The ERGonomics of hematopoietic stem cell self-renewal

Genes and Development

Volumn 25, Issue 4, 2011, Pages 289-293

  Lacadie, Scott A ^a   Zon, Leonard I ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

ERG; ETS family transcription factors; Gata2; Hematopoietic development; Hematopoietic stem cells; Runx1; Self renewal

Indexed keywords

MESSENGER RNA; TRANSCRIPTION FACTOR ERG; TRANSCRIPTION FACTOR GATA 2; TRANSCRIPTION FACTOR RUNX1;

CELL DIVISION; CELL RENEWAL; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; GENE EXPRESSION; GENE LOCUS; HEMATOPOIETIC STEM CELL; MUTATION; NONHUMAN; PRIORITY JOURNAL; REVIEW;

CELL DIFFERENTIATION; CELL PROLIFERATION; EMBRYO, MAMMALIAN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENOMICS; HEMATOPOIETIC STEM CELLS; HUMANS; MODELS, BIOLOGICAL; TRANS-ACTIVATORS;

EID: 79951713761     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.2031511     Document Type: Review

References (45)

1. Baek D, Villen J, Shin C, Camargo FD, Gygi SP, Bartel DP. 2008. The impact of microRNAs on protein output. Nature 455: 64-71.
2. Bertrand JY, Chi NC, Santoso B, Teng S, Stainier DY, Traver D. 2010. Haematopoietic stem cells derive directly from aortic endothelium during development. Nature 464: 108-111.
3. Birdsey GM, Dryden NH, Amsellem V, Gebhardt F, Sahnan K, Haskard DO, Dejana E, Mason JC, Randi AM. 2008. Transcription factor erg regulates angiogenesis and endothelial apoptosis through VE-cadherin. Blood 111: 3498-3506.
4. Boisset JC, van Cappellen W, Andrieu-Soler C, Galjart N, Dzierzak E, Robin C. 2010. In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium. Nature 464: 116-120.
5. Burda P, Laslo P, Stopka T. 2010. The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis. Leukemia 24: 1249-1257.
6. Burns CE, Traver D, Mayhall E, Shepard JL, Zon LI. 2005. Hematopoietic stem cell fate is established by the notch-runx pathway. Genes Dev 19: 2331-2342. (Pubitemid 41396910)
7. Chen MJ, Yokomizo T, Zeigler BM, Dzierzak E, Speck NA. 2009. Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter. Nature 457: 887-891.
8. Clark JP, Cooper CS. 2009. ETS gene fusions in prostate cancer. Nat Rev Urol 6: 429-439.
9. Dalgin G, Goldman DC, Donley N, Ahmed R, Eide CA, Christian JL. 2007. GATA-2 functions downstream of BMPs and CaM KIV in ectodermal cells during primitive hematopoiesis. Dev Biol 310: 454-469. (Pubitemid 47483688)
10. Galan-Caridad JM, Harel S, Arenzana TL, Hou ZE, Doetsch FK, Mirny LA, Reizis B. 2007. Zfx controls the self-renewal of embryonic and hematopoietic stem cells. Cell 129: 345-357. (Pubitemid 46574969)
11. Gupta S, Iljin K, Sara H, Mpindi JP, Mirtti T, Vainio P, Rantala J, Alanen K, Nees M, Kallioniemi O. 2010. FZD4 as a mediator of ERG oncogene-induced WNT signaling and epithelial-to-mesenchymal transition in human prostate cancer cells. Cancer Res 70: 6735-6745.
12. He S, Nakada D, Morrison SJ. 2009. Mechanisms of stem cell self-renewal. Annu Rev Cell Dev Biol 25: 377-406.
13. Hock H, Hamblen MJ, Rooke HM, Traver D, Bronson RT, Cameron S, Orkin SH. 2003. Intrinsic requirement for zinc finger transcription factor gfi-1 in neutrophil differentiation. Immunity 18: 109-120. (Pubitemid 36120692)
