Mapping heat exchange in an allosteric protein

Biophysical Journal

Volumn 100, Issue 4, 2011, Pages 904-911

  Gupta, Shaweta ^a   Auerbach, Anthony ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79951831689     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2010.12.3739     Document Type: Article

References (43)

1. Monod, J., J. Wyman, and J. P. Changeux. 1965. On the nature of allosteric transitions: a plausible model. J. Mol. Biol. 12:88-118.
2. Jackson, M. 2006. Molecular and Cellular Biophysics. Cambridge University Press, New York.
3. Engel, A. G., X. M. Shen, ..., S. M. Sine. 2010. Whathavewelearned from the congenital myasthenic syndromes. J. Mol. Neurosci. 40:143-153.
4. Jadey, S., P. Purohit, ..., A. Auerbach. 2011. Design and control of acetylcholine receptor conformational change. Proc. Natl. Acad. Sci. USA., In press.
5. Purohit, P., and A. Auerbach. 2009. Unliganded gating of acetylcholine receptor channels. Proc. Natl. Acad. Sci. USA. 106:115-120.
6. Dill, K. A., and S. Bromberg. 2003. Molecular driving forces. In Statistical Thermodynamics in Chemistry and Biology. Garland Science, London, UK.
7. Unwin, N. 1998. The nicotinic acetylcholine receptor of the Torpedo electric ray. J. Struct. Biol. 121:181-190. (Pubitemid 28361445)
8. Brejc, K., W. J. van Dijk, ..., T. K. Sixma. 2001. Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors. Nature. 411:269-276. (Pubitemid 32467026)
9. Celie, P. H., R. V. Klaassen, ..., T. K. Sixma. 2005. Crystal structure of acetylcholine-binding protein from Bulinus truncatus reveals the conserved structural scaffold and sites of variation in nicotinic acetylcholine receptors. J. Biol. Chem. 280:26457-26466. (Pubitemid 41022242)
10. Unwin, N. 2005. Refined structure of the nicotinic acetylcholine receptor at 4Å resolution. J. Mol. Biol. 346:967-989. (Pubitemid 40215523)
11. Dellisanti, C. D., Y. Yao, ..., L. Chen. 2007. Crystal structure of the extracellular domain of nAChR alpha1 bound to a-bungarotoxin at 1.94 Ã resolution. Nat. Neurosci. 10:953-962. (Pubitemid 47185209)
12. Hilf, R. J., and R. Dutzler. 2008. X-ray structure of a prokaryotic pentameric ligand-gated ion channel. Nature. 452:375-379. (Pubitemid 351430790)
13. Bocquet, N., H. Nury, ..., P. J. Corringer. 2009. X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation. Nature. 457:111-114.
14. Hilf, R. J., and R. Dutzler. 2009. Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel. Nature. 457:115-118.
15. Gonzalez-Gutierrez, G., and C. Grosman. 2010. Bridging the gap between structural models of nicotinic receptor superfamily ion channels and their corresponding functional states. J. Mol. Biol. 403:693-705.
16. Gupta, S., and A. Auerbach. 2011. Temperature dependence of acetylcholine receptor-channels activated by different agonists. Biophys. J. 100:895-903.
17. Purohit, P., and A. Auerbach. 2010. Energeticsofgatingattheapo- acetylcholine receptor transmitter binding site. J. Gen. Physiol. 135:321-331.
18. Auerbach, A. 2005. Gating of acetylcholine receptor channels: Brownian motion across a broad transition state. Proc. Natl. Acad. Sci. USA. 102:1408-1412. (Pubitemid 40209183)
19. Purohit, P., and A. Auerbach. 2011. Glycine hinges with opposing actions at the acetylcholine receptor-channel transmitter binding site. Mol. Pharmacol. 7:1-9.
20. Cadugan, D. J., and A. Auerbach. 2010. Linking the acetylcholine receptor-channel agonist-binding sites with the gate. Biophys. J. 99:798-807.
21. Purohit, P., and A. Auerbach. 2007. Acetylcholine receptor gating: movement in the a-subunit extracellular domain. J. Gen. Physiol. 130:569-579. (Pubitemid 350179575)
