Sleep and sleep disorders in older adults

Neuropsychology Review

Volumn 21, Issue 1, 2011, Pages 41-53

  Crowley, Kate ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Aging; Circadian rhythms; Insomnia; Sleep; Sleep apnea; Sleep changes; Sleep disorders; Slow wave sleep

Indexed keywords

AGED; AGING; CIRCADIAN RHYTHM; ELECTROENCEPHALOGRAPHY; FEMALE; HUMAN; INSOMNIA; MALE; MIDDLE AGED; NEUROLOGIC DISEASE; PARASOMNIA; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; REM SLEEP; REVIEW; SLEEP; SLEEP APNEA SYNDROME; SLEEP DISORDER;

AGED; AGING; CIRCADIAN RHYTHM; ELECTROENCEPHALOGRAPHY; FEMALE; HUMANS; MALE; MIDDLE AGED; NERVOUS SYSTEM DISEASES; REM SLEEP BEHAVIOR DISORDER; SLEEP; SLEEP APNEA SYNDROMES; SLEEP DISORDERS; SLEEP INITIATION AND MAINTENANCE DISORDERS; SLEEP, REM;

EID: 79951674720     PISSN: 10407308     EISSN: 15736660     Source Type: Journal    
DOI: 10.1007/s11065-010-9154-6     Document Type: Review

References (153)

1. P Achermann AA Borbely 1997 Low-frequency (< 1 Hz) oscillations in the human sleep electroencephalogram Neuroscience 81 213 222 1:CAS:528: DyaK2sXlvVWgsLg%3D 9300413 (Pubitemid 27373640)
2. P Achermann AA Borbély 1994 Simulation of daytime vigilance by the additive interaction of a homeostatic and a circadian process Biological Cybernetics 71 115 121 1:STN:280:DyaK2czkslyrsg%3D%3D 8068773
3. T Åkerstedt M Gillberg 1986 Sleep duration and the power spectral density of the EEG Electroencephalography and Clinical Neurophysiology 64 119 122 2424728 (Pubitemid 16057726)
4. MS Aloia N Ilniczky P Di Dio ML Perlis DW Greenblatt DE Giles 2003 Neuropsychological changes and treatment compliance in older adults with sleep apnea Journal of Psychosomatic Research 54 71 76 12505557 (Pubitemid 36168034)
5. F Amzica M Massimini 2002 Glial and neuronal interactions during slow wave and paroxysmal activities in the neocortex Cerebral Cortex 12 1101 1113 12217974
6. F Amzica M Steriade 1997 The K-complex: its slow (<1-Hz) rhythmicity and relation to delta waves Neurology 49 952 959 1:STN:280:DyaK2svnvFGqsA%3D%3D 9339673
7. F Amzica M Steriade 1998 Electrophysiological correlates of sleep delta waves Electroencephalography and Clinical Neurophysiology 107 69 83 1:STN:280:DyaK1cvitFyqug%3D%3D 9751278 (Pubitemid 28396638)
8. S Ancoli-Israel 2005 Sleep and aging: prevalence of disturbed sleep and treatment considerations in older adults The Journal of Clinical Psychiatry 66 Suppl 9 24 30 16336039 (Pubitemid 43011560)
9. S Ancoli-Israel MR Klauber N Butters L Parker DF Kripke 1991 Dementia in institutionalized elderly: relation to sleep apnea Journal of the American Geriatrics Society 39 258 263 1:STN:280:DyaK3M7ntVKgsg%3D%3D 2005339
10. S Ancoli-Israel MR Klauber JC Gillin SS Campbell CR Hofstetter 1994 Sleep in non-institutionalized Alzheimer's disease patients Aging (Milano.) 6 451 458 1:STN:280:DyaK2M3mslyhuw%3D%3D
11. S Ancoli-Israel MR Klauber DW Jones DF Kripke J Martin W Mason, et al. 1997 Variations in circadian rhythms of activity, sleep, and light exposure related to dementia in nursing-home patients Sleep 20 18 23 1:STN:280: DyaK2s3ns1GktA%3D%3D 9130329 (Pubitemid 27176315)
12. S Ancoli-Israel DF Kripke MR Klauber WJ Mason R Fell O Kaplan 1991 Periodic limb movements in sleep in community-dwelling elderly Sleep 14 496 500 1:STN:280:DyaK387ovVSltg%3D%3D 1798881
13. S Ancoli-Israel DF Kripke MR Klauber WJ Mason R Fell O Kaplan 1991 Sleep-disordered breathing in community-dwelling elderly Sleep 14 486 495 1:STN:280:DyaK387ovVSlsQ%3D%3D 1798880
14. S Ancoli-Israel D Kripke MR Klauber L Parker C Stepnowsky A Kullen, et al. 1993 Natural history of sleep disordered breathing in community dwelling elderly Sleep 16 S25 S29 1:STN:280:DyaK2c3jtlagtA%3D%3D 8178017
15. S Ancoli-Israel DF Kripke W Mason OJ Kaplan 1985 Sleep apnea and periodic movements in an aging sample Journal of Gerontology 49 419 425 (Pubitemid 15028956)
16. S Ancoli-Israel L Parker R Sinaee RL Fell DF Kripke 1989 Sleep fragmentation in patients from a nursing home Journal of Gerontology 44 M18 M21 1:STN:280:DyaL1M%2FptlOrsg%3D%3D 2910988
