메뉴 건너뛰기




Volumn 112, Issue 3, 2011, Pages 745-749

Loss of runt-related transcription factor 3 causes development and progression of hepatocellular carcinoma

Author keywords

Angiogenesis; Apoptosis; Epithelial mesenchymal transition; Tumor suppressor gene

Indexed keywords

TRANSCRIPTION FACTOR RUNX3;

EID: 79951802134     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22973     Document Type: Review
Times cited : (30)

References (50)
  • 1
    • 20044379409 scopus 로고    scopus 로고
    • Expression of RUNX3 protein in human lung adenocarcinoma: Implications for tumor progression and prognosis
    • DOI 10.1111/j.1349-7006.2005.00033.x
    • Araki K, Osaki M, Nagahama Y, Hiramatsu T, Nakamura H, Ohgi S, Ito H. 2005. Expression of RUNX3 protein in human lung adenocarcinoma: Implications for tumor progression and prognosis. Cancer Sci 96:227-231. (Pubitemid 40767060)
    • (2005) Cancer Science , vol.96 , Issue.4 , pp. 227-231
    • Araki, K.1    Osaki, M.2    Nagahama, Y.3    Hiramatsu, T.4    Nakamura, H.5    Ohgi, S.6    Ito, H.7
  • 2
    • 0037879095 scopus 로고    scopus 로고
    • Kip1 is an independent predictor of recurrence after surgical resection in patients with small hepatocellular carcinoma
    • DOI 10.1016/S0168-8278(03)00025-4
    • Armengol C, Boix L, Bachs O, Sole M, Fuster J, Sala M, Llovet JM, Rodes J, Bruix J. 2003. p27(Kip1) is an independent predictor of recurrence after surgical resection in patients with small hepatocellular carcinoma. J Hepatol 38:591-597. (Pubitemid 36560643)
    • (2003) Journal of Hepatology , vol.38 , Issue.5 , pp. 591-597
    • Armengol, C.1    Boix, L.2    Bachs, O.3    Sole, M.4    Fuster, J.5    Sala, M.6    Llovet, J.M.7    Rodes, J.8    Bruix, J.9
  • 3
    • 0033867475 scopus 로고    scopus 로고
    • Genetics of hepatocellular carcinoma
    • Buendia MA. 2000. Genetics of hepatocellular carcinoma. Semin Cancer Biol 10:185-200.
    • (2000) Semin Cancer Biol , vol.10 , pp. 185-200
    • Buendia, M.A.1
  • 4
  • 5
    • 77950151788 scopus 로고    scopus 로고
    • Hypermethylation downregulates Runx3 gene expression and its restoration suppresses gastric epithelial cell growth by inducing p27 and caspase3 in human gastric cancer
    • Chen W, Gao N, Shen Y, Cen JN. 2010. Hypermethylation downregulates Runx3 gene expression and its restoration suppresses gastric epithelial cell growth by inducing p27 and caspase3 in human gastric cancer. J Gastroenterol Hepatol 25:823-831.
    • (2010) J Gastroenterol Hepatol , vol.25 , pp. 823-831
    • Chen, W.1    Gao, N.2    Shen, Y.3    Cen, J.N.4
  • 9
    • 0028804071 scopus 로고
    • M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity
    • De Souza AT, Hankins GR, Washington MK, Orton TC, Jirtle RL. 1995. M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity. Nat Genet 11:447-449.
    • (1995) Nat Genet , vol.11 , pp. 447-449
    • De Souza, A.T.1    Hankins, G.R.2    Washington, M.K.3    Orton, T.C.4    Jirtle, R.L.5
  • 10
    • 0033545541 scopus 로고    scopus 로고
    • Rising incidence of hepatocellular carcinoma in the United States
    • DOI 10.1056/NEJM199903113401001
    • El-Serag HB, Mason AC. 1999. Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med 340:745-750. (Pubitemid 29114292)
    • (1999) New England Journal of Medicine , vol.340 , Issue.10 , pp. 745-750
    • El-Serag, H.B.1    Mason, A.C.2
  • 11
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis
    • DOI 10.1053/j.gastro.2007.04.061, PII S0016508507007998
