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Volumn 26, Issue 1, 2010, Pages 112-119

Docosahexaenoic acid decreases plasma homocysteine via regulating enzyme activity and mRNA expression involved in methionine metabolism

Author keywords

Cystathionine synthase; Cystathionine lyase; Fish oil; Gene expression; Hydrogen sulfide; Methionine adenosyltransferase; S adenosylhomocysteine hydrolase

Indexed keywords

ADENOSYLHOMOCYSTEINASE; CYSTATHIONINE BETA SYNTHASE; CYSTATHIONINE GAMMA LYASE; DOCOSAHEXAENOIC ACID; FISH OIL; HOMOCYSTEINE; HYDROGEN SULFIDE; MESSENGER RNA; METHIONINE; METHIONINE ADENOSYLTRANSFERASE; OLIVE OIL; OMEGA 3 FATTY ACID; PHOSPHOLIPID;

EID: 71949093334     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nut.2009.05.015     Document Type: Article
Times cited : (43)

References (52)
  • 2
    • 0014545138 scopus 로고
    • Vascular pathology of homocysteinemia implication for the pathogenesis of arteriosclerosis
    • McCully K.S. Vascular pathology of homocysteinemia implication for the pathogenesis of arteriosclerosis. Am J Pathol 56 (1969) 111-128
    • (1969) Am J Pathol , vol.56 , pp. 111-128
    • McCully, K.S.1
  • 4
    • 33747879556 scopus 로고    scopus 로고
    • Homocysteine hypothesis for atherothrombotic cardiovascular disease, not validated
    • Kaul S., Zadeh A.A., and Shah P.K. Homocysteine hypothesis for atherothrombotic cardiovascular disease, not validated. J Am Coll Cardiol 48 (2006) 914-923
    • (2006) J Am Coll Cardiol , vol.48 , pp. 914-923
    • Kaul, S.1    Zadeh, A.A.2    Shah, P.K.3
  • 5
    • 33748120033 scopus 로고    scopus 로고
    • Plasma total homocysteine levels in children with type 1 diabetes: relationship with vitamin status, methylene tetrahydrofolate reductase genotype, disease parameters and coronary risk factors
    • Dinleyici E.C., Kirel B., Alatas O., Muslumanoglu H., Kilic Z., and Dogruel N. Plasma total homocysteine levels in children with type 1 diabetes: relationship with vitamin status, methylene tetrahydrofolate reductase genotype, disease parameters and coronary risk factors. J Trop Pediatr 52 (2006) 260-266
    • (2006) J Trop Pediatr , vol.52 , pp. 260-266
    • Dinleyici, E.C.1    Kirel, B.2    Alatas, O.3    Muslumanoglu, H.4    Kilic, Z.5    Dogruel, N.6
  • 6
    • 40949142885 scopus 로고    scopus 로고
    • Low vitamin B6 and folic acid levels are associated with retinal vein occlusion independently of homocysteine levels
    • Sofi F., Marcucci R., Bolli P., Giambene B., Sodi A., Fedi S., et al. Low vitamin B6 and folic acid levels are associated with retinal vein occlusion independently of homocysteine levels. Atherosclerosis 198 (2008) 223-227
    • (2008) Atherosclerosis , vol.198 , pp. 223-227
    • Sofi, F.1    Marcucci, R.2    Bolli, P.3    Giambene, B.4    Sodi, A.5    Fedi, S.6
  • 7
    • 0037591864 scopus 로고    scopus 로고
    • The cellular molecular mechanism of hyperhomocysteine in atherosclerosis
    • Gao S., and Tang C.S. The cellular molecular mechanism of hyperhomocysteine in atherosclerosis. Dev Physiol 33 (2002) 335-338
    • (2002) Dev Physiol , vol.33 , pp. 335-338
    • Gao, S.1    Tang, C.S.2
  • 8
    • 0032771346 scopus 로고    scopus 로고
    • Homocysteine metabolism
    • Selhub J. Homocysteine metabolism. Annu Rev Nutr 19 (1999) 217-246
    • (1999) Annu Rev Nutr , vol.19 , pp. 217-246
    • Selhub, J.1
  • 9
    • 33751527922 scopus 로고    scopus 로고
    • Hyperhomocysteinemia due to cystathionine beta synthase deficiency induces dysregulation of genes involved in hepatic lipid homeostasis in mice
    • Hamelet J., Demuth K., Paul J.L., Delabar J.M., and Janel N. Hyperhomocysteinemia due to cystathionine beta synthase deficiency induces dysregulation of genes involved in hepatic lipid homeostasis in mice. J Hepatol 46 (2007) 151-159
    • (2007) J Hepatol , vol.46 , pp. 151-159