17. S Ancoli-Israel GS Richardson RM Mangano L Jenkins P Hall WS Jones 2005 Long-term use of sedative hypnotics in older patients with insomnia Sleep Medicine 6 107 113 15716214 (Pubitemid 40247172)
18. C Anderson JA Horne 2003 Prefrontal cortex: links between low frequency delta EEG in sleep and neuropsychological performance in healthy, older people Psychophysiology 40 349 357 12946109 (Pubitemid 36596904)
19. SI Barbar PL Enright P Boyle D Foley DS Sharp H Petrovitch, et al. 2000 Sleep disturbances and their correlates in elderly Japanese American men residing in Hawaii Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 55 M406 M411 1:STN:280:DC%2BD3czlsVKhsQ%3D%3D
20. C Bassetti MS Aldrich 1999 Sleep apnea in acute cerebrovascular diseases: final report on 128 patients Sleep 22 217 223 1:STN:280:DyaK1M3hslWhsQ%3D%3D 10201066 (Pubitemid 29143220)
21. C Bastien K Campbell 1992 The evoked K-complex: all-or-none phenomenon? Sleep 15 236 245 1:STN:280:DyaK38zitVWksQ%3D%3D 1621024
22. K Blatter P Graw M Munch V Knoblauch A Wirz-Justice C Cajochen 2006 Gender and age differences in psychomotor vigilance performance under differential sleep pressure conditions Behavioural Brain Research 168 312 317 16386807 (Pubitemid 43201949)
23. PD Bliese NJ Wesensten TJ Balkin 2006 Age and individual variability in performance during sleep restriction Journal of Sleep Research 15 376 385 17118094
24. DL Bliwise 1993 Sleep in normal aging and dementia Sleep 16 40 81 1:STN:280:DyaK3s3gsF2lsw%3D%3D 8456235 (Pubitemid 23024697)
25. DL Bliwise MA Carskadon WC Dement 1988 Nightly variation of periodic leg movements in sleep in middle aged and elderly individuals Archives of Gerontology and Geriatrics 7 273 279 1:STN:280:DyaL1M7kvFanug%3D%3D 3228331 (Pubitemid 19001048)
26. DL Bliwise AC King RB Harris WL Haskell 1992 Prevalence of self-reported poor sleep in a healthy population aged 50-65 Social Science & Medicine 34 49 55 1:STN:280:DyaK387ltFWjtQ%3D%3D
27. DL Bliwise LM Trotti SA Greer JJ Juncos DB Rye 2010 Phasic muscle activity in sleep and clinical features of Parkinson disease Annals of Neurology 68 353 359 20626046
28. R Blois I Feinberg JM Gaillard DJ Kupfer WB Webb 1983 Sleep in normal and pathological aging Experientia 39 551 558 1:STN:280:DyaL3s3htVSksw%3D%3D 6343111 (Pubitemid 13053530)
29. R Bodizs M Bekesy A Szucs P Barsi P Halasz 2002 Sleep-dependent hippocampal slow activity correlates with waking memory performance in humans Neurobiology of Learning and Memory 78 441 457 12431428 (Pubitemid 35366021)
30. MH Bonnet 1986 Performance and sleepiness following moderate sleep disruption and slow wave sleep deprivation Physiology & Behavior 37 915 918 1:STN:280:DyaL2s%2Fmslyguw%3D%3D (Pubitemid 16051653)
31. MH Bonnet 1989 The effect of sleep fragmentation on sleep and performance in younger and older subjects Neurobiology of Aging 10 21 25 1:STN:280:DyaL1MzjtVKqtg%3D%3D 2755554 (Pubitemid 19164496)
32. GS Brassington AC King DL Bliwise 2000 Sleep problems as a risk factor for falls in a sample of community-dwelling adults aged 64-99 years Journal of the American Geriatrics Society 48 1234 1240 1:STN:280:DC%2BD3cvos1GlsA%3D%3D 11037010
33. G Buzsaki RG Bickford G Ponomareff LJ Thal R Mandel FH Gage 1988 Nucleus basalis and thalamic control of neocortical activity in the freely moving rat The Journal of Neuroscience 8 4007 4026 1:STN:280:DyaL1M%2Fjs1egsw%3D%3D 3183710 (Pubitemid 19017388)
34. DJ Capampangan KE Wellik JM Parish MI Aguilar CR Snyder D Wingerchuk, et al. 2010 Is obstructive sleep apnea an independent risk factor for stroke? A critically appraised topic The Neurologist 16 269 273 20592572
35. AL Chesson Jr M Wise D Davila S Johnson M Littner WM Anderson, et al. 1999 Practice parameters for the treatment of restless legs syndrome and periodic limb movement disorder. An american academy of sleep medicine report. Standards of practice committee of the american academy of sleep medicine Sleep 22 961 968 10566915
36. Chotinaiwattarakul, W., Dayalu, P., Chervin, R. D., & Albin, R. L. (2010). Risk of sleep-disordered breathing in Parkinson's disease. Sleep Breath.
