메뉴 건너뛰기




Volumn 34, Issue 2, 2011, Pages 188-200

Nuclear Export of the NF-κB Inhibitor IκBα Is Required for Proper B Cell and Secondary Lymphoid Tissue Formation

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B ALPHA; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P100; TRANSCRIPTION FACTOR RELB;

EID: 79951768852     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2011.01.014     Document Type: Article
Times cited : (30)

References (52)
  • 1
    • 0023724778 scopus 로고
    • I κ B: A specific inhibitor of the NF-κ B transcription factor
    • Baeuerle P.A., Baltimore D. I κ B: A specific inhibitor of the NF-κ B transcription factor. Science 1988, 242:540-546.
    • (1988) Science , vol.242 , pp. 540-546
    • Baeuerle, P.A.1    Baltimore, D.2
  • 3
    • 0034731365 scopus 로고    scopus 로고
    • Dynamic shuttling of nuclear factor κ B between the nucleus and cytoplasm as a consequence of inhibitor dissociation
    • Carlotti F., Dower S.K., Qwarnstrom E.E. Dynamic shuttling of nuclear factor κ B between the nucleus and cytoplasm as a consequence of inhibitor dissociation. J. Biol. Chem. 2000, 275:41028-41034.
    • (2000) J. Biol. Chem. , vol.275 , pp. 41028-41034
    • Carlotti, F.1    Dower, S.K.2    Qwarnstrom, E.E.3
  • 4
    • 67649216120 scopus 로고    scopus 로고
    • B cell receptor-mediated sustained c-Rel activation facilitates late transitional B cell survival through control of B cell activating factor receptor and NF-kappaB2
    • Castro I., Wright J.A., Damdinsuren B., Hoek K.L., Carlesso G., Shinners N.P., Gerstein R.M., Woodland R.T., Sen R., Khan W.N. B cell receptor-mediated sustained c-Rel activation facilitates late transitional B cell survival through control of B cell activating factor receptor and NF-kappaB2. J. Immunol. 2009, 182:7729-7737.
    • (2009) J. Immunol. , vol.182 , pp. 7729-7737
    • Castro, I.1    Wright, J.A.2    Damdinsuren, B.3    Hoek, K.L.4    Carlesso, G.5    Shinners, N.P.6    Gerstein, R.M.7    Woodland, R.T.8    Sen, R.9    Khan, W.N.10
  • 5
    • 47149093727 scopus 로고    scopus 로고
    • A critical role of Rap1b in B-cell trafficking and marginal zone B-cell development
    • Chen Y., Yu M., Podd A., Wen R., Chrzanowska-Wodnicka M., White G.C., Wang D. A critical role of Rap1b in B-cell trafficking and marginal zone B-cell development. Blood 2008, 111:4627-4636.
    • (2008) Blood , vol.111 , pp. 4627-4636
    • Chen, Y.1    Yu, M.2    Podd, A.3    Wen, R.4    Chrzanowska-Wodnicka, M.5    White, G.C.6    Wang, D.7
  • 10
  • 11
    • 0033812335 scopus 로고    scopus 로고
    • Generation, expansion, migration and activation of mouse B1 cells
    • Fagarasan S., Watanabe N., Honjo T. Generation, expansion, migration and activation of mouse B1 cells. Immunol. Rev. 2000, 176:205-215.
    • (2000) Immunol. Rev. , vol.176 , pp. 205-215
    • Fagarasan, S.1    Watanabe, N.2    Honjo, T.3
  • 13
    • 54949147176 scopus 로고    scopus 로고
    • New regulators of NF-kappaB in inflammation
    • Ghosh S., Hayden M.S. New regulators of NF-kappaB in inflammation. Nat. Rev. Immunol. 2008, 8:837-848.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 837-848
    • Ghosh, S.1    Hayden, M.S.2
  • 14
    • 0036234459 scopus 로고    scopus 로고
    • Missing pieces in the NF-kappaB puzzle
    • Ghosh S., Karin M. Missing pieces in the NF-kappaB puzzle. Cell 2002, 109(Suppl):S81-S96.
    • (2002) Cell , vol.109 , Issue.SUPPL.
    • Ghosh, S.1    Karin, M.2
  • 15
    • 0028154853 scopus 로고
    • The subunit composition of NF-κ B complexes changes during B-cell development
    • Grumont R.J., Gerondakis S. The subunit composition of NF-κ B complexes changes during B-cell development. Cell Growth Differ. 1994, 5:1321-1331.