14. Hock H, Hamblen MJ, Rooke HM, Schindler JW, Saleque S, Fujiwara Y, Orkin SH. 2004a. Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature 431: 1002-1007. (Pubitemid 39434423)
15. Hock H, Meade E, Medeiros S, Schindler JW, Valk PJ, Fujiwara Y, Orkin SH. 2004b. Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. Genes Dev 18: 2336-2341. (Pubitemid 39304679)
16. Hope KJ, Cellot S, Ting SB, MacRae T, Mayotte N, Iscove NN, Sauvageau G. 2010. An RNAi screen identifies Msi2 and Prox1 as having opposite roles in the regulation of hematopoietic stem cell activity. Cell Stem Cell 7: 101-113.
17. Kim I, Saunders TL, Morrison SJ. 2007. Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell 130: 470-483.
18. Kissa K, Herbomel P. 2010. Blood stem cells emerge from aortic endothelium by a novel type of cell transition. Nature 464: 112-115.
19. Kruse EA, Loughran SJ, Baldwin TM, Josefsson EC, Ellis S, Watson DK, Nurden P, Metcalf D, Hilton DJ, Alexander WS, et al. 2009. Dual requirement for the ETS transcription factors fli-1 and erg in hematopoietic stem cells and the megakaryocyte lineage. Proc Natl Acad Sci 106: 13814-13819.
20. Lengerke C, Schmitt S, Bowman TV, Jang IH, Maouche-Chretien L, McKinney-Freeman S, Davidson AJ, Hammerschmidt M, Rentzsch F, Green JB, et al. 2008. BMP and wnt specify hematopoietic fate by activation of the cdx-hox pathway. Cell Stem Cell 2: 72-82.
21. Loughran SJ, Kruse EA, Hacking DF, de Graaf CA, Hyland CD, Willson TA, Henley KJ, Ellis S, Voss AK, Metcalf D, et al. 2008. The transcription factor erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells. Nat Immunol 9: 810-819. (Pubitemid 351859165)
22. Maeno M, Mead PE, Kelley C, Xu RH, Kung HF, Suzuki A, Ueno N, Zon LI. 1996. The role of BMP-4 and GATA-2 in the induction and differentiation of hematopoietic mesoderm in Xenopus laevis. Blood 88: 1965-1972. (Pubitemid 26307898)
23. Maroulakou IG, Bowe DB. 2000. Expression and function of ets transcription factors in mammalian development: A regulatory network. Oncogene 19: 6432-6442. (Pubitemid 32108433)
24. Mikkola HK, Klintman J, Yang H, Hock H, Schlaeger TM, Fujiwara Y, Orkin SH. 2003. Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature 421: 547-551. (Pubitemid 36168449)
25. Nikolova-Krstevski V, Yuan L, Le Bras A, Vijayaraj P, Kondo M, Gebauer I, Bhasin M, Carman CV, Oettgen P. 2009. ERG is required for the differentiation of embryonic stem cells along the endothelial lineage. BMC Dev Biol 9: 72. doi: 10.1186/1471-213X-9-72.
26. North TE, Goessling W, Walkley CR, Lengerke C, Kopani KR, Lord AM, Weber GJ, Bowman TV, Jang IH, Grosser T, et al. 2007. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature 447: 1007-1011. (Pubitemid 46975751)
27. Orkin SH, Zon LI. 2008. Hematopoiesis: An evolving paradigm for stem cell biology. Cell 132: 631-644. (Pubitemid 351260057)
28. Paik EJ, de Jong JL, Pugach E, Opara P, Zon LI. 2010. A chemical genetic screen in zebrafish for pathways interacting with cdx4 in primitive hematopoiesis. Zebrafish 7: 61-68.
29. Papathanasiou P, Tunningley R, Pattabiraman DR, Ye P, Gonda TJ, Whittle B, Hamilton AE, Cridland SO, Lourie R, Perkins AC. 2010. A recessive screen for genes regulating hematopoietic stem cells. Blood 116: 5849-5858.
