Neuroendocrinology of the skin: An overview and selective analysis

Dermato-Endocrinology

Volumn 3, Issue 1, 2011, Pages 3-10

  Zmijewski, Michal A ^a   Slominski, Andrzej T ^b  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Corticotropin releasing factor (CRF); Homeostasis; Hormones; Melatonin; Neurotransmitters; POMC; Regulatory network; Skin; Stress

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; NEUROPEPTIDE; STEROID;

CELLULAR STRESS RESPONSE; CELLULAR STRESS SIGNAL; HORMONE SYNTHESIS; HUMAN; MOLECULAR INTERACTION; NEUROENDOCRINE SYSTEM; NEUROENDOCRINOLOGY; NONHUMAN; REVIEW; SKIN; SKIN APPENDAGE; SKIN CELL;

EID: 79951784372     PISSN: 19381972     EISSN: 19381980     Source Type: Journal    
DOI: 10.4161/derm.3.1.14617     Document Type: Review

References (108)

1. Slominski A, Wortsman J. Neuroendocrinology of the skin. Endocr Rev 2000; 21:457-87.
2. Slominski A, Wortsman J, Paus R, Elias PM, Tobin DJ, Feingold KR. Skin as an endocrine organ: implications for its function. Drug Discov Today Dis Mech 2008; 5:137-44.
3. Slominski A. Neuroendocrine system of the skin. Dermatology 2005; 211:199-208. (Pubitemid 41415859)
4. Slominski A, Wortsman J, Linton E, Pisarchik A, Zbytek B. The skin as a model for the immunomodulatory effects of corticotropin-releasing hormone. In: Schaefer M, Stein C, Ed. Mind over Matter - Regulation of Peripheral Inflammation by the CNS. Basel, Boston, Berlin: Birkhaeuser Verlag 2003; 149-76.
5. Slominski A, Wortsman J. Self-regulated endocrine systems in the skin. Minerva Endocrinol 2003; 28:135-43.
6. Slominski A. Neuroendocrine activity of the melanocyte. Exp Dermatol 2009; 18:760-3.
7. Slominski A. A nervous breakdown in the skin: stress and the epidermal barrier. J Clin Invest 2007; 117:3166-9. (Pubitemid 350096970)
8. Holick MF. Vitamin D: Evolutionary, Physiological and Health Perspectives. Curr Drug Targets.
9. Slominski A, Paus R, Wortsman J. On the potential role of proopiomelanocortin in skin physiology and pathology. Mol Cell Endocrinol 1993; 93:1-6.
10. Slominski A, Mihm MC. Potential mechanism of skin response to stress. Int J Dermatol 1996; 35:849-51. (Pubitemid 26426633)
11. Slominski AT, Botchkarev V, Choudhry M, Fazal N, Fechner K, Furkert J, et al. Cutaneous expression of CRH and CRH-R. Is there a "skin stress response system?" Ann NY Acad Sci 1999; 885:287-311.
12. Slominski A, Wortsman J, Tuckey RC, Paus R. Differential expression of HPA axis homolog in the skin. Mol Cell Endocrinol 2007; 265:143-9. (Pubitemid 46273958)
13. Slominski A, Wortsman J, Kohn L, Ain KB, Venkataraman GM, Pisarchik A, et al. Expression of hypothalamic-pituitary-thyroid axis related genes in the human skin. J Invest Dermatol 2002; 119:1449-55. (Pubitemid 36005634)
14. Bodo E, Kany B, Gaspar E, Knuver J, Kromminga A, Ramot Y, et al. Thyroid-stimulating hormone, a novel, locally produced modulator of human epidermal functions, is regulated by thyrotropin-releasing hormone and thyroid hormones. Endocrinology 2010; 151:1633-42.
15. Cianfarani F, Baldini E, Cavalli A, Marchioni E, Lembo L, Teson M, et al. TSH receptor and thyroid-specific gene expression in human skin. J Invest Dermatol 2010; 130:93-101.
16. Gaspar E, Hardenbicker C, Bodo E, Wenzel B, Ramot Y, Funk W, et al. Thyrotropin releasing hormone (TRH): a new player in human hair-growth control. Faseb J 2010; 24:393-403.