    • (1994) Cell Growth Differ. , vol.5 , pp. 1321-1331
    • Grumont, R.J.1    Gerondakis, S.2
  • 17
    • 0344549859 scopus 로고    scopus 로고
    • Regulation of RelA subcellular localization by a putative nuclear export signal and p50
    • Harhaj E.W., Sun S.C. Regulation of RelA subcellular localization by a putative nuclear export signal and p50. Mol. Cell. Biol. 1999, 19:7088-7095.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 7088-7095
    • Harhaj, E.W.1    Sun, S.C.2
  • 18
    • 33645312379 scopus 로고    scopus 로고
    • Circuitry of nuclear factor kappaB signaling
    • Hoffmann A., Baltimore D. Circuitry of nuclear factor kappaB signaling. Immunol. Rev. 2006, 210:171-186.
    • (2006) Immunol. Rev. , vol.210 , pp. 171-186
    • Hoffmann, A.1    Baltimore, D.2
  • 19
    • 77749245810 scopus 로고    scopus 로고
    • C-Rel: A pioneer in directing regulatory T-cell lineage commitment?
    • Hori S. c-Rel: A pioneer in directing regulatory T-cell lineage commitment?. Eur. J. Immunol. 2010, 40:664-667.
    • (2010) Eur. J. Immunol. , vol.40 , pp. 664-667
    • Hori, S.1
  • 20
    • 0033953587 scopus 로고    scopus 로고
    • A nuclear export signal in the N-terminal regulatory domain of IkappaBalpha controls cytoplasmic localization of inactive NF-kappaB/IkappaBalpha complexes
    • Huang T.T., Kudo N., Yoshida M., Miyamoto S. A nuclear export signal in the N-terminal regulatory domain of IkappaBalpha controls cytoplasmic localization of inactive NF-kappaB/IkappaBalpha complexes. Proc. Natl. Acad. Sci. USA 2000, 97:1014-1019.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 1014-1019
    • Huang, T.T.1    Kudo, N.2    Yoshida, M.3    Miyamoto, S.4
  • 21
    • 0032217268 scopus 로고    scopus 로고
    • The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation
    • Huxford T., Huang D.B., Malek S., Ghosh G. The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation. Cell 1998, 95:759-770.
    • (1998) Cell , vol.95 , pp. 759-770
    • Huxford, T.1    Huang, D.B.2    Malek, S.3    Ghosh, G.4
  • 24
    • 0033486033 scopus 로고    scopus 로고
    • An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of IkappaBalpha
    • Johnson C., Van Antwerp D., Hope T.J. An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of IkappaBalpha. EMBO J. 1999, 18:6682-6693.
    • (1999) EMBO J. , vol.18 , pp. 6682-6693
    • Johnson, C.1    Van Antwerp, D.2    Hope, T.J.3
  • 25
    • 54349095910 scopus 로고    scopus 로고
    • Recent progress in understanding the phenotype and function of intestinal dendritic cells and macrophages
    • Kelsall B. Recent progress in understanding the phenotype and function of intestinal dendritic cells and macrophages. Mucosal Immunol. 2008, 1:460-469.
    • (2008) Mucosal Immunol. , vol.1 , pp. 460-469
    • Kelsall, B.1
  • 27
    • 0030917003 scopus 로고    scopus 로고
    • Distinct roles in lymphoid organogenesis for lymphotoxins α and β revealed in lymphotoxin β-deficient mice
    • Koni P.A., Sacca R., Lawton P., Browning J.L., Ruddle N.H., Flavell R.A. Distinct roles in lymphoid organogenesis for lymphotoxins α and β revealed in lymphotoxin β-deficient mice. Immunity 1997, 6:491-500.
    • (1997) Immunity , vol.6 , pp. 491-500
    • Koni, P.A.1    Sacca, R.2    Lawton, P.3    Browning, J.L.4    Ruddle, N.H.5    Flavell, R.A.6
  • 28
    • 0029150389 scopus 로고
    • Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
    • Köntgen F., Grumont R.J., Strasser A., Metcalf D., Li R., Tarlinton D., Gerondakis S. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev. 1995, 9:1965-1977.
    • (1995) Genes Dev. , vol.9 , pp. 1965-1977
    • Köntgen, F.1    Grumont, R.J.2    Strasser, A.3    Metcalf, D.4    Li, R.5    Tarlinton, D.6    Gerondakis, S.7
  • 30
    • 71749088574 scopus 로고    scopus 로고
    • Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor
    • Long M., Park S.G., Strickland I., Hayden M.S., Ghosh S. Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor. Immunity 2009, 31:921-931.
