메뉴 건너뛰기




Volumn 186, Issue 4, 2011, Pages 2238-2244

Regulatory T cells more effectively suppress Th1-induced airway inflammation compared with Th2

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP;

EID: 79951843072     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1002027     Document Type: Article
Times cited : (30)

References (49)
  • 2
    • 0030689729 scopus 로고    scopus 로고
    • Induction of airway mucus production by T helper 2 (Th2) cells: A critical role for interleukin 4 in cell recruitment but not mucus production
    • Cohn, L., R. J. Homer, A. Marinov, J. Rankin, and K. Bottomly. 1997. Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production. J. Exp. Med. 186: 1737-1747.
    • (1997) J. Exp. Med. , vol.186 , pp. 1737-1747
    • Cohn, L.1    Homer, R.J.2    Marinov, A.3    Rankin, J.4    Bottomly, K.5
  • 3
    • 5644221318 scopus 로고    scopus 로고
    • Insights into the pathogenesis of asthma utilizing murine models
    • Taube, C., A. Dakhama, and E. W. Gelfand. 2004. Insights into the pathogenesis of asthma utilizing murine models. Int. Arch. Allergy Immunol. 135: 173-186.
    • (2004) Int. Arch. Allergy Immunol. , vol.135 , pp. 173-186
    • Taube, C.1    Dakhama, A.2    Gelfand, E.W.3
  • 4
    • 33747756534 scopus 로고    scopus 로고
    • Asthma: Defining of the persistent adult phenotypes
    • DOI 10.1016/S0140-6736(06)69290-8, PII S0140673606692908
    • Wenzel, S. E. 2006. Asthma: defining of the persistent adult phenotypes. Lancet 368: 804-813. (Pubitemid 44279058)
    • (2006) Lancet , vol.368 , Issue.9537 , pp. 804-813
    • Wenzel, S.E.1
  • 5
    • 33645059692 scopus 로고    scopus 로고
    • Evaluation of airway inflammation by quantitative Th1/Th2 cytokine mRNA measurement in sputum of asthma patients
    • Truyen, E., L. Coteur, E. Dilissen, L. Overbergh, L. J. Dupont, J. L. Ceuppens, and D. M. Bullens. 2006. Evaluation of airway inflammation by quantitative Th1/Th2 cytokine mRNA measurement in sputum of asthma patients. Thorax 61: 202-208.
    • (2006) Thorax , vol.61 , pp. 202-208
    • Truyen, E.1    Coteur, L.2    Dilissen, E.3    Overbergh, L.4    Dupont, L.J.5    Ceuppens, J.L.6    Bullens, D.M.7
  • 7
    • 0033557718 scopus 로고    scopus 로고
    • Modulation of airway inflammation by passive transfer of allergen-specific Th1 and Th2 cells in a mouse model of asthma
    • Randolph, D. A., C. J. Carruthers, S. J. Szabo, K. M. Murphy, and D. D. Chaplin. 1999. Modulation of airway inflammation by passive transfer of allergen-specific Th1 and Th2 cells in a mouse model of asthma. J. Immunol. 162: 2375-2383.
    • (1999) J. Immunol. , vol.162 , pp. 2375-2383
    • Randolph, D.A.1    Carruthers, C.J.2    Szabo, S.J.3    Murphy, K.M.4    Chaplin, D.D.5
  • 9
    • 0027496775 scopus 로고
    • Inhibition of antigen-induced bronchoconstriction and eosinophil infiltration in the guinea pig by the cyclic AMP-specific phosphodiesterase inhibitor, rolipram
    • Underwood, D. C., R. R. Osborn, L. B. Novak, J. K. Matthews, S. J. Newsholme, B. J. Undem, J. M. Hand, and T. J. Torphy. 1993. Inhibition of antigen-induced bronchoconstriction and eosinophil infiltration in the guinea pig by the cyclic AMP-specific phosphodiesterase inhibitor, rolipram. J. Pharmacol. Exp. Ther. 266: 306-313.