17. Slominski A, Tobin DJ, Zmijewski MA, Wortsman J, Paus R. Melatonin in the skin: synthesis, metabolism and functions. Trends Endocrinol Metab 2008; 19:17-24.
18. Slominski A, Wortsman J, Tobin DJ. The cutaneous serotoninergic/ melatoninergic system: securing a place under the sun. Faseb J 2005; 19:176-94. (Pubitemid 40189259)
19. Slominski A, Pisarchik A, Semak I, Sweatman T, Wortsman J, Szczesniewski A, et al. Serotoninergic and melatoninergic systems are fully expressed in human skin. Faseb J 2002; 16:896-8.
20. Slominski A, Pisarchik A, Zbytek B, Tobin DJ, Kauser S, Wortsman J. Functional activity of serotoninergic and melatoninergic systems expressed in the skin. J Cell Physiol 2003; 196:144-53. (Pubitemid 36676452)
21. Nordlind K, Azmitia EC, Slominski A. The skin as a mirror of the soul: exploring the possible roles of serotonin. Exp Dermatol 2008; 17:301-11. (Pubitemid 351338673)
22. Fischer TW, Slominski A, Zmijewski MA, Reiter RJ, Paus R. Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair. Exp Dermatol 2008; 17:713-30.
23. Slominski A, Wortsman J, Pisarchik A, Zbytek B, Linton EA, Mazurkiewicz JE, et al. Cutaneous expression of corticotropin-releasing hormone (CRH), urocortin and CRH receptors. Faseb J 2001; 15:1678-93. (Pubitemid 32730215)
24. Slominski A, Wortsman J, Luger T, Paus R, Solomon S. Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol Rev 2000; 80:979-1020. (Pubitemid 30452009)
25. Vale W, Spiess J, Rivier C, Rivier J. Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science 1981; 213:1394-7. (Pubitemid 12243637)
26. Chrousos GP. The Hypothalamic-Pituitary-Adrenal Axis and Immune-Mediated Inflammation. N Engl J Med 1995; 332:1351-63.
27. Smith AI, Funder JW. Proopiomelanocortin processing in the pituitary, central nervous system and peripheral tissues. Endocr Rev 1988; 9:159-79.
28. Slominski A, Tobin DJ, Shibahara S, Wortsman J. Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev 2004; 84:1155-228. (Pubitemid 39287950)
29. Slominski A, Ermak G, Mihm M. ACTH receptor, CYP11A1, CYP17 and CYP21A2 genes are expressed in skin. J Clin Endocrinol Metab 1996; 81:2746-9. (Pubitemid 26240307)
30. Slominski A, Baker J, Ermak G, Chakraborty A, Pawelek J. Ultraviolet B stimulates production of corticotropin releasing factor (CRF) by human melanocytes. FEBS Lett 1996; 399:175-6. (Pubitemid 27007978)
31. Slominski A, Ermak G, Mazurkiewicz JE, Baker J, Wortsman J. Characterization of corticotropin-releasing hormone (CRH) in human skin. J Clin Endocrinol Metab 1998; 83:1020-4. (Pubitemid 28496487)
32. Slominski A, Pisarchik A, Tobin DJ, Mazurkiewicz JE, Wortsman J. Differential expression of a cutaneous corticotropin-releasing hormone system. Endocrinology 2004; 145:941-50. (Pubitemid 38183838)
33. Slominski A, Roloff B, Curry J, Dahiya M, Szczesniewski A, Wortsman J. The skin produces urocortin. J Clin Endocrinol Metab 2000; 85:815-23. (Pubitemid 32273673)
34. Slominski A, Szczesniewski A, Wortsman J. Liquid chromatography-mass spectrometry detection of corticotropin-releasing hormone and proopiomelanocortin-derived peptides in human skin. J Clin Endocrinol Metab 2000; 85:3582-8.