    • (2009) Immunity , vol.31 , pp. 921-931
    • Long, M.1    Park, S.G.2    Strickland, I.3    Hayden, M.S.4    Ghosh, S.5
  • 31
    • 0035976962 scopus 로고    scopus 로고
    • IkappaBbeta, but not IkappaBalpha, functions as a classical cytoplasmic inhibitor of NF-kappaB dimers by masking both NF-kappaB nuclear localization sequences in resting cells
    • Malek S., Chen Y., Huxford T., Ghosh G. IkappaBbeta, but not IkappaBalpha, functions as a classical cytoplasmic inhibitor of NF-kappaB dimers by masking both NF-kappaB nuclear localization sequences in resting cells. J. Biol. Chem. 2001, 276:45225-45235.
    • (2001) J. Biol. Chem. , vol.276 , pp. 45225-45235
    • Malek, S.1    Chen, Y.2    Huxford, T.3    Ghosh, G.4
  • 33
    • 2442656670 scopus 로고    scopus 로고
    • Regulation of constitutive p50/c-Rel activity via proteasome inhibitor-resistant IkappaBalpha degradation in B cells
    • O'Connor S., Shumway S.D., Amanna I.J., Hayes C.E., Miyamoto S. Regulation of constitutive p50/c-Rel activity via proteasome inhibitor-resistant IkappaBalpha degradation in B cells. Mol. Cell. Biol. 2004, 24:4895-4908.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 4895-4908
    • O'Connor, S.1    Shumway, S.D.2    Amanna, I.J.3    Hayes, C.E.4    Miyamoto, S.5
  • 34
    • 13244273517 scopus 로고    scopus 로고
    • Inhibition of IkappaBalpha nuclear export as an approach to abrogate nuclear factor-kappaB-dependent cancer cell survival
    • O'Connor S., Shumway S., Miyamoto S. Inhibition of IkappaBalpha nuclear export as an approach to abrogate nuclear factor-kappaB-dependent cancer cell survival. Mol. Cancer Res. 2005, 3:42-49.
    • (2005) Mol. Cancer Res. , vol.3 , pp. 42-49
    • O'Connor, S.1    Shumway, S.2    Miyamoto, S.3
  • 35
    • 0030832150 scopus 로고    scopus 로고
    • Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses
    • Oliver A.M., Martin F., Gartland G.L., Carter R.H., Kearney J.F. Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses. Eur. J. Immunol. 1997, 27:2366-2374.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 2366-2374
    • Oliver, A.M.1    Martin, F.2    Gartland, G.L.3    Carter, R.H.4    Kearney, J.F.5
  • 36
    • 33845768987 scopus 로고    scopus 로고
    • Integrating cell-signalling pathways with NF-kappaB and IKK function
    • Perkins N.D. Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat. Rev. Mol. Cell Biol. 2007, 8:49-62.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 49-62
    • Perkins, N.D.1
  • 37
    • 33846939291 scopus 로고    scopus 로고
    • TNF receptor-associated factor 2-dependent canonical pathway is crucial for the development of Peyer's patches
    • Piao J.H., Yoshida H., Yeh W.C., Doi T., Xue X., Yagita H., Okumura K., Nakano H. TNF receptor-associated factor 2-dependent canonical pathway is crucial for the development of Peyer's patches. J. Immunol. 2007, 178:2272-2277.
    • (2007) J. Immunol. , vol.178 , pp. 2272-2277
    • Piao, J.H.1    Yoshida, H.2    Yeh, W.C.3    Doi, T.4    Xue, X.5    Yagita, H.6    Okumura, K.7    Nakano, H.8
  • 38
    • 0037007143 scopus 로고    scopus 로고
    • The combined absence of NF-κ B1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells
    • Pohl T., Gugasyan R., Grumont R.J., Strasser A., Metcalf D., Tarlinton D., Sha W., Baltimore D., Gerondakis S. The combined absence of NF-κ B1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells. Proc. Natl. Acad. Sci. USA 2002, 99:4514-4519.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 4514-4519
    • Pohl, T.1    Gugasyan, R.2    Grumont, R.J.3    Strasser, A.4    Metcalf, D.5    Tarlinton, D.6    Sha, W.7    Baltimore, D.8    Gerondakis, S.9
  • 40
    • 33845422163 scopus 로고    scopus 로고
    • Control of B lymphocyte apoptosis by the transcription factor NF-kappaB
    • Sen R. Control of B lymphocyte apoptosis by the transcription factor NF-kappaB. Immunity 2006, 25:871-883.