    • (1993) J. Pharmacol. Exp. Ther. , vol.266 , pp. 306-313
    • Underwood, D.C.1    Osborn, R.R.2    Novak, L.B.3    Matthews, J.K.4    Newsholme, S.J.5    Undem, B.J.6    Hand, J.M.7    Torphy, T.J.8
  • 10
    • 0031036056 scopus 로고    scopus 로고
    • Effects of inhibitors of phosphodiesterase, on antigen-induced bronchial hyperreactivity in conscious sensitized guinea-pigs and airway leukocyte infiltration
    • Danahay, H., and K. J. Broadley. 1997. Effects of inhibitors of phosphodiesterase, on antigen-induced bronchial hyperreactivity in conscious sensitized guinea-pigs and airway leukocyte infiltration. Br. J. Pharmacol. 120: 289-297.
    • (1997) Br. J. Pharmacol. , vol.120 , pp. 289-297
    • Danahay, H.1    Broadley, K.J.2
  • 11
    • 0028231180 scopus 로고
    • Effects of rolipram on responses to acute and chronic antigen exposure in monkeys
    • Turner, C. R., C. J. Andresen, W. B. Smith, and J. W. Watson. 1994. Effects of rolipram on responses to acute and chronic antigen exposure in monkeys. Am. J. Respir. Crit. Care Med. 149: 1153-1159.
    • (1994) Am. J. Respir. Crit. Care Med. , vol.149 , pp. 1153-1159
    • Turner, C.R.1    Andresen, C.J.2    Smith, W.B.3    Watson, J.W.4
  • 12
    • 0035155146 scopus 로고    scopus 로고
    • Inhibition of phosphodiesterase 4 attenuates airway hyperresponsiveness and airway inflammation in a model of secondary allergen challenge
    • Kanehiro, A., T. Ikemura, M. J. Mäkelä, M. Lahn, A. Joetham, A. Dakhama, and E. W. Gelfand. 2001. Inhibition of phosphodiesterase 4 attenuates airway hyperresponsiveness and airway inflammation in a model of secondary allergen challenge. Am. J. Respir. Crit. Care Med. 163: 173-184.
    • (2001) Am. J. Respir. Crit. Care Med. , vol.163 , pp. 173-184
    • Kanehiro, A.1    Ikemura, T.2    Mäkelä, M.J.3    Lahn, M.4    Joetham, A.5    Dakhama, A.6    Gelfand, E.W.7
  • 14
    • 0021875276 scopus 로고
    • Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1
    • Ohara, J., and W. E. Paul. 1985. Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1. Nature 315: 333-336.
    • (1985) Nature , vol.315 , pp. 333-336
    • Ohara, J.1    Paul, W.E.2
  • 16
    • 0026649765 scopus 로고
    • Identification and distribution of the costimulatory receptor CD28 in the mouse
    • Gross, J. A., E. Callas, and J. P. Allison. 1992. Identification and distribution of the costimulatory receptor CD28 in the mouse. J. Immunol. 149: 380-388.
    • (1992) J. Immunol. , vol.149 , pp. 380-388
    • Gross, J.A.1    Callas, E.2    Allison, J.P.3
  • 17
    • 0023622458 scopus 로고
    • Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies
    • Cherwinski, H. M., J. H. Schumacher, K. D. Brown, and T. R. Mosmann. 1987. Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. J. Exp. Med. 166: 1229-1244.
    • (1987) J. Exp. Med. , vol.166 , pp. 1229-1244
    • Cherwinski, H.M.1    Schumacher, J.H.2    Brown, K.D.3    Mosmann, T.R.4
  • 19
    • 77951638740 scopus 로고    scopus 로고
    • Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells
    • Thornton, A. M., P. E. Korty, D. Q. Tran, E. A. Wohlfert, P. E. Murray, Y. Belkaid, and E. M. Shevach. 2010. Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J. Immunol. 184: 3433-3441.
    • (2010) J. Immunol. , vol.184 , pp. 3433-3441
    • Thornton, A.M.1    Korty, P.E.2    Tran, D.Q.3    Wohlfert, E.A.4    Murray, P.E.5    Belkaid, Y.6    Shevach, E.M.7
  • 20
    • 0026611676 scopus 로고
    • Strategies of anti-cytokine monoclonal antibody development: Immunoassay of IL-10 and IL-5 in clinical samples
    • Abrams, J. S., M. G. Roncarolo, H. Yssel, U. Andersson, G. J. Gleich, and J. E. Silver. 1992. Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. Immunol. Rev. 127: 5-24.