35. Slominski A, Zbytek B, Pisarchik A, Slominski RM, Zmijewski MA, Wortsman J. CRH functions as a growth factor/cytokine in the skin. J Cell Physiol 2006; 206:780-91. (Pubitemid 43191053)
36. Slominski A, Zbytek B, Zmijewski M, Slominski RM, Kauser S, Wortsman J, et al. Corticotropin releasing hormone and the skin. Front Biosci 2006; 11:2230-48. (Pubitemid 43832722)
37. Zouboulis CC, Seltmann H, Hiroi N, Chen W, Young M, Oeff M, et al. Corticotropin-releasing hormone: an autocrine hormone that promotes lipogenesis in human sebocytes. Proc Natl Acad Sci USA 2002; 99:7148-53. (Pubitemid 34526270)
38. Ito N, Ito T, Betterman A, Paus R. The human hair bulb is a source and target of CRH. J Invest Dermatol 2004; 122:235-7. (Pubitemid 38114662)
39. Slominski A, Paus R, Mazurkiewicz J. Proopiomelanocortin expression in the skin during induced hair growth in mice. Experientia 1992; 48:50-4.
40. Slominski A. POMC gene expression in hamster and mouse melanoma cells. FEBS Lett 1991; 291:165-8.
41. Schauer E, Trautinger F, Kock A, Schwarz A, Bhardwaj R, Simon M, et al. Proopiomelanocortin-derived peptides are synthesized and released by human keratinocytes. J Clin Invest 1994; 93:2258-62. (Pubitemid 24143110)
42. Slominski A, Ermak G, Hwang J, Chakraborty A, Mazurkiewicz JE, Mihm M. Proopiomelanocortin, corticotropin releasing hormone and corticotropin releasing hormone receptor genes are expressed in human skin. FEBS Lett 1995; 374:113-6.
43. Slominski A. Identification of beta-endorphin, alpha-MSH and ACTH peptides in cultured human melanocytes, melanoma and squamous cell carcinoma cells by RP-HPLC. Exp Dermatol 1998; 7:213-6. (Pubitemid 28419413)
44. Slominski A, Heasley D, Mazurkiewicz JE, Ermak G, Baker J, Carlson JA. Expression of proopiomelanocortin (POMC)-derived melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH) peptides in skin of basal cell carcinoma patients. Hum Pathol 1999; 30:208-15.
45. Zbytek B, Wortsman J, Slominski A. Characterization of a ultraviolet B-induced corticotropin-releasing hormone-proopiomelanocortin system in human melanocytes. Mol Endocrinol 2006; 20:2539-47. (Pubitemid 44496421)
46. Chakraborty AK, Funasaka Y, Slominski A, Bolognia J, Sodi S, Ichihashi M, et al. UV light and MSH receptors. Ann NY Acad Sci 1999; 885:100-16.
47. Slominski A, Zjawiony J, Wortsman J, Semak I, Stewart J, Pisarchik A, et al. A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin. Eur J Biochem 2004; 271:4178-88. (Pubitemid 39506746)
48. Slominski A, Zbytek B, Szczesniewski A, Semak I, Kaminski J, Sweatman T, et al. CRH stimulation of corticosteroids production in melanocytes is mediated by ACTH. Am J Physiol Endocrinol Metab 2005; 288:701-6.
49. Slominski A, Zbytek B, Semak I, Sweatman T, Wortsman J. CRH stimulates POMC activity and corticosterone production in dermal fibroblasts. J Neuroimmunol 2005; 162:97-102.
50. Slominski A, Zbytek B, Szczesniewski A, Wortsman J. Cultured human dermal fibroblasts do produce cortisol. J Invest Dermatol 2006; 126:1177-8.
51. Slominski A, Gomez-Sanchez CE, Foecking MF, Wortsman J. Metabolism of progesterone to DOC, corticosterone and 18OHDOC in cultured human melanoma cells. FEBS Lett 1999; 455:364-6. (Pubitemid 29333068)
52. Ito N, Ito T, Kromminga A, Bettermann A, Takigawa M, Kees F, et al. Human hair follicles display a functional equivalent of the hypothalamic-pituitary- adrenal axis and synthesize cortisol. Faseb J 2005; 19:1332-4. (Pubitemid 41113740)
53. Slominski A, Gomez-Sanchez CE, Foecking MF, Wortsman J. Active steroidogenesis in the normal rat skin. Biochim Biophys Acta 2000; 1474:1-4. (Pubitemid 30103525)
54. Slominski A, Wortsman J, Foecking MF, Shackleton C, Gomez-Sanchez C, Szczesniewski A. Gas chromatography/mass spectrometry characterization of corticosteroid metabolism in human immortalized keratinocytes. J Invest Dermatol 2002; 118:310-5. (Pubitemid 34158486)
55. Slominski AT, Zmijewski MA, Semak I, Sweatman T, Janjetovic Z, Li W, et al. Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin. PLoS One 2009; 4:4309.
