The novel S527F mutation in the integrin β3 chain induces a high affinity αIIbβ3 receptor by hindering adoption of the bent conformation

Journal of Biological Chemistry

Volumn 284, Issue 22, 2009, Pages 14914-14920

  Vanhoorelbeke, Karen ^a   De Meyer, Simon F ^a   Pareyn, Inge ^a   Melchior, Chantal ^b   Plançon, Sebastien ^b   Margue, Christiane ^b   Pradier, Olivier ^c   Fondu, Pierre ^d   Kieffer, Nelly ^b   Springer, Timothy A ^e   Deckmyn, Hans ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF LUXEMBOURG   (Luxembourg)

^c ERASME HOSPITAL   (Belgium)

^d BRUGMANN UNIVERSITY HOSPITAL   (Belgium)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY BINDING; CELL SURFACES; CONFORMATIONAL CHANGE; CONSTITUTIVELY ACTIVES; EPIDERMAL GROWTH FACTORS; GENES ENCODING; HIGH AFFINITY; HIGH-AFFINITY LIGAND BINDING; INTEGRIN; MOLECULAR MODELS; PLATELET INTEGRIN; STABLE CHINESE HAMSTER OVARY CELL LINES; STERIC HINDRANCES; WILD TYPES;

ANTIBODIES; BEARINGS (STRUCTURAL); BINDING ENERGY; BINDING SITES; BLOOD SUBSTITUTES; CELL CULTURE; CELL MEMBRANES; CHEMICAL REACTIONS; CRYSTAL STRUCTURE; GENE ENCODING; LIGANDS;

BIOACTIVITY;

ALPHAIIBBETA3 RECEPTOR; ARGININE; BETA3 INTEGRIN; DUAL SPECIFICITY PHOSPHATASE 2; ENZYME ANTIBODY; EPIDERMAL GROWTH FACTOR; FIBRINOGEN; LEUCINE; METHIONINE; PHENYLALANINE; RECEPTOR PROTEIN; RECOMBINANT PROTEIN; SERINE; TRYPTOPHAN; UNCLASSIFIED DRUG; ANTIBODY; EPITOPE; FIBRINOGEN RECEPTOR; MUTANT PROTEIN;

ADULT; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CASE REPORT; CONTROLLED STUDY; CRYSTAL STRUCTURE; GENE MUTATION; HETEROZYGOTE DETECTION; HUMAN; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; RECEPTOR BINDING; THROMBOCYTE DISORDER; AMINO ACID SUBSTITUTION; ANIMAL; CELL MEMBRANE; CHEMISTRY; CHO CELL; CRICETULUS; GENETICS; HAMSTER; IMMUNOLOGY; METABOLISM; MUTATION; PROTEIN BINDING;

CRICETULUS GRISEUS;

ADULT; AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES; BINDING SITES; BLOOD PLATELET DISORDERS; CELL MEMBRANE; CHO CELLS; CRICETINAE; CRICETULUS; EPITOPES; FIBRINOGEN; HUMANS; INTEGRIN BETA3; MALE; MUTANT PROTEINS; MUTATION; PHENYLALANINE; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN BINDING; PROTEIN CONFORMATION; SERINE;

EID: 67649373064     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M809167200     Document Type: Article

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