytokine release syndrome and leukemic cell clearance in chronic lymphocytic leukemia
    • Aue G, Njuguna N, Tian X, et al. Lenalidomide-induced upregulation of CD80 on tumor cells correlates with T-cell activation, the rapid onset of a cytokine release syndrome and leukemic cell clearance in chronic lymphocytic leukemia. Haematologica 2009;94:1266-73.
    • (2009) Haematologica , vol.94 , pp. 1266-73
    • Aue, G.1    Njuguna, N.2    Tian, X.3
  • 46
    • 0033001312 scopus 로고    scopus 로고
    • Characterisation of tumour infiltrating lymphocytes and correlations with immunological surface molecules in colorectal cancer
    • DOI 10.1016/S0959-8049(99)00033-7, PII S0959804999000337
    • Diederichsen ACP, Zeuthen J, Christensen PB, Kristensen T. Characterisation of tumour infiltrating lymphocytes and correlations with immunological surface molecules in colorectal cancer. Eur J Cancer 1999;35:721-6. (Pubitemid 29258140)
    • (1999) European Journal of Cancer , vol.35 , Issue.5 , pp. 721-726
    • Diederichsen, A.C.P.1    Zeuthen, J.2    Christensen, P.B.3    Kristensen, T.4
  • 47
    • 0141891466 scopus 로고    scopus 로고
    • Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patients with gastric and esophageal cancers
    • Ichihara F, Kono K, Takahashi A, et al. Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patients with gastric and esophageal cancers. Clin Cancer Res 2003;9:4404-8. (Pubitemid 37248397)
    • (2003) Clinical Cancer Research , vol.9 , Issue.12 , pp. 4404-4408
    • Ichihara, F.1    Kono, K.2    Takahashi, A.3    Kawaida, H.4    Sugai, H.5    Fujii, H.6
  • 48
    • 27144559654 scopus 로고    scopus 로고
    • Increased expression of CD152 (CTLA-4) by normal T lymphocytes in untreated patients with B-cell chronic lymphocytic leukemia
    • DOI 10.1038/sj.leu.2403907, PII 2403907
    • Motta M, Rassenti L, Shelvin BJ, et al. Increased expression of CD152 (CTLA-4) by normal T lymphocytes in untreated patients with B-cell chronic lymphocytic leukemia. Leukemia 2005;19:1788-93. (Pubitemid 41486157)
    • (2005) Leukemia , vol.19 , Issue.10 , pp. 1788-1793
    • Motta, M.1    Rassenti, L.2    Shelvin, B.J.3    Lerner, S.4    Kipps, T.J.5    Keating, M.J.6    Wierda, W.G.7
  • 49
    • 67649402915 scopus 로고    scopus 로고
    • Lenalidomide (Revlimid(R), CC-5013) and ActimidTM (CC-4047) inhibit the function and expansion of T regulatory (Treg) cells in vitro: Implications for anti-tumor activity in vivo
    • Galustian C, Klaschka DC, Meyer B, et al. Lenalidomide (Revlimid(R), CC-5013) and ActimidTM (CC-4047) inhibit the function and expansion of T regulatory (Treg) cells in vitro: implications for anti-tumor activity in vivo. AACR Meeting Abstracts;. p. 1147.
    • AACR Meeting Abstracts , pp. 1147
    • Galustian, C.1    Klaschka, D.C.2    Meyer, B.3
  • 50
    • 67349107194 scopus 로고    scopus 로고
    • The anti-cancer agents lenalidomide and pomalidomide inhibit the proliferation and function of T regulatory cells
    • Galustian C, Meyer B, Labarthe MC, et al. The anti-cancer agents lenalidomide and pomalidomide inhibit the proliferation and function of T regulatory cells. Cancer Immunol Immunother 2009;58:1033-45.