56. Slominski A, Semak I, Zjawiony J, Wortsman J, Li W, Szczesniewski A, et al. The cytochrome P450scc system opens an alternate pathway of vitamin D3 metabolism. FEBS J 2005; 272:4080-90. (Pubitemid 41160916)
57. Tuckey RC, Li W, Zjawiony JK, Zmijewski MA, Nguyen MN, Sweatman T, et al. Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc. FEBS J 2008; 275:2585-96. (Pubitemid 351600097)
58. Tuckey RC, Janjetovic Z, Li W, Nguyen MN, Zmijewski MA, Zjawiony JK, et al. Metabolism of 1alfa-hydroxyvitamin D3 by cytochrome P450scc to biologically active 1alfa,20-dihydroxyvitamin D3. J Steroid Biochem Molec Biol 2008; 112:213-9.
59. Slominski A, Semak I, Wortsman J, Zjawiony J, Li W, Zbytek B, et al. An alternative pathway of vitamin D2 metabolism. Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2. FEBS Journal 2006; 273:2891-901.
60. Slominski A, Semak I, Zjawiony J, Wortsman J, Gandy MN, Li J, et al. Enzymatic metabolism of ergosterol by cytochrome p450scc to biologically active 17alpha,24-dihydroxyergosterol. Chem Biol 2005; 12:931-9. (Pubitemid 41206807)
61. Zbytek B, Janjetovic Z, Tuckey RC, Zmijewski MA, Sweatman TW, Jones E, et al. 20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiation. J Invest Dermatol 2008; 128:2271-80.
62. Janjetovic Z, Zmijewski MA, Tuckey RC, DeLeon DA, Nguyen MN, Pfeffer LM, et al. 20-Hydroxycholecalciferol, product of vitamin D3 hydroxylation by P450scc, decreases NFkappaB activity by increasing IkappaB alpha levels in human keratinocytes. PLoS One 2009; 4:5988.
63. Slominski AT, Janjetovic Z, Fuller BE, Zmijewski MA, Tuckey RC, Nguyen MN, et al. Products of Vitamin D3 or 7-Dehydrocholesterol Metabolism by Cytochrome P450scc Show Anti-leukemia Effects, Having Low or Absent Calcemic Activity. PLoS One 2010; 5:9907.
64. Zmijewski MA, Li W, Zjawiony JK, Sweatman TW, Chen J, Miller DD, et al. Photo-conversion of two epimers (20R and 20S) of pregna-5,7-diene-3beta, 17alpha, 20-triol and their bioactivity in melanoma cells. Steroids 2009; 74:218-28.
65. Zmijewski MA, Li W, Zjawiony JK, Sweatman TW, Chen J, Miller DD, et al. Synthesis and photo-conversion of androsta- and pregna-5,7-dienes to vitamin D3-like derivatives. Photochem Photobiol Sci 2008; 7:1570-6.
66. Zbytek B, Pfeffer LM, Slominski AT. CRH inhibits NFkappaB signaling in human melanocytes. Peptides 2006; 27:3276-83. (Pubitemid 44738166)
67. Kauser S, Slominski A, Wei ET, Tobin DJ. Modulation of the human hair follicle pigmentary unit by corticotropin-releasing hormone and urocortin peptides. Faseb J 2006; 20:882-95. (Pubitemid 44961991)
68. Zbytek B, Slominski AT. Corticotropin-releasing hormone induces keratinocyte differentiation in the adult human epidermis. J Cell Physiol 2005; 203:118-26. (Pubitemid 40328178)
69. Zbytek B, Pikula M, Slominski RM, Mysliwski A, Wei E, Wortsman J, et al. Corticotropin-releasing hormone triggers differentiation in HaCaT keratinocytes. Br J Dermatol 2005; 152:474-80. (Pubitemid 40547121)
70. Zbytek B, Pfeffer LM, Slominski AT. Corticotropin-releasing hormone stimulates NFkappaB in human epidermal keratinocytes. J Endocrinol 2004; 181:1-7.
