Total blood mercury, plasma homocysteine, methylmalonic acid and folate in US children aged 3-5years, NHANES 1999-2004

Science of the Total Environment

Volumn 409, Issue 8, 2011, Pages 1399-1405

  Gallagher, Carolyn M ^a,b   Meliker, Jaymie R ^b,c  

^a Doctoral Program in Population Health and Clinical Outcomes Research   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c Graduate Program in Public Health   (United States)

Author keywords

Children; Folate; Homocysteine; Mercury; Methylmalonic acid; Vitamin B 12

Indexed keywords

CHILDREN; FOLATE; HOMOCYSTEINE; MERCURY; METHYLMALONIC ACID; VITAMIN B-12;

AMINO ACIDS; BLOOD; ENZYME INHIBITION; LINEAR REGRESSION; MERCURY (METAL); NUTRITION; RATING;

VITAMINS;

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; MERCURY; METHYLMALONIC ACID;

AMINO ACID; BLOOD; CHILD HEALTH; MERCURY (ELEMENT); METABOLISM; ORGANIC ACID; PLASMA; POLLUTION EXPOSURE;

AMINO ACID METABOLISM; ARTICLE; BLOOD LEVEL; CHILD; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; FOLIC ACID BLOOD LEVEL; HOMOCYSTEINE BLOOD LEVEL; HUMAN; MALE; MERCURY BLOOD LEVEL; PRESCHOOL CHILD; PRIORITY JOURNAL; SEX DIFFERENCE; UNITED STATES;

CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; FEMALE; FOLIC ACID; HOMOCYSTEINE; HUMANS; LINEAR MODELS; MALE; MERCURY; METHYLMALONIC ACID; NUTRITION SURVEYS; UNITED STATES;

UNITED STATES;

EID: 79951813082     PISSN: 00489697     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.scitotenv.2011.01.021     Document Type: Article

References (63)

