메뉴 건너뛰기




Volumn 5, Issue 1, 2011, Pages 63-70

Glycoprotein IIb/IIIa inhibitors: An update on the mechanism of action and use of functional testing methods to assess antiplatelet efficacy

Author keywords

glycoprotein IIb IIIa; monitoring; platelets; therapy; thrombosis

Indexed keywords

ABCIXIMAB; EPTIFIBATIDE; FIBRINOGEN RECEPTOR ANTAGONIST; TIROFIBAN;

EID: 79951796382     PISSN: 17520363     EISSN: None     Source Type: Journal    
DOI: 10.2217/bmm.10.119     Document Type: Review
Times cited : (37)

References (66)
  • 1
    • 0028940694 scopus 로고
    • On the structure and function of platelet integrin αiIbβ3, the fibrinogen receptor
    • Calvete JJ: On the structure and function of platelet integrin αIIbβ3, the fibrinogen receptor. Proc. Soc. Exp. Biol. Med. 208, 346-360 (1995).
    • (1995) Proc. Soc. Exp. Biol. Med. , vol.208 , pp. 346-360
    • Calvete, J.J.1
  • 2
    • 0016246099 scopus 로고
    • An abnormal platelet glycoprotein pattern in three cases of Glanzmanns thrombasthenia
    • Nurden AT, Caen JP: An abnormal platelet glycoprotein pattern in three cases of Glanzmanns thrombasthenia. Br. J. Haematol. 28, 253-260 (1974).
    • (1974) Br. J. Haematol. , vol.28 , pp. 253-260
    • Nurden, A.T.1    Caen, J.P.2
  • 3
    • 0020438172 scopus 로고
    • Purification of glycoproteins IIb and III from human platelet plasma membranes and characterization of a calcium-dependent glycoprotein IIb-III complex
    • Jennings LK, Phillips DR: Purification of glycoproteins IIb and III from human platelet plasma membranes and characterization of a calcium-dependent glycoprotein IIb-III complex. J. Biol. Chem. 257, 10458-10466 (1982). (Pubitemid 13252245)
    • (1982) Journal of Biological Chemistry , vol.257 , Issue.17 , pp. 10458-10466
    • Jennings, L.K.1    Phillips, D.R.2
  • 5
    • 0028358415 scopus 로고
    • Clues for understanding the structure and function of a prototypic human integrin: The platelet glycoprotein IIb/IIIa complex
    • Calvete JJ: Clues for understanding the structure and function of a prototypic human integrin: the platelet glycoprotein IIb/IIIa complex. Thromb. Haemost. 72, 1-15 (1994). (Pubitemid 24202287)
    • (1994) Thrombosis and Haemostasis , vol.72 , Issue.1 , pp. 1-15
    • Calvete, J.J.1
  • 8
    • 0025362234 scopus 로고
    • The genomic organization of platelet glycoprotein IIIa
    • Zimrin AB, Gidwitz S, Lord S et al.: The genomic organization of platelet glycoprotein IIIa. J. Biol. Chem. 265, 8590-8595 (1990).
    • (1990) J. Biol. Chem. , vol.265 , pp. 8590-8595
    • Zimrin, A.B.1    Gidwitz, S.2    Lord, S.3
  • 12
  • 13
    • 0025910094 scopus 로고
    • Selective recognition of adhesive sites in surface-bound fibrinogen by glycoprotein IIb-IIIa on nonactivated platelets
    • Savage B, Ruggeri ZM: Selective recognition of adhesive sites in surface-bound fibrinogen by glycoprotein IIb-IIIa on nonactivated platelets. J. Biol. Chem. 266, 11227-11233 (1991). (Pubitemid 21906936)
    • (1991) Journal of Biological Chemistry , vol.266 , Issue.17 , pp. 11227-11233
    • Savage, B.1    Ruggeri, Z.M.2
  • 14
    • 2142708565 scopus 로고    scopus 로고
    • Glycoprotein Ib-IX-mediated activation of integrin αiIbβ3: Effects of receptor clustering and von Willebrand factor adhesion
    • Arya M, López JA, Romo GM et al.: Glycoprotein Ib-IX-mediated activation of integrin αIIbβ3: effects of receptor clustering and von Willebrand factor adhesion. J. Thromb. Haemost. 1, 1150-1157 (2003).