37. IM Colrain KE Crowley CL Nicholas L Afifi FC Baker M Padilla, et al. 2010 Sleep evoked delta frequency responses show a linear decline in amplitude across the adult lifespan Neurobiology of Aging 31 874 883 18657881
38. IM Colrain KE Webster G Hirst 1999 The N550 component of the evoked K-complex: a modality non-specific response? Journal of Sleep Research 8 273 280 1:STN:280:DC%2BD3c7htFKgtA%3D%3D 10646167 (Pubitemid 30000370)
39. KA Cote TM Epps KB Campbell 2000 The role of the spindle in human information processing of high-intensity stimuli during sleep Journal of Sleep Research 9 19 26 1:STN:280:DC%2BD3c7pvVGjtg%3D%3D 10733685 (Pubitemid 30195289)
40. K Crowley EV Sullivan E Adalsteinsson A Pfefferbaum IM Colrain 2005 Differentiating pathologic delta from healthy physiologic delta in patients with Alzheimer disease Sleep 28 865 870 16124667 (Pubitemid 40993718)
41. K Crowley J Trinder IM Colrain 2002f An examination of evoked K-complex amplitude and frequency of occurrence in the elderly Journal of Sleep Research 11 129 140 (Pubitemid 34587804)
42. K Crowley J Trinder IM Colrain 2004 Evoked K-complex generation: the impact of sleep spindles and age Clinical Neurophysiology 115 471 476 14744590 (Pubitemid 38117269)
43. K Crowley J Trinder Y Kim M Carrington IM Colrain 2002 The effects of normal aging on sleep spindle and K-complex production Clinical Neurophysiology 113 1615 1622 12350438 (Pubitemid 35283949)
44. CA Czeisler M Dumont JF Duffy JD Steinberg GS Richardson EN Brown, et al. 1992 Association of sleep-wake habits in older people with changes in output of circadian pacemaker Lancet 340 933 936 1:STN:280:DyaK3s%2Fitlalug%3D%3D 1357348
45. CA Czeisler ED Weitzman MC Moore-Ede RE Kronauer JC Zimmerman C Campbell 1980 Human sleep: its duration and structure depend on the interaction of two separate circadian oscillators Sleep Research 9 270
46. Daan, S., & Beersma, D. (1984). Circadian gating of human sleep-wake cycles. In M. C. Moore-Ede & C. A. Czeisler (Eds.), Mathematical models of the circadian sleep-wake cycle (pp. 129-158). New York: Raven.
47. WC Dement LE Miles MA Carskadon 1982 "White paper" on sleep and aging Journal of the American Geriatrics Society 30 25 50 1:STN:280: DyaL387itV2htw%3D%3D 7035529
48. Dement, W. C., Richardson, G. S., Prinz, P., Carskadon, M. A., Kripke, D., & Czeisler, C. A. (1985). Changes of sleep and wakefulness with age. In C. E. Finch & E. L. Schneider (Eds.), Handbook of the biology of aging (pp. 692-717). New York: Van Nostrand Reinhold Company.
49. MA Dew CC Hoch DJ Buysse TH Monk AE Begley P Houck, et al. 2003 Healthy older adults' sleep predicts all-cause mortality at 4 to 19 years of follow-up Psychosomatic Medicine 65 63 73 12554816 (Pubitemid 36143197)
50. MJ Dickel SS Mosko 1990 Morbidity cut-offs for sleep apnea and periodic leg movements in predicting subjective complaints in seniors Sleep 13 155 166 1:STN:280:DyaK3c3jt1aksA%3D%3D 2330474 (Pubitemid 20112676)
51. DJ Dijk DGM Beersma S Daan 1987 EEG power density during nap sleep: reflection of an hourglass measuring the duration of prior wakefulness Journal of Biological Rhythms 2 207 219 1:STN:280:DyaK387htVKiuw%3D%3D 2979661
52. DJ Dijk DGM Beersma S Daan GM Bloem RH VandenHoofdakker 1987 Quantitative analysis of the effects of slow wave sleep deprivation during the first 3 h of sleep on subsequent EEG power density European Archives of Psychiatry and Neurological Sciences 236 323 328 1:STN:280:DyaL1c%2FlsFWltQ%3D%3D 3678290
53. DJ Dijk C Cajochen 1997 Melatonin and the circadian regulation of sleep initiation, consolidation, structure, and the sleep EEG Journal of Biological Rhythms 12 627 635 1:CAS:528:DyaK1cXhsF2luro%3D 9406038 (Pubitemid 127477099)