30. Park IK, Qian D, Kiel M, Becker MW, Pihalja M, Weissman IL, Morrison SJ, Clarke MF. 2003. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 423: 302-305. (Pubitemid 40852701)
31. Rodrigues NP, Janzen V, Forkert R, Dombkowski DM, Boyd AS, Orkin SH, Enver T, Vyas P, Scadden DT. 2005. Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis. Blood 106: 477-484. (Pubitemid 40981241)
32. Salek-Ardakani S, Smooha G, de Boer J, Sebire NJ, Morrow M, Rainis L, Lee S, Williams O, Izraeli S, Brady HJ. 2009. ERG is a megakaryocytic oncogene. Cancer Res 69: 4665-4673.
33. Souroullas GP, Salmon JM, Sablitzky F, Curtis DJ, Goodell MA. 2009. Adult hematopoietic stem and progenitor cells require either Lyl1 or scl for survival. Cell Stem Cell 4: 180-186.
34. Spooncer E, Brouard N, Nilsson SK, Williams B, Liu MC, Unwin RD, Blinco D, Jaworska E, Simmons PJ, Whetton AD. 2008. Developmental fate determination and marker discovery in hematopoietic stem cell biology using proteomic fingerprinting. Mol Cell Proteomics 7: 573-581. (Pubitemid 351472466)
35. Stankiewicz MJ, Crispino JD. 2009. ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells. Blood 113: 3337-3347.
36. Taoudi S, Bee T, Hilton A, Knezevic K, Scott J, Willson TA, Collin C, Thomas T, Voss AK, Kile BT, et al. 2011. ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification. Genes Dev 25: 251-262.
37. Trojanowska M. 2000. Ets factors and regulation of the extracellular matrix. Oncogene 19: 6464-6471. (Pubitemid 32108436)
38. Tsai FY, Orkin SH. 1997. Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation. Blood 89: 3636-3643. (Pubitemid 27227086)
39. Tsai FY, Keller G, Kuo FC, Weiss M, Chen J, Rosenblatt M, Alt FW, Orkin SH. 1994. An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature 371: 221-226. (Pubitemid 24293019)
40. van der Lugt NM, Domen J, Linders K, van Roon M, Robanus-Maandag E, te Riele H, van der Valk M, Deschamps J, Sofroniew M, van Lohuizen M. 1994. Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 protooncogene. Genes Dev 8: 757-769.
41. Wilson NK, Foster SD, Wang X, Knezevic K, Schutte J, Kaimakis P, Chilarska PM, Kinston S, Ouwehand WH, Dzierzak E, et al. 2010a. Combinatorial transcriptional control in blood stem/progenitor cells: Genome-wide analysis of ten major transcriptional regulators. Cell Stem Cell 7: 532-544.
42. Wilson NK, Timms RT, Kinston SJ, Cheng YH, Oram SH, Landry JR, Mullender J, Ottersbach K, Gottgens B. 2010b. Gfi1 expression is controlled by five distinct regulatory regions spread over 100 kilobases, with Scl/Tal1, Gata2, PU.1, erg, Meis1, and Runx1 acting as upstream regulators in early hematopoietic cells. Mol Cell Biol 30: 3853-3863.
43. Yeh JR, Munson KM, Elagib KE, Goldfarb AN, Sweetser DA, Peterson RT. 2009. Discovering chemical modifiers of oncogene- regulated hematopoietic differentiation. Nat Chem Biol 5: 236-243.
44. Zeng H, Yucel R, Kosan C, Klein-Hitpass L, Moroy T. 2004. Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells. EMBO J 23: 4116-4125. (Pubitemid 39472432)
45. Zon LI. 2008. Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal. Nature 453: 306-313. (Pubitemid 351693136)