Lactone form 3-hydroxy-3-methylglutaryl-coenzymeA reductase inhibitors (statins) stimulate the osteoblastic differentiation of mouse periodontal ligament cells via the ERK pathway

Journal of Periodontal Research

Volumn 46, Issue 2, 2011, Pages 204-213

  Kim, I S ^a   Jeong, B C ^a   Kim, O S ^a   Kim, Y J ^a   Lee, S E ^a   Lee, K N ^a   Koh, J T ^a   Chung, H J ^a  

^a Chonnam National University   (South Korea)

Author keywords

ERK; Lovastatin; Osteoblastic differentiation; Periodontal ligament cells; Simvastatin

Indexed keywords

1,3 BUTADIENE DERIVATIVE; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ALIZARIN RED S; ALKALINE PHOSPHATASE; ANTHRAQUINONE DERIVATIVE; BMP2 PROTEIN, MOUSE; BONE MORPHOGENETIC PROTEIN 2; BONE SIALOPROTEIN; COLORING AGENT; DIAGNOSTIC AGENT; ENZYME INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; NITRILE; OSTEOCALCIN; SIMVASTATIN;

ANIMAL; ARTICLE; BONE MINERALIZATION; CELL DIFFERENTIATION; CELL LINE; CELL SURVIVAL; COMPARATIVE STUDY; CULTURE TECHNIQUE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; MOUSE; OSTEOBLAST; PERIODONTAL LIGAMENT; PROMOTER REGION; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

ALKALINE PHOSPHATASE; ANIMALS; ANTHRAQUINONES; BLOTTING, WESTERN; BONE MORPHOGENETIC PROTEIN 2; BUTADIENES; CALCIFICATION, PHYSIOLOGIC; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL LINE; CELL SURVIVAL; COLORING AGENTS; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INTEGRIN-BINDING SIALOPROTEIN; LOVASTATIN; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; NITRILES; OSTEOBLASTS; OSTEOCALCIN; PERIODONTAL LIGAMENT; PROMOTER REGIONS, GENETIC; SIMVASTATIN; TRANSCRIPTIONAL ACTIVATION;

EID: 79951860576     PISSN: 00223484     EISSN: 16000765     Source Type: Journal    
DOI: 10.1111/j.1600-0765.2010.01329.x     Document Type: Article

References (31)