54. DJ Dijk CA Czeisler 1994 Paradoxical timing of the circadian rhythm of sleep propensity serves to consolidate sleep and wakefulness in humans Neuroscience Letters 166 63 68 1:STN:280:DyaK2c3kslOnsQ%3D%3D 8190360 (Pubitemid 24047900)
55. DJ Dijk JF Duffy CA Czeisler 1992 Circadian and sleep/wake dependent aspects of subjective alertness and cognitive performance Journal of Sleep Research 1 112 117 1:STN:280:DC%2BD3Mnls1Sgtg%3D%3D 10607036
56. DJ Dijk JF Duffy CA Czeisler 2000 Contribution of circadian physiology and sleep homeostasis to age-related changes in human sleep Chronobiology International 17 285 311 1:STN:280:DC%2BD3cvotFOmsw%3D%3D 10841208 (Pubitemid 30366507)
57. DJ Dijk TK Kelly E Riel JF Duffy CA Czeisler 1999 Altered homeostatic delta EEG response to sleep loss in older people? Sleep 22 suppl S226
58. DJ Dijk TL Shanahan JF Duffy JM Ronda CA Czeisler 1997 Variation of electroencephalographic activity during non-rapid eye movement and rapid eye movement sleep with phase of circadian melatonin rhythm in humans Journal of Physiology, London 505 3 851 858 1:CAS:528:DyaK1cXitVertA%3D%3D (Pubitemid 28022381)
59. I Driscoll C Davatzikos Y An X Wu D Shen M Kraut, et al. 2009 Longitudinal pattern of regional brain volume change differentiates normal aging from MCI Neurology 72 1906 1913 1:STN:280:DC%2BD1Mzot1yisA%3D%3D 19487648
60. JF Duffy CA Czeisler 2002 Age-related change in the relationship between circadian period, circadian phase, and diurnal preference in humans Neuroscience Letters 318 117 120 1:CAS:528:DC%2BD38XmsFKitg%3D%3D 11803113 (Pubitemid 34136023)
61. JF Duffy DJ Dijk EB Klerman CA Czeisler 1998 Later endogenous circadian temperature nadir relative to an earlier wake time in older people The American Journal of Physiology 275 R1478 R1487 1:CAS:528:DyaK1cXnsF2gurc%3D 9791064
62. JF Duffy HJ Willson W Wang CA Czeisler 2009 Healthy older adults better tolerate sleep deprivation than young adults Journal of the American Geriatrics Society 57 1245 1251 19460089
63. S Durston HE Hulshoff Pol BJ Casey JN Giedd JK Buitelaar EH Van 2001 Anatomical MRI of the developing human brain: what have we learned? Journal of the American Academy of Child and Adolescent Psychiatry 40 1012 1020 1:STN:280:DC%2BD3Mrgslygtw%3D%3D 11556624 (Pubitemid 32803813)
64. CL Ehlers DJ Kupfer 1989 Effects of age on delta and REM sleep parameters Electroencephalography and Clinical Neurophysiology 72 118 125 1:STN:280:DyaL1M7itVOlug%3D%3D 2464482 (Pubitemid 19045231)
65. CL Ehlers DJ Kupfer 1997 Slow-wave sleep: Do young adult men and women age differently? Journal of Sleep Research 6 211 215 1:STN:280: DyaK1c%2FitlagtQ%3D%3D 9358400 (Pubitemid 27414462)
66. I Eisensehr R Linke S Noachtar J Schwarz FJ Gildehaus K Tatsch 2000 Reduced striatal dopamine transporters in idiopathic rapid eye movement sleep behaviour disorder. Comparison with Parkinson's disease and controls Brain 123 Pt 6 1155 1160 10825354 (Pubitemid 30312107)
67. M Elton O Winter D Heslenfeld D Loewy K Campbell A Kok 1997 Event-related potentials to tones in the absence and presence of sleep spindles Journal of Sleep Research 6 78 83 1:STN:280:DyaK1c%2FitVKhsA%3D%3D 9377537 (Pubitemid 27300265)
68. I Feinberg IG Campbell 2003 Kinetics of non-rapid eye movement delta production across sleep and waking in young and elderly normal subjects: theoretical implications Sleep 26 192 200 12683479 (Pubitemid 39610696)
69. I Feinberg RL Koresko N Heller 1967 EEG sleep patterns as a function of normal and pathological aging in man Journal of Psychiatric Research 5 107 144 1:STN:280:DyaF1c%2FktFKnsg%3D%3D 6056816
70. D Foley S Ancoli-Israel P Britz J Walsh 2004 Sleep disturbances and chronic disease in older adults: results of the 2003 National Sleep Foundation Sleep in America Survey Journal of Psychosomatic Research 56 497 502 15172205 (Pubitemid 38686688)