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 1033-45
    • Galustian, C.1    Meyer, B.2    Labarthe, M.C.3
  • 52
    • 0035214909 scopus 로고    scopus 로고
    • Thalidomide: A novel template for anticancer drugs
    • Stirling D. Thalidomide: a novel template for anticancer drugs. Semin Oncol 2001;28:602-6. (Pubitemid 33134419)
    • (2001) Seminars in Oncology , vol.28 , Issue.6 , pp. 602-606
    • Stirling, D.1
  • 53
    • 0035412366 scopus 로고    scopus 로고
    • Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma
    • Davies FE, Raje N, Hideshima T, et al. Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma. Blood 2001;98:210-16.
    • (2001) Blood , vol.98 , pp. 210-16
    • Davies, F.E.1    Raje, N.2    Hideshima, T.3
  • 54
    • 51649123319 scopus 로고    scopus 로고
    • Lenalidomide enhances natural killer cell and monocyte-mediated antibody-dependent cellular cytotoxicity of rituximab-treated CD20+ tumor cells
    • Wu L, Adams M, Carter T, et al. Lenalidomide enhances natural killer cell and monocyte-mediated antibody-dependent cellular cytotoxicity of rituximab-treated CD20+ tumor cells. Clin Cancer Res 2008;14:4650-7.
    • (2008) Clin Cancer Res , vol.14 , pp. 4650-7
    • Wu, L.1    Adams, M.2    Carter, T.3
  • 55
    • 19944430437 scopus 로고    scopus 로고
    • Molecular mechanisms where by immunomodulatory drugs activate natural killer cells: Clinical application
    • Hayashi T, Hideshima T, Akiyama M, et al. Molecular mechanisms where by immunomodulatory drugs activate natural killer cells: clinical application. Br J Haematol 2005;128:192-203.
    • (2005) Br J Haematol , vol.128 , pp. 192-203
    • Hayashi, T.1    Hideshima, T.2    Akiyama, M.3
  • 56
    • 79951913869 scopus 로고    scopus 로고
    • Lenalidomide enhances tumor killing in vitro during ADCC mediated by trastuzumab, cetuximab, and rituximab. ASCO Meeting Abstracts
    • Bartlett JB. Lenalidomide enhances tumor killing in vitro during ADCC mediated by trastuzumab, cetuximab, and rituximab. ASCO Meeting Abstracts. J Clin Oncol 2007;25:18S.
    • (2007) J Clin Oncol , vol.25
    • Bartlett, J.B.1
  • 57
    • 33745961875 scopus 로고    scopus 로고
    • Enhancement of ligand dependent activation of human natural killer T cells by lenalidomide: Therapeutic implications
    • Chang DH, Liu N, Klimek V, et al. Enhancement of ligand dependent activation of human natural killer T cells by lenalidomide: therapeutic implications. Blood 2006;108:2005-10.
    • (2006) Blood , vol.108 , pp. 2005-10
    • Chang, D.H.1    Liu, N.2    Klimek, V.3
  • 58
    • 77649218963 scopus 로고    scopus 로고
    • Lenalidomide treatment of chronic lymphocytic leukaemia patients reduces regulatory T cells and induces Th17 T helper cells
    • Idler I, Giannopoulos K, Zenz T, et al. Lenalidomide treatment of chronic lymphocytic leukaemia patients reduces regulatory T cells and induces Th17 T helper cells. Br J Haematol 2010;148:948-50.
    • (2010) Br J Haematol , vol.148 , pp. 948-50
    • Idler, I.1    Giannopoulos, K.2    Zenz, T.3
  • 59
    • 0034331194 scopus 로고    scopus 로고
    • Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy
    • Hideshima T, Chauhan D, Shima Y, et al. Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy. Blood 2000;96:2943-50.
    • (2000) Blood , vol.96 , pp. 2943-50
    • Hideshima, T.1    Chauhan, D.2    Shima, Y.3
  • 60
    • 74949110293 scopus 로고    scopus 로고
    • Lenalidomide abrogates the protective influence of nurse-like cells on primary chronic lymphocytic leukemia cells in vitro. ASH Annual Meeting Abstracts
    • James DF, Betty MR, Mosadeghi R, Kipps TJ. Lenalidomide abrogates the protective influence of nurse-like cells on primary chronic lymphocytic leukemia cells in vitro. ASH Annual Meeting Abstracts. Blood 2007;110:3116.