    • El-Serag HB, Rudolph KL. 2007. Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis. Gastroenterology 132:2557-2576. (Pubitemid 46890874)
    • (2007) Gastroenterology , vol.132 , Issue.7 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 12
    • 2942580742 scopus 로고    scopus 로고
    • Growth regulation of gastric epithelial cells by Runx3
    • DOI 10.1038/sj.onc.1207121
    • Fukamachi H, Ito K. 2004. Growth regulation of gastric epithelial cells by Runx3. Oncogene 23:4330-4335. (Pubitemid 38758598)
    • (2004) Oncogene , vol.23 , Issue.24 , pp. 4330-4335
    • Fukamachi, H.1    Ito, K.2
  • 13
  • 14
    • 21044445452 scopus 로고    scopus 로고
    • Apoptosis: A mechanism of acute and chronic liver injury
    • DOI 10.1136/gut.2004.053850
    • Guicciardi ME, Gores GJ. 2005. Apoptosis: A mechanism of acute and chronic liver injury. Gut 54:1024-1033. (Pubitemid 40873921)
    • (2005) Gut , vol.54 , Issue.7 , pp. 1024-1033
    • Guicciardi, M.E.1    Gores, G.J.2
  • 17
    • 2342641616 scopus 로고    scopus 로고
    • Methylation of RUNX3 in various types of human cancers and premalignant stages of gastric carcinoma
    • DOI 10.1038/labinvest.3700060
    • Kim TY, Lee HJ, Hwang KS, Lee M, Kim JW, Bang YJ, Kang GH. 2004. Methylation of RUNX3 in various types of human cancers and premalignant stages of gastric carcinoma. Lab Invest 84:479-484. (Pubitemid 41656475)
    • (2004) Laboratory Investigation , vol.84 , Issue.4 , pp. 479-484
    • Kim, T.Y.1    Lee, H.J.2    Hwang, K.S.3    Lee, M.4    Kim, J.W.5    Bang, Y.-J.6    Kang, G.H.7
  • 18
    • 4644363411 scopus 로고    scopus 로고
    • Promoter hypermethylation downregulates RUNX3 gene expression in colorectal cancer cell lines
    • DOI 10.1038/sj.onc.1207731
    • Ku JL, Kang SB, Shin YK, Kang HC, Hong SH, Kim IJ, Shin JH, Han IO, Park JG. 2004. Promoter hypermethylation downregulates RUNX3 gene expression in colorectal cancer cell lines. Oncogene 23:6736-6742. (Pubitemid 39280005)
    • (2004) Oncogene , vol.23 , Issue.40 , pp. 6736-6742
    • Ku, J.-L.1    Kang, S.-B.2    Shin, Y.-K.3    Kang, H.C.4    Hong, S.-H.5    Kim, I.-J.6    Shin, J.-H.7    Han, I.-O.8    Park, J.-G.9
  • 19
    • 0028136578 scopus 로고
    • AML1, AML2, and AML3, the human members of the runt domain gene-family: CDNA structure, expression, and chromosomal localization
    • DOI 10.1006/geno.1994.1519
    • Levanon D, Negreanu V, Bernstein Y, Bar-Am I, Avivi L, Groner Y. 1994. AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization. Genomics 23:425-432. (Pubitemid 24308264)
    • (1994) Genomics , vol.23 , Issue.2 , pp. 425-432
    • Levanon, D.1    Negreanu, V.2    Bernstein, Y.3    Bar-Am, I.4    Avivi, L.5    Groner, Y.6
  • 22
    • 45349105189 scopus 로고    scopus 로고
    • RUNX3 inhibits growth of HCC cells and HCC xenografts in mice in combination with adriamycin
    • Li X, Zhang Y, Qiao T, Wu K, Ding J, Liu J, Fan D. 2008. RUNX3 inhibits growth of HCC cells and HCC xenografts in mice in combination with adriamycin. Cancer Biol Ther 7:669-676.
    • (2008) Cancer Biol Ther , vol.7 , pp. 669-676
    • Li, X.1    Zhang, Y.2    Qiao, T.3    Wu, K.4    Ding, J.5    Liu, J.6    Fan, D.7
  • 29
    • 0034223661 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma
    • Williston Park discussion 1098-1102
    • Nakakura EK, Choti MA. 2000. Management of hepatocellular carcinoma. Oncology (Williston Park) 14:1085-1098, discussion 1098-1102.
    • (2000) Oncology , vol.14 , pp. 1085-1098