71. DJ Foley K Masaki L White EK Larkin A Monjan S Redline 2003 Sleep-disordered breathing and cognitive impairment in elderly Japanese-American men Sleep 26 596 599 12938814 (Pubitemid 39610653)
72. DJ Foley AA Monjan SL Brown EM Simonsick RB Wallace DG Blazer 1995 Sleep complaints among elderly persons: An epidemiologic study of three communities Sleep 18 425 432 1:STN:280:DyaK28%2Fms1Whtg%3D%3D 7481413
73. JF Gagnon RB Postuma S Mazza J Doyon J Montplaisir 2006 Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases Lancet Neurology 5 424 432 16632313
74. PR Gehrman JL Martin T Shochat S Nolan J Corey-Bloom S Ancoli-Israel 2003 Sleep-disordered breathing and agitation in institutionalized adults with Alzheimer disease The American Journal of Geriatric Psychiatry 11 426 433 12837671 (Pubitemid 36807638)
75. JN Giedd 2004 Structural magnetic resonance imaging of the adolescent brain Annals of the New York Academy of Sciences 1021 77 85 15251877 (Pubitemid 38879613)
76. JC Gillin WF Byerley 1990 Drug therapy: the diagnosis and management of insomnia New England Journal of Medicine 322 239 248 1:STN:280: DyaK3c%2FpvVSmsA%3D%3D 2242104 (Pubitemid 20034512)
77. J Godoy P Mellado J Tapia J Santin 2009 Obstructive sleep apnea as an independent stroke risk factor: possible mechanisms Current Molecular Medicine 9 203 209 1:CAS:528:DC%2BD1MXkvVSgs74%3D 19275628
78. CD Good IS Johnsrude J Ashburner RN Henson KJ Friston RS Frackowiak 2001 A voxel-based morphometric study of ageing in 465 normal adult human brains Neuroimage 14 21 36 1:STN:280:DC%2BD3MvotFCntg%3D%3D 11525331 (Pubitemid 32552740)
79. FO Goulart BA Godke V Borges SM Azevedo-Silva MF Mendes MS Cendoroglo, et al. 2009 Fatigue in a cohort of geriatric patients with and without Parkinson's disease Brazilian Journal of Medical and Biological Research 42 771 775 1:STN:280:DC%2BD1MrivFygsw%3D%3D 19649404
80. P Hauri J Whisby 1992 Wrist actigraph in insomnia Sleep 15 293 301 1:STN:280:DyaK38zptVKgtQ%3D%3D 1519002
81. PJ Hauri J Wisbey 1994 Actigraphy and insomnia: a closer look part 2: A reply to Dr. Mark J. Chambers Sleep 17 408 410
82. TS Horowitz BE Cade JM Wolfe CA Czeisler 2003 Searching night and day: a dissociation of effects of circadian phase and time awake on visual selective attention and vigilance Psychological Science 14 549 557 14629685 (Pubitemid 37550856)
83. R Huber MF Ghilardi M Massimini G Tononi 2004 Local sleep and learning Nature 430 78 81 1:CAS:528:DC%2BD2cXlt1CqtLo%3D 15184907 (Pubitemid 38915227)
84. TL Jernigan SL Archibald C Fennema-Notestine AC Gamst JC Stout J Bonner, et al. 2001 Effects of age on tissues and regions of the cerebrum and cerebellum Neurobiology of Aging 22 581 594 1:STN:280:DC%2BD3MzptFaqsA%3D%3D 11445259 (Pubitemid 32607743)
85. P Johansson U Alehagen E Svanborg U Dahlstrom A Brostrom 2009 Sleep disordered breathing in an elderly community-living population: relationship to cardiac function, insomnia symptoms and daytime sleepiness Sleep Medicine 10 1005 1011 19464948
86. MP Johnson JF Duffy DJ Dijk JM Ronda CM Dyal CA Czeisler 1992 Short-term memory, alertness and performance: a reappraisal of their relationship to body temperature Journal of Sleep Research 1 24 29 1:STN:280:DC%2BD3Mnls1SgsQ%3D%3D 10607021
87. KG Johnson DC Johnson 2010 Frequency of sleep apnea in stroke and TIA patients: a meta-analysis Journal of Clinical Sleep Medicine 6 131 137 20411688
88. KG Johnson DC Johnson 2010 Obstructive sleep apnea is a risk factor for stroke and atrial fibrillation Chest 138 239 240 20605835
89. Klein, D. C., Moore, R. Y., & Reppert, S. M. (1991). Suprachiasmatic nucleus: The mind's clock. New York: Oxford University Press.