    • (2007) Blood , vol.110 , pp. 3116
    • James, D.F.1    Betty, M.R.2    Mosadeghi, R.3    Kipps, T.J.4
  • 61
    • 23844435619 scopus 로고    scopus 로고
    • Immunomodulatory drug CC-5013 or CC-4047 and rituximab enhance antitumor activity in a severe combined immunodeficient mouse lymphoma model
    • DOI 10.1158/1078-0432.CCR-05-0577
    • Hernandez-Ilizaliturri FJ, Reddy N, Holkova B, et al. Immunomodulatory drug CC-5013 or CC- 4047 and rituximab enhance antitumor activity in a severe combined immunodeficient mouse lymphoma model. Clin Cancer Res 2005;11:5984-92. (Pubitemid 41170330)
    • (2005) Clinical Cancer Research , vol.11 , Issue.16 , pp. 5984-5992
    • Hernandez-Ilizaliturri, F.J.1    Reddy, N.2    Holkova, B.3    Ottman, E.4    Czuczman, M.S.5
  • 62
    • 36849024949 scopus 로고    scopus 로고
    • Immunomodulatory drugs stimulate natural killer-cell function, alter cytokine production by dendritic cells, and inhibit angiogenesis enhancing the anti-tumour activity of rituximab in vivo
    • DOI 10.1111/j.1365-2141.2007.06841.x
    • Reddy N, Hernandez-Ilizaliturri FJ, Deeb G, et al. Immunomodulatory drugs stimulate natural killer-cell function, alter cytokine production by dendritic cells, and inhibit angiogenesis enhancing the anti-tumour activity of rituximab in vivo. Br J Haematol 2008;140:36-45. (Pubitemid 350233246)
    • (2008) British Journal of Haematology , vol.140 , Issue.1 , pp. 36-45
    • Reddy, N.1    Hernandez-Ilizaliturri, F.J.2    Deeb, G.3    Roth, M.4    Vaughn, M.5    Knight, J.6    Wallace, P.7    Czuczman, M.S.8
  • 63
    • 27644591608 scopus 로고    scopus 로고
    • Properties of thalidomide and its analogues: Implications for anticancer therapy
    • DOI 10.1208/aapsj070103, 3
    • Teo SK. Properties of thalidomide and its analogues: implications for anticancer therapy. AAPS J 2005;7:E14-19. (Pubitemid 41554303)
    • (2005) AAPS Journal , vol.7 , Issue.1
    • Teo, S.K.1
  • 64
    • 69249140986 scopus 로고    scopus 로고
    • Direct inhibitory effects of lenalidomide on the proliferation and VEGF production of non-Hodgkin lymphoma cells are associated with increased SPARC expression. ASH Annual Meeting Abstracts
    • Zhang L-H, Schafer PH, Muller G, et al. Direct inhibitory effects of lenalidomide on the proliferation and VEGF production of non-Hodgkin lymphoma cells are associated with increased SPARC expression. ASH Annual Meeting Abstracts. Blood 2008;112:2612.
    • (2008) Blood , vol.112 , pp. 2612
    • Zhang, L.-H.1    Schafer, P.H.2    Muller, G.3
  • 65
    • 77950644007 scopus 로고    scopus 로고
    • Dexamethasone synergizes with lenalidomide to inhibit multiple myeloma tumor growth, but reduces lenalidomide-induced immunomodulation of T and NK cell function
    • Gandhi AK, Kang J, Capone L, et al. Dexamethasone synergizes with lenalidomide to inhibit multiple myeloma tumor growth, but reduces lenalidomide-induced immunomodulation of T and NK cell function. Curr Cancer Drug Targets 2010;10:155-67.