    • (2006) Immunity , vol.25 , pp. 871-883
    • Sen, R.1
  • 42
    • 0033998441 scopus 로고    scopus 로고
    • Cytoplasmic sequestration of rel proteins by IkappaBalpha requires CRM1-dependent nuclear export
    • Tam W.F., Lee L.H., Davis L., Sen R. Cytoplasmic sequestration of rel proteins by IkappaBalpha requires CRM1-dependent nuclear export. Mol. Cell. Biol. 2000, 20:2269-2284.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 2269-2284
    • Tam, W.F.1    Lee, L.H.2    Davis, L.3    Sen, R.4
  • 43
    • 0034961236 scopus 로고    scopus 로고
    • Cell-specific association and shuttling of IkappaBalpha provides a mechanism for nuclear NF-kappaB in B lymphocytes
    • Tam W.F., Wang W., Sen R. Cell-specific association and shuttling of IkappaBalpha provides a mechanism for nuclear NF-kappaB in B lymphocytes. Mol. Cell. Biol. 2001, 21:4837-4846.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 4837-4846
    • Tam, W.F.1    Wang, W.2    Sen, R.3
  • 44
    • 36749081534 scopus 로고    scopus 로고
    • Crossing the nuclear envelope: hierarchical regulation of nucleocytoplasmic transport
    • Terry L.J., Shows E.B., Wente S.R. Crossing the nuclear envelope: hierarchical regulation of nucleocytoplasmic transport. Science 2007, 318:1412-1416.
    • (2007) Science , vol.318 , pp. 1412-1416
    • Terry, L.J.1    Shows, E.B.2    Wente, S.R.3
  • 45
    • 0028799457 scopus 로고
    • Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3
    • Thomis D.C., Gurniak C.B., Tivol E., Sharpe A.H., Berg L.J. Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science 1995, 270:794-797.
    • (1995) Science , vol.270 , pp. 794-797
    • Thomis, D.C.1    Gurniak, C.B.2    Tivol, E.3    Sharpe, A.H.4    Berg, L.J.5
  • 46
    • 67650724069 scopus 로고    scopus 로고
    • Regulation and function of NF-kappaB transcription factors in the immune system
    • Vallabhapurapu S., Karin M. Regulation and function of NF-kappaB transcription factors in the immune system. Annu. Rev. Immunol. 2009, 27:693-733.
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 693-733
    • Vallabhapurapu, S.1    Karin, M.2
  • 49
    • 0141567432 scopus 로고    scopus 로고
    • Regulation of secondary lymphoid organ development by the nuclear factor-kappaB signal transduction pathway
    • Weih F., Caamaño J. Regulation of secondary lymphoid organ development by the nuclear factor-kappaB signal transduction pathway. Immunol. Rev. 2003, 195:91-105.
    • (2003) Immunol. Rev. , vol.195 , pp. 91-105
    • Weih, F.1    Caamaño, J.2
  • 50
    • 54049097968 scopus 로고    scopus 로고
    • T cell receptor-mediated activation of CD4+CD44hi T cells bypasses Bcl10: An implication of differential NF-kappaB dependence of naïve and memory T cells during T cell receptor-mediated responses
    • Zeng H., Chen Y., Yu M., Xue L., Gao X., Morris S.W., Wang D., Wen R. T cell receptor-mediated activation of CD4+CD44hi T cells bypasses Bcl10: An implication of differential NF-kappaB dependence of naïve and memory T cells during T cell receptor-mediated responses. J. Biol. Chem. 2008, 283:24392-24399.
    • (2008) J. Biol. Chem. , vol.283 , pp. 24392-24399
    • Zeng, H.1    Chen, Y.2    Yu, M.3    Xue, L.4    Gao, X.5    Morris, S.W.6    Wang, D.7    Wen, R.8
  • 51
    • 0344406188 scopus 로고    scopus 로고
    • Combined deficiency of p50 and cRel in CD4+ T cells reveals an essential requirement for nuclear factor kappaB in regulating mature T cell survival and in vivo function
    • Zheng Y., Vig M., Lyons J., Van Parijs L., Beg A.A. Combined deficiency of p50 and cRel in CD4+ T cells reveals an essential requirement for nuclear factor kappaB in regulating mature T cell survival and in vivo function. J. Exp. Med. 2003, 197:861-874.
    • (2003) J. Exp. Med. , vol.197 , pp. 861-874
    • Zheng, Y.1    Vig, M.2    Lyons, J.3    Van Parijs, L.4    Beg, A.A.5
  • 52
    • 76749133610 scopus 로고    scopus 로고
    • Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
    • Zheng Y., Josefowicz S., Chaudhry A., Peng X.P., Forbush K., Rudensky A.Y. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 2010, 463:808-812.
    • (2010) Nature , vol.463 , pp. 808-812
    • Zheng, Y.1    Josefowicz, S.2    Chaudhry, A.3    Peng, X.P.4    Forbush, K.5    Rudensky, A.Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.