1. Aschner M. Astrocyte metallothioneins (MTs) and their neuroprotective role. Ann NY Acad Sci 1997, 825:334-347.
2. Aschner M., Ceccatelli S. Are neuropathological conditions relevant to ethylmercury exposure?. Neurotox Res 2010, 18:59-68.
3. ATSDR (Agency for Toxic Substances Disease Registry) ToxFAQs: CABS/Chemical Agent Briefing Sheet, Mercury 2006, Last accessed November, 20, 2010. http://www.kuskokwimcouncil.org/documents/mercury.pdf.
4. ATSDR (Agency for Toxic Substances and Disease Registry). Toxicological profile for mercury. U.S. Department of Health and Human Services, Public Health Service, Atlanta, GA; 1999. Last accessed: November 20, 2010. http://www.atsdr.cdc.gov/toxprofiles/tp.asp?id=115&tid=24.
5. Ball L.K., Ball R., Pratt D. An assessment of thimerosal use in childhood vaccines. Pediatrics 2001, 107:1147-1153.
6. Barbato J.C., Catanescu O., Murray K., DiBello P.M., Jacobsen D.W. Targeting of metallothionein by l-homocysteine: a novel mechanism for disruption of zinc and redox homeostasis. Arterioscler Thromb Vasc Biol 2007, 27:49-54.
7. Bates C.J., Mansoor M.A., Gregory J., Pentiev K., Prentice A. Correlates of plasma homocysteine, cysteine and cysteinyl-glycine in respondents in the British National Diet and Nutrition Survey of young people aged 4-18years, and a comparison with the survey of people aged 65years and over. Br J Nutr 2002, 87:71-79.
8. Brattstrom L., Israelsson B., Norrving B., Bergqvist D., Thorne J., Hultberg B., et al. Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease. Effects of pyridoxine and folic acid treatment. Atherosclerosis 1990, 81:51-60.
9. Burbacher T.M., Shen D.D., Liberato N., grant K.S., Cernichiar E., Clarkson T. Comparison of blood and brain mercury levels in infant monkeys exposed to methylmercury or vaccines containing thimerosal. Environ Health Perspect 2005, 113:1015-1021.
10. Canfield R.L., Henderson C.R., Cory-Slechta D.A., Cox C., Jusko T.A., Lanphear B.P. Intellectual impairment in children with blood lead concentrations below 10 microg per deciliter. N Engl J Med 2003, 348:1517-1526.
11. CDC (Centers for Disease Control and Prevention). National Center for Health Statistics (NCHS). National Health and Nutrition Examination Survey Laboratory Protocol. U.S. Department of Health and Human Services. Centers for Disease Control and Prevention. Hyattsville, MD: 2004. Last accessed November 20, 2010. http://www.cdc.gov/nchs/data/nhanes/nhanes_03_04/lab_pm.pdf.
12. CDC (Centers for Disease Control and Prevention). National Center for Health Statistics. National Health and Nutrition Examination Survey: NHANES 1999-2004. US Department of Health and Human Services, Centers for Disease Control and Prevention. Hyattsville, MD: 2009. Last accessed November 20, 2010. http://www.cdc.gov/nchs/nhanes/nhanes_questionnaires.htm.
13. CDC (Centers for Disease Control and Prevention). National Center for Health Statistics (NCHS). Continuous NHANES Web Tutorial, 2009b. U.S. Department of Health and Human Services, Centers for Disease Control and Prevention. Hyattsville, MD: 2009b. Last accessed November 20, 2010. http://www.cdc.gov/nchs/tutorials/Nhanes/SurveyOrientation/SurveyOverview/intro.htm.
14. CDC (Centers for Disease Control and Prevention). National Report on Human Exposure to Environmental Chemicals. Atlanta, GA: 2010. Last accessed January 6, 2011. http://www.cdc.gov/exposurereport/data_tables/LBXIHG_DataTables.html.
15. Cordier S., Garel M., Mandereau L., Morcel H., Doineau P., Gosme-Seguret S., et al. Neurodevelopmental investigations among methylmercury-exposed children in French Guiana. Environ Res 2002, 89:1-11.
16. Counter S.A., Buchanan L.H. Mercury exposure in children: a review. Toxicol Appl Pharmacol 2004, 198:209-230.
17. Deth R., Muratore C., Benzecry J., Power-Charnitsky V.A., Waly M. How environmental and genetic factors combine to cause autism: a redox/methylation hypothesis. Neurotox 2008, 29:190-201.
18. Dorea J.G. More on low-level non-occupational mercury exposure and health concerns. Sci Total Environ 2010, 408:2008-2009.
19. Dufault R., Schnoll R., Lukiw W.J., Leblanc B., Cornett C., Patrick L., et al. Mercury exposure, nutritional deficiencies and metabolic disruptions may affect learning in children. Behav Brain Funct 2009, 5:44.
