Hydrazine-sensitive thiol protecting group for peptide and protein chemistry

Organic Letters

Volumn 13, Issue 4, 2011, Pages 568-571

  Shen, Fei ^a   Zhang, Zhi Ping ^a   Li, Jia Bin ^a   Lin, Yun ^a   Liu, Lei ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; DEFENSIN; HYDRAZINE DERIVATIVE; NEUTROPHIL DEFENSIN HNP2, HUMAN; PEPTIDE; TRIFOLITOXIN;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; PH; SYNTHESIS;

CYSTEINE; DEFENSINS; HUMANS; HYDRAZINES; HYDROGEN-ION CONCENTRATION; MOLECULAR STRUCTURE; PEPTIDES;

EID: 79951662569     PISSN: 15237060     EISSN: 15237052     Source Type: Journal    
DOI: 10.1021/ol1028755     Document Type: Article

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36. Note that the deprotection of Hqm at pH 8.5 may cause disulfide-bond isomerization. Our HPLC analysis indicated that this did not occur in the synthesis of hNP2. Detailed enzymatic degradation analysis on this problem will be reported in our ensuing studies.