    • (2010) Curr Cancer Drug Targets , vol.10 , pp. 155-67
    • Gandhi, A.K.1    Kang, J.2    Capone, L.3
  • 68
    • 51349161197 scopus 로고    scopus 로고
    • Pro-apoptotic effect of lenalidomide in patients with chronic lymphocytic leukemia is possibly mediated through interruption of phosphatidylinositol pathway. ASH Annual Meeting Abstracts
    • Chanan-Khan A. Pro-apoptotic effect of lenalidomide in patients with chronic lymphocytic leukemia is possibly mediated through interruption of phosphatidylinositol pathway. ASH Annual Meeting Abstracts. Blood 2006;108:2102.
    • (2006) Blood , vol.108 , pp. 2102
    • Chanan-Khan, A.1
  • 69
    • 45149115902 scopus 로고    scopus 로고
    • Higher doses of lenalidomide are associated with unacceptable toxicity including life threatening tumor flare in patients with chronic lymphocytic leukemia
    • Andritsos L, Johnson AJ, Lozanski G, et al. Higher doses of lenalidomide are associated with unacceptable toxicity including life threatening tumor flare in patients with chronic lymphocytic leukemia. J Clin Oncol 2008;26:2519-25.
    • (2008) J Clin Oncol , vol.26 , pp. 2519-25
    • Andritsos, L.1    Johnson, A.J.2    Lozanski, G.3
  • 70
    • 58149399362 scopus 로고    scopus 로고
    • Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells
    • Lapalombella R, Yu B, Triantafillou G, et al. Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells. Blood 2008;112:5180-9.
    • (2008) Blood , vol.112 , pp. 5180-9
    • Lapalombella, R.1    Yu, B.2    Triantafillou, G.3
  • 71
    • 79951917839 scopus 로고    scopus 로고
    • Lenalidomide alone and in combination with rituximab enhances NK cell immune synapse formation in chronic lymphocytic leukemia (CLL) cells in vitro through activation of Rho and Rac1 GTPases. ASH Annual Meeting Abstracts
    • Gaidarova S, Li JW, Corral LG, et al. Lenalidomide alone and in combination with rituximab enhances NK cell immune synapse formation in chronic lymphocytic leukemia (CLL) cells in vitro through activation of Rho and Rac1 GTPases. ASH Annual Meeting Abstracts. Blood 2009;114:3441.
    • (2009) Blood , vol.114 , pp. 3441
    • Gaidarova, S.1    Li, J.W.2    Corral, L.G.3
  • 72
    • 60749120363 scopus 로고    scopus 로고
    • The humanized CD40 antibody SGN-40 demonstrates pre-clinical activity that is enhanced by lenalidomide in chronic lymphocytic leukaemia
    • Lapalombella R, Gowda A, Joshi T, et al. The humanized CD40 antibody SGN-40 demonstrates pre-clinical activity that is enhanced by lenalidomide in chronic lymphocytic leukaemia. Br J Haematol 2009;144:848-55.
    • (2009) Br J Haematol , vol.144 , pp. 848-55
    • Lapalombella, R.1    Gowda, A.2    Joshi, T.3
  • 73
    • 77950966887 scopus 로고    scopus 로고
    • Lenalidomide treatment promotes CD154 expression on CLL cells and enhances production of antibodies by normal B cells through a PI3-kinase dependent pathway
    • Lapalombella R, Andritsos L, Liu Q, et al. Lenalidomide treatment promotes CD154 expression on CLL cells and enhances production of antibodies by normal B cells through a PI3-kinase dependent pathway. Blood 2010;115:2619-29.
    • (2010) Blood , vol.115 , pp. 2619-29
    • Lapalombella, R.1    Andritsos, L.2    Liu, Q.3
  • 75
    • 70449483516 scopus 로고    scopus 로고
    • Clinical efficacy of lenalidomide in fludarabine-refractory chronic lymphocytic leukemia patients
    • Chanan-Khan A, Czuczman MS, Padmanabhan S, et al. Clinical efficacy of lenalidomide in fludarabine-refractory chronic lymphocytic leukemia patients. ASH Annual Meeting Abstracts. Blood 2007;110:3108.