    • Nakakura, E.K.1    Choti, M.A.2
  • 30
    • 40949161396 scopus 로고    scopus 로고
    • Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma
    • DOI 10.1002/hep.22110
    • Nishida N, Nagasaka T, Nishimura T, Ikai I, Boland CR, Goel A. 2008. Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma. Hepatology 47:908-918. (Pubitemid 351449682)
    • (2008) Hepatology , vol.47 , Issue.3 , pp. 908-918
    • Nishida, N.1    Nagasaka, T.2    Nishimura, T.3    Ikai, I.4    Boland, C.R.5    Goel, A.6
  • 33
    • 0032847563 scopus 로고    scopus 로고
    • Genetic aspects of hepatocellular carcinogenesis
    • Ozturk M. 1999. Genetic aspects of hepatocellular carcinogenesis. Semin Liver Dis 19:235-242. (Pubitemid 29488766)
    • (1999) Seminars in Liver Disease , vol.19 , Issue.3 , pp. 235-242
    • Ozturk, M.1
  • 34
    • 0004623809 scopus 로고    scopus 로고
    • Increased expression of vascular endothelial growth factor and angiogenesis in the early stage of multistep hepatocarcinogenesis
    • Park YN, Kim YB, Yang KM, Park C. 2000. Increased expression of vascular endothelial growth factor and angiogenesis in the early stage of multistep hepatocarcinogenesis. Arch Pathol Lab Med 124:1061-1065. (Pubitemid 30602050)
    • (2000) Archives of Pathology and Laboratory Medicine , vol.124 , Issue.7 , pp. 1061-1065
    • Park, Y.N.1    Kim, Y.-B.2    Yang, K.M.3    Park, C.4
  • 36
    • 33751266107 scopus 로고    scopus 로고
    • RUNX3 inhibits the expression of vascular endothelial growth factor and reduces the angiogenesis, growth, and metastasis of human gastric cancer
    • DOI 10.1158/1078-0432.CCR-05-2359
    • Peng Z, Wei D, Wang L, Tang H, Zhang J, Le X, Jia Z, Li Q, Xie K. 2006. RUNX3 inhibits the expression of vascular endothelial growth factor and reduces the angiogenesis, growth, and metastasis of human gastric cancer. Clin Cancer Res 12:6386-6394. (Pubitemid 44799709)
    • (2006) Clinical Cancer Research , vol.12 , Issue.21 , pp. 6386-6394
    • Peng, Z.1    Wei, D.2    Wang, L.3    Tang, H.4    Zhang, J.5    Le, X.6    Jia, Z.7    Li, Q.8    Xie, K.9
  • 38
    • 0028083222 scopus 로고
    • Overexpression of transforming growth factor-α in hepatocellular carcinoma and focal nodular hyperplasia from European patients
    • DOI 10.1016/0046-8177(94)90296-8
    • Schaff Z, Hsia CC, Sarosi I, Tabor E. 1994. Overexpression of transforming growth factor-alpha in hepatocellular carcinoma and focal nodular hyperplasia from European patients. Hum Pathol 25:644-651. (Pubitemid 24230741)
    • (1994) Human Pathology , vol.25 , Issue.7 , pp. 644-651
    • Schaff, Z.1    Chu, C.H.2    Sarosi, I.3    Tabor, E.4
  • 39
    • 0025169651 scopus 로고
    • Analysis of ras gene mutations in human hepatic malignant tumors by polymerase chain reaction and direct sequencing
    • Tada M, Omata M, Ohto M. 1990. Analysis of ras gene mutations in human hepatic malignant tumors by polymerase chain reaction and direct sequencing. Cancer Res 50:1121-1124. (Pubitemid 20083997)
    • (1990) Cancer Research , vol.50 , Issue.4 , pp. 1121-1124
    • Tada, M.1    Omata, M.2    Ohto, M.3
  • 40
    • 0028180458 scopus 로고
    • p53 gene abnormalities are closely related to hepatoviral infections and occur at a late stage of hepatocarcinogenesis
    • Teramoto T, Satonaka K, Kitazawa S, Fujimori T, Hayashi K, Maeda S. 1994. p53 gene abnormalities are closely related to hepatoviral infections and occur at a late stage of hepatocarcinogenesis. Cancer Res 54:231-235.