71. Zbytek B, Pfeffer LM, Slominski AT. Corticotropin-releasing hormone inhibits nuclear factor kappaB pathway in human HaCaT keratinocytes. J Invest Dermatol 2003; 121:1496-9. (Pubitemid 38005504)
72. Zbytek B, Mysliwski A, Slominski A, Wortsman J, Wei ET, Mysliwska J. Corticotropin-releasing hormone affects cytokine production in human HaCaT keratinocytes. Life Sci 2002; 70:1013-21. (Pubitemid 34085093)
73. Quevedo ME, Slominski A, Pinto W, Wei E, Wortsman J. Pleiotropic effects of corticotropin releasing hormone on normal human skin keratinocytes. In Vitro Cell Dev Biol Anim 2001; 37:50-4. (Pubitemid 32245954)
74. O'Kane M, Murphy EP, Kirby B. The role of corticotropin-releasing hormone in immune-mediated cutaneous inflammatory disease. Exp Dermatol 2006; 15:143-53.
75. Zmijewski MA, Slominski AT. Emerging role of alternative splicing of CRF1 receptor in CRF signaling. Acta Biochim Pol 2010; 57:1-13.
76. Pisarchik A, Slominski AT. Alternative splicing of CRH-R1 receptors in human and mouse skin: identification of new variants and their differential expression. Faseb J 2001; 15:2754-6.
77. Pisarchik A, Slominski A. Corticotropin releasing factor receptor type 1: molecular cloning and investigation of alternative splicing in the hamster skin. J Invest Dermatol 2002; 118:1065-72. (Pubitemid 34639187)
78. Pisarchik A, Slominski A. Molecular and functional characterization of novel CRFR1 isoforms from the skin. Eur J Biochem 2004; 271:2821-30. (Pubitemid 38869983)
79. Zmijewski MA, Slominski AT. Modulation of CRF singaling throught receptor splicing in mouse AtT-20 pituitary cells - Emerging role of soluble isofroms. Journal Physiology and Pharmacology 2009; 60:39-46.
80. Zmijewski MA, Slominski AT. CRF1 receptor splicing in epidermal keratinocytes: potential biological role and environmental regulations. J Cell Physiol 2009; 218:593-602.
81. Slominski AT, Zmijewski MA, Pisarchik A, Wortsman J. Molecular cloning and initial characterization of African green monkey (Cercopithecus aethiops) corticotropin releasing factor receptor type 1 (CRF1) from COS-7 cells. Gene 2007; 389:154-62.
82. Bubenik GA. Gastrointestinal melatonin: localization, function and clinical relevance. Dig Dis Sci 2002; 47:2336-48. (Pubitemid 35205309)
83. Zmijewski MA, Sweatman TW, Slominski AT. The melatonin-producing system is fully functional in retinal pigment epithelium (ARPE-19). Mol Cell Endocrinol 2009; 307:211-6.
84. Slominski A, Baker J, Rosano TG, Guisti LW, Ermak G, Grande M, et al. Metabolism of serotonin to N-acetylserotonin, melatonin and 5-methoxytryptamine in hamster skin culture. J Biol Chem 1996; 271:12281-6. (Pubitemid 126515696)
85. Slominski A, Pisarchik A, Johansson O, Jing C, Semak I, Slugocki G, et al. Tryptophan hydroxylase (TPH) expression in human skin cells. Biochim Biophys Acta 2003; 1639:80-6. (Pubitemid 38366211)
86. Zhang X, Beaulieu JM, Sotnikova TD, Gainetdinov RR, Caron MG. Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science 2004; 305:217. (Pubitemid 38886729)
87. Schallreuter KU, Schulz-Douglas V, Bunz A, Beazley W, Korner C. Pteridines in the control of pigmentation. J Invest Dermatol 1997; 109:31-5. (Pubitemid 27305645)
88. Gaudet SJ, Slominski A, Etminan M, Pruski D, Paus R, Namboordiri MAA. Identification and characterization of two isozymic forms of arylamine N-acetyltransferase in Syrian hamster skin. J Invest Dermatol 1993; 101:660-5. (Pubitemid 23322020)
89. Semak I, Korik E, Naumova M, Wortsman J, Slominski A. Serotonin metabolism in rat skin: characterization by liquid chromatography-mass spectrometry. Arch Biochem Biophys 2004; 421:61-6. (Pubitemid 37543496)
90. Roseboom PH, Namboodiri MA, Zimonjic DB, Popescu NC, Rodriguez IR, Gastel JA, et al. Natural melatonin 'knockdown' in C57BL/6J mice: rare mechanism truncates serotonin N-acetyltransferase. Brain Res Mol Brain Res 1998; 63:189-97.