    • (2007) ASH Annual Meeting Abstracts. Blood , vol.110 , pp. 3108
    • Chanan-Khan, A.1    Czuczman, M.S.2    Padmanabhan, S.3
  • 76
    • 74949083498 scopus 로고    scopus 로고
    • Efficacy of lenalidomide in patients with chronic lymphocytic leukemia with high-risk cytogenetics
    • Sher T, Miller KC, Lawrence D, et al. Efficacy of lenalidomide in patients with chronic lymphocytic leukemia with high-risk cytogenetics. Leuk Lymphoma 2010;51:85-8.
    • (2010) Leuk Lymphoma , vol.51 , pp. 85-8
    • Sher, T.1    Miller, K.C.2    Lawrence, D.3
  • 77
    • 73949145763 scopus 로고    scopus 로고
    • Lenalidomide oral monotherapy produces durable responses in relapsed or refractory indolent non-Hodgkin's Lymphoma
    • Witzig TE, Wiernik PH, Moore T, et al. Lenalidomide oral monotherapy produces durable responses in relapsed or refractory indolent non-Hodgkin's Lymphoma. J Clin Oncol 2009;27:5404-9.
    • (2009) J Clin Oncol , vol.27 , pp. 5404-9
    • Witzig, T.E.1    Wiernik, P.H.2    Moore, T.3
  • 79
    • 79951902839 scopus 로고    scopus 로고
    • Preliminary results of a Phase i study of lenalidomide in relapsed chronic lymphocytic leukemia. ASH Annual Meeting Abstracts
    • Maddocks K, Lapalombella R, Blum KA, et al. Preliminary results of a Phase I study of lenalidomide in relapsed chronic lymphocytic leukemia. ASH Annual Meeting Abstracts. Blood 2009;114:3446.
    • (2009) Blood , vol.114 , pp. 3446
    • Maddocks, K.1    Lapalombella, R.2    Blum, K.A.3
  • 80
    • 71649085254 scopus 로고    scopus 로고
    • Preliminary results of a phase 1/2, multi-center, open-label study (CLL-001) investigating a stepwise dose-escalation schedule of lenalidomide in relapsed or refractory chronic lymphocytic leukemia. ASH Annual Meeting Abstracts
    • Wendtner CM, Mahadevan D, Stilgenbauer S, et al. Preliminary results of a phase 1/2, multi-center, open-label study (CLL-001) investigating a stepwise dose-escalation schedule of lenalidomide in relapsed or refractory chronic lymphocytic leukemia. ASH Annual Meeting Abstracts. Blood 2008;112:2104.
    • (2008) Blood , vol.112 , pp. 2104
    • Wendtner, C.M.1    Mahadevan, D.2    Stilgenbauer, S.3
  • 81
    • 79951886217 scopus 로고    scopus 로고
    • A phase II trial of pulse dosing lenalidomide: 3 weeks on 3 weeks off in previously treated chronic lymphocytic leukemia/ small lymphocytic lymphoma. ASH Annual Meeting Abstracts
    • Aue G, Soto S, Valdez J, et al. A phase II trial of pulse dosing lenalidomide: 3 weeks on 3 weeks off in previously treated chronic lymphocytic leukemia/ small lymphocytic lymphoma. ASH Annual Meeting Abstracts. Blood 2009;114:3427.
    • (2009) Blood , vol.114 , pp. 3427
    • Aue, G.1    Soto, S.2    Valdez, J.3
  • 82
    • 77955465251 scopus 로고    scopus 로고
    • Safety and efficacy of slow dose escalation of lenalidomide for frontline treatment in chronic lymphocytic leukemia (CLL) - Results of a phase II study
    • Chen CI, Paul H, Xu W, et al. Safety and efficacy of slow dose escalation of lenalidomide for frontline treatment in chronic lymphocytic leukemia (CLL) - results of a phase II study. Haematologica 2009;94:S93.
    • (2009) Haematologica , vol.94
    • Chen, C.I.1    Paul, H.2    Xu, W.3
  • 83
    • 77955447636 scopus 로고    scopus 로고
    • Experience with lenalidomide as initial treatment of elderly patients with chronic lymphocytic leukemia
    • Badoux XC, Wierda WG, O'Brien SM, et al. Experience with lenalidomide as initial treatment of elderly patients with chronic lymphocytic leukemia. Haematologica 2009;94:S93.