90. V Knoblauch M Münch K Blatter WLJ Martens C Schröder C Schnitzler, et al. 2005 Age-related changes in the circadian modulation of sleep-spindle frequency during nap sleep Sleep 28 1093 1101 16268378 (Pubitemid 41279506)
91. S Kubicki W Scheuler M Jobert C Pastelak-Price 1989 The effect of age on sleep spindle and K complex density EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb 20 59 63 1:STN:280:DyaL1M3htVCnsQ%3D%3D 2495925 (Pubitemid 19095817)
92. H-P Landolt DJ Dijk P Achermann AA Borbély 1996 Effect of age on the sleep EEG: slow-wave activity and spindle frequency activity in young and middle-aged men Brain Research 738 205 212 1:CAS:528:DyaK28Xms1CjsLg%3D 8955514 (Pubitemid 26378913)
93. LH Larsen KE Moe MV Vitiello PN Prinz 1995 Age trends in the sleep EEG of healthy older men and women Journal of Sleep Research 4 160 172 10607155
94. SM McCurry CF Reynolds S Ancoli-Israel L Teri MV Vitiello 2000 Treatment of sleep disturbance in Alzheimer's disease Sleep Medicine Reviews 4 603 628 12531038 (Pubitemid 32104354)
95. TH Monk 2005 Aging human circadian rhythms: conventional wisdom may not always be right Journal of Biological Rhythms 20 366 374 16077155 (Pubitemid 41022979)
96. J Montplaisir S Boucher A Gosselin G Poirier G Lavigne 1996 Persistence of repetitive EEG arousals (K-alpha complexes) in RLS treated with L-Dopa Sleep 19 196 199 1:STN:280:DyaK28zgtlymsg%3D%3D 8723375 (Pubitemid 26138223)
97. SS Mosko MJ Dickel J Ashurst 1988a Night-to-night variability in sleep apnea and sleep-related periodic leg movements in the elderly Sleep 11 340 348 1:STN:280:DyaL1M%2FosValtA%3D%3D
98. SS Mosko MJ Dickel T Paul 1988b Sleep apnea and sleep-related periodic leg movements in community seniors Journal of the American Geriatrics Society 36 502 508 1:STN:280:DyaL1c3ivVyguw%3D%3D
99. MS Mourtazaev B Kemp AH Zwinderman HAC Kamphuisen 1995 Age and gender affect different characteristics of slow wave in the sleep EEG Sleep 18 557 564 1:STN:280:DyaK28%2FpvVOmtA%3D%3D 8552926
100. SL Naismith NL Rogers J Mackenzie IB Hickie SJ Lewis 2010 The relationship between actigraphically defined sleep disturbance and REM sleep behaviour disorder in Parkinson's Disease Clinical Neurology and Neurosurgery 112 420 423 20303647
101. KA Niggemyer A Begley T Monk DJ Buysse 2004 Circadian and homeostatic modulation of sleep in older adults during a 90-minute day study Sleep 27 1535 1541 15683145 (Pubitemid 40041623)
102. Y Niiyama M Fushimi A Sekine Y Hishikawa 1995 K-complex evoked in NREM sleep is accompanied by a slow negative potential related to cognitive process Electroencephalography and Clinical Neurophysiology 95 27 33 1:STN:280:DyaK2MzkslaltQ%3D%3D 7621767
103. MM Ohayon MA Carskadon C Guilleminault MV Vitiello 2004 Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan Sleep 27 1255 1273 15586779 (Pubitemid 44138893)
104. EJ Olson BF Boeve MH Silber 2000 Rapid eye movement sleep behaviour disorder: demographic, clinical and laboratory findings in 93 cases Brain 123 331 339 10648440 (Pubitemid 30055156)
105. PE Peppard T Young M Palta J Skatrud 2000 Prospective study of the association between sleep-disordered breathing and hypertension The New England Journal of Medicine 342 1378 1384 1:STN:280:DC%2BD3c3kvVyhuw%3D%3D 10805822 (Pubitemid 30262394)
106. CM Peralta B Frauscher K Seppi E Wolf GK Wenning B Hogl, et al. 2009 Restless legs syndrome in Parkinson's disease Movement Disorders 24 2076 2080 19691124
107. A Pfefferbaum E Adalsteinsson D Spielman EV Sullivan KO Lim 1999 In vivo spectroscopic quantification of the N-acetyl moiety, creatine, and choline from large volumes of brain gray and white matter: effects of normal aging Magnetic Resonance in Medicine 41 276 284 1:CAS:528:DyaK1MXhvVSitbg%3D 10080274 (Pubitemid 29104512)
108. A Pfefferbaum DH Mathalon EV Sullivan JM Rawles RB Zipursky KO Lim 1994 A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood Archives of Neurology 51 874 887 1:STN:280:DyaK2czmtFKhuw%3D%3D 8080387 (Pubitemid 24286042)
109. B Phillips T Young L Finn K Asher W Hening C Purvis 2000 Epidemiology of restless legs syndrome in adults Archives of Internal Medicine 160 2137 2141 1:STN:280:DC%2BD3czptVKnsA%3D%3D 10904456 (Pubitemid 30482720)
110. CP Pollak D Perlick 1991 Sleep problems and institutionalization of the elderly Journal of Geriatric Psychiatry and Neurology 4 204 210 1:STN:280:DyaK387mt1WmtQ%3D%3D 1789908
111. PC Portela JC Fumado HQ Garcia FR Borrego 2009 Sleep-disordered breathing and acute stroke Cerebrovascular Diseases 27 Suppl 1 104 110 19342839
112. RB Postuma JF Gagnon M Vendette JY Montplaisir 2009 Idiopathic REM sleep behavior disorder in the transition to degenerative disease Movement Disorders 24 2225 2232 19768814
113. N Raz KM Rodrigue 2006 Differential aging of the brain: patterns, cognitive correlates and modifiers Neuroscience and Biobehavioral Reviews 30 730 748 16919333 (Pubitemid 44292292)
114. N Raz KM Rodrigue EM Haacke 2007 Brain aging and its modifiers: insights from in vivo neuromorphometry and susceptibility weighted imaging Annals of the New York Academy of Sciences 1097 84 93 17413014 (Pubitemid 47084893)
115. Rechtschaffen, A., & Kales, A. (1968). A manual of standardized terminology, techniques and scoring system for sleep stages of human Subjects. Washington: U.S. Government Printing Office.