    • (1992) Immunol. Rev. , vol.127 , pp. 5-24
    • Abrams, J.S.1    Roncarolo, M.G.2    Yssel, H.3    Andersson, U.4    Gleich, G.J.5    Silver, J.E.6
  • 23
    • 0032828226 scopus 로고    scopus 로고
    • The failure of STAT6-deficient mice to develop airway eosinophilia and airway hyperresponsiveness is overcome by interleukin-5
    • Tomkinson, A., A. Kanehiro, N. Rabinovitch, A. Joetham, G. Cieslewicz, and E. W. Gelfand. 1999. The failure of STAT6-deficient mice to develop airway eosinophilia and airway hyperresponsiveness is overcome by interleukin-5. Am. J. Respir. Crit. Care Med. 160: 1283-1291.
    • (1999) Am. J. Respir. Crit. Care Med. , vol.160 , pp. 1283-1291
    • Tomkinson, A.1    Kanehiro, A.2    Rabinovitch, N.3    Joetham, A.4    Cieslewicz, G.5    Gelfand, E.W.6
  • 24
    • 0036256471 scopus 로고    scopus 로고
    • Adoptive transfer of T cells induces airway hyperresponsiveness independently of airway eosinophilia but in a signal transducer and activator of transcription 6-dependent manner
    • Tomkinson, A., C. Duez, M. Lahn, and E. W. Gelfand. 2002. Adoptive transfer of T cells induces airway hyperresponsiveness independently of airway eosinophilia but in a signal transducer and activator of transcription 6-dependent manner. J. Allergy Clin. Immunol. 109: 810-816.
    • (2002) J. Allergy Clin. Immunol. , vol.109 , pp. 810-816
    • Tomkinson, A.1    Duez, C.2    Lahn, M.3    Gelfand, E.W.4
  • 26
    • 0029847368 scopus 로고    scopus 로고
    • Functional diversity of helper T lymphocytes
    • DOI 10.1038/383787a0
    • Abbas, A. K., K. M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature 383: 787-793. (Pubitemid 26372655)
    • (1996) Nature , vol.383 , Issue.6603 , pp. 787-793
    • Abbas, A.K.1    Murphy, K.M.2    Sher, A.3
  • 28
    • 0028821825 scopus 로고
    • Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice
    • Gavett, S. H., D. J.O'Hearn, X.Li, S. K.Huang, F. D. Finkelman, and M.Wills-Karp. 1995. Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. J. Exp. Med. 182: 1527-1536.
    • (1995) J. Exp. Med. , vol.182 , pp. 1527-1536
    • Gavett, S.H.1    O'Hearn, D.J.2    Li, X.3    Huang, S.L.4    Finkelman, F.D.5    Wills-Karp, M.6
  • 30
    • 34247485053 scopus 로고    scopus 로고
    • Noneosinophilic asthma: A distinct clinical and pathologic phenotype
    • Haldar, P., and I. D. Pavord. 2007. Noneosinophilic asthma: a distinct clinical and pathologic phenotype. J. Allergy Clin. Immunol. 119: 1043-1052.
    • (2007) J. Allergy Clin. Immunol. , vol.119 , pp. 1043-1052
    • Haldar, P.1    Pavord, I.D.2
  • 31
    • 0032945548 scopus 로고    scopus 로고
    • Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation
    • Hansen, G., G. Berry, R. H. DeKruyff, and D. T. Umetsu. 1999. Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J. Clin. Invest. 103: 175-183.
    • (1999) J. Clin. Invest. , vol.103 , pp. 175-183
    • Hansen, G.1    Berry, G.2    DeKruyff, R.H.3    Umetsu, D.T.4
  • 32
    • 77949511131 scopus 로고    scopus 로고
    • Allergen challenge induces Ifng dependent GTPases in the lungs as part of a Th1 transcriptome response in a murine model of allergic asthma
    • Dharajiya, N., S. Vaidya, M. Sinha, B. Luxon, I. Boldogh, and S. Sur. 2009. Allergen challenge induces Ifng dependent GTPases in the lungs as part of a Th1 transcriptome response in a murine model of allergic asthma. PLoS ONE 4: e8172.
