Modeled microgravity and hindlimb unloading sensitize osteoclast precursors to RANKL-mediated osteoclastogenesis

Journal of Bone and Mineral Metabolism

Volumn 29, Issue 1, 2011, Pages 111-122

  Saxena, Ritu ^a   Pan, George ^b   Dohm, Erik D ^c   McDonald, Jay M ^d  

^a UNIVERSITY OF ILLINOIS   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d BIRMINGHAM VA MEDICAL CENTER   (United States)

Author keywords

Hindlimb unloading; Modeled microgravity; Osteoblasts; Osteoclasts; Rotary cell culture system

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; CATHEPSIN K; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; OSTEOCLAST DIFFERENTIATION FACTOR; PHOSPHOLIPASE C GAMMA2; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFATC1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; BONE DENSITY; BONE STRUCTURE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL FUNCTION; CONTROLLED STUDY; CORTICAL BONE; EXPERIMENTAL MODEL; HINDLIMB; IN VITRO STUDY; IN VIVO STUDY; MALE; MICRO-COMPUTED TOMOGRAPHY; MICROGRAVITY; MOLECULAR DYNAMICS; MORPHOMETRICS; MOUSE; MULTINUCLEAR CELL; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THREE DIMENSIONAL IMAGING; TRABECULAR BONE; UPREGULATION; VALIDATION PROCESS;

ACID PHOSPHATASE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BONE DENSITY; CELL LINE; HINDLIMB SUSPENSION; ISOENZYMES; MALE; MICE; MICE, INBRED BALB C; OSTEOBLASTS; OSTEOCLASTS; RANK LIGAND; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; WEIGHTLESSNESS;

EID: 79951675302     PISSN: 09148779     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00774-010-0201-4     Document Type: Article

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