Facilitated transporters mediate net efflux of amino acids to the fetus across the basal membrane of the placental syncytiotrophoblast

Journal of Physiology

Volumn 589, Issue 4, 2011, Pages 987-997

  Cleal, J K ^a   Glazier, J D ^d   Ntani, G ^b   Crozier, S R ^b   Day, P E ^a   Harvey, N C ^b   Robinson, S M ^b   Cooper, C ^b   Godfrey, K M ^b,c   Hanson, M A ^a,c   Lewis, R M ^a  

^a Institute of Developmental Sciences   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^d ST MARY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOBICYCLO[2.2.1]HEPTANE 2 CARBOXYLIC ACID; ALANINE; AMINO ACID; AMINO ACID TRANSPORTER; GLUTAMIC ACID; GLUTAMINE; LEUCINE; LYSINE; MESSENGER RNA; SERINE; THREONINE; TRYPTOPHAN;

ADULT; AMINO ACID TRANSPORT; ANTHROPOMETRY; ARTICLE; BASEMENT MEMBRANE; CONTROLLED STUDY; DIFFUSION; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FETUS BLOOD; FETUS GROWTH; HUMAN; HUMAN TISSUE; HYPOTHESIS; MATERNAL BLOOD; PLACENTAL TRANSFER; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SYNCYTIOTROPHOBLAST; WESTERN BLOTTING;

ADULT; AMINO ACID TRANSPORT SYSTEMS; AMINO ACID TRANSPORT SYSTEMS, BASIC; AMINO ACID TRANSPORT SYSTEMS, NEUTRAL; AMINO ACIDS; DATA COLLECTION; FEMALE; FETUS; HUMANS; INFANT, NEWBORN; MATERNAL-FETAL EXCHANGE; PLACENTA; PREGNANCY; TROPHOBLASTS; YOUNG ADULT;

EID: 79951709782     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2010.198549     Document Type: Article

References (41)