116. CF Reynolds III JR Jennings CC Hoch TH Monk SR Berman FT Hall, et al. 1991a Daytime sleepiness in healthy "old old": A comparison with young adults Journal of the American Geriatrics Society 39 957 962
117. CF Reynolds III TH Monk CC Hoch JR Jennings DJ Buysse PR Houck, et al. 1991b Electroencephalographic sleep in the healthy "Old Old"; a comparison with the "Young Old" in visually scored and automated measures Journal of Gerontology 46 M39 M46
118. P Riekkinen G Buzsaki P Riekkinen H Soininen J Partanen 1991 The cholinergic system and EEG slow waves Electroencephalography and Clinical Neurophysiology 78 2 89 96 1:STN:280:DyaK3M7jvVGltA%3D%3D 1704840
119. P Riekkinen J Sirviö P Riekkinen 1990 Relationship between the cortical choline acetyltransferase content and EEG delta-power Neuroscience Research 8 1 12 20 1:CAS:528:DyaK3MXisVWjtbw%3D 2163045 (Pubitemid 20115652)
120. GV Robinson JR Stradling RJ Davies 2004 Sleep. 6: obstructive sleep apnoea/hypopnoea syndrome and hypertension Thorax 59 1089 1094 1:STN:280:DC%2BD2cnhtlWntA%3D%3D 15563710 (Pubitemid 39573930)
121. T Roth S Ancoli-Israel 1999 Daytime consequences and correlates of insomnia in the United States: results of the 1991 national sleep foundation survey II Sleep 22 S354 S358 10394607
122. AS Shamsuzzaman BJ Gersh VK Somers 2003 Obstructive sleep apnea: implications for cardiac and vascular disease JAMA. 290 1906 1914 1:CAS:528:DC%2BD3sXotVWktbo%3D 14532320 (Pubitemid 37430608)
123. T Shochat R Luboshitzky P Lavie 1997 Nocturnal melatonin onset is phase locked to the primary sleep gate The American Journal of Physiology 273 R364 R370 1:CAS:528:DyaK2sXltFCqs78%3D 9249573
124. Silva, E. J., Wang, W., Ronda, J. M., Wyatt, J. K., & Duffy, J. F. (2010). Circadian and wake-dependent influences on subjective sleepiness, cognitive throughput, and reaction time performance in older and young adults. Sleep.
125. ER Sowell BS Peterson E Kan RP Woods J Yoshii R Bansal, et al. 2007 Sex differences in cortical thickness mapped in 176 healthy individuals between 7 and 87 years of age Cerebral Cortex 17 1550 1560 16945978
126. ER Sowell DA Trauner A Gamst TL Jernigan 2002 Development of cortical and subcortical brain structures in childhood and adolescence: a structural MRI study Developmental Medicine and Child Neurology 44 4 16 11811649 (Pubitemid 34051455)
127. DA Spriggs JM French JM Murdy RH Curless D Bates OF James 1992 Snoring increases the risk of stroke and adversely affects prognosis Quarterly Journal of Medicine 83 555 562 1:STN:280:DyaK3s7jsVSjsA%3D%3D 1484933
128. M Steriade 1994 Sleep oscillations and their blockage by activating systems Journal of Psychiatry & Neuroscience 19 354 358 1:STN:280: DyaK2M7gtFGqug%3D%3D
129. M Steriade 1997 Synchronized activities of coupled oscillators in the cerebral cortex and thalamus at different levels of vigilance Cerebral Cortex 7 583 604 1:STN:280:DyaK2svit1Sqtw%3D%3D 9276182
130. M Steriade F Amzica D Contreras 1996 Synchronizaton of fast (30-40 Hz) spontaneous cortical rhythms during brain activation The Journal of Neuroscience 16 392 417 1:CAS:528:DyaK28Xht1Wisg%3D%3D 8613806 (Pubitemid 26010725)
131. M Steriade D Contreras DR Curro A Nunez 1993 The slow (< 1 Hz) oscillation in reticular thalamic and thalamocortical neurons: scenario of sleep rhythm generation in interacting thalamic and neocortical networks The Journal of Neuroscience 13 3284 3299 1:STN:280:DyaK3szktVOjsQ%3D%3D 8340808 (Pubitemid 23241168)
132. M Steriade RC Dossi A Nunez 1991 Network modulation of a slow intrinsic oscillation of cat thalamocortical neurons implicated in sleep delta waves: cortically induced synchronization and brainstem cholinergic suppression The Journal of Neuroscience 11 3200 3217 1:STN:280:DyaK38%2FksVOlug%3D%3D 1941080
133. M Steriade DA McCormick TJ Sejnowski 1993 Thalamocortical oscillations in the sleeping and aroused brain Science 262 679 685 1:STN:280: DyaK2c%2FltlOjsg%3D%3D 8235588 (Pubitemid 23350685)
134. M Steriade A Nunez F Amzica 1993 Intracellular analysis of relations between the slow (< 1 Hz) neocortical oscillation and other sleep rhythms of the electroencephalogram The Journal of Neuroscience 13 3266 3283 1:STN:280:DyaK3szktVOjsA%3D%3D 8340807 (Pubitemid 23241167)