    • (2003) J. Thromb. Haemost. , vol.1 , pp. 1150-1157
    • Arya, M.1    López, J.A.2    Romo, G.M.3
  • 16
    • 70449566822 scopus 로고    scopus 로고
    • Structure of an integrin αiIbβ3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activation
    • Yang J, Ma YQ, Page RC, Misra S, Plow EF, Qin J: Structure of an integrin αIIbβ3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activation. Proc. Natl Acad. Sci. USA 106, 17729-17734 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 17729-17734
    • Yang, J.1    Ma, Y.Q.2    Page, R.C.3    Misra, S.4    Plow, E.F.5    Qin, J.6
  • 17
    • 4444352570 scopus 로고    scopus 로고
    • 3
    • Calvete JJ: Structures of integrin domains and concerted conformational changes in the bidirectional signaling mechanism of αIIbβ3. Exp. Biol. Med. (Maywood) 229, 732-744 (2004). (Pubitemid 39166477)
    • (2004) Experimental Biology and Medicine , vol.229 , Issue.8 , pp. 732-744
    • Calvete, J.J.1
  • 18
    • 0021319857 scopus 로고
    • Platelet receptor recognition site on human fibrinogen. Synthesis and structure-function relationship of peptides corresponding to the carboxy-terminal segment of the γ chain
    • Kloczewiak M, Timmons S, Lukas TJ, Hawiger J: Platelet receptor recognition site on human fibrinogen. Synthesis and structure-function relationship of peptides corresponding to the carboxy-terminal segment of the γ-chain. Biochemistry 23, 1767-1774 (1984). (Pubitemid 14139817)
    • (1984) Biochemistry , vol.23 , Issue.8 , pp. 1767-1774
    • Kloczewiak, M.1    Timmons, S.2    Lukas, T.J.3    Hawiger, J.4
  • 19
    • 0034704162 scopus 로고    scopus 로고
    • A redox site involved in integrin activation
    • DOI 10.1074/jbc.M007041200
    • Yan B, Smith JW: A redox site involved in integrin activation. J. Biol. Chem. 275, 39964-39972 (2000). (Pubitemid 32064618)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.51 , pp. 39964-39972
    • Yan, B.1    Smith, J.W.2
  • 20
    • 0035979337 scopus 로고    scopus 로고
    • Mechanism of integrin activation by disulfide bond reduction
    • DOI 10.1021/bi002902i
    • Yan B, Smith JW: Mechanism of integrin activation by disulfide bond reduction. Biochemistry 40, 8861-8867 (2001). (Pubitemid 32709519)
    • (2001) Biochemistry , vol.40 , Issue.30 , pp. 8861-8867
    • Yan, B.1    Smith, J.W.2
  • 21
    • 67649373064 scopus 로고    scopus 로고
    • The novel S527F mutation in the integrin β3 chain induces a high affinity αiIbβ3 receptor by hindering adoption of the bent conformation
    • Vanhoorelbeke K, De Meyer SF, Pareyn I et al.: The novel S527F mutation in the integrin β3 chain induces a high affinity αIIbβ3 receptor by hindering adoption of the bent conformation. J. Biol. Chem. 284, 14914-14920 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 14914-14920
    • Vanhoorelbeke, K.1    De Meyer, S.F.2    Pareyn, I.3
  • 22
    • 63649083644 scopus 로고    scopus 로고
    • TA: Rationally designed integrin β3 mutants stabilized in the high affinity conformation
    • Springer
    • Luo BH, Karanicolas J, Harmacek LD, Baker D, Springer TA: Rationally designed integrin β3 mutants stabilized in the high affinity conformation. J. Biol. Chem. 284, 3917-3924 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 3917-3924
    • Luo, B.H.1    Karanicolas, J.2    Harmacek, L.D.3    Baker, D.4
  • 23
    • 73449126569 scopus 로고    scopus 로고
    • Control of integrin αiIbβ3 outside-in signaling and platelet adhesion by sensing the physical properties of fibrin(ogen) substrates
    • Podolnikova NP, Yermolenko IS, Fuhrmann A et al.: Control of integrin αIIbβ3 outside-in signaling and platelet adhesion by sensing the physical properties of fibrin(ogen) substrates. Biochemistry 49, 68-77 (2010).