    • (2009) Haematologica , vol.94
    • Badoux, X.C.1    Wierda, W.G.2    O'Brien, S.M.3
  • 84
    • 77954096721 scopus 로고    scopus 로고
    • Lenalidomide therapy is associated with normalization of lymphocyte populations and increase in immunoglobulin levels in elderly patients with chronic lymphocytic leukemia
    • Badoux XC, Reuben J, Lee B, et al. Lenalidomide therapy is associated with normalization of lymphocyte populations and increase in immunoglobulin levels in elderly patients with chronic lymphocytic leukemia. Haematologica 2009;94:S94.
    • (2009) Haematologica , vol.94
    • Badoux, X.C.1    Reuben, J.2    Lee, B.3
  • 85
    • 79951909612 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia/nurse-like cells interactions: Release of soluble factor(s) that inhibit rituximab-dependent normal B cell depletion, and reversion by lenalidomide
    • Guegan JP, Quillet-Mary A, Laurent G, et al. Chronic lymphocytic leukemia/nurse-like cells interactions: release of soluble factor(s) that inhibit rituximab-dependent normal B cell depletion, and reversion by lenalidomide. Haematologica 2009;94:S28.
    • (2009) Haematologica , vol.94
    • Guegan, J.P.1    Quillet-Mary, A.2    Laurent, G.3
  • 86
    • 78149466993 scopus 로고    scopus 로고
    • A phase i study of lenalidomide in combination with fludarabine and rituximab in previously untreated CLL/SLL
    • Brown JR, Abramson JS, Hochberg EP, et al. A phase I study of lenalidomide in combination with fludarabine and rituximab in previously untreated CLL/SLL. Leukemia 2010;24:1972-5.
    • (2010) Leukemia , vol.24 , pp. 1972-5
    • Brown, J.R.1    Abramson, J.S.2    Hochberg, E.P.3
  • 87
    • 77955451515 scopus 로고    scopus 로고
    • A phase i study of lenalidomide in combination with fludarabine and rituximab in previously untreated CLL/SLL
    • Brown JR, Abramson JS, Hochberg EP, et al. A phase I study of lenalidomide in combination with fludarabine and rituximab in previously untreated CLL/SLL. Haematologica 2009;94:S86.
    • (2009) Haematologica , vol.94
    • Brown, J.R.1    Abramson, J.S.2    Hochberg, E.P.3
  • 88
    • 77956218553 scopus 로고    scopus 로고
    • The REVLIRIT CLL5 AGMT study - A phase I/II trial combining fludarabine/ rituximab with escalating doses of lenalidomide followed by rituximab/ lenalidomide in untreated CLL: Results of a planned interim analysis. ASH Annual Meeting Abstracts
    • Egle A, Steurer M, Melchardt T, et al. The REVLIRIT CLL5 AGMT study - a phase I/II trial combining fludarabine/ rituximab with escalating doses of lenalidomide followed by rituximab/ lenalidomide in untreated CLL: results of a planned interim analysis. ASH Annual Meeting Abstracts. Blood 2009;114:3453.
    • (2009) Blood , vol.114 , pp. 3453
    • Egle, A.1    Steurer, M.2    Melchardt, T.3
  • 89
    • 76149124676 scopus 로고    scopus 로고
    • Combination therapy with lenalidomide and rituximab in patients with relapsed chronic lymphocytic leukemia (CLL)
    • Ferrajoli A, Badoux XC, O'Brien S, et al. Combination therapy with lenalidomide and rituximab in patients with relapsed chronic lymphocytic leukemia (CLL). ASH Annual Meeting Abstracts. Blood 2009;114:206.