    • Hamelet, J.1    Demuth, K.2    Paul, J.L.3    Delabar, J.M.4    Janel, N.5
  • 11
    • 0032949296 scopus 로고    scopus 로고
    • Dietary Intake of α-linolenic acid and risk of fatal ischemic heart disease among women
    • Hu F.B., Stampfer M.J., Manson J.E., Rimm E.B., Wolk A., Colditz G.A., et al. Dietary Intake of α-linolenic acid and risk of fatal ischemic heart disease among women. Am J Clin Nutr 69 (1999) 890-897
    • (1999) Am J Clin Nutr , vol.69 , pp. 890-897
    • Hu, F.B.1    Stampfer, M.J.2    Manson, J.E.3    Rimm, E.B.4    Wolk, A.5    Colditz, G.A.6
  • 13
    • 0037161373 scopus 로고    scopus 로고
    • Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione
    • Marchioli R., Barzi F., Bomba E., Chieffo C., Di Gregorio D., Di Mascio R., et al. Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione. Circulation 105 (2002) 1897-1903
    • (2002) Circulation , vol.105 , pp. 1897-1903
    • Marchioli, R.1    Barzi, F.2    Bomba, E.3    Chieffo, C.4    Di Gregorio, D.5    Di Mascio, R.6
  • 14
    • 4544296205 scopus 로고    scopus 로고
    • Fish intake is associated with a reduced progression of coronary artery atherosclerosis in postmenopausal women with coronary artery disease
    • Erkkila A.T., Lichtenstein A.H., Mozaffarian D., and Herrington D.M. Fish intake is associated with a reduced progression of coronary artery atherosclerosis in postmenopausal women with coronary artery disease. Am J Clin Nutr 80 (2004) 626-632
    • (2004) Am J Clin Nutr , vol.80 , pp. 626-632
    • Erkkila, A.T.1    Lichtenstein, A.H.2    Mozaffarian, D.3    Herrington, D.M.4
  • 15
    • 0027284492 scopus 로고
    • A meta-analysis of controlled trials
    • Morris M.C., Sack F., and RosnerDoes fish oil lower blood pressure? B. A meta-analysis of controlled trials. Circulation 88 (1993) 523-533
    • (1993) Circulation , vol.88 , pp. 523-533
    • Morris, M.C.1    Sack, F.2    Rosner3
  • 16
    • 0028293514 scopus 로고
    • The acute effects of a single very high dose of n-3 fatty acids on plasma lipids and lipoproteins in healthy subjects
    • Svaneborg N., Moller J.M., Schmidt E.B., Varming K., Lervang H.H., and Dyerberg J. The acute effects of a single very high dose of n-3 fatty acids on plasma lipids and lipoproteins in healthy subjects. Lipids 29 (1994) 145-147
    • (1994) Lipids , vol.29 , pp. 145-147
    • Svaneborg, N.1    Moller, J.M.2    Schmidt, E.B.3    Varming, K.4    Lervang, H.H.5    Dyerberg, J.6
  • 17
    • 0021909524 scopus 로고
    • A comparative study of eicosapentaenoic acid metabolism by human platelets in vivo and in vitro
    • Schacky C.V., Siess W., Fischer S., and Weber P.C. A comparative study of eicosapentaenoic acid metabolism by human platelets in vivo and in vitro. J Lipid Res 26 (1985) 457-464
    • (1985) J Lipid Res , vol.26 , pp. 457-464
    • Schacky, C.V.1    Siess, W.2    Fischer, S.3    Weber, P.C.4
  • 18
    • 0034845224 scopus 로고    scopus 로고
    • Heart rate variability and n-3 polyunsaturated fatty acids in patients with diabetes mellitus
    • Christensen J.H., Skou H.A., Madsen T., Torring I., and Schmidt E.B. Heart rate variability and n-3 polyunsaturated fatty acids in patients with diabetes mellitus. J Intern Med 249 (2001) 545-552
    • (2001) J Intern Med , vol.249 , pp. 545-552
    • Christensen, J.H.1    Skou, H.A.2    Madsen, T.3    Torring, I.4    Schmidt, E.B.5
  • 19
    • 34249093550 scopus 로고    scopus 로고
    • Platelet phospholipids n-3 PUFA negatively associated with plasma homocysteine in middle aged and geriatric hyperlipaemia patients
    • Li D., Yu X.M., Xie H.B., Zhang Y., Wang Q., Zhou X., et al. Platelet phospholipids n-3 PUFA negatively associated with plasma homocysteine in middle aged and geriatric hyperlipaemia patients. Prostaglandins Leukot Essent Fatty Acids 76 (2007) 293-297