    • (2010) Biochemistry , vol.49 , pp. 68-77
    • Podolnikova, N.P.1    Yermolenko, I.S.2    Fuhrmann, A.3
  • 24
    • 70350015034 scopus 로고    scopus 로고
    • Proteomic analysis of integrin αiIbβ3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions
    • Senis YA, Antrobus R, Severin S et al.: Proteomic analysis of integrin αIIbβ3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions. J. Thromb. Haemost. 7, 1718-1726 (2009).
    • (2009) J. Thromb. Haemost. , vol.7 , pp. 1718-1726
    • Senis, Y.A.1    Antrobus, R.2    Severin, S.3
  • 25
    • 70350568827 scopus 로고    scopus 로고
    • New antiplatelet agents: Why they are needed
    • Franchini M, Mannucci PM: New antiplatelet agents: why they are needed. Eur. J. Intern. Med. 20, 733-738 (2009).
    • (2009) Eur. J. Intern. Med. , vol.20 , pp. 733-738
    • Franchini, M.1    Mannucci, P.M.2
  • 26
    • 77950635286 scopus 로고    scopus 로고
    • Basic principles of platelet biology and clinical implications
    • Angiolillo DJ, Ueno M, Goto S: Basic principles of platelet biology and clinical implications. Circ. J. 74, 597-607 (2010).
    • (2010) Circ. J. , vol.74 , pp. 597-607
    • Angiolillo, D.J.1    Ueno, M.2    Goto, S.3
  • 28
    • 0033573790 scopus 로고    scopus 로고
    • Of platelets, integrin αiIbβ3 and GPIIb-IIIa blockers: Past, present and future perspectives
    • Topol EJ, Byzova T, Plow EF: Of platelets, integrin αIIbβ3 and GPIIb-IIIa blockers: past, present and future perspectives. Lancet 353, 227-231 (1999).
    • (1999) Lancet , vol.353 , pp. 227-231
    • Topol, E.J.1    Byzova, T.2    Plow, E.F.3
  • 31
    • 34248371253 scopus 로고    scopus 로고
    • Clinical aspects of platelet inhibitors and thrombus formation
    • DOI 10.1161/01.RES.0000264509.36234.51, PII 0000301220070511000004
    • Meadows TA, Bhatt TL: Clinical aspects of platelet inhibition and thrombus formation. Circ. Res. 100, 1261-1275 (2007). (Pubitemid 46742917)
    • (2007) Circulation Research , vol.100 , Issue.9 , pp. 1261-1275
    • Meadows, T.A.1    Bhatt, D.L.2
  • 32
    • 0033230771 scopus 로고    scopus 로고
    • Effect of glycoprotein IIb/IIIa receptor blockade on platelet-leukocyte interaction and surface expression of the leukocyte integrin Mac-1 in acute myocardial infarction
    • DOI 10.1016/S0735-1097(99)00350-2, PII S0735109799003502
    • Neumann FJ, Zohlnhofer D, Fakhoury L, Ott I, Gawaz M, Shomig A: Effect of glycoprotein IIb/IIIa receptor blockade on platelet leukocyte interaction and surface expression of the leukocyte integrin Mac-1 in acute myocardial infarction. J. Am. Coll. Cardiol. 34, 1420-1426 (1999). (Pubitemid 29528652)
    • (1999) Journal of the American College of Cardiology , vol.34 , Issue.5 , pp. 1420-1426
    • Neumann, F.-J.1    Zohlnhofer, D.2    Fakhoury, L.3    Ott, I.4    Gawaz, M.5    Schomig, A.6
  • 33
    • 0033869435 scopus 로고    scopus 로고
    • Thrombocytopenia complicating treatment with intravenous glycoprotein IIb/IIIa receptor inhibitors: A pooled analysis