91. Fischer TW, Sweatman TW, Semak I, Sayre RM, Wortsman J, Slominski A. Constitutive and UV-induced metabolism of melatonin in keratinocytes and cell-free systems. Faseb J 2006; 20:1564-6.
92. Slominski A, Semak I, Pisarchik A, Sweatman T, Szczesniewski A, Wortsman J. Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells. FEBS Lett 2002; 511:102-6. (Pubitemid 34127831)
93. Slominski A, Pisarchik A, Wortsman J. Expression of genes coding melatonin and serotonin receptors in rodent skin. Biochim Biophys Acta 2004; 1680:67-70. (Pubitemid 39361125)
94. Kobayashi H, Kromminga A, Dunlop TW, Tychsen B, Conrad F, Suzuki N, et al. A role of melatonin in neuroectodermal-mesodermal interactions: the hair follicle synthesizes melatonin and expresses functional melatonin receptors. Faseb J 2005; 19:1710-2. (Pubitemid 41429538)
95. Fischer TW, Zmijewski MA, Zbytek B, Sweatman TW, Slominski RM, Wortsman J, et al. Oncostatic effects of the indole melatonin and expression of its cytosolic and nuclear receptors in cultured human melanoma cell lines. Int J Oncol 2006; 29:665-72.
96. Slominski A, Chassalevris N, Mazurkiewicz J, Maurer M, Paus R. Murine skin as a target for melatonin bioregulation. Exp Dermatol 1994; 3:45-50. (Pubitemid 24160578)
97. Slominski A, Wortsman J, Plonka PM, Schallreuter KU, Paus R, Tobin DJ. Hair follicle pigmentation. J Invest Dermatol 2005; 124:13-21. (Pubitemid 40100943)
98. Slominski A, Pruski D. Melatonin inhibits proliferation and melanogenesis in rodent melanoma cells. Exp Cell Res 1993; 206:189-294.
99. Fischer TW, Zmijewski MA, Wortsman J, Slominski A. Melatonin maintains mitochondrial membrane potential and attenuates activation of initiator (casp-9) and effector caspases (casp-3/casp-7) and PARP in UVR-exposed HaCaT keratinocytes. J Pineal Res 2008; 44:397-407. (Pubitemid 351533524)
100. Fischer TW, Zbytek B, Sayre RM, Apostolov EO, Basnakian AG, Sweatman TW, et al. Melatonin increases survival of HaCaT keratinocytes by suppressing UV-induced apoptosis. J Pineal Res 2006; 40:18-26.
101. Arck PC, Slominski A, Theoharides TC, Peters EM, Paus R. Neuroimmunology of stress: skin takes center stage. J Invest Dermatol 2006; 126:1697-704. (Pubitemid 44086503)
102. Slominski A, Zmijewski MA, Zbytek B, Brozyna A, Granese J, Pisarchik A, et al. Regulated proenkephalin expression in human skin and cultured skin cells. J Invest Dermatol 2010; In press.
103. Slominski A, Paus R. Melanogenesis is coupled to murine anagen: Toward new concepts for the role of melanocytes and the regulation of melanogenesis in hair growth. J Invest Dermatol 1993; 101:90-7.
104. Slominski A, Paus R, Schadendorf D. Melanocytes as "sensory" and regulatory cells in the epidermis. J Theor Biol 1993; 164:103-20.
105. Slominski A, Paus R. Towards defining receptors for L-tyrosine and L-dopa. Mol Cell Endocrinol 1994; 99:7-11.
106. Slominski A, Paus R. Are L-tyrosine and L-dopa hormone-like bioregulators? J Theor Biol 1990; 143:123-38.
107. Theoharides TC, Donelan JM, Papadopoulou N, Cao J, Kempuraj D, Conti P. Mast cells as targets of corticotropin-releasing factor and related peptides. Trends Pharmacol Sci 2004; 25:563-8. (Pubitemid 39371146)
108. Theoharides TC, Cochrane DE. Critical role of mast cells in inflammatory diseases and the effect of acute stress. J Neuroimmunol 2004; 146:1-12. (Pubitemid 38032950)