    • (1994) Cancer Res , vol.54 , pp. 231-235
    • Teramoto, T.1    Satonaka, K.2    Kitazawa, S.3    Fujimori, T.4    Hayashi, K.5    Maeda, S.6
  • 41
    • 0344845003 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and pathologies
    • DOI 10.1016/j.ceb.2003.10.006
    • Thiery JP. 2003. Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol 15:740-746. (Pubitemid 37487967)
    • (2003) Current Opinion in Cell Biology , vol.15 , Issue.6 , pp. 740-746
    • Thiery, J.P.1
  • 42
    • 58849136702 scopus 로고    scopus 로고
    • Molecular targeted therapy for hepatocellular carcinoma
    • Thomas M. 2009. Molecular targeted therapy for hepatocellular carcinoma. J Gastroenterol 44(Suppl 19): 136-141.
    • (2009) J Gastroenterol , vol.44 , Issue.SUPPL. 19 , pp. 136-141
    • Thomas, M.1
  • 45
    • 0036890030 scopus 로고    scopus 로고
    • Prognostic significance of c-myc and AIB1 amplification in hepatocellular carcinoma. A broad survey using high-throughput tissue microarray
    • Wang Y, Wu MC, Sham JS, Zhang W, Wu WQ, Guan XY. 2002. Prognostic significance of c-myc and AIB1 amplification in hepatocellular carcinoma. A broad survey using high-throughput tissue microarray. Cancer 95:2346-2352.
    • (2002) Cancer , vol.95 , pp. 2346-2352
    • Wang, Y.1    Wu, M.C.2    Sham, J.S.3    Zhang, W.4    Wu, W.Q.5    Guan, X.Y.6
  • 46
    • 21144440536 scopus 로고    scopus 로고
    • Loss of RUNX3 expression significantly affects the clinical outcome of gastric cancer patients and its restoration causes drastic suppression of tumor growth and metastasis
    • DOI 10.1158/0008-5472.CAN-04-3741
    • Wei D, Gong W, Oh SC, Li Q, Kim WD, Wang L, Le X, Yao J, Wu TT, Huang S, Xie K. 2005. Loss of RUNX3 expression significantly affects the clinical outcome of gastric cancer patients and its restoration causes drastic suppression of tumor growth and metastasis. Cancer Res 65:4809-4816. (Pubitemid 40740819)
    • (2005) Cancer Research , vol.65 , Issue.11 , pp. 4809-4816
    • Wei, D.1    Gong, W.2    Oh, S.C.3    Li, Q.4    Kim, W.D.5    Wang, L.6    Le, X.7    Yao, J.8    Wu, T.T.9    Huang, S.10    Xie, K.11
  • 47
    • 1142299739 scopus 로고    scopus 로고
    • Hemizygous deletion and hypermethylation of RUNX3 gene in hepatocellular carcinoma
    • Xiao WH, Liu WW. 2004. Hemizygous deletion and hypermethylation of RUNX3 gene in hepatocellular carcinoma. World J Gastroenterol 10:376-380.
    • (2004) World J Gastroenterol , vol.10 , pp. 376-380
    • Xiao, W.H.1    Liu, W.W.2
  • 48
    • 0038745381 scopus 로고    scopus 로고
    • The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis
    • Xue C, Plieth D, Venkov C, Xu C, Neilson EG. 2003. The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis. Cancer Res 63:3386-3394. (Pubitemid 36735899)
    • (2003) Cancer Research , vol.63 , Issue.12 , pp. 3386-3394
    • Xue, C.1    Plieth, D.2    Venkov, C.3    Xu, C.4    Neilson, E.G.5
  • 50
    • 0031807538 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor in human hepatocellular carcinoma
    • DOI 10.1002/hep.510280111
    • Yamaguchi R, Yano H, Iemura A, Ogasawara S, Haramaki M, Kojiro M. 1998. Expression of vascular endothelial growth factor in human hepatocellular carcinoma. Hepatology 28:68-77. (Pubitemid 28299987)
    • (1998) Hepatology , vol.28 , Issue.1 , pp. 68-77
    • Yamaguchi, R.1    Yano, H.2    Iemura, A.3    Ogasawara, S.4    Haramaki, M.5    Kojiro, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.