    • DOI 10.1067/mhj.2000.107554
    • Dasgupta H BJ, Wood GC, Frey CM, Demko SL, Menapace FJ: Thrombocytopenia complicating treatment with intravenous glycoprotein IIb/IIIa receptor inhibitors: a pooled analysis. Am. Heart. J. 140, 206-211 (2000). (Pubitemid 30641579)
    • (2000) American Heart Journal , vol.140 , Issue.2 , pp. 206-211
    • Dasgupta, H.1    Blankenship, J.C.2    Wood, G.C.3    Frey, C.M.4    Demko, S.L.5    Menapace, F.J.6
  • 37
    • 0035897893 scopus 로고    scopus 로고
    • Effect of GPpIIb/IIIa receptor blocker abciximab on outcome in patients with acute coronary syndrome without early coronary revascularization: The GUSTO IV-ACS trial
    • Investigators GI-A
    • Investigators GI-A: Effect of GPpIIb/IIIa receptor blocker abciximab on outcome in patients with acute coronary syndrome without early coronary revascularization: the GUSTO IV-ACS trial. Lancet 357, 1915-1924 (2001).
    • (2001) Lancet , vol.357 , pp. 1915-1924
  • 38
    • 0032886556 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of glycoprotein IIb-IIIa inhibitors
    • Kleiman NS: Pharmacokinetics and pharmacodynamics of glycoprotein IIb-IIIa inhibitors. Am. Heart. J. 138, 263-275 (1999).
    • (1999) Am. Heart. J. , vol.138 , pp. 263-275
    • Kleiman, N.S.1
  • 39
    • 0037118664 scopus 로고    scopus 로고
    • Platelet glycoprotein IIb/IIIa inhibitors. Recognition of a two-edge sword?
    • Quinn MJ, Plow EF, Topol EJ: Platelet glycoprotein IIb/IIIa inhibitors. Recognition of a two-edge sword? Circulation 106, 379-385 (2000).
    • (2000) Circulation , vol.106 , pp. 379-385
    • Quinn, M.J.1    Plow, E.F.2    Topol, E.J.3
  • 40
    • 31644437324 scopus 로고    scopus 로고
    • Randomized comparison of upstream tirofiban versus downstream high bolus dose tirofiban or abciximab on tissue-level perfusion and troponin release in high-risk acute coronary syndromes treated with percutaneous coronary interventions: The EVEREST trial
    • DOI 10.1016/j.jacc.2005.11.012, PII S0735109705026422
    • Bolognese L, Falsini G, Liistro F et al.: Randomized comparison of upstream tirofiban versus downstream high bolus dose tirofiban or abciximab on tissue-level perfusion and troponin release in high-risk acute coronary syndromes treated with percutaneous coronary interventions: the EVEREST trial. J. Am. Coll. Cardiol. 47, 522-528 (2006). (Pubitemid 43170839)
    • (2006) Journal of the American College of Cardiology , vol.47 , Issue.3 , pp. 522-528
    • Bolognese, L.1    Falsini, G.2    Liistro, F.3    Angioli, P.4    Ducci, K.5    Taddei, T.6    Tarducci, R.7    Cosmi, F.8    Baldassarre, S.9    Burali, A.10
  • 43
    • 0035799340 scopus 로고    scopus 로고
    • Randomized trial of aspirin, sibrafiban, or both for secondary prevention after acute coronary syndromes
    • Second SYMPHONY Investigators
    • Second SYMPHONY Investigators: Randomized trial of aspirin, sibrafiban, or both for secondary prevention after acute coronary syndromes. Circulation 103, 1727-1733 (2001).