    • (2007) Prostaglandins Leukot Essent Fatty Acids , vol.76 , pp. 293-297
    • Li, D.1    Yu, X.M.2    Xie, H.B.3    Zhang, Y.4    Wang, Q.5    Zhou, X.6
  • 20
    • 33644596828 scopus 로고    scopus 로고
    • A significant inverse relationship between concentrations of plasma homocysteine and phospholipid docosahexaenoic acid in healthy male subjects
    • Li D., Mann N.J., and Sinclair A.J. A significant inverse relationship between concentrations of plasma homocysteine and phospholipid docosahexaenoic acid in healthy male subjects. Lipids 41 (2006) 85-89
    • (2006) Lipids , vol.41 , pp. 85-89
    • Li, D.1    Mann, N.J.2    Sinclair, A.J.3
  • 21
    • 33646553621 scopus 로고    scopus 로고
    • N-3 fatty acid supplementation decreases plasma homocysteine in diabetic dyslipidemia treated with statin-fibrate combination
    • Zeman M., Žák A., Vecka M., Tvrzická E., Písaříková A., and Staňková B. N-3 fatty acid supplementation decreases plasma homocysteine in diabetic dyslipidemia treated with statin-fibrate combination. J Nutr Biochem 17 (2006) 379-384
    • (2006) J Nutr Biochem , vol.17 , pp. 379-384
    • Zeman, M.1    Žák, A.2    Vecka, M.3    Tvrzická, E.4    Písaříková, A.5    Staňková, B.6
  • 22
    • 0344493770 scopus 로고    scopus 로고
    • Reduction in homocysteine by n-3 polyunsaturated fatty acids after 1 year in a randomised double-blind study following an acute myocardial infarction: no effect on endothelial adhesion properties
    • Grundt H., Nilsen D.W., Mansoor M.A., Hetland O., and Nordoy A. Reduction in homocysteine by n-3 polyunsaturated fatty acids after 1 year in a randomised double-blind study following an acute myocardial infarction: no effect on endothelial adhesion properties. Pathophysiol Haemost Thromb 33 (2003) 88-95
    • (2003) Pathophysiol Haemost Thromb , vol.33 , pp. 88-95
    • Grundt, H.1    Nilsen, D.W.2    Mansoor, M.A.3    Hetland, O.4    Nordoy, A.5
  • 24
    • 85088334188 scopus 로고    scopus 로고
    • Evaluation of the AxSYM homocysteine assay and comparison with the IMx homocysteine assay
    • Pascal P., Elisabeth L., and Michel V. Evaluation of the AxSYM homocysteine assay and comparison with the IMx homocysteine assay. Clin Chem 46 (2000) 1440-1441
    • (2000) Clin Chem , vol.46 , pp. 1440-1441
    • Pascal, P.1    Elisabeth, L.2    Michel, V.3
  • 25
    • 0032840060 scopus 로고    scopus 로고
    • The effect of habitual diet on the thrombotic risk factors in healthy male subjects
    • Li D., Sinclair A.J., Mann N., Turner A., Ball M., Kelly F., et al. The effect of habitual diet on the thrombotic risk factors in healthy male subjects. Eur J Clin Nutr 53 (1999) 612-619
    • (1999) Eur J Clin Nutr , vol.53 , pp. 612-619
    • Li, D.1    Sinclair, A.J.2    Mann, N.3    Turner, A.4    Ball, M.5    Kelly, F.6
  • 26
    • 0023840449 scopus 로고
    • Purification and comparison of two forms of S-adenosyl-L-methionine synthetase from rat liver
    • Cabrero C., Puerta J., and Alemany S. Purification and comparison of two forms of S-adenosyl-L-methionine synthetase from rat liver. Eur J Biochem 170 (1987) 299-304
    • (1987) Eur J Biochem , vol.170 , pp. 299-304
    • Cabrero, C.1    Puerta, J.2    Alemany, S.3
  • 27
    • 0031588757 scopus 로고    scopus 로고
    • Copper ions differ from other thiol reactive metal ions in their effects on the concentration and redox status of thiols in Hela cell cultures
    • Hultberg B., Andersson A., and Isaksson A. Copper ions differ from other thiol reactive metal ions in their effects on the concentration and redox status of thiols in Hela cell cultures. Toxicology 117 (1997) 89-97
    • (1997) Toxicology , vol.117 , pp. 89-97
    • Hultberg, B.1    Andersson, A.2    Isaksson, A.3
  • 28
    • 0028347021 scopus 로고
    • Folate-deficiency-induced homocysteinaemia in rats: disruption of S-adenosylmethionine's co-ordinate regulation of homocysteine metabolism