20. Dufault R., LeBlanc B., Schnoll R., Cornett C., Schweitzer L., Wallinga D., et al. Mercury from chlor-alkali plants: measured concentrations in food product sugar. Environ Health 2009, 8:2.
21. EFSA (European Food Safety Authority). Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission related to mercury and methylmercury in food. Request No EFSA-Q-2003-030, 2004. Internet: Last accessed: November 20, 2010. http://www.efsa.europa.eu/EFSA/efsa_locale-1178620753812_1178620763245.htm.
22. Ercal N., Gurer-Orhan H., Aykin-Burns N. Toxic metals and oxidative stress part I: mechanisms involved in metal induced oxidative damage. Curr Top Med Chem 2001, 1:529-539.
23. Gallistl S., Sudi K., Mangge H., Erwa W., Borkenstein M. Insulin is an independent correlate of plasma homocysteine levels in obese children and adolescents. Diab Care 2000, 23:1348-1352.
24. Grandjean P., Weihe P., White R.F., Debes F. Cognitive performance of children prenatally exposed to "safe" levels of methylmercury. Environ Res 1998, 77:165-172.
25. Grotto D., Valentini J., Fillion M., Souza Passos C.J., Garcia S.C., Mergler D., et al. Mercury exposure and oxidative stress in communities of the Brazilian Amazon. Sci Total Environ 2010, 408:806-811.
26. Guallar E., Silbergeld E.K., Navas-Acien A., Malhotra S., Astor C., Sharrett A.R., et al. Confounding of the relation between homocysteine and peripheral arterial disease by lead, cadmium, and renal function. Am J Epidemiol 2006, 163:700-708.
27. Havarinasab S., Hultman P. Organic mercury compounds and autoimmunity. Autoimmun Rev 2005, 4:270-275.
28. Holmes P., James K.A.F., Levy L.S. Is low-level environmental mercury exposure of concern to human health?. Sci Total Environ 2009, 408:171-182.
29. Huang T., Wahlqvist M.L., Li D. Docosahexaenoic acid decreases plasma homocysteine via regulating enzyme activity and mRNA expression involved in methionine metabolism. Nutrition 2010, 26:112-119.
30. Jacques P.F., Bostom A.G., Williams R.R., et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 1996, 93:7-9.
31. James S.J. Chapter 11: Oxidative stress and the metabolic pathology of autism. Autism: Current theories and evidence 2010, 246-248. Humana Press, Totowa, NJ. A.W. Zimmerman (Ed.).
32. James S.J., Cutler P., Melnyk S., Jernigan S., Janak L., Gaylor D.W., et al. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am J Clin Nutr 2004, 80:1611-1617.
33. James S.J., Slikker W., Melnyk S., New E., Pogribna M., Jernigan S. Thimerosal neurotoxicity is associated with glutathione depletion: protection with glutathione precursors. Neurotoxicology 2005, 26:1-8.
34. James S.J., Melnyk S., Fuchs G., et al. Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism. Am J Clin Nutr 2009, 89:425-430.
35. Kerr M.A., Livingstone B., Bates C.J., Bradbury I., Scott J.M., Ward M., et al. Folate, related B vitamins, and homocysteine in childhood and adolescence: potential implications for disease risk in later life. Pediatrics 2009, 123:627-635.
36. Klaassen C.D. Casarett and Doull's toxicology: The basic science of poisons 2008, The McGraw Hill Companies, New York.
37. Lee D.H., Jacobs D.R., Porta M. Hypothesis: a unifying mechanism for nutrition and chemicals as lifelong modulators of DNA hypomethylation. Environ Health Perspect 2009, 117:1799-1802.
38. Li Y., Yan X.P., Chen C., Xia Y.L., Jiang Y. Human serum albumin-mercurial species interactions. J Proteome Res 2007, 6:2277-2286.
39. Mahaffey K.R., Clickner R.P., Jeffries R.A. Methylmercury and omega-3 fatty acids: co-occurrence of dietary sources with emphasis on fish and shellfish. Environ Res 2008, 107:20-29.
40. Main P.A.E., Angley M.T., Thomas P., O'Doherty C.E., Fenech M. Folate and methionine metabolism in autism: a systematic review. Am J Clin Nutr 2010, 91:1598-1620.
41. Marsh D.O., Clarkson T.W., Cox C., Myers G.J., Amin-Zaki L., Al-Tikriti S. Arch Neurol 1987, 44:1017-1022.
42. Mattson M.P., Shea T.B. Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci 2003, 26:137-146.