    • (2001) Circulation , vol.103 , pp. 1727-1733
  • 44
    • 0034728088 scopus 로고    scopus 로고
    • Comparison of sibrafiban with aspirin for prevention of cardiovascular events after acute coronary syndromes: A randomised trial. The SYMPHONY Investigators. Sibrafiban versus Aspirin to Yield Maximum Protection from Ischemic Heart Events Post-acute Coronary Syndromes
    • Comparison of sibrafiban with aspirin for prevention of cardiovascular events after acute coronary syndromes: a randomised trial. The SYMPHONY Investigators. Sibrafiban versus Aspirin to Yield Maximum Protection from Ischemic Heart Events Post-acute Coronary Syndromes. Lancet 355, 337-345 (2000).
    • (2000) Lancet , vol.355 , pp. 337-345
  • 45
    • 0035895332 scopus 로고    scopus 로고
    • Increased mortality with oral platelet glycoprotein IIb/IIIa antagonists: A meta-analysis of phase III multicenter randomized trials
    • Chew DP, Bhatt DL, Sapp S, Topol EJ: Increased mortality with oral platelet glycoprotein IIb/IIIa antagonists: a meta-analysis of Phase III multicenter randomized trials. Circulation 103, 201-206 (2001). (Pubitemid 32095403)
    • (2001) Circulation , vol.103 , Issue.2 , pp. 201-206
    • Chew, D.P.1    Bhatt, D.L.2    Sapp, S.3    Topol, E.J.4
  • 47
    • 60549104066 scopus 로고    scopus 로고
    • Clinical utility of the PFA-100
    • Favaloro EJ: Clinical utility of the PFA-100. Semin. Thromb. Hemost. 34, 709-733 (2008).
    • (2008) Semin. Thromb. Hemost. , vol.34 , pp. 709-733
    • Favaloro, E.J.1
  • 50
    • 0036305723 scopus 로고    scopus 로고
    • Determination of platelet aggregation inhibition during percutaneous coronary intervention with the platelet function analyzer PFA-100
    • DOI 10.1067/mhj.2002.123581
    • Madan M, Berkowitz SD, Christie DJ, Smit AC, Sigmon KN, Tcheng JE: Determination of platelet aggregation inhibition during percutaneous coronary intervention with the platelet function analyzer PFA-100. Am. Heart. J. 144, 151-158 (2002). (Pubitemid 34734769)
    • (2002) American Heart Journal , vol.144 , Issue.1 , pp. 151-158
    • Madan, M.1    Berkowitz, S.D.2    Christie, D.J.3    Smit, A.C.4    Sigmon, K.N.5    Tcheng, J.E.6
  • 51
    • 0037126041 scopus 로고    scopus 로고
    • Randomized COMparison of platelet inhibition with abciximab, tiRofiban and eptifibatide during percutaneous coronary intervention in acute coronary syndromes: The COMPARE trial. Comparison of Measurements of Platelet aggregation with Aggrastat, Reopro, and Eptifibatide
    • Batchelor WB, Tolleson TR, Huang Y et al.: Randomized COMparison of platelet inhibition with abciximab, tiRofiban and eptifibatide during percutaneous coronary intervention in acute coronary syndromes: the COMPARE trial. Comparison Of Measurements of Platelet aggregation with Aggrastat, Reopro, and Eptifibatide. Circulation 106, 1470-1476 (2002).