    • (2009) ASH Annual Meeting Abstracts. Blood , vol.114 , pp. 206
    • Ferrajoli, A.1    Badoux, X.C.2    O'Brien, S.3
  • 90
    • 79951895363 scopus 로고    scopus 로고
    • Phase II study of lenalidomide in combination with rituximab for patients with CD5+/CD20+ hematologic malignancies who relapse or progress after rituximab. Interim analysis. ASH Annual Meeting Abstracts
    • Veliz M, Santana R, Lancet JE, et al. Phase II study of lenalidomide in combination with rituximab for patients with CD5+/CD20+ hematologic malignancies who relapse or progress after rituximab. Interim analysis. ASH Annual Meeting Abstracts. Blood 2009;114:2376.
    • (2009) Blood , vol.114 , pp. 2376
    • Veliz, M.1    Santana, R.2    Lancet, J.E.3
  • 91
    • 70349638578 scopus 로고    scopus 로고
    • Lenalidomide associated tumor flare reaction correlates with clinical response in patients with relapsed or refractory B-cell chronic lymphocytic leukemia (CLL) [abstract 0928]
    • Sher T, Miller K, Patel M, et al. Lenalidomide associated tumor flare reaction correlates with clinical response in patients with relapsed or refractory B-cell chronic lymphocytic leukemia (CLL) [abstract 0928]. Haematologica 2009;94(Suppl 2):373.
    • (2009) Haematologica , vol.94 , Issue.SUPPL. 2 , pp. 373
    • Sher, T.1    Miller, K.2    Patel, M.3
  • 92
    • 73849140334 scopus 로고    scopus 로고
    • Lenalidomide induced cytokine release syndrome in chronic lymphocytic leukemia (CLL): Clinical and laboratory correlates of immune activation. ASH Annual Meeting Abstracts
    • Aue G, Njuguna N, Tian X, et al. Lenalidomide induced cytokine release syndrome in chronic lymphocytic leukemia (CLL): clinical and laboratory correlates of immune activation. ASH Annual Meeting Abstracts. Blood 2008;112:2099.
    • (2008) Blood , vol.112 , pp. 2099
    • Aue, G.1    Njuguna, N.2    Tian, X.3
  • 93
    • 79951925287 scopus 로고    scopus 로고
    • Lenalidomide administered for the initial treatment of CLL patients - In vivo modulation of the leukemia cell surface phenotype and association with tumor flare reaction (TFR)
    • ASH Annual Meeting Abstracts
    • James D, Avery ED, Zhang L, et al. Lenalidomide administered for the initial treatment of CLL patients - in vivo modulation of the leukemia cell surface phenotype and association with tumor flare reaction (TFR). ASH Annual Meeting Abstracts. Blood 2009;114:3440.
    • (2009) Blood , vol.114 , pp. 3440
    • James, D.1    Avery, E.D.2    Zhang, L.3
  • 94
    • 79951887102 scopus 로고    scopus 로고
    • Increased incidence of thrombosis with lenalidomide in chronic lymphocytic leukemia: Effect of lenalidomide on inflammation, endothelial cell damage and coagulation. ASH Annual Meeting Abstracts
    • Aue G, Lozier JN, Cullinane AM, et al. Increased incidence of thrombosis with lenalidomide in chronic lymphocytic leukemia: effect of lenalidomide on inflammation, endothelial cell damage and coagulation. ASH Annual Meeting Abstracts. Blood 2009;114:455.
    • (2009) Blood , vol.114 , pp. 455
    • Aue, G.1    Lozier, J.N.2    Cullinane, A.M.3
  • 95
    • 79951900724 scopus 로고    scopus 로고
    • Prophylaxis of venous thromboembolism using weight-adjusted low-dose warfarin sodium in chronic lymphocytic leukemia (CLL) patients treated with immunomodulatory drugs (IMiDs)
    • Miller KC, Depaolo D, Padmanabhan S, et al. Prophylaxis of venous thromboembolism using weight-adjusted low-dose warfarin sodium in chronic lymphocytic leukemia (CLL) patients treated with immunomodulatory drugs (IMiDs). Leuk Lymphoma 2007;48(Suppl 1):131
    • (2007) Leuk Lymphoma , vol.48 , Issue.SUPPL. 1 , pp. 131
    • Miller, K.C.1    Depaolo, D.2    Padmanabhan, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.