    • Miller J.W., Nadeau M.R., Smith D., and Selhub J. Folate-deficiency-induced homocysteinaemia in rats: disruption of S-adenosylmethionine's co-ordinate regulation of homocysteine metabolism. Biochem J 298 (1994) 415-419
    • (1994) Biochem J , vol.298 , pp. 415-419
    • Miller, J.W.1    Nadeau, M.R.2    Smith, D.3    Selhub, J.4
  • 30
    • 33645007540 scopus 로고    scopus 로고
    • Intake of fish and n-3 fatty acids and risk of coronary heart disease among Japanese: the Japan Public Health Center-Based (JPHC) study cohort I
    • Iso H., Kobayashi M., Ishihara J., Sasaki S., Okada K., Kita Y., et al. Intake of fish and n-3 fatty acids and risk of coronary heart disease among Japanese: the Japan Public Health Center-Based (JPHC) study cohort I. Circulation 113 (2006) 195-202
    • (2006) Circulation , vol.113 , pp. 195-202
    • Iso, H.1    Kobayashi, M.2    Ishihara, J.3    Sasaki, S.4    Okada, K.5    Kita, Y.6
  • 31
    • 0027479873 scopus 로고
    • Fish oil decreases serum homocysteine in hyperlipemic men
    • Olszewski A.J., and McCully K.S. Fish oil decreases serum homocysteine in hyperlipemic men. Coron Artery Dis 4 (1993) 53-60
    • (1993) Coron Artery Dis , vol.4 , pp. 53-60
    • Olszewski, A.J.1    McCully, K.S.2
  • 32
    • 0032924121 scopus 로고    scopus 로고
    • Atherothrombogenic risk modulation by n-3 fatty acids was not associated with changes in homocysteine in subjects with combined hyperlipidaemia
    • Grundt H., Nilsen D.W.T., Hetland A., Mansoor M.A., Aarsland T., and Woie L. Atherothrombogenic risk modulation by n-3 fatty acids was not associated with changes in homocysteine in subjects with combined hyperlipidaemia. Thromb Haemost 81 (1999) 561-566
    • (1999) Thromb Haemost , vol.81 , pp. 561-566
    • Grundt, H.1    Nilsen, D.W.T.2    Hetland, A.3    Mansoor, M.A.4    Aarsland, T.5    Woie, L.6
  • 33
    • 0026691381 scopus 로고
    • Age dependency of cystathionine beta-synthase activity in human fibroblasts in homocyst(e)inemia and atherosclerotic vascular disease
    • Nordstrom M., and Kjellstrom T. Age dependency of cystathionine beta-synthase activity in human fibroblasts in homocyst(e)inemia and atherosclerotic vascular disease. Atherosclerosis 94 (1992) 213-221
    • (1992) Atherosclerosis , vol.94 , pp. 213-221
    • Nordstrom, M.1    Kjellstrom, T.2
  • 37
    • 34447537984 scopus 로고    scopus 로고
    • 12 in vascular dementia and in Alzheimer disease
    • 12 in vascular dementia and in Alzheimer disease. Clin Biochem 40 (2007) 859-863
    • (2007) Clin Biochem , vol.40 , pp. 859-863
    • Köseoglua, E.1    Karaman, Y.2
  • 40
    • 2242477014 scopus 로고    scopus 로고
    • Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomized trials
    • Homocysteine Lowering Trialists Collaboration
    • Homocysteine Lowering Trialists Collaboration. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomized trials. Br Med J 316 (1998) 894-898
    • (1998) Br Med J , vol.316 , pp. 894-898
  • 41
    • 0033551352 scopus 로고    scopus 로고
    • The effect of folic acid fortification on plasma folate and total homocysteine concentrations
    • Jacques P.F., Sclhub J., Bostom A.G., Wilson P.W.F., and Rosenberg J.H. The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N Engl J Med 340 (1999) 49-54
    • (1999) N Engl J Med , vol.340 , pp. 49-54
    • Jacques, P.F.1    Sclhub, J.2    Bostom, A.G.3    Wilson, P.W.F.4    Rosenberg, J.H.5
  • 43
    • 0029416812 scopus 로고
    • Resistance to inhibitors of S-adenosyl-L-homocysteine hydrolase in C1300 murine neuroblastoma tumor cells is associated with increased methionine adenosyltransferase activity
    • Hamre M.R., Clark S.H., and Mirkin B.L. Resistance to inhibitors of S-adenosyl-L-homocysteine hydrolase in C1300 murine neuroblastoma tumor cells is associated with increased methionine adenosyltransferase activity. Oncol Res 7 (1995) 487-492