1. Arriza JL, Kavanaugh MP, Fairman WA, Wu YN, Murdoch GH, North RA & Amara SG (1993). Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family. J Biol Chem 268, 15329-15332.
2. Ayuk PT, Sibley CP, Donnai P, D'Souza S & Glazier JD (2000). Development and polarization of cationic amino acid transporters and regulators in the human placenta. Am J Physiol Cell Physiol 278, C1162-C1171.
3. Bodoy S, Martin L, Zorzano A, Palacin M, Estevez R & Bertran J (2005). Identification of LAT4, a novel amino acid transporter with system L activity. J Biol Chem 280, 12002-12011.
4. Broer A, Wagner CA, Lang F & Broer S (2000). The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine. Biochem J 349, 787-795.
5. Cetin I (2003). Placental transport of amino acids in normal and growth-restricted pregnancies. Eur J Obstet Gynecol Reprod Biol 110(Suppl 1), S50-S54.
6. Cetin I, Marconi AM, Bozzetti P, Sereni LP, Corbetta C, Pardi G & Battaglia FC (1988). Umbilical amino acid concentrations in appropriate and small for gestational age infants: a biochemical difference present in utero. Am J Obstet Gynecol 158, 120-126.
7. Cleal JK, Brownbill P, Godfrey KM, Jackson JM, Jackson AA, Sibley CP, Hanson MA & Lewis RM (2007). Modification of fetal plasma amino acid composition by placental amino acid exchangers in vitro. J Physiol 582, 871-882.
8. Cleal JK, Day P, Hanson MA & Lewis RM (2009). Measurement of housekeeping genes in human placenta. Placenta 30, 1002-1003.
9. Cleal JK, Day PL, Hanson MA & Lewis RM (2010). Sex differences in the mRNA levels of housekeeping genes in human placenta. Placenta 31, 556-557.
10. Cleal JK & Lewis RM (2008). The mechanisms and regulation of placental amino acid transport to the human foetus. J Neuroendocrinol 20, 419-426.
11. +-independent system L amino acid transporter 3 in mice: a potential role in supply of branched-chain amino acids under nutrient starvation. Am J Pathol 170, 888-898.
12. + with basal membrane. Am J Physiol Cell Physiol 268, C755-C761.
13. Furesz TC & Smith CH (1997). Identification of two leucine-sensitive lysine transport activities in human placental basal membrane. Placenta 18, 649-655.
14. Glazier JD, Cetin I, Perugino G, Ronzoni S, Grey AM, Mahendran D, Marconi AM, Pardi G & Sibley CP (1997). Association between the activity of the system A amino acid transporter in the microvillous plasma membrane of the human placenta and severity of fetal compromise in intrauterine growth restriction. Pediatr Res 42, 514-519.
15. Glazier JD & Sibley CP (2006). In vitro methods for studying human placental amino acid transport: placental plasma membrane vesicles. Methods Mol Med 122, 241-252.
16. Gluckman PD, Hanson MA, Cooper C & Thornburg KL (2008). Effect of in utero and early-life conditions on adult health and disease. N Engl J Med 359, 61-73.
17. Godfrey KM, Matthews N, Glazier J, Jackson A, Wilman C & Sibley CP (1998). Neutral amino acid uptake by the microvillous plasma membrane of the human placenta is inversely related to fetal size at birth in normal pregnancy. J Clin Endocrinol Metab 83, 3320-3326.
18. Illsley NP, Hall S, Penfold P & Stacey TE (1985). Diffusional permeability of the human placenta. Contrib Gynecol Obstet 13, 92-97.
19. Inskip HM, Godfrey KM, Robinson SM, Law CM, Barker DJ & Cooper C (2006). Cohort profile: The Southampton Women's Survey. Int J Epidemiol 35, 42-48.
20. Jansson N, Pettersson J, Haafiz A, Ericsson A, Palmberg I, Tranberg M, Ganapathy V, Powell TL & Jansson T (2006). Down-regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet. J Physiol 576, 935-946.
21. Jansson T, Scholtbach V & Powell TL (1998). Placental transport of leucine and lysine is reduced in intrauterine growth restriction. Pediatr Res 44, 532-537.
22. Jauniaux E, Gulbis B & Gerloo E (1999). Free amino acids in human fetal liver and fluids at 12-17 weeks of gestation. Hum Reprod 14, 1638-1641.
23. Kekuda R, Prasad PD, Fei YJ, Torres-Zamorano V, Sinha S, Yang-Feng TL, Leibach FH & Ganapathy V (1996). Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line. J Biol Chem 271, 18657-18661.
24. +/monocarboxylate transporters. J Biol Chem 276, 17221-17228.
25. Kim DK, Kanai Y, Matsuo H, Kim JY, Chairoungdua A, Kobayashi Y, Enomoto A, Cha SH, Goya T & Endou H (2002). The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location. Genomics 79, 95-103.
26. Kudo Y & Boyd CA (2001). Characterisation of l-tryptophan transporters in human placenta: a comparison of brush border and basal membrane vesicles. J Physiol 531, 405-416.
27. Lewis RM, Glazier J, Greenwood SL, Bennett EJ, Godfrey KM, Jackson AA, Sibley CP, Cameron IT & Hanson MA (2007). l-Serine uptake by human placental microvillous membrane vesicles. Placenta 28, 445-452.
28. Loubiere LS, Vasilopoulou E, Bulmer JN, Taylor PM, Stieger B, Verrey F, McCabe CJ, Franklyn JA, Kilby MD & Chan SY (2010). Expression of thyroid hormone transporters in the human placenta and changes associated with intrauterine growth restriction. Placenta 31, 295-304.
29. Mahendran D, Donnai P, Glazier JD, D'Souza SW, Boyd RD & Sibley CP (1993). Amino acid (system A) transporter activity in microvillous membrane vesicles from the placentas of appropriate and small for gestational age babies. Pediatr Res 34, 661-665.
30. Paolini CL, Marconi AM, Ronzoni S, Di Noio M, Fennessey PV, Pardi G & Battaglia FC (2001). Placental transport of leucine, phenylalanine, glycine, and proline in intrauterine growth-restricted pregnancies. J Clin Endocrinol Metab 86, 5427-5432.
31. Pfeiffer R, Rossier G, Spindler B, Meier C, Kuhn L & Verrey F (1999). Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family. EMBO J 18, 49-57.
32. Philipps AF, Holzman IR, Teng C & Battaglia FC (1978). Tissue concentrations of free amino acids in term human placentas. Am J Obstet Gynecol 131, 881-887.
33. Ramadan T, Camargo SM, Herzog B, Bordin M, Pos KM & Verrey F (2007). Recycling of aromatic amino acids via TAT1 allows efflux of neutral amino acids via LAT2-4F2hc exchanger. Pflugers Arch 454, 507-516.
34. Ramadan T, Camargo SM, Summa V, Hunziker P, Chesnov S, Pos KM & Verrey F (2006). Basolateral aromatic amino acid transporter TAT1 (Slc16a10) functions as an efflux pathway. J Cell Physiol 206, 771-779.
35. Rosenberg A (2008). The IUGR newborn. Semin Perinatol 32, 219-224.
36. Schneider H, Panigel M & Dancis J (1972). Transfer across the perfused human placenta of antipyrine, sodium and leucine. Am J Obstet Gynecol 114, 822-828.
37. Sengers BG, Please CP & Lewis RM (2010). Computational modelling of amino acid transfer interactions in the placenta. Exp Physiol 95, 829-840.
38. Settle P, Mynett K, Speake P, Champion E, Doughty IM, Sibley CP, D'Souza SW & Glazier J (2004). Polarized lactate transporter activity and expression in the syncytiotrophoblast of the term human placenta. Placenta 25, 496-504.
39. Shibata E, Hubel CA, Powers RW, von Versen-Hoeynck F, Gammill H, Rajakumar A & Roberts JM (2008). Placental system A amino acid transport is reduced in pregnancies with small for gestational age (SGA) infants but not in preeclampsia with SGA infants. Placenta 29, 879-882.
40. Sibley C, Glazier J & D'Souza S (1997). Placental transporter activity and expression in relation to fetal growth. Exp Physiol 82, 389-402.
41. Zerangue N & Kavanaugh MP (1996). ASCT-1 is a neutral amino acid exchanger with chloride channel activity. J Biol Chem 271, 27991-27994.