43. McKeown-Eyssen G.E., Ruedy J., Neims A. Methyl mercury exposure in northern Quebec. II. Neurologic findings in children. Am J Epidemiol 1983, 118:470-479.
44. Minami T., Miyata E., Sakamoto Y., Yamazaki H., Ichida S. Induction of metallothionein in mouse cerebellum and cerebrum with low-dose thimerosal injection. Cell Biol Toxicol 2010, 26:143-152.
45. Moelby L., Rasmussen K., Jensen M.K., Pedersen K.O. The relationship between clinically confirmed cobalamin deficiency and serum methylmalonic acid. J Intern Med 1990, 228:373-378.
46. Myers G.J., Davidson P.W. Does methylmercury have a role in causing developmental disabilities in children?. Environ Health Perspect 2000, 108:413-420.
47. NCHS (National Center for Health Statistics). Body mass index-for-age percentiles, 2 to 20 years: girls, boys. Developed by the National Center for Health Statistics in collaboration with the National Center for Chronic Disease Prevention and Health Promotion, 2000. Last accessed November 20, 2010. http://www.cdc.gov/growthcharts.
48. NRC (National Research Council) Toxicological effects of methyl mercury. Committee on the toxicological effects of methyl mercury 2000, National Academy Press, Washington, DC.
49. Oken E., Wright R.O., Kleinman K.P., Bellinger D., Amarasiriwardena C.J., Hu H., et al. Maternal fish consumption, hair mercury, and infant cognition in a U.S. cohort. Environ Health Perspect 2005, 113:1376-1380.
50. Osganian S.K., Stampfer M.J., Spiegelman D., et al. Distribution of and factors associated with serum homocysteine levels in children, child and adolescent trial for cardiovascular health. JAMA 1999, 281:1189-1196.
51. Pasca S., Nemes B., Vlase L., Gagyi C.E., Dronca E., Miu A.C., et al. High levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism. Life Sci 2005, 78:2244-2248.
52. Persa C., Pierce A., Ma Z., Kabil O., Our M.F. The presence of a transsulfuration pathway in the lens: a new oxidative stress defense system. Exp Eye Res 2004, 79:875-886.
53. Poirier L.A., Wise C.K., Delongechamp R.R., Sinha R. Blood determinations of S-adenosylmethionine, S-adenosylhomocysteine, and homocysteine: correlations with diet. Cancer Epidemiol Biomark Prev 2001, 10:649-655.
54. Rising L.D., Vitarell H.K., Kemelberg Aschner M. Metallothionein induction in neonatal rat primary astrocyte cultures protects against methylmercury cytotoxicity. J Neurochem 1995, 65:1562-1568.
55. Sakamoto M., Nakano A., Akagi H. Declining minimata male birth ratio associated with increased male fetal death due to heavy methylmerucy pollution. Environ Res 2001, 87:92-98.
56. Shanker G., Allen J.W., Mutkus L.A., Aschner M. Methylmercury inhibits cysteine uptake in cultured primary astrocytes, but not in neurons. Brain Res 2001, 914:159-165.
57. Simmons-Willis T.A., Koh A.S., Clarkson T.W., Ballator N. Transport of a neurotoxicant by molecular mimicry: the methylmercury-L-cysteine complex is a substrate for human L-type large neutral amino acid transporter (LAT)1 and LAT2. Biochem J 2002, 367:239-246.
58. US EPA (United States Environmental Protection Agency). Mercury Study Report to Congress, Volume IV: An Assessment of exposure to mercury in the United States. Office of Air Quality Planning and Standards and Office of Research and Development: December 1997. Last accessed January 7, 2011. http://www.epa.gov/hg/report.htm.
59. US EPA (United States Environmental Protection Agency). Mercury, Human Exposure, 2010. Last accessed January 22, 2011. http://www.epa.gov/hg/exposure.htm.
60. Vitarella D., Conklin D.R., Kemelberg H.K., Aschner M. Metallothionein induction protects swollen rat primary astrocyte cultures from methylmercury-induced inhibition of regulatory volume decrease. Brain Res 1996, 738:213-221.
61. Waly M., Olteanu H., Banerjee R., Choi S.W., Mason J.B., Parker B.S., et al. Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal. Mol Psychiatry 2004, 9:358-370.
62. Wang X., Horisberger J. Mercury binding site on Na+/K+ -ATPase: a cysteine in the first transmembrane segment. Mol Pharmacol 1996, 50:687-691.
63. Yao C.P., Allen J.W., Aschner M. Metallothioneins attenuate methylmercury-induced neurotoxicity in cultured astrocytes and astrocytoma cells. Ann NY Acad Sci 1999, 890:223-226.