Complex effects of drug/silicate ratio, solid-state equivalent pH, and moisture on chemical stability of amorphous quinapril hydrochloride coground with silicates

Journal of Pharmaceutical Sciences

Volumn 100, Issue 4, 2011, Pages 1503-1515

  Hailu, Shumet A ^a,b   Bogner, Robin H ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

RH; Amorphous; Chemical stability; Cogrinding; Drug silicate ratio; Milling; Moisture; Neusilin; Quinapril hydrochloride; Relative humidity; Silicates; Stability; Stabilization; Surface acidity

Indexed keywords

DICARBOXYLIC ACID; NEUSILIN FL2; NEUSILIN US2; PIPERAZINEDIONE; QUINAPRIL; SILICATE; UNCLASSIFIED DRUG; ANTIHYPERTENSIVE AGENT; MAGNESIUM; TETRAHYDROISOQUINOLINE DERIVATIVE;

ACIDITY; ARTICLE; COMPLEX FORMATION; CYCLIZATION; DRUG ADSORPTION; DRUG FORMULATION; DRUG MANUFACTURE; DRUG PACKAGING; DRUG STABILITY; DRUG STRUCTURE; INFRARED SPECTROSCOPY; IONIZATION; MOISTURE; PH; SOLID STATE; SURFACE PROPERTY; X RAY DIFFRACTION; CHEMISTRY; HUMIDITY; MEDICINAL CHEMISTRY;

ANTIHYPERTENSIVE AGENTS; CHEMISTRY, PHARMACEUTICAL; DRUG STABILITY; HUMIDITY; HYDROGEN-ION CONCENTRATION; MAGNESIUM; SILICATES; TETRAHYDROISOQUINOLINES;

EID: 79951859183     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22387     Document Type: Article

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