135. F Stocchi L Barbato G Nordera A Berardelli S Ruggieri 1998 Sleep disorders in Parkinson's disease Journal of Neurology 245 Suppl 1 S15 S18 9617717
136. CG Swift B Tiplady 1988 The effects of age on the response to caffeine Psychopharmacology (Berl) 94 29 31 1:CAS:528:DyaL1cXmvVymtA%3D%3D (Pubitemid 18009060)
137. G Tononi C Cirelli 2003 Sleep and synaptic homeostasis: a hypothesis Brain Research Bulletin 62 143 150 14638388 (Pubitemid 37443660)
138. LM Trotti 2010 REM sleep behaviour disorder in older individuals: epidemiology, pathophysiology and management Drugs & Aging 27 457 470 1:CAS:528:DC%2BC3cXhtVajs73K
139. A Van Coevorden J Mockel E Laurent M Kerkhofs M L'Hermite- Balériaux C Decoster, et al. 1991 Neuroendocrine rhythms and sleep in aging men The American Journal of Physiology 260 E651 E661 2018128
140. MV Vitiello DL Bliwise PN Prinz 1992 Sleep in Alzheimer's disease and the sundown syndrome Neurology 42 83 93 1:STN:280:DyaK38zjsVKguw%3D%3D 1630644
141. MV Vitiello LH Larsen KE Moe 2004 Age-related sleep change: Gender and estrogen effects on the subjective-objective sleep quality relationships of healthy, noncomplaining older men and women Journal of Psychosomatic Research 56 503 510 15172206 (Pubitemid 38686689)
142. Walhovd, K. B., Westlye, L. T., Amlien, I., Espeseth, T., Reinvang, I., Raz, N. et al. (2009). Consistent neuroanatomical age-related volume differences across multiple samples. Neurobiology of Aging.
143. WB Webb 1982 Sleep in older persons: sleep structures of 50- to 60-year-old men and women Journal of Gerontology 37 581 586 1:STN:280: DyaL383ktVCmsw%3D%3D 7096931 (Pubitemid 12064353)
144. HG Wei E Riel CA Czeisler DJ Dijk 1999 Attenuated amplitude of circadian and sleep-dependent modulation of electroencephalographic sleep spindle characteristics in elderly human subjects Neuroscience Letters 260 29 32 1:CAS:528:DyaK1MXhslejtA%3D%3D 10027692 (Pubitemid 29066894)
145. ED Weitzman ML Moline CA Czeisler JC Zimmerman 1982 Chronobiology of aging: Temperature, sleep-wake rhythms and entrainment Neurobiology of Aging 3 299 309 1:STN:280:DyaL3s7pt1Ogsg%3D%3D 7170047 (Pubitemid 13086150)
146. JK Wyatt A Ritz-De Cecco CA Czeisler DJ Dijk 1999 Circadian temperature and melatonin rhythms, sleep, and neurobehavioral function in humans living on a 20-h day American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 277 R1152 R1163 1:CAS:528:DyaK1MXntF2gsb8%3D
147. HK Yaggi J Concato WN Kernan JH Lichtman LM Brass V Mohsenin 2005 Obstructive sleep apnea as a risk factor for stroke and death The New England Journal of Medicine 353 2034 2041 1:CAS:528:DC%2BD2MXht1SrtrnO 16282178 (Pubitemid 41609096)
148. T Young M Palta J Dempsey J Skatrud S Weber S Badr 1993 The occurrence of sleep-disordered breathing among middle-aged adults The New England Journal of Medicine 328 1230 1235 1:STN:280:DyaK3s3hvVKlug%3D%3D 8464434 (Pubitemid 23115702)
149. T Young E Shahar FJ Nieto S Redline AB Newman DJ Gottlieb, et al. 2002 Predictors of sleep-disordered breathing in community-dwelling adults: the sleep heart health study Archives of Internal Medicine 162 893 900 11966340 (Pubitemid 34299121)
150. SD Youngstedt DF Kripke MR Klauber RS Sepulveda WJ Mason 1998 Periodic leg movements during sleep and sleep disturbances in elders Journal of Gerontology 53A M391 M394
151. JM Zeitzer JE Daniels JF Duffy EB Klerman TL Shanahan DJ Dijk, et al. 1999 Do plasma melatonin concentrations decline with age? The American Journal of Medicine 107 432 436 1:CAS:528:DyaK1MXnvFymurY%3D 10569297 (Pubitemid 29528331)
152. H Zepelin CS McDonald GK Zammit 1984 Effects of age on auditory awakening thresholds Journal of Gerontology 39 294 300 1:STN:280:DyaL2c7os1Ojug%3D%3D 6715806 (Pubitemid 14140692)
153. Zoccolella, S., Savarese, M., Lamberti, P., Manni, R., Pacchetti, C., & Logroscino, G. (2010) Sleep disorders and the natural history of Parkinson's disease: The contribution of epidemiological studies. Sleep Med Rev, Jul 13.