Assessment of insulin secretion in relation to insulin resistance

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 8, Issue 5, 2005, Pages 529-533

  Mari, Andrea ^a   Ahrén, Bo ^b   Pacini, Giovanni ^a  

^a CNR   (Italy)

^b LUND UNIVERSITY   (Sweden)

Author keywords

Disposition index; Glucose tolerance; Hyperbolic relationship; Insulin secretion; Insulin sensitivity; Type 2 diabetes

Indexed keywords

BLOOD GLUCOSE MONITORING; CELL FUNCTION; DISEASE COURSE; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; HUMAN; HYPERGLYCEMIA; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN RESPONSE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRACTICE GUIDELINE; REGULATORY MECHANISM; REVIEW;

EID: 23944518906     PISSN: 13631950     EISSN: 15353885     Source Type: Journal    
DOI: 10.1097/01.mco.0000171130.23441.59     Document Type: Review

References (29)

1. Kahn SE. The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia 2003; 46:3-19.
2. Ahrén B, Pacini G. Importance of quantifying insulin secretion in relation to insulin sensitivity to accurately assess beta cell function in clinical studies. Eur J Endocrinol 2004; 150:97-104. Summarizes work demonstrating the importance of assessing insulin secretion in relation to insulin sensitivity in clinical studies.
3. Bergman RN, Ader M, Huecking K, Van Citters G. Accurate assessment of beta-cell function: the hyperbolic correction. Diabetes 2002; 51 (Suppl 1):S212-S220.
4. Chiasson JL, Rabasa-Lhoret R. Prevention of type 2 diabetes: insulin resistance and beta-cell function. Diabetes 2004; 53 (Suppl 3):S34-S38. Emphasizes the importance of the assessment of the relationship between insulin sensitivity and secretion in the studies on prevention of type 2 diabetes.
5. Stumvoll M. Control of glycaemia: from molecules to men. Minkowski Lecture 2004. Diabetologia 2004; 47:770-781. Discusses the relationship between insulin sensitivity and secretion in relation to glucose tolerance in a general context.
6. Ferrannini E, Mari A. Beta cell function and its relation to insulin action in humans: a critical appraisal. Diabetologia 2004; 47:943-956. Provides a critical account of the methods for the assessment of insulin secretion per se and in relation to insulin sensitivity.
7. Pacini G, Mari A. Methods for clinical assessment of insulin sensitivity and beta-cell function. Best Pract Res Clin Endocrinol Metab 2003; 17: 305-322.
8. Ferrannini E, Mari A. How to measure insulin sensitivity. J Hypertens 1998; 16:895-906.
9. Rabinowitz D, Zierler KL. Forearm metabolism in obesity and its response to intra-arterial insulin: characterization of insulin resistance and evidence for adaptive hyperinsulinism. J Clin Invest 1962; 41:2173-2181.
10. Stumvoll M, Tataranni PA, Bogardus C. The hyperbolic law: a 25-year perspective. Diabetologia 2005; 48:207-209. Commentary on the development of the hyperbola concept.
11. Hockaday TD. Letter to the editor. Diabetologia 2005; 48:403-404.
12. Bergman R, Toffolo G, Bowden C, Cobelli C. Minimal modeling, partition analysis and identification of glucose disposal in animals and man. In: International Conference on Cybernetics and Society; Cambridge, MA. New York IEEE Press; 1980. pp. 129-135.
13. Bergman RN, Phillips LS, Cobelli C. Physiologic evaluation of factors controlling glucose tolerance in man. J Clin Invest 1981; 68:1456-1467.
14. Kahn SE, Prigeon RL, McCulloch DK, et al. Quantification of the relationship between insulin sensitivity and β-cell function in human subjects: evidence for a hyperbolic function. Diabetes 1993; 42:1663-1672.
15. Clausen JO, Borch-Johnsen K, Ibsen H, et al. Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians. J Clin Invest 1996; 98:1195-1209.
16. Weyer C, Bogardus C, Mott DM, Pratley RE. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 1999; 104:787-794.
17. Ahrén B, Pacini G. Islet adaptation to insulin resistance: mechanisms and implications for intervention. Diabetes Obes Metab 2005; 7:2-8. Discusses the possible mechanisms that signal changes in insulin sensitivity to the β cell.
18. Ferrannini E, Gastaldelli A, Miyazaki Y, et al. β-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis. J Clin Endocrinol Metab 2005; 90:493-500. Demonstrates the important role of islet dysfunction in deterioration of glucose tolerance within the normal range and shows that not all β-cell function parameters are related to insulin sensitivity.
19. Mari A, Gastaldelli A, Natali A, et al. Characterization of β-cell function impairment in first-degree relatives of type 2 diabetic subjects: modeling analysis of 24-h triple-meal tests. Am J Physiol Endocrinol Metab 2005; 288:E541-E546. Examines the relationships between multiple parameters of β-cell function and insulin sensitivity.
20. Ahrén B, Larsson H. Quantification of insulin secretion in relation to insulin sensitivity in nondiabetic postmenopausal women. Diabetes 2002; 51 (Suppl 1):S202-S211.
21. Jenkins AB, Furler SM, Campbell LV. Letter to the editor on: Gastaldelli A, et al. (2004) Beta cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study. Diabetologia 2004; 47:1642-1643.
22. Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28:412-419.
23. Albareda M, Rodriguez-Espinosa J, Murugo M, et al. Assessment of insulin sensitivity and beta-cell function from measurements in the fasting state and during an oral glucose tolerance test. Diabetologia 2000; 43:1507-1511.
24. van Haeften TW, Stumvoll M. Letter to the editor on: Albareda M, et al. (2000) Assessment of insulin sensitivity and beta-cell function from measurements in the fasting state and during an oral glucose tolerance test. Diabetologia 2001; 44:783.
25. Mari A, Pacini G, Brazzale AR, Ahrén B. Comparative evaluation of simple insulin sensitivity methods based on the oral glucose tolerance test. Diabetologia 2005; 48:748-751. Shows that not all the surrogate insulin sensitivity indices are equivalent for the study of the relationship between insulin sensitivity and secretion.
26. Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing. Comparison with the euglycemic insulin clamp. Diabetes Care 1999; 22:1462-1470.
27. Utzschneider KM, Carr DB, Hull RL, et al. Impact of intra-abdominal fat and age on insulin sensitivity and beta-cell function. Diabetes 2004; 53:2867-2872.
28. Bonadonna RC, Stumvoll M, Fritsche A, et al. Altered homeostatic adaptation of first- and second-phase beta-cell secretion in the offspring of patients with type 2 diabetes: studies with a minimal model to assess beta-cell function. Diabetes 2003; 52:470-480.
29. Ehrmann DA, Sturis J, Byrne MM, et al. Insulin secretory defects in polycystic ovary syndrome: relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus. J Clin Invest 1995; 96: 520-527.