    • (2002) Circulation , vol.106 , pp. 1470-1476
    • Batchelor, W.B.1    Tolleson, T.R.2    Huang, Y.3
  • 52
    • 0035967468 scopus 로고    scopus 로고
    • Monitoring platelet function in glycoprotein IIb/IIIa inhibitor therapy
    • Wu KK, Willerson JT: Monitoring platelet function in glycoprotein IIB/IIIA inhibitor therapy. Circulation 103, 2528-2530 (2001). (Pubitemid 32521958)
    • (2001) Circulation , vol.103 , Issue.21 , pp. 2528-2530
    • Wu, K.K.1    Willerson, J.T.2
  • 53
    • 0041357014 scopus 로고    scopus 로고
    • Genetic and acquired determinants of individual variability of response to antiplatelet drugs
    • DOI 10.1161/01.CIR.0000088843.52678.8A
    • Schafer AI: Genetic and acquired determinants of individual variability of response to antiplatelet drugs. Circulation 108, 910-911 (2003). (Pubitemid 37048214)
    • (2003) Circulation , vol.108 , Issue.8 , pp. 910-911
    • Schafer, A.I.1
  • 54
    • 67349244826 scopus 로고    scopus 로고
    • Laboratory assessment and perioperative management of patients on antiplatelet therapy: From the bench to the bedside
    • Lippi G, Favaloro EJ, Salvagno GL, Franchini M: Laboratory assessment and perioperative management of patients on antiplatelet therapy: from the bench to the bedside. Clin. Chim. Acta 405, 8-16 (2009).
    • (2009) Clin. Chim. Acta , vol.405 , pp. 8-16
    • Lippi, G.1    Favaloro, E.J.2    Salvagno, G.L.3    Franchini, M.4
  • 55
    • 63149194068 scopus 로고    scopus 로고
    • Light transmission aggregometry and ATP release for the diagnostic assessment of platelet function
    • Cattaneo M: Light transmission aggregometry and ATP release for the diagnostic assessment of platelet function. Semin. Thromb. Hemost. 35, 158-167 (2009).
    • (2009) Semin. Thromb. Hemost. , vol.35 , pp. 158-167
    • Cattaneo, M.1
  • 56
    • 63149094900 scopus 로고    scopus 로고
    • Screening tests of platelet function: Update on their appropriate uses for diagnostic testing
    • Harrison P, Mumford A: Screening tests of platelet function: update on their appropriate uses for diagnostic testing. Semin. Thromb. Hemost. 35, 150-157 (2009).
    • (2009) Semin. Thromb. Hemost. , vol.35 , pp. 150-157
    • Harrison, P.1    Mumford, A.2
  • 57
    • 67349085301 scopus 로고    scopus 로고
    • Diagnostic assessment of platelet disorders: What are the challenges to standardization?
    • Pai M, Hayward CP: Diagnostic assessment of platelet disorders: what are the challenges to standardization? Semin. Thromb. Hemost. 35, 131-138 (2009).
    • (2009) Semin. Thromb. Hemost. , vol.35 , pp. 131-138
    • Pai, M.1    Hayward, C.P.2
  • 58
    • 77149179733 scopus 로고    scopus 로고
    • Intracoronary eptifibatide bolus administration during percutaneous coronary revascularization for acute coronary syndromes with evaluation of platelet glycoprotein IIb/IIIa receptor occupancy and platelet function: The Intracoronary Eptifibatide (ICE) Trial
    • Deibele AJ, Jennings LK, Tcheng JE et al.: Intracoronary eptifibatide bolus administration during percutaneous coronary revascularization for acute coronary syndromes with evaluation of platelet glycoprotein IIb/IIIa receptor occupancy and platelet function: the Intracoronary Eptifibatide (ICE) Trial. Circulation 121, 784-791 (2010).
