Cholesterol regulates VEGFR-1 (FLT-1) expression and signaling in acute leukemia cells

Molecular Cancer Research

Volumn 9, Issue 2, 2011, Pages 215-224

  Casalou, Cristina ^a,b,c   Costa, Ana ^a,b,c   Carvalho, Tânia ^a,b,c   Gomes, Ana L ^a,b,c   Zhu, Zhenping ^d   Wu, Yan ^d   Dias, Sérgio ^a,b,c  

^a INSTITUTO PORTUGUÊS DE ONCOLOGIA DE LISBOA FRANCISCO GENTIL   (Portugal)

^b INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

^c NOVA MEDICAL SCHOOL   (Portugal)

^d ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAVEOLIN 1; CHOLESTEROL; METHYL BETA CYCLODEXTRIN; NYSTATIN; PLACENTAL GROWTH FACTOR; VASCULOTROPIN RECEPTOR 1;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; ANIMAL TISSUE; ARTICLE; BONE MARROW; CELL MIGRATION; CELL VIABILITY; CHEMOTAXIS; DISEASE COURSE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LEUKEMIA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SEVERE COMBINED IMMUNODEFICIENCY; SIGNAL TRANSDUCTION; XENOGRAFT;

ADULT; ANIMALS; BONE MARROW CELLS; CAVEOLIN 1; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; CHILD; CHOLESTEROL; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; LEUKEMIA, MYELOID, ACUTE; MEMBRANE MICRODOMAINS; MICE; PREGNANCY PROTEINS; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TUMOR MICROENVIRONMENT; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

MUS;

EID: 79951847932     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-10-0155     Document Type: Article

References (20)

1. Hicklin DJ, Ellis LM. Role of vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 2005;23:1011-27. (Pubitemid 46202320)
2. Casalou C, Fragoso R, Nunes JFM, Dias S. VEGF/PLGF induces leukemia cell migration via P38/ERK1/2 kinase pathway, resulting in Rho GTPases activation and caveolae formation. Leukemia 2007;21:1590-4. (Pubitemid 46965311)
3. Fragoso R, Elias AP, Dias S. Autocrine VEGF loops, signaling pathways, and acute leukemia regulation. Leuk Lymphoma 2007;48:481-8. (Pubitemid 46487754)
4. Fragoso R, Pereira T, Wu Y, Zhu Z, Cabeçadas J, Dias S. VEGFR-1 (FLT-1) activation modulates acute lymphoblastic leukemia localization and survival within the bone marrow, determining the onset of extramedullary disease. Blood 2006;107:1608-16. (Pubitemid 43245539)
5. Patra SK. Dissecting lipid raft facilitated cell signaling pathways in cancer. Biochem Biophys Acta 2008;1785:182-206.
6. Labrecque L, Royal I, Surprenant DS, Patterson C, Gingras D, Beβliveau R. Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol. Mol Biol Cell 2003;14:334-47. (Pubitemid 36106041)
7. Hamada T, Mohle R, Hesselgesser J, Hoxie J, Nachman RL, Moore MA, Rafii S, et al. Transendothelial migration of megakaryocytes in response to stromal cell-derived factors (SDF-1) enhances platelet production. J EXP Med 1998:188:539-48. (Pubitemid 28369143)
8. Greenspan P, Fowler SD. Spectrofluorometric studies of the lipid probe, Nile Red. J Lipid Res 1985;26:781-9. (Pubitemid 15046441)
9. Santos SC, Dias S. Internal and external autocrine VEGF/KDR loops regulate survival of subsets of acute leukemia through distinct signaling pathways. Blood 2004;103:3883-9. (Pubitemid 38596309)
10. Diaz G, Melis M, Batetta B, Angius F, Falchi AM. Hydrophobic characterization of intracellular lipids in situ by Nile Red/Yellow emission ratio. Micron 2008;39:819-24.
11. Morishita K, Johnson DE, Williams LT. A novel promoter for vascular endothelial growth factor receptor (flt-1) that confers endothelial-specific gene expression. J Bio Chem 1995;270:27948-53.
12. Colmone A, Amorim M, Pontier AL, Wang S, Jacblonski E, Sipkins DA. Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells. Science 2008;322:1861-5.
13. Peled A, Kollet O, Ponomaryov T, Petit I, Franitza S, Grabovsky V, et al. The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice. Blood 2000;95:3289-96.
14. Kijowski J, Baj-Krzyworzeka M, Majka M, Reca R, Marquez LA, Christofidou-Solomidou M, et al. The SDF-1-CXCR4 axis stimulates VEGF secretion and activates integrins but does not affect proliferation and survival in lymphohematopoietic cells. Stem Cells 2001;19:453-66. (Pubitemid 32900088)
15. Hidalgo A, Sanz-Rodriguez F, Rodriguez-Fernandez JL, Albella B, Blaya C, Wright N, et al. Chemokine stromal cell-derived factor-1alpha modulates VLA-4 integrin-dependent adhesion to fibronectin and VCAM-1 on bone marrow hematopoietic progenitor cells. Exp Hematol 2001;29:345-55. (Pubitemid 32220127)
16. Gomes AL, Carvalho T, Serpa J, Torre C, Dias S. Hypercholesterolemia promotes bone marrow cell mobilization by perturbing the SDF-1:CXCR4 axis. Blood 2010. [Epub ahead of print].
17. Li HY, Appelbaum FR, Willman CL, Zager RA, Banker DE. Cholesterol-modulating agents kill acute myeloid leukemia cells and sensitize them to therapeutics by blocking adaptive cholesterol responses. Blood 2003;101:3628-34. (Pubitemid 36857952)
18. Banker DE, Mayer SJ, Li HY, Willman CL, Appelbaum FR, Zager RA. Cholesterol synthesis and import contribute to protective cholesterol increments in acute myeloid leukemia cells. Blood 2004;104:1816-24. (Pubitemid 39202292)
19. Sassano A, Katsoulidis E, Antico G, Altman JK, Redig AJ, Minucci S, et al. Suppressive effects of statins on acute promyelocytic leukemia cells. Cancer Res 2007;67:4524-32. (Pubitemid 46815104)
20. Kornblau SM, Banker DE, Stirewalt D, Shen D, Lemker E, Verstovsek S, et al. Blockade of adaptive defensive changes in cholesterol uptake and synthesis in AML by the addition of pravastatin to idarubicin + high-dose Ara-C: a phase 1 study. Blood 2007;109:2999-3006. (Pubitemid 46482100)