    • (1995) Oncol Res , vol.7 , pp. 487-492
    • Hamre, M.R.1    Clark, S.H.2    Mirkin, B.L.3
  • 44
    • 0033561556 scopus 로고    scopus 로고
    • S-adenosylmethionine synthetase is overexpressed in murine neuroblastoma cells resistant to nucleoside analogue inhibitors of S-adenosylhomocysteine hydrolase: a novel mechanism of drug resistance
    • Dwivedi R.S., Wang L.J., and Mirkin B.L. S-adenosylmethionine synthetase is overexpressed in murine neuroblastoma cells resistant to nucleoside analogue inhibitors of S-adenosylhomocysteine hydrolase: a novel mechanism of drug resistance. Cancer Res 59 (1999) 1852-1856
    • (1999) Cancer Res , vol.59 , pp. 1852-1856
    • Dwivedi, R.S.1    Wang, L.J.2    Mirkin, B.L.3
  • 45
    • 0033818441 scopus 로고    scopus 로고
    • Pathways and regulation of homocysteine metabolism in mammals
    • Finkelstein J.D. Pathways and regulation of homocysteine metabolism in mammals. Semin Thromb Hemost 26 (2000) 219-225
    • (2000) Semin Thromb Hemost , vol.26 , pp. 219-225
    • Finkelstein, J.D.1
  • 46
    • 0021220516 scopus 로고
    • Methionine metabolism in mammals: distribution of homocysteine between competing pathways
    • Finkelstein J.D., and Martin J.J. Methionine metabolism in mammals: distribution of homocysteine between competing pathways. J Biol Chem 259 (1984) 9508-9513
    • (1984) J Biol Chem , vol.259 , pp. 9508-9513
    • Finkelstein, J.D.1    Martin, J.J.2
  • 47
    • 0036326660 scopus 로고    scopus 로고
    • Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology
    • James S.J., Melnyk S., Pogribna M., Pogribny I.P., and Caudill M.A. Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology. J Nutr 132 (2002) 2361S-2366S
    • (2002) J Nutr , vol.132
    • James, S.J.1    Melnyk, S.2    Pogribna, M.3    Pogribny, I.P.4    Caudill, M.A.5
  • 48
    • 0031748093 scopus 로고    scopus 로고
    • The metabolism of homocysteine: pathways and regulation
    • Finkelstein J.D. The metabolism of homocysteine: pathways and regulation. Eur J Pediatr 157 (1998) S40-S44
    • (1998) Eur J Pediatr , vol.157
    • Finkelstein, J.D.1
  • 49
    • 33846308476 scopus 로고    scopus 로고
    • Inhibition of cystathionine-γ-lyase leads to loss of glutathione and aggravation of mitochondrial dysfunction mediated by excitatory amino acid in the CNS
    • Diwakar L., and Ravindranath V. Inhibition of cystathionine-γ-lyase leads to loss of glutathione and aggravation of mitochondrial dysfunction mediated by excitatory amino acid in the CNS. Neurochem Int 50 (2007) 418-426
    • (2007) Neurochem Int , vol.50 , pp. 418-426
    • Diwakar, L.1    Ravindranath, V.2
  • 51
    • 33947686073 scopus 로고    scopus 로고
    • Imbalance of endogenous homocysteine and hydrogen sulfide metabolic pathway in essential hypertensive children
    • Chen L., Ingrid S., Ding Y.G., Liu Y., Qi J.G., Tang C.S., and Du J.B. Imbalance of endogenous homocysteine and hydrogen sulfide metabolic pathway in essential hypertensive children. Chin Med J 120 (2007) 389-393
    • (2007) Chin Med J , vol.120 , pp. 389-393
    • Chen, L.1    Ingrid, S.2    Ding, Y.G.3    Liu, Y.4    Qi, J.G.5    Tang, C.S.6    Du, J.B.7
  • 52
    • 33646839620 scopus 로고    scopus 로고
    • Impact of L-arginine on hydrogen sulfide/cystathionine-γ-lyase pathway in rats with high blood flow-induced pulmonary hypertension
    • Wang Y.F., Shi L., Du J.B., and Tang C.S. Impact of L-arginine on hydrogen sulfide/cystathionine-γ-lyase pathway in rats with high blood flow-induced pulmonary hypertension. Biochem Biophy Res Commun 345 (2006) 851-857
    • (2006) Biochem Biophy Res Commun , vol.345 , pp. 851-857
    • Wang, Y.F.1    Shi, L.2    Du, J.B.3    Tang, C.S.4


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