22. Lummis, S. C., D. L. Beene, ..., D. A. Dougherty. 2005. Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel. Nature. 438:248-252. (Pubitemid 41599879)
23. Jha, A., D. J. Cadugan, ..., A. Auerbach. 2007. Acetylcholine receptor gating at extracellular transmembrane domain interface: the Cys-loop and M2-M3 linker. J. Gen. Physiol. 130:547-558. (Pubitemid 350179573)
24. Bafna, P. A., P. G. Purohit, and A. Auerbach. 2008. Gating at the mouth of the acetylcholine receptor channel: energetic consequences of mutations in the αM2-cap. PLoS ONE. 3: e2515.
25. Lee, W. Y., and S. M. Sine. 2005. Principal pathway coupling agonist binding to channel gating in nicotinic receptors. Nature. 438:243-247. (Pubitemid 41599878)
26. A receptor activation. J. Neurosci. 26:2031-2040.
27. Bruhova, I., and A. Auerbach. 2010. Subunit symmetry at the extracellular domain-transmembrane domain interface in acetylcholine receptor channel gating. J. Biol. Chem. 285:38898-38904.
28. Mitra, A., T. D. Bailey, and A. L. Auerbach. 2004. Structural dynamics of the M4 transmembrane segment during acetylcholine receptor gating. Structure. 12:1909-1918. (Pubitemid 39298974)
29. Cymes, G. D., C. Grosman, and A. Auerbach. 2002. Structure of the transition state of gating in the acetylcholine receptor channel pore: a f-value analysis. Biochemistry. 41:5548-5555. (Pubitemid 34429388)
30. Purohit, P., A. Mitra, and A. Auerbach. 2007. A stepwise mechanism for acetylcholine receptor channel gating. Nature. 446:930-933. (Pubitemid 46633166)
31. Jha, A., P. Purohit, and A. Auerbach. 2009. Energy and structure of the M2 helix in acetylcholine receptor-channel gating. Biophys. J. 96:4075-4084.
32. Horovitz, A., and A. R. Fersht. 1990. Strategy for analyzing the co-operativity of intramolecular interactions in peptides and proteins. J. Mol. Biol. 214:613-617.
33. Auerbach, A. 2010. The gating isomerization of neuromuscular acetylcholine receptors. J. Physiol. 588:573-586.
34. Yao, J., B. Liu, and F. Qin. 2010. Kinetic and energetic analysis of thermally activated TRPV1 channels. Biophys. J. 99:1743-1753.
35. Cadugan, D. J., and A. Auerbach. 2007. Conformational dynamics of the aM3 transmembrane helix during acetylcholine receptor channel gating. Biophys. J. 93:859-865. (Pubitemid 47219777)
36. Purohit, P., and A. Auerbach. 2007. Acetylcholine receptor gating at extracellular transmembrane domain interface: the "pre-M1" linker. J. Gen. Physiol. 130:559-568. (Pubitemid 350179574)
37. Lee, W. Y., C. R. Free, and S. M. Sine. 2008. Nicotinic receptor interloop proline anchors β1-β2 and Cys loops in coupling agonist binding to channel gating. J. Gen. Physiol. 132:265-278.
38. Wang, H. L., A. Auerbach, ..., S. M. Sine. 1997. Mutation in the M1 domain of the acetylcholine receptor α-subunit decreases the rate of agonist dissociation. J. Gen. Physiol. 109:757-766. (Pubitemid 27255940)
39. Chen, J., and A. Auerbach. 1998. A distinct contribution of the Δ-subunit to acetylcholine receptor channel activation revealed by mutations of the M2 segment. Biophys. J. 75:218-225. (Pubitemid 28311810)
40. Shelley, C., and D. Colquhoun. 2005. A human congenital myastheniacausing mutation (εL78P) of the muscle nicotinic acetylcholine receptor with unusual single channel properties. J. Physiol. 564:377-396. (Pubitemid 40585040)
41. Shelley, C., and D. Colquhoun. 2008. Corrigendum. J. Physiol. 588:5277.
42. Bouzat, C., F. Barrantes, and S. Sine. 2000. Nicotinic receptor fourth transmembrane domain: hydrogen bonding by conserved threonine contributes to channel gating kinetics. J. Gen. Physiol. 115:663-672.
43. Mukhtasimova, N., W. Y. Lee, ..., S. M. Sine. 2009. Detection and trapping of intermediate states priming nicotinic receptor channel opening. Nature. 459:451-454.