    • (2009) PLoS ONE , vol.4
    • Dharajiya, N.1    Vaidya, S.2    Sinha, M.3    Luxon, B.4    Boldogh, I.5    Sur, S.6
  • 33
    • 0033135134 scopus 로고    scopus 로고
    • Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma
    • Sampath, D., M. Castro, D. C. Look, and M. J. Holtzman. 1999. Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma. J. Clin. Invest. 103: 1353-1361.
    • (1999) J. Clin. Invest. , vol.103 , pp. 1353-1361
    • Sampath, D.1    Castro, M.2    Look, D.C.3    Holtzman, M.J.4
  • 34
    • 0032531571 scopus 로고    scopus 로고
    • Cutting edge: IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells
    • Cohn, L., J. S. Tepper, and K. Bottomly. 1998. IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells. J. Immunol. 161: 3813-3816. (Pubitemid 28468952)
    • (1998) Journal of Immunology , vol.161 , Issue.8 , pp. 3813-3816
    • Cohn, L.1    Tepper, J.S.2    Bottomly, K.3
  • 37
    • 0037514382 scopus 로고    scopus 로고
    • Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial hyperreactivity
    • Hadeiba, H., and R. M. Locksley. 2003. Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial hyperreactivity. J. Immunol. 170: 5502-5510.
    • (2003) J. Immunol. , vol.170 , pp. 5502-5510
    • Hadeiba, H.1    Locksley, R.M.2
  • 38
    • 28544444024 scopus 로고    scopus 로고
    • Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent
    • Kearley, J., J. E. Barker, D. S. Robinson, and C. M. Lloyd. 2005. Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent. J. Exp. Med. 202: 1539-1547.
    • (2005) J. Exp. Med. , vol.202 , pp. 1539-1547
    • Kearley, J.1    Barker, J.E.2    Robinson, D.S.3    Lloyd, C.M.4
  • 39
    • 33846513614 scopus 로고    scopus 로고
    • Naturally occurring lung CD4 (+)CD25(+) T cell regulation of airway allergic responses depends on IL-10 induction of TGF-beta
    • Joetham, A., K. Takeda, C. Taube, N. Miyahara, S. Matsubara, T. Koya, Y. H. Rha, A. Dakhama, and E. W. Gelfand. 2007. Naturally occurring lung CD4 (+)CD25(+) T cell regulation of airway allergic responses depends on IL-10 induction of TGF-beta. J. Immunol. 178: 1433-1442.
    • (2007) J. Immunol. , vol.178 , pp. 1433-1442
    • Joetham, A.1    Takeda, K.2    Taube, C.3    Miyahara, N.4    Matsubara, S.5    Koya, T.6    Rha, Y.H.7    Dakhama, A.8    Gelfand, E.W.9
  • 40
    • 65249179610 scopus 로고    scopus 로고
    • Pathogenesis of steroid-resistant airway hyperresponsiveness: Interaction between IFN-gamma and TLR4/MyD88 pathways
    • Yang, M., R. K. Kumar, and P. S. Foster. 2009. Pathogenesis of steroid-resistant airway hyperresponsiveness: interaction between IFN-gamma and TLR4/MyD88 pathways. J. Immunol. 182: 5107-5115.
    • (2009) J. Immunol. , vol.182 , pp. 5107-5115
    • Yang, M.1    Kumar, R.K.2    Foster, P.S.3
  • 41
    • 49649101595 scopus 로고    scopus 로고
    • Th1, Th2, and Th17 effector T cell-induced autoimmune gastritis differs in pathological pattern and in susceptibility to suppression by regulatory T cells
    • Stummvoll, G. H., R. J. DiPaolo, E. N. Huter, T. S. Davidson, D. Glass, J. M. Ward, and E. M. Shevach. 2008. Th1, Th2, and Th17 effector T cell-induced autoimmune gastritis differs in pathological pattern and in susceptibility to suppression by regulatory T cells. J. Immunol. 181: 1908-1916.