    • (2010) Circulation , vol.121 , pp. 784-791
    • Deibele, A.J.1    Jennings, L.K.2    Tcheng, J.E.3
  • 59
    • 55349114710 scopus 로고    scopus 로고
    • Ten Berg JM, Hackeng CM: The use of the VerifyNow system to monitor antiplatelet therapy: A review of the current evidence
    • van Werkum JW, Harmsze AM, Elsenberg EH, Bouman HJ, ten Berg JM, Hackeng CM: The use of the VerifyNow system to monitor antiplatelet therapy: a review of the current evidence. Platelets 19, 479-488 (2008).
    • (2008) Platelets , vol.19 , pp. 479-488
    • Van Werkum, J.W.1    Harmsze, A.M.2    Elsenberg, E.H.3    Bouman, H.J.4
  • 60
    • 25444508270 scopus 로고    scopus 로고
    • Investigation of the PADA as a method for monitoring: GPIIb/IIIa inhibitors and other antiplatelet agents
    • DOI 10.1055/s-2005-916685
    • Graff J, Harder S: Investigation of the PADA as a method for monitoring GPIIb/IIIa inhibitors and other antiplatelet agents. Semin. Thromb. Hemost. 31, 482-485 (2005). (Pubitemid 41362356)
    • (2005) Seminars in Thrombosis and Hemostasis , vol.31 , Issue.4 , pp. 482-485
    • Graff, J.1    Harder, S.2
  • 61
    • 34249939815 scopus 로고    scopus 로고
    • Measuring antiplatelet drug effects in the laboratory
    • DOI 10.1016/j.thromres.2006.11.012, PII S0049384806005007
    • Harrison P, Frelinger AL 3rd, Furman MI, Michelson AD: Measuring antiplatelet drug effects in the laboratory. Thromb. Res. 120, 323-336 (2007). (Pubitemid 46879909)
    • (2007) Thrombosis Research , vol.120 , Issue.3 , pp. 323-336
    • Harrison, P.1    Frelinger III, A.L.2    Furman, M.I.3    Michelson, A.D.4
  • 62
    • 25444461992 scopus 로고    scopus 로고
    • Is platelet adhesion assay able to quantify drug-induced platelet dysfunction?
    • DOI 10.1055/s-2005-916684
    • Schumann A, Bucha E, Nowak G: Is platelet adhesion assay able to quantify drug-induced platelet dysfunction? Semin. Thromb. Hemost. 31, 476-481 (2005). (Pubitemid 41362355)
    • (2005) Seminars in Thrombosis and Hemostasis , vol.31 , Issue.4 , pp. 476-481
    • Schumann, A.1    Bucha, E.2    Nowak, G.3
  • 63
    • 25444475545 scopus 로고    scopus 로고
    • Platelet function tests and flow cytometry to monitor antiplatelet therapy
    • DOI 10.1055/s-2005-916672
    • Matzdorff A: Platelet function tests and flow cytometry to monitor antiplatelet therapy. Semin. Thromb. Hemost. 31, 393-399 (2005). (Pubitemid 41362343)
    • (2005) Seminars in Thrombosis and Hemostasis , vol.31 , Issue.4 , pp. 393-399
    • Matzdorff, A.1
  • 64
    • 35648995509 scopus 로고    scopus 로고
    • Utility of PFA-100® closure time vs. optical aggregometry in assessing the efficacy of platelet membrane glycoprotein IIb/IIIa antagonists in vitro
    • DOI 10.1515/CCLM.2007.318
    • Stegnar M, Bozic M, Dolenc MS, Anderluh PS, Kikelj D: Utility of PFA-100 closure time vs. optical aggregometry in assessing the efficacy of platelet membrane glycoprotein IIb/IIIa antagonists in vitro. Clin. Chem. Lab. Med. 45, 1542-1548 (2007). (Pubitemid 350036573)
    • (2007) Clinical Chemistry and Laboratory Medicine , vol.45 , Issue.11 , pp. 1542-1548
    • Stegnar, M.1    Bozic, M.2    Dolenc, M.S.3    Anderluh, P.S.4    Kikelj, D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.