1. Sodek J, McKee MD. Molecular and cellular biology of alveolar bone. Periodontol 2000 2000;24:99-126.
2. Lekic P, McCulloch C. Periodontal ligament cell population: the central role of fibroblasts in creating a unique tissue. Anat Rec 2004;245:327-341.
3. Melcher AH. On the repair potential of periodontal tissues. J Periodontol 1976;47:256-260.
4. Zhang D, Yang YQ, Li XT, Fu MK. The expression of osteoprotegerin and the receptor activator of nuclear factor kappa B ligand in human periodontal ligament cells cultured with and without 1alpha, 25-dihydroxyvitamin D3. Arch Oral Biol 2004;49:71-76.
5. Mundy G, Garrett R, Harris S et al. Stimulation of bone formation in vitro and in rodents by statins. Science 1999;286:1946-1949.
6. Sugiyama M, Kodama T, Konishi K, Abe K, Asami S, Oikawa S. Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells. Biochem Biophys Res Commun 2000;271:688-692.
7. Ohnaka K, Shimoda S, Nawata H et al. Pitavastatin enhanced BMP-2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts. Biochem Biophys Res Commun 2001;287:337-342.
8. Parhami F, Mody N, Gharavi N, Ballard AJ, Tintut Y, Demer LL. Role of the cholesterol biosynthetic pathway in osteoblastic differentiation of marrow stromal cells. J Bone Miner Res 2002;17:1997-2003.
9. Thylin MR, McConnell JC, Schmid MJ et al. Effects of simvastatin gels on murine calvarial bone. J Periodontol 2002;73:1141-1148.
10. Wong RW, Rabie AB. Early healing pattern of statin-induced osteogenesis. Br J Oral Maxillofac Surg 2005;43:46-50.
11. Sugiyama T, Nakagawa T, Sato C et al. Subcutaneous administration of lactone form of simvastatin stimulates ectopic osteoinduction by rhBMP-2. Oral Dis 2007;13:228-233.
12. D'Errico JA, Ouyang H, Berry JE et al. Immortalized cementoblasts and periodontal ligament cells in culture. Bone 1999;25:39-47.
13. Pitaru S, Pritzki A, Bar-Kana I, Grosskopf A, Savion N, Narayanan AS. Bone morphogenetic protein 2 induces the expression of cementum attachment protein in human periodontal ligament clones. Connect Tissue Res 2002;43:257-264.
14. Nakamura T, Yamamoto M, Tamura M, Izumi Y. Effects of growth/differentiation factor-5 on human periodontal ligament cells. J Periodontal Res 2003;38:597-605.
15. Basdra EK, Komposch G. Osteoblast-like properties of human periodontal ligament cells: an in vitro analysis. Eur J Orthod 1997;19:615-621.
16. Zhou Y, Hutmacher DW, Sae-Lim V, Zhou Z, Woodruff M, Lim TM. Osteogenic and adipogenic induction potential of human periodontal cells. J Periodontol 2008;79:525-534.
17. Ruiz-Gaspa S, Nogues X, Enjuanes A et al. Simvastatin and atorvastatin enhance gene expression of collagen type 1 and osteocalcin in primary human osteoblasts and MG-63 cultures. J Cell Biochem 2007;101:1430-1438.
18. Aubin J, Heersche J. Osteoprogenitor cell differentiation to mature bone-forming osteoblasts. Drug Dev Res 2000;49:206-215.
19. Mundy GR. Statins and their potential for osteoporosis. Bone 2001;29:495-497.
20. Franceschi RT, Ge C, Xiao G, Roca H, Jiang D. Transcriptional regulation of osteoblasts. Ann N Y Acad Sci 2007;1116:196-207.
21. Lai CF, Chaudhary L, Fausto A et al. Erk is essential for growth, differentiation, integrin expression, and cell function in human osteoblastic cells. J Biol Chem 2001;276:14443-14450.
22. Mukherjee A, Rotwein P. Akt promotes BMP2-mediated osteoblast differentiation and bone development. J Cell Sci 2009;122:716-726.
23. Ghosh-Choudhury N, Mandal CC, Choudhury GG. Statin-induced Ras activation integrates the phosphatidylinositol 3-kinase signal to Akt and MAPK for bone morphogenetic protein-2 expression in osteoblast differentiation. J Biol Chem 2007;282:4983-4993.
24. Mimori K, Komaki M, Iwasaki K, Ishikawa I. Extracellular signal-regulated kinase 1/2 is involved in ascorbic acid-induced osteoblastic differentiation in periodontal ligament cells. J Periodontol 2007;78:328-334.
25. Chambard JC, Lefloch R, Pouyssegur J, Lenormand P. ERK implication in cell cycle regulation. Biochim Biophys Acta 2007;1773:1299-1310.
26. van Vliet AK, Negre-Aminou P, van Thiel GC, Bolhuis PA, Cohen LH. Action of lovastatin, simvastatin, and pravastatin on sterol synthesis and their antiproliferative effect in cultured myoblasts from human striated muscle. Biochem Pharmacol 1996;52:1387-1392.
27. Negre-Aminou P, van Vliet AK, van Erck M, van Thiel GC, van Leeuwen RE, Cohen LH. Inhibition of proliferation of human smooth muscle cells by various HMG-CoA reductase inhibitors; comparison with other human cell types. Biochim Biophys Acta 1997;1345:259-268.
28. Axel DI, Riessen R, Runge H, Viebahn R, Karsch KR. Effects of cerivastatin on human arterial smooth muscle cell proliferation and migration in transfilter cocultures. J Cardiovasc Pharmacol 2000;35:619-629.
29. Vincent L, Chen W, Hong L et al. Inhibition of endothelial cell migration by cerivastatin, an HMG-CoA reductase inhibitor: contribution to its anti-angiogenic effect. FEBS Lett 2001;495:159-166.
30. Yazawa H, Zimmermann B, Asami Y, Bernimoulin JP. Simvastatin promotes cell metabolism, proliferation, and osteoblastic differentiation in human periodontal ligament cells. J Periodontol 2005;76:295-302.
31. Fu L, Tang T, Miao Y, Zhang S, Qu Z, Dai K. Stimulation of osteogenic differentiation and inhibition of adipogenic differentiation in bone marrow stromal cells by alendronate via ERK and JNK activation. Bone 2008;43:40-47.