    • (2008) J. Immunol. , vol.181 , pp. 1908-1916
    • Stummvoll, G.H.1    DiPaolo, R.J.2    Huter, E.N.3    Davidson, T.S.4    Glass, D.5    Ward, J.M.6    Shevach, E.M.7
  • 42
    • 0037099733 scopus 로고    scopus 로고
    • + regulatory, contact-dependent T cells induce interleukin 1-producing, contact-independent type 1-like regulatory T cells
    • DOI 10.1084/jem.20020642
    • Dieckmann, D., C. H. Bruett, H. Ploettner, M. B. Lutz, and G. Schuler. 2002. Human CD4(+)CD25(+) regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells [corrected]. [corrected] J. Exp. Med. 196: 247-253. (Pubitemid 34787514)
    • (2002) Journal of Experimental Medicine , vol.196 , Issue.2 , pp. 247-253
    • Dieckmann, D.1    Bruett, C.H.2    Ploettner, H.3    Lutz, M.B.4    Schuler, G.5
  • 43
    • 15444363794 scopus 로고    scopus 로고
    • T cells that cannot respond to TGF-beta escape control by CD4 (+)CD25(+) regulatory T cells
    • Fahlén, L., S. Read, L. Gorelik, S. D. Hurst, R. L. Coffman, R. A. Flavell, and F. Powrie. 2005. T cells that cannot respond to TGF-beta escape control by CD4 (+)CD25(+) regulatory T cells. J. Exp. Med. 201: 737-746.
    • (2005) J. Exp. Med. , vol.201 , pp. 737-746
    • Fahlén, L.1    Read, S.2    Gorelik, L.3    Hurst, S.D.4    Coffman, R.L.5    Flavell, R.A.6    Powrie, F.7
  • 44
    • 0037099719 scopus 로고    scopus 로고
    • Infectious tolerance: Human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells
    • Jonuleit, H., E. Schmitt, H. Kakirman, M. Stassen, J. Knop, and A. H. Enk. 2002. Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells. J. Exp. Med. 196: 255-260.
    • (2002) J. Exp. Med. , vol.196 , pp. 255-260
    • Jonuleit, H.1    Schmitt, E.2    Kakirman, H.3    Stassen, M.4    Knop, J.5    Enk, A.H.6
  • 46
    • 33750832563 scopus 로고    scopus 로고
    • T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5′-adenosine monophosphate to adenosine
    • Kobie, J. J., P. R. Shah, L. Yang, J. A. Rebhahn, D. J. Fowell, and T. R. Mosmann. 2006. T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5′-adenosine monophosphate to adenosine. J. Immunol. 177: 6780-6786.
    • (2006) J. Immunol. , vol.177 , pp. 6780-6786
    • Kobie, J.J.1    Shah, P.R.2    Yang, L.3    Rebhahn, J.A.4    Fowell, D.J.5    Mosmann, T.R.6
  • 47
    • 33747785278 scopus 로고    scopus 로고
    • Cutting edge: Critical role for A2A adenosine receptors in the T cell-mediated regulation of colitis
    • Naganuma, M., E. B. Wiznerowicz, C. M. Lappas, J. Linden, M. T. Worthington, and P. B. Ernst. 2006. Cutting edge: Critical role for A2A adenosine receptors in the T cell-mediated regulation of colitis. J. Immunol. 177: 2765-2769.
    • (2006) J. Immunol. , vol.177 , pp. 2765-2769
    • Naganuma, M.1    Wiznerowicz, E.B.2    Lappas, C.M.3    Linden, J.4    Worthington, M.T.5    Ernst, P.B.6
  • 49
    • 0025338731 scopus 로고
    • Cholera toxin discriminates between T helper 1 and 2 cells in T cell receptor-mediated activation: Role of cAMP in T cell proliferation
    • Muñoz, E., A. M. Zubiaga, M. Merrow, N. P. Sauter, and B. T. Huber. 1990. Cholera toxin discriminates between T helper 1 and 2 cells in T cell receptor-mediated activation: role of cAMP in T cell proliferation. J. Exp. Med. 172: 95-103.
    • (1990) J. Exp. Med. , vol.172 , pp. 95-103
    • Muñoz, E.1    Zubiaga, A.M.2    Merrow, M.3    Sauter, N.